2. Apoptosis MAPK/ERK Pathway Immunology/Inflammation
  3. MDM-2/p53 JNK SOD
  4. S-Diclofenac

S-Diclofenac  (Synonyms: ACS 15; ATB-337)

Cat. No.: HY-15035 Purity: 99.20%
COA
SDS
Handling Instructions Technical Support

S-Diclofenac (ACS 15) is a hybrid molecule of an H2S donor and the NSAID diclofenac. S-Diclofenac activates the p53 signaling pathway, and inhibits the activation of JNK. S-Diclofenac exhibits antioxidant and anti-inflammatory activities.

For research use only. We do not sell to patients.

S-Diclofenac Chemical Structure

S-Diclofenac Chemical Structure

CAS No. : 912758-00-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of S-Diclofenac:

S-Diclofenac Related Antibodies

Top Publications Citing Use of Products

View All JNK Isoform Specific Products:

View All Isoforms
JNK1 JNK2 JNK3 JNK

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

S-Diclofenac (ACS 15) is a hybrid molecule of an H2S donor and the NSAID diclofenac. S-Diclofenac activates the p53 signaling pathway, and inhibits the activation of JNK. S-Diclofenac exhibits antioxidant and anti-inflammatory activities[1][2][3][4].

In Vitro

S-Diclofenac (0-100 μM, 48 h) induces the expression of p53 protein, thereby activating downstream proteins such as p21, p53AIP1 and Bax. S-Diclofenac arrests the cell cycle at sub-G1 phase, and induces apoptosis in rat aortic vascular smooth muscle cells[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

S-Diclofenac Related Antibodies

Western Blot Analysis[4]

Cell Line: rat aortic vascular smooth muscle cells
Concentration: 50 μM
Incubation Time: 48 h
Result: Upregulated the expressions of p53, p21, p53AIP1 and Bax protein.

Apoptosis Analysis[4]

Cell Line: rat aortic vascular smooth muscle cells
Concentration: 0-100 μM
Incubation Time: 48 h
Result: Induced apoptosis.
In Vivo

S-Diclofenac (6-24 mg/kg, ip, single dose) releases hydrogen sulfide (H2S) and inhibits cyclooxygenase-mediated inflammatory responses, ameliorates Carrageenan (HY-125474)-induced hindpaw edema in rats models[2].
S-Diclofenac (12.5-25 mg/kg, ip, one daily for 14 days) reverses the remodeling of cardiac gap junctions, alleviates oxidative stress and inflammatory response, thereby reducing Doxorubicin (HY-15142)-induced myocardial injury and cardiac dysfunction in mouse models[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Carrageenan-induced rats hindpaw edema models[2]
Dosage: 6-24 mg/kg
Administration: ip, single dose
Result: Decreased the myeloperoxidase activity, inhibited hind paw edema.
Animal Model: Doxorubicin-induced mouse cardiomyopathy models[3]
Dosage: 12.5-25 mg/kg
Administration: ip, one daily for 14 days
Result: Inhibited the downregulation of cardiac gap junction proteins Cx43 and Cx45.
Increased the activity of SOD, MPO and GSH-Px in the heart and reduced the level of MDA.
Improved the survival rate of mice.
Molecular Weight

504.47

Formula

C23H15Cl2NO2S3
CAS No.
Appearance

Solid

Color

Reddish brown to red

SMILES

O=C(CC1=C(NC2=C(Cl)C=CC=C2Cl)C=CC=C1)OC3=CC=C(C(SS4)=CC4=S)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (198.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9823 mL 9.9114 mL 19.8228 mL
5 mM 0.3965 mL 1.9823 mL 3.9646 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9823 mL 9.9114 mL 19.8228 mL 49.5570 mL
5 mM 0.3965 mL 1.9823 mL 3.9646 mL 9.9114 mL
10 mM 0.1982 mL 0.9911 mL 1.9823 mL 4.9557 mL
15 mM 0.1322 mL 0.6608 mL 1.3215 mL 3.3038 mL
20 mM 0.0991 mL 0.4956 mL 0.9911 mL 2.4778 mL
25 mM 0.0793 mL 0.3965 mL 0.7929 mL 1.9823 mL
30 mM 0.0661 mL 0.3304 mL 0.6608 mL 1.6519 mL
40 mM 0.0496 mL 0.2478 mL 0.4956 mL 1.2389 mL
50 mM 0.0396 mL 0.1982 mL 0.3965 mL 0.9911 mL
60 mM 0.0330 mL 0.1652 mL 0.3304 mL 0.8259 mL
80 mM 0.0248 mL 0.1239 mL 0.2478 mL 0.6195 mL
100 mM 0.0198 mL 0.0991 mL 0.1982 mL 0.4956 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

S-Diclofenac Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S-Diclofenac912758-00-0ACS 15 ATB-337ACS15ACS-15ATB337ATB 337ATB-337MDM-2/p53JNKSODc-Jun N-terminal kinaseSuperoxide DismutaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
S-Diclofenac
Cat. No.:
HY-15035
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (252 KB) Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB) Italian - IT (252 KB) Portuguese - PT (252 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.