1. Apoptosis
  2. MDM-2/p53 Apoptosis
  3. TRAP-1

TRAP-1 (XJZ-06-462) is a selective p53Y220C transcriptional activator. TRAP-1 can engage p53Y220C and BRD4 in a ternary complex, which potently activates mutant p53 and triggers robust p53 target gene transcription. TRAP-1 rapidly upregulates p21 and other p53 target genes in pancreatic cell lines with p53Y220C. TRAP-1 exhibits higher antiproliferative activity in BxPC-3 (p53Y220C) cells than in A549 cells (p53WT), with IC50 values of 0.531 μM and 3.94 μM, respectively. TRAP-1 can be used for the study of p53Y220C-bearing cancer.

For research use only. We do not sell to patients.

TRAP-1 Chemical Structure

TRAP-1 Chemical Structure

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Based on 1 publication(s) in Google Scholar

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Description

TRAP-1 (XJZ-06-462) is a selective p53Y220C transcriptional activator. TRAP-1 can engage p53Y220C and BRD4 in a ternary complex, which potently activates mutant p53 and triggers robust p53 target gene transcription. TRAP-1 rapidly upregulates p21 and other p53 target genes in pancreatic cell lines with p53Y220C. TRAP-1 exhibits higher antiproliferative activity in BxPC-3 (p53Y220C) cells than in A549 cells (p53WT), with IC50 values of 0.531 μM and 3.94 μM, respectively. TRAP-1 can be used for the study of p53Y220C-bearing cancer.

Molecular Weight

1108.69

Formula

C57H66ClF3N11O3PS

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N1CCN(CC2CCN(C(CN3CCC(NC4=CC=CC5=C4C=C(C#CCNC6=CC=C(P(C)(C)=O)C=C6)N5CC(F)(F)F)CC3)=O)CC2)CC1)C[C@H]7C8=NN=C(C)N8C9=C(C(C)=C(C)S9)C(C%10=CC=C(Cl)C=C%10)=N7

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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TRAP-1
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HY-169369
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