IGFBP2 Protein, Cynomolgus (HEK293, His)

IGFBP2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IGFBP2 protein, expressed by HEK293, with C-His tag.

IGFBP2 is a multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors, thereby controlling IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type-specific manner. It functions coordinately with receptor protein tyrosine phosphatase beta/PTPRB and the IGF1 receptor to modulate IGF1-mediated signaling by stimulating PTEN phosphorylation, leading to its inactivation and AKT1 activation. Additionally, IGFBP2 promotes cell migration via interaction with integrin alpha5/ITGA5 through an RGD motif, while its interaction with ITGA5/ITGB1 enhances endothelial progenitor cell adhesion to endothelial cells. Upon mitochondrial damage, IGFBP2 facilitates apoptosis in podocytes alongside ITGA5 and activates focal adhesion kinase (FAK)-mediated mitochondrial injury phosphorylation.

Cynomolgus

HEK293

C-8*His

A0A2K5WZA2 (G33-Q325)

/

Full Length of Mature Protein

Approximately 35-45 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

Greater than 95% as determined by Bis-Tris PAGE.

<1 EU/μg, determined by LAL method.