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Lecanemab (Mouse IGG2a) is a monoclonal antibody that targets soluble β-amyloid and has the potential to reduce cognitive decline. The variable region of Lecanemab (Mouse IGG2a) is consistent with that of Lecanemab, while the constant region is of Mouse IGG2a sequence. Lecanemab (Mouse IGG2a) holds promise for research in the field of Alzheimer's disease .
Platycoside E is a platycodigenin-type saponin isolated from the root of Platycodon grandiflorum with haemolytic activity and adjuvant potential. Platycoside E promotes the production of the sera OVA-specific IgG2a and IgG2b antibody in the ovalbumin (OVA)-immunized mice .
Enlimomab (BI-RR 0001), a murine IgG2a monoclonal antibody to the human ICAM-1, inhibits leukocyte adhesion to the vascular endothelium, thereby decreasing leukocyte extravasation and inflammatory tissue injury. Enlimomab has anti-inflammatory effects, and can be used for stroke research [2] .
Fremanezumab (TEV-48125) is a humanized IgG2a monoclonal antibody that selectively and potently binds to calcitonin gene-related peptide (CGRP). CGRP is a 37-amino acid neuropeptide involved in central and peripheral pathophysiological events of migraine. Fremanezumab has the potential for chronic migraine research .
Anti-CD28 Antibody (9.3) is an anti-human CD28IgG2a monoclonal antibody. Anti-CD28 Antibody (9.3) can activate T cells. Anti-CD28 Antibody (9.3) can be used for research on immunology. The recommend isotype control of Anti-CD28 Antibody (9.3): Mouse IgG2a kappa, Isotype Control (HY-P99978) [2].
Aducanumab (Mouse IGG2a) is a monoclonal antibody that selectively targets aggregated amyloid-beta (Aβ). The variable region of Aducanumab (Mouse IGG2a) is consistent with that of Aducanumab (HY-P9967), while the constant region is of Mouse IGG2a sequence. Aducanumab (Mouse IGG2a) has strong selectivity for Aβ fibrils with EC50s of >1 μM and 0.2 nM for monomeric Aβ1-40 and fibrillar Aβ1-42, respectively. Aducanumab (Mouse IGG2a) can be used for Alzheimer's disease (AD) research .
Anti-Mouse VEGFR-2 Antibody (DC101-Mouse IgG2a) is an anti-mouse VEGFR-2IgG2a monoclonal antibody. Anti-Mouse VEGFR-2 Antibody (DC101-Mouse IgG2a) is a chimeric antibody of the original DC101 antibody (HY-P990106). Anti-Mouse VEGFR-2 Antibody (DC101-Mouse IgG2a) can react with mouse VEGFR-2 .
Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1-Mouse IgG2a) is a mouse-derived IgG2a κ antibody inhibitor that targets mouse 4-1BBL/CD137L. Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1-Mouse IgG2a) is a chimeric version of the original TKS-1 antibody (HY-P990304). The variable domain sequences are identical to the original TKS-1 but the constant region sequences have been switched from rat IgG2a to mouse IgG2a. Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1-Mouse IgG2a) reacts with mouse 4-1BB ligand (4-1BBL). Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1-Mouse IgG2a) can be used for the researches of cancer, infection, inflammation and immunology.
Donanemab (Mouse IgG2a) is a chimeric antibody composed of humanized variable regions and a mouse IgG2b backbone. Donanemab (Mouse IgG2b) is an anti-amyloid inhibitor used in Alzheimer's disease research.
Tositumomab (Anti-Human CD20 Recombinant Antibody) is a mouse-derived IgG2a monoclonal antibody, targeting to human CD20. Tositumomab can deplete B cells. Tositumomab can be used for the research of cancer, such as lymphoma [2].
VSA 2, a saponin-based vaccine adjuvant, is a derivative of Momordica saponin (MS) II. VSA 2 is an immunostimulant, shows consistent enhancement of immunoglobulin G2a (IgG2a) production when it was in formulation with either ovalbumin or recombinant hemagglutinin B (rHagB) antigen .
Anti-Mouse PD-1 Antibody (RMP1-14) is an anti-mouse PD-1IgG2a antibody. Anti-Mouse PD-1 Antibody (RMP1-14) can be used for the study of colon carcinoma .
Anti-Mouse GITR (LALA-PG) Antibody (DTA-1) is an anti-mouse GITRIgG2a monoclonal antibody. Anti-Mouse GITR (LALA-PG) Antibody (DTA-1) is a chimeric antibody of the original DTA-1 antibody (HY-P990124). Anti-Mouse GITR (LALA-PG) Antibody (DTA-1) contains the LALA-PG mutation region. Anti-Mouse GITR (LALA-PG) Antibody (DTA-1) can be used for research on cancer and allergic conditions. The recommed isotype control of Anti-Mouse GITR (LALA-PG) Antibody (DTA-1) is Mouse IgG2a kappa, Isotype Control (HY-P99978).
Anti-Mouse CD20 Antibody (AISB12) is an anti-mouse CD20IgG2a monoclonal antibody. Anti-Mouse CD20 Antibody (AISB12) can deplete B cells. Anti-Mouse CD20 Antibody (AISB12) can be used for research on immunology [2].
Anti-CD8α Antibody (OKT-8) is an anti-human CD8αIgG2a monoclonal antibody. Anti-CD8α Antibody (OKT-8) can reduce the secretion of IFNγ. Anti-CD8α Antibody (OKT-8) can deplete CD8 + T cells. Anti-CD8α Antibody (OKT-8) can be used for researches on inflammation conditions and cancer such as B non-Hodgkin lymphomas (B-NHLs). The recommend isotype control of Anti-CD8α Antibody (OKT-8): Mouse IgG2a kappa, Isotype Control (HY-P99978) [2].
Anti-Mouse 4-1BBL/CD137L (LALA-PG) Antibody (TKS-1) is a mouse-derived IgG2a κ antibody inhibitor that targets mouse 4-1BBL/CD137L.Anti-Mouse 4-1BBL/CD137L (LALA-PG) Antibody (TKS-1) is a chimeric version of the original TKS-1 antibody (HY-P990304). The variable domain sequences are identical to the original TKS-1 but the constant region sequences have been switched from rat IgG2a to mouse IgG2a. Anti-Mouse 4-1BBL/CD137L (LALA-PG) Antibody (TKS-1) contains a LALA-PG mutation in the Fc fragment rendering it unable to bind to endogenous Fcγ receptors. Anti-Mouse 4-1BBL/CD137L (LALA-PG) Antibody (TKS-1) reacts with mouse 4-1BB ligand (4-1BBL). Anti-Mouse 4-1BBL/CD137L (LALA-PG) Antibody (TKS-1) can be used for the researches of cancer, infection, inflammation and immunology.
Anti-Mouse CD29 Antibody (KMI6) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD29. Anti-Mouse CD29 Antibody (KMI6) can neutralize CD29. Anti-Mouse CD29 Antibody (KMI6) can be used for the research of cancer, such as glioma .
Anti-CD133/PROM1 Antibody (CMab-43) is a human IgG2a monoclonal antibody (mAb) targeting PROM1/CD133. Anti-CD133/PROM1 Antibody (CMab-43) can be used in colon cancer research .
Anti-CD25/IL-2Rα Antibody (7G7B6) is an anti-human CD25/IL-2RαIgG2a monoclonal antibody. Anti-CD25/IL-2Rα Antibody (7G7B6) can inhibit the growth of tumors. Anti-CD25/IL-2Rα Antibody (7G7B6) can be used for research on leukemia. The recommend isotype control of Anti-CD25/IL-2Rα Antibody (7G7B6): Mouse IgG2a kappa, Isotype Control (HY-P99978) .
Anti-Mouse VEGF-A Antibody (2G11-2A05) is a rat-derived IgG2a κ type antibody inhibitor, tragrting to mouse VEGF-A with high affinity. Anti-Mouse VEGF-A Antibody (2G11-2A05) shows good anti-tumor effect in gastric cancer xenograft models .
Anti-Mouse TSLP Antibody (28F12) is an anti-mouse TSLPIgG2a monoclonal antibody. Anti-Mouse TSLP Antibody (28F12) weakens skin inflammation and allergic reactions by reducing Treg cells and lymph node cells. Anti-Mouse TSLP Antibody (28F12) can be used for research on allergic conditions [2] .
Anti-Mouse CD3ε Antibody (KT3) is a rat-derived IgG2a type antibody inhibitor, targeting to mouse CD3ε. Anti-Mouse CD3ε Antibody (KT3) increases thymocytes proliferation. Anti-Mouse CD3ε Antibody (KT3) can be used for the research of immunology [2] .
Anti-CD3 Antibody (OKT-3) is a kind of mouse IgG2a κ antibody inhibitor, targeting to human CD3. Anti-CD3 Antibody (OKT-3) decreases T cells. Anti-CD3 Antibody (OKT-3) can be used for the research of immunology, such as graft-versus-host disease [2] .
Bectumomab (IMMU-LL 2) is an humanized IgG2a mAb against human CD22 (antigen). Bectumomab is also an anti-lymphoma antibody fragment. Bectumomab can be used for imaging in combination with technetium 99 (Tc99m LL2 Fab). Moreover, Bectumomab examines in the staging of recurrent or newly diagnosed non-Hodgkin's lymphoma (NHL) and to assess targeting before radioimmunoresearch (RIT) .
Anti-Mouse IL-2 Antibody (S4B6-1) is an anti-mouse IL-2IgG2a monoclonal antibody. Anti-Mouse IL-2 Antibody (S4B6-1) can reduce CD4 + T cells and increase Tregs. Anti-Mouse IL-2 Antibody (S4B6-1) can induce Th17 cell differentiation. Anti-Mouse IL-2 Antibody (S4B6-1) can be used for research on cancer such as melanoma. The recommend isotype control of Anti-Mouse IL-2 Antibody (S4B6-1): Rat IgG2a kappa, Isotype Control (HY-P990679) [2] .
Anti-Mouse CD8 beta Antibody (53-5.8) is an anti-mouse CD8 betaIgG2a monoclonal antibody. Anti-Mouse CD8 beta Antibody (53-5.8) can deplete CD8 + T cells and enhance cytotoxicity. Anti-Mouse CD8 beta Antibody (53-5.8) can be used for research on immunology [2].
VSA 1, a semisynthetic QS-21 (HY-101092) analog, is a saponin adjuvant. VSA 1 potentiates antigen-specific IgG1 and IgG2a immune responses in BALB/c mice, indicating a mixed Th1/Th2 immune response. VSA 1 significantly improves vaccine efficacy after primary immunization and enhances homologous protection .
Anti-Fy3 Antibody (MIMA-29) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human Fy3. Anti-Fy3 Antibody (MIMA-29) binds to erythrocytes and induces RBC (red blood cells) clearance. Anti-Fy3 Antibody (MIMA-29) can be used for the research of metabolic disease .
Anti-Rat CD4 Antibody (OX-38) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to rat CD4. Anti-Rat CD4 Antibody (OX-38) can deplete CD4+ cells. Anti-Rat CD4 Antibody (OX-38) can be used for the researches of immunology and infection, such as borna disease and transplantation [2] .
Anti-Mouse CD86/B7-2 Antibody (GL-1) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD86/B7-2. Anti-Mouse CD86/B7-2 Antibody (GL-1) can be used for the researches of inflammation and immunology, such as allergic pulmonary inflammation [2] .
Anti-Mouse CD103 Antibody (M290) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD103. Anti-Mouse CD103 Antibody (M290) can neutralize CD103. Anti-Mouse CD103 Antibody (M290) can be used for the researches of cancer, inflammation, immunology and metabolic disease, such as B16.gp33 tumor, colitis and diabetes [2] .
Anti-Mouse CD73 Antibody (TY/23) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD73. Anti-Mouse CD73 Antibody (TY/23) can neutralize CD73. Anti-Mouse CD73 Antibody (TY/23) can be used for the researches of cancer, infection and immunology, such as B16F10 tumor and murine cytomegalovirus infection [2].
Anti-Mouse CD18 Antibody (M18/2) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD18. Anti-Mouse CD18 Antibody (M18/2) can neutralize lymphocyte function-associated antigen 1 (LFA-1). Anti-Mouse CD18 Antibody (M18/2) can be used for the researches of immunology, such as heart transplantation [2] .
Anti-Mouse/Rat/Human v-H-Ras Antibody (Y13-238) is an anti-mouse/rat/human v-H-RasIgG2a monoclonal antibody. Anti-Mouse/Rat/Human v-H-Ras Antibody (Y13-238) can be used as a control antibody. Anti-Mouse/Rat/Human v-H-Ras Antibody (Y13-238) is often used for immunofluorescence and immunoprecipitation [2] .
Anti-Rat CD2 Antibody (OX-34) is mouse-derived IgG2a κ type antibody inhibitor, targeting to rat CD2. Anti-Rat CD2 Antibody (OX-34) can block CD2 and inhibit the mixed lymphocyte reaction. Anti-Rat CD2 Antibody (OX-34) can be used for the researches of cancer, inflammation and immunology, such as RNK-16 tumor and arthritis [2] .
Anti-Mouse Ly6C Antibody (Monts 1) is a rat-derived anti-mouse Ly6CIgG2a type antibody inhibitor. Anti-Mouse Ly6C Antibody (Monts 1) depletes monocytes, neutrophils, and some other granulocyte populations. Anti-Mouse Ly6C Antibody (Monts 1) can be used for the researches of cancer, immunology and infection, such as chikungunya (CHIKV) and aggressive tumor [2] .
Luspatercept (mIgG2a) (RAP-536) is a fusion protein, consisting of a modified extracellular domain of human ActRIIB linked to the murine IgG2a Fc domain. Luspatercept (mIgG2a) inhibits Smad2/3 signaling, promotes differentiation of late-stage erythroid precursors and mitigates ineffective erythropoiesis (IE) in murine β-thalassemia. Luspatercept (mIgG2a) reduces anemia, α-globin aggregates, hemolysis, and disease complications of IE such as iron overload, splenomegaly, and bone defects .
Anti-LCMV Nucleoprotein Antibody (VL-4) is rat-derived IgG2a κ type antibody inhibitor, targeting to LCMV nucleoprotein. Anti-LCMV Nucleoprotein Antibody (VL-4) reacts with lymphocytic choriomeningitis virus (LCMV) nucleoprotein. Anti-LCMV Nucleoprotein Antibody (VL-4) stain LCMV-infected cell internally with no surface staining. Anti-LCMV Nucleoprotein Antibody (VL-4) can be used for the detections of immunofluorescence and flow cytometry in LCMV infection .
Anti-Mouse/Human Integrin β7 Antibody (FIB504) is an anti-mouse/human Integrin β7IgG2a monoclonal antibody. Anti-Mouse/Human Integrin β7 Antibody (FIB504) can reduce the residence of type 2 innate lymphoid cells (ILC2s). Anti-Mouse/Human Integrin β7 Antibody (FIB504) can be used for researches on inflammation conditions and cancer such as lupus nephritis and glioma [2].
Anti-Mouse CD45.2 Antibody (104.2) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse CD45.2. Anti-Mouse CD45.2 Antibody (104.2) can inhibit B Cell differentiation. Anti-Mouse CD45.2 Antibody (104.2) can be used for the researches of inflammation and immunology, such as LPS (HY-D1056)-induced inflammation and autoimmunity [2] .
Anti-Mouse CD11a/LFA-1α Antibody (M17/4) is an anti-mouse CD11a/LFA-1αIgG2a monoclonal antibody. Anti-Mouse CD11a/LFA-1α Antibody (M17/4) can reduce the recruitment of effector memory CD8 T cells. Anti-Mouse CD11a/LFA-1α Antibody (M17/4) promotes the formation of xenograft tumors by reducing immune rejection reactions. Anti-Mouse CD11a/LFA-1α Antibody (M17/4) can be used for researches on cancer, infection conditions and immunology such as glioblastoma, parasitic and bacterial infections. The recommend isotype control of Anti-Mouse CD11a/LFA-1α Antibody (M17/4): Rat IgG2a kappa, Isotype Control (HY-P990679) [2].
Anti-Mouse RGMb Antibody (307.9D1) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse RGMb. Anti-Mouse RGMb Antibody (307.9D1) blocks RGMb binding to PD-L2. Anti-Mouse RGMb Antibody (307.9D1) can be used for the researches of cancer inflammation and immunology, such as acute myeloid leukemia (AML) and graft versus-host disease (GVHD) [2] .
Anti-Mouse IL-21R Antibody (4A9) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IL-21R. Anti-Mouse IL-21R Antibody (4A9) blocks IL-21 signaling. Anti-Mouse IL-21R Antibody (4A9) can be used for the researches of cancer, infection immunology and inflammation, such as psoriasis, hepatocellular carcinoma and C. rodentium infection [2] .
Anti-Mouse CD27 Antibody (RM27-3E5) is an agonistic rat-derived IgG2a κ type antibody, targeting to mouse CD27. Anti-Mouse CD27 Antibody (RM27-3E5) stimulates CD 27. Anti-Mouse CD27 Antibody (RM27-3E5) can be used for the researches of cancer and immunology, such as B16cOVA tumor [2].
Anti-Mouse/Human TYRP1 Antibody (TA99) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse/human TYRP1. Anti-Mouse/Human TYRP1 Antibody (TA99) binds to Tyrp1 (tyrosinase related protein-1) on tumor. Anti-Mouse/Human TYRP1 Antibody (TA99) enhances infiltration of the tumor by CD8+ T cells. Anti-Mouse/Human TYRP1 Antibody (TA99) can be used for the research of melanoma .
Anti-Mouse CD8 Antibody (HB-129) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse CD8. Anti-Mouse CD8 Antibody (HB-129) can deplete CD8 + T cells. Anti-Mouse CD8 Antibody (HB-129) can be used for the researches of cancer, inflammation, immunology and metabolic disease, such as P815 tumor, experimental autoimmune thyroiditis (EAT) and graft versus host disease (GVHD) [2] .
Anti-Mouse/Human PrP/prion protein Antibody (TW1) is a mouse-derived IgG2a type antibody inhibitor, targeting to mouse/human PrP/prion protein. Anti-Mouse/Human PrP/prion protein Antibody (TW1) binds to both PrPc (cellular prion protein) and PrPSc (Scrapie Prion Protein) and blocks the interaction of prion protein with tau protein. Anti-Mouse/Human PrP/prion protein Antibody (TW1) can be used for the researches of Alzheimer’s disease (AD) .
Anti-West Nile/dengue virus E protein Antibody (E60) is mouse-derived IgG2a κ type antibody inhibitor, targeting to West Nile/dengue virus E protein. Anti-West Nile/dengue virus E protein Antibody (E60) can cross-neutralize West Nile virus (WNV) and dengue virus (DENV) envelope (E) protein. Anti-West Nile/dengue virus E protein Antibody (E60) can be used for the researches of WNV and DENV infection [2].
Anti-Mouse CD205 Antibody (NLDC-145) is a rat-derived IgG2aκ type antibody inhibitor, targeting to mouse CD205. Anti-Mouse CD205 Antibody (NLDC-145) reacts with CD205 also known as DEC-205. Anti-Mouse CD205 Antibody (NLDC-145) can be used for the researches of cancer, inflammation, immunology and metabolic disease, such as colitis, D2F2/E2 tumor and diabetes [2] .
Anti-Mouse CD45RB Antibody (MB23G2) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD45RB. Anti-Mouse CD45RB Antibody (MB23G2) blocks CD45RB and induces transplantation tolerance. Anti-Mouse CD45RB Antibody (MB23G2) can be used for the researches of infection, immunology and metabolic disease, such as diabetes and Mem71 (H3N1) virus-infection [2].
Anti-Mouse/Human phosphorylated PD-1/CD279 Antibody (407.6G12) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse/human phosphorylated PD-1/CD279. Anti-Mouse/Human phosphorylated PD-1/CD279 Antibody (407.6G12) can detect the phosphorylated form of the PD-1 ITSM by both western blot and flow cytometry .
Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC Class I. Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) reacts with the mouse H-2Kd MHC class I alloantigen. Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) can be used for immunology research, such as cardiac graft .
Anti-Mouse IL-12 p40 Antibody (C17.8) is a rat-derived anti-mouse IL-12 p40IgG2a κ type antibody inhibitor. Anti-Mouse IL-12 p40 Antibody (C17.8) binds p40 subunit of IL-12. Anti-Mouse IL-12 p40 Antibody (C17.8) can be used for the researches of inflammation, immunology and metabolic disease, such as diabetes and arthritis [2] .
Anti-Mouse NK1.1 Antibody (PK136) is an anti-mouse NK1.1IgG2a monoclonal antibody. Anti-Mouse NK1.1 Antibody (PK136) can deplete natural killer (NK) cells. Anti-Mouse NK1.1 Antibody (PK136) inhibits the JAK-STAT and NF-κB signaling pathways. Anti-Mouse NK1.1 Antibody (PK136) can be used for research on inflammation conditions such as non-alcoholic steatohepatitis (NASH) [2].
Anti-Human/Rat HER2 (neu) Antibody (7.16.4) is an anti-mouse HER2IgG2a monoclonal antibody. Anti-Human/Rat HER2 (neu) Antibody (7.16.4) reduces tumor cell proliferation by inhibiting the HER2 signaling pathway. Anti-Human/Rat HER2 (neu) Antibody (7.16.4) can activate CD8 + T cells. Anti-Human/Rat HER2 (neu) Antibody (7.16.4) can be used for research on cancer such as breast cancer [2].
Anti-CD44 Antibody (Hermes-1) is a kind of rat IgG2a κ chimeric antibody, targeting to human CD44. Anti-CD44 Antibody (Hermes-1) blocks the binding of hyaluronan to CD44. Anti-CD44 Antibody (Hermes-1) restores (Platelet-derived Growth Factor-BB)-induced β-receptor activation and motility in fibroblasts. Anti-CD44 Antibody (Hermes-1) causes partial loss of the anti-aging effect of hyaluronic [2] .
Anti-Mouse IL-12 p35 Antibody (C18.2) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IL-12 p35. Anti-Mouse IL-12 p35 Antibody (C18.2) can neutralize IL-12. Anti-Mouse IL-12 p35 Antibody (C18.2) can be used for the researches of infection, inflammation and immunology, such as airway inflammation and F. tularensis infection [2].
Anti-Mouse FGL-1 Antibody (177R4) is an anti-mouse FGL-1IgG2a monoclonal antibody. Anti-Mouse FGL-1 Antibody (177R4) can increase CD8 + T cell infiltration. Anti-Mouse FGL-1 Antibody (177R4) enhances the anti-tumor immune effect by blocking FGL1. Anti-Mouse FGL-1 Antibody (177R4) can be used for research on cancer such as lung cancer and breast cancer [2].
Anti-Mouse GM-CSF Antibody (MP1-22E9) is a rat-derived anti-mouse GM-CSFIgG2a antibody inhibitor. Anti-Mouse GM-CSF Antibody (MP1-22E9) can neutralize GM-CSF. Anti-Mouse GM-CSF Antibody (MP1-22E9) can be used for the researches of cancer, infection inflammation and immunology, such as cholangiocarcinoma and arthritis [2] .
Anti-Mouse IL-12 Antibody (R1-5D9) is a rat-derived IgG2a type antibody inhibitor, targeting to mouse IL-12. Anti-Mouse IL-12 Antibody (R1-5D9) can neutralize IL-12. Anti-Mouse IL-12 Antibody (R1-5D9) can be used for the researches of infection, inflammation and immunology, such as Leishmania infection and skin inflammation [2].
Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse CD40L/CD154. Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1) is a chimeric version of the original MR-1 antibody (HY-P990134). The variable domain sequences are identical to the original MR-1 but the constant region sequences have been switched from Armenian hamster IgG to mouse IgG2a. Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1) contains a LALA-PG mutation in the Fc fragment rendering it unable to bind to endogenous Fcγ receptors. Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1) blocks CD40/CD40L signaling. Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1) can be used for researches of cancer, inflammation and immunology.
Anti-Mouse IL-18 Antibody (YIGIF74-1G7) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IL-18. Anti-Mouse IL-18 Antibody (YIGIF74-1G7) can neutralize IL-18. Anti-Mouse IL-18 Antibody (YIGIF74-1G7) can be used for the researches of cancer, infection, inflammation and immunology, such as hepatocellular carcinoma and eosinophilic esophagitis [2] .
Anti-E-Selectin Antibody (CL2) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human E-Selectin. Anti-E-Selectin Antibody (CL2) reacts with human E-selectin also known as CD62E, endothelial-leukocyte adhesion molecule 1 (ELAM-1), and leukocyte-endothelial cell adhesion molecule 2 (LECAM2). Anti-E-Selectin Antibody (CL2) directly blocks the binding of E selectin to carbohydrate ligands. Anti-E-Selectin Antibody (CL2) can be used for the detection of flow cytometry [2].
Anti-Mouse 4-1BB/CD137 Antibody (3H3) is an anti-mouse 4-1BB/CD137IgG2a monoclonal antibody. Anti-Mouse 4-1BB/CD137 Antibody (3H3) can effectively activate memory T cells and inhibit tumors by increasing Bcl-xL and granzyme B levels. Anti-Mouse 4-1BB/CD137 Antibody (3H3) can be used for research on cancer such as lymphoma and colon cancer [2].
Anti-c-Kit/CD117 Antibody (SR-1) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human c-Kit/CD117. Anti-c-Kit/CD117 Antibody (SR-1) binds to the extracellular domain of human c-Kit (also known as CD117) and blocks stem cell factor (SCF) binding to CD117. Anti-c-Kit/CD117 Antibody (SR-1) can be used for the researches of cancer and immunology, such as gastrointestinal stromal tumor (GIST) and xenograft [2].
Anti-CTLA-4/CD152 Antibody (BN13) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human CTLA-4/CD152. Anti-CTLA-4/CD152 Antibody (BN13) can neutralize CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152. Anti-CTLA-4/CD152 Antibody (BN13) can be used for the researches of infection and immunology, such as human immunodeficiency virus (HIV) .
Anti-MHC Class I Antibody (W6/32) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human MHC Class I. Anti-MHC Class I Antibody (W6/32) reacts with the human major histocompatibility complex (MHC) class I, HLA-A, B, and C. Anti-MHC Class I Antibody (W6/32) increases adherence of monocytes to human endothelial cells. Anti-MHC Class I Antibody (W6/32) can be used for the research of immunology [2].
Anti-Monkey/Human CD40L/CD154 Antibody (5C8) is a mouse-derived IgG2a type antibody inhibitor, targeting to monkey/human CD40L/CD154. Anti-Monkey/Human CD40L/CD154 Antibody (5C8) blocks the interactionbetween CD154 and CD40. Anti-Monkey/Human CD40L/CD154 Antibody (5C8) can be used for the researches of inflammation and immunology, such as colitis and transplant [2].
Anti-Mouse CD71/TfR1 Antibody (8D3) is a rat-derived anti-mouse CD71/TfR1 IgG2a type antibody inhibitor. Anti-Mouse CD71/TfR1 Antibody (8D3) depletes of CD71+ erythroid cells but does not change percentages of Tregs in neonatal mice. Anti-Mouse CD71/TfR1 Antibody (8D3) enhances neonatal mice defence against infection [2].
Anti-Mouse MAdCAM-1 Antibody (MECA-367) is an anti-mouse MAdCAM-1IgG2a monoclonal antibody. Anti-Mouse MAdCAM-1 Antibody (MECA-367) significantly inhibits the migration of pig peripheral blood lymphocytes (PBL) by blocking the function of MAdCAM-1. Anti-Mouse MAdCAM-1 Antibody (MECA-367) selectively inhibits B cell migration to exacerbate inflammation. Anti-Mouse MAdCAM-1 Antibody (MECA-367) can be used for researches on inflammation, metabolic conditions and xenotransplantation such as colitis and diabetes [2] .
Anti-Mouse Thy1/CD90 Antibody (M5/49.4.1) is an anti-mouse Thy1/CD90IgG2a monoclonal antibody. Anti-Mouse Thy1/CD90 Antibody (M5/49.4.1) can clear T cells from the spleen and bone marrow. Anti-Mouse Thy1/CD90 Antibody (M5/49.4.1) can be used for researches on immunology and inflammation conditions such as colitis [2] .
Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) is a mouse-derived IgG2a κ type antibody, targeting to mouse/rat CD71/TfR1. Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) targets the transferrin receptor and binds to an extracellular domain for the transferrin receptor. Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) can be used for the research in drug delivery, especially for drug delivery to the brain .
Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC Class I. Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8) reacts with the mouse H-2 MHC class I alloantigen (all haplotypes). Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8) can be used for the flow cytometry and immunofluorescence experiments .
Anti-Mouse CD40 Antibody (FGK4.5/FGK45) is an agonistic rat-derived IgG2a monoclonal antibody targeting mouse CD40. Anti-Mouse CD40 Antibody (FGK4.5/FGK45) enhances T cells responses, dendritic cells maturation and NK cells activation. Anti-Mouse CD40 Antibody (FGK4.5/FGK45) can be used for the researches of cancer, infection, inflammation and immunology, such as CT26 tumor, vesicular stomatitis virus (VSV) infection and transplantation [2] .
Anti-Mouse/Human Mac-2/Galectin-3 Antibody (TIB-166) is a rat-derived anti-mouse/human Mac-2/Galectin-3IgG2a monoclonal antibody. Anti-Mouse/Human Mac-2/Galectin-3 Antibody (TIB-166) significantly inhibits IL-6 expression (inhibition rates 34.7% and 55.3%). Anti-Mouse/Human Mac-2/Galectin-3 Antibody (TIB-166) is often used for immunoprecipitation, western blot, immunofluorescence, and flow cytometry [2] .
Anti-Mouse Vβ8 TCR Antibody (F23.1) is an anti-mouse Vβ8 TCRIgG2a monoclonal antibody. Anti-Mouse Vβ8 TCR Antibody (F23.1) can clear Vβ8 + T cells to alleviate immune conditions. Anti-Mouse Vβ8 TCR Antibody (F23.1) can be used for research on autoimmune conditions. Anti-Mouse Vβ8 TCR Antibody (F23.1) is often used in flow cytometry [2].
Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) is a mouse-derived IgG2a κ type antibody inhibitor targeting to mouse CTLA-4/CD152. Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) contains a LALA-PG mutation in the Fc fragment rendering it unable to bind to endogenous Fcγ receptors. Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) can be used for the researches of cancer and immunology, such as colon [2].
Anti-Mouse TIM-4 Antibody (RMT4-54) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse TIM-4. Anti-Mouse TIM-4 Antibody (RMT4-54) reacts with mouse T cell immunoglobulin and mucin domain 4 (TIM-4) and blocks TIM-4 signaling. Anti-Mouse TIM-4 Antibody (RMT4-54) inhibits phagocytosis of apoptotic cells. Anti-Mouse TIM-4 Antibody (RMT4-54) can be used for the researches of immunology and metabolic disease [2].
Anti-Mouse PD-1 Antibody (29F.1A12) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse PD-1. Anti-Mouse PD-1 Antibody (29F.1A12) blocks the binding of PD-1 to its two ligands, PD-L1 and PD-L2. Anti-Mouse PD-1 Antibody (29F.1A12) can be used for the researches of cancer and immunology, such as CT26 tumor and pancreatic cancer [2] .
Anti-Mouse L-Selectin/CD62L Antibody (Mel-14) is an anti-mouse L-Selectin/CD62LIgG2a monoclonal antibody. Anti-Mouse L-Selectin/CD62L Antibody (Mel-14) can significantly inhibit the migration of T cells and B cells. Anti-Mouse L-Selectin/CD62L Antibody (Mel-14) can block initial lymphocyte homing. Anti-Mouse L-Selectin/CD62L Antibody (Mel-14) can be used for researches on inflammation, metabolic and infection conditions such as diabetes and parasitic infections [2] .
Anti-Mouse (CSF1R/CD115) Antibody (AFS98) is an anti-mouse CSF1RIgG2a antibody inhibitor derived from rats. Anti-Mouse (CSF1R/CD115) Antibody (AFS98) inhibits M-CSF-dependent colony formation and cell growth by blocking the binding of M-CSF to its receptor. Anti-Mouse (CSF1R/CD115) Antibody (AFS98) can be used for the researches of inflammation, metabolic disease, cardiovascular disease and neurological disease, such as such as stroke, diabetes and arthritis [2] .
Anti-Mouse CD122/IL-2Rβ Antibody (5H4) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD122/IL-2Rβ. Anti-Mouse CD122/IL-2Rβ Antibody (5H4) can inhibit IL-2. Anti-Mouse CD122/IL-2Rβ Antibody (5H4) can be used for the researches of cancer and immunology, such as hepatocellular carcinoma [2].
Anti-Mouse CD8a Antibody (53-6.7) is an anti-mouse CD8a IgG2a antibody inhibitor derived from host Rat. Anti-Mouse CD8a Antibody (53-6.7) binds to CD8αβ stabilizes a conformation with a higher affinity for interaction with MHC class I. Anti-Mouse CD8a Antibody (53-6.7) induces the phosphorylation and activation of TCR proximal signaling pathway components Lck and ZAP70 in polyclonal memory T cells. Anti-Mouse CD8a Antibody (53-6.7) depletes CD8+ T cells and neutralizes cytokine in mice [2] .
Anti-Mouse CD38 Antibody (NIMR5) is an anti-mouse CD38IgG2a monoclonal antibody. Anti-Mouse CD38 Antibody (NIMR5) can activate the ERK signaling pathway and promote cell apoptosis. Anti-Mouse CD38 Antibody (NIMR5) can restore T cell function. Anti-Mouse CD38 Antibody (NIMR5) upregulates the expression of CD1d protein and enhances spleen cell proliferation, dendritic cell (DC) and natural killer T cell (NKT) expansion. Anti-Mouse CD38 Antibody (NIMR5) can be used for researches on cancer and immunology such as melanoma and colon cancer [2] .
Anti-Mouse TIM-3 Antibody (RMT3-23) is a kind of rat-derived anti-mouse TIM-3IgG2a antibody inhibitor. Anti-Mouse TIM-3 Antibody (RMT3-23) blocks Tim-3 binding to phosphatidylserine (PtdSer) and carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1). Anti-Mouse TIM-3 Antibody (RMT3-23) inhibits phagocytosis of apoptotic cells in peritoneal exudate Mac1+ cells. Anti-Mouse TIM-3 Antibody (RMT3-23) can be used for the researches of inflammation and immunology, such as rheumatoid arthritis [2] .
Anti-Mouse CD28 (LALA-PG) Antibody (D665) is an anti-mouse CD28IgG2a monoclonal antibody. Anti-Mouse CD28 (LALA-PG) Antibody (D665) is a chimeric antibody of the original D665 antibody (HY-P990793). Anti-Mouse CD28 (LALA-PG) Antibody (D665) contains the LALA-PG mutation region. Anti-Mouse CD28 Antibody (D665) induces the activation of T cells. Anti-Mouse CD28 Antibody (D665) can be used for research on neurological conditions, inflammation, immunology and cancer, such as Parkinson disease (PD), arthritis and graft-versus-host disease (GVHD).
Anti-Mouse NKG2A/C/E Antibody (20D5) is an anti-mouse NKG2A/C/EIgG2a monoclonal antibody. Anti-Mouse NKG2A/C/E Antibody (20D5) can activate natural killer (NK) and CD8 + T cells. Anti-Mouse NKG2A/C/E Antibody (20D5) can exacerbate liver pathological damage by enhancing the activation of iNKT cells. Anti-Mouse NKG2A/C/E Antibody (20D5) can be used for researches on cancer and immunology such as lymphoma [2].
Anti-Mouse IL-9 Antibody (9C1) is an anti-mouse IL-9IgG2a monoclonal antibody. Anti-Mouse IL-9 Antibody (9C1) can reduce the activation of NF-κB signaling pathway and decrease the infiltration of inflammatory cells. Anti-Mouse IL-9 Antibody (9C1) effectively reduces Th9 cell-mediated allergic reactions and anti-tumor effects. Anti-Mouse IL-9 Antibody (9C1) can be used for researches on inflammation, infection conditions and cancer such as parasitic infections, allergic reactions, breast cancer and osteosarcoma [2] .
Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to monkey/human MHC class II. Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243) can inhibits tumor cells proliferation and induce apoptosis. Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243) increases cellular reactive oxygen species (ROS) and loss of mitochondrial membrane potential in human endothelial cells. Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243) can be used for the researches of cancer and infection, such as lymphoma [2] .
Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) is an anti-monkey/human MDR-1/CD243IgG2a monoclonal antibody. Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) can efficiently inhibit P-glycoprotein. Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) enhances the inhibitory effect on multidrug resistance (MDR) by suppressing drug efflux. Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) can be used for research on cancer [2].
Anti-Mouse CD31/PECAM-1 Antibody (390) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD31/PECAM-1. Anti-Mouse CD31/PECAM-1 Antibody (390) reacts with mouse CD31, also known as PECAM-1 (platelet endothelial cell adhesion molecule). Anti-Mouse CD31/PECAM-1 Antibody (390) inhibits angiogenesis. Anti-Mouse CD31/PECAM-1 Antibody (390) can be used for the research of cancer, such as A549 tumor [2].
Anti-Mouse RANKL/CD254 Antibody (IK22/5) is an anti-mouse RANKL/CD254IgG2a monoclonal antibody. Anti-Mouse RANKL/CD254 Antibody (IK22/5) inhibits osteoclast formation and activity by specifically blocking the binding of RANKL and RANK. Anti-Mouse RANKL/CD254 Antibody (IK22/5) can inhibit the expression of MuRF1/Trogin-1 and activation of NF-κB. Anti-Mouse RANKL/CD254 Antibody (IK22/5) can be used for research on cancer such as melanoma or colon cancer and osteoporosis [2] .
Anti-Mouse ICOSL/CD275 Antibody (HK5.3) is an anti-mouse ICOSL/CD275IgG2a monoclonal antibody. Anti-Mouse ICOSL/CD275 Antibody (HK5.3) can inhibit the adhesion between T cells and endothelial cells. Anti-Mouse ICOSL/CD275 Antibody (HK5.3) can reduce the expansion of tissue resident (TR) Treg cells. Anti-Mouse ICOSL/CD275 Antibody (HK5.3) can be used for researches on inflammation and infection conditions such as influenza virus infection and arthritis [2] .
Anti-MAGEC2/CT10 Antibody (LX-CT10.5) is a kind of mouse IgG2a κ chimeric antibody, targeting to human MAGEC2/CT10. Anti-MAGEC2/CT10 Antibody (LX-CT10.5) reacts with human melanoma-associated antigen C2 (MAGEC2), also known as CT10. Anti-MAGEC2/CT10 Antibody (LX-CT10.5) can be used for identifying MAGEC2 expressing cells in immunohistochemistry, immunofluorescence and western blot studies .
Anti-Mouse OX40/CD134 (LALA-PG) Antibody (OX86) is an anti-mouse OX40/CD134 (LALA-PG)IgG2a monoclonal antibody. Anti-Mouse OX40/CD134 (LALA-PG) Antibody (OX86) is a chimeric antibody of the original OX86 antibody (HY-P990115). Anti-Mouse OX40/CD134 (LALA-PG) Antibody (OX86) can significantly enhance the generation of antigen-specific effector T cells. Anti-Mouse OX40/CD134 (LALA-PG) Antibody (OX86) can be used for research on cancer .
Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) is an anti-mouse MHC Class I (H-2Kd, H-2Dd)IgG2a monoclonal antibody. Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) can block the interaction between Ly49 and MHC-I. Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) can be used for the construction of acute lung injury models [2].
Anti-Mouse CD326/EpCAM Antibody (G8.8) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD326/EpCAM. Anti-Mouse CD326/EpCAM Antibody (G8.8) reacts with CD326 also known as EpCAM (Epithelial Cell Adhesion Molecule). Anti-Mouse CD326/EpCAM Antibody (G8.8) can be used for cancer research, such as lung carcinoma and colorectal carcinoma. Anti-Mouse CD326/EpCAM Antibody (G8.8) can be used for detections of western blot, immunohistochemistry, immunofluorescence and flow cytometry [2].
Anti-Mouse PD-L2/B7-DC Antibody (TY25) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse PD-L2/B7-DC. Anti-Mouse PD-L2/B7-DC Antibody (TY25) blocks PD-L2 binding to PD-1 and blocks PD-1 signaling. Anti-Mouse PD-L2/B7-DC Antibody (TY25) can be used for the researches of inflammation and immunology, such as conjunctivitis and transplantation [2] .
Anti-CD54/ICAM-1 Antibody (R6-5-D6) is a kind of mouse IgG2a chimeric antibody inhibitor, targeting to human CD54/ICAM-1. Anti-CD54/ICAM-1 Antibody (R6-5-D6) can block CD54 binding to its ligand Lymphocyte Function-Associated Antigen 1 (LFA-1). Anti-CD54/ICAM-1 Antibody (R6-5-D6) can be used for the researches of inflammation and immunology [2].
Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD71/TfR1. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can deplete CD71 + cells and inhibit transferrin receptor. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can be used for the researches of cancer, infection, inflammation and immunology, such as lung cancer, lymphocytic choriomeningitis virus (LCMV) infection and Cardiac allograft [2] .
Anti-Mouse TIM-1/CD365 Antibody (3B3) is a rat-derived IgG2a κ type agonistic antibody, targeting to mouse TIM-1/CD365. Anti-Mouse TIM-1/CD365 Antibody (3B3) enhances T-cell proliferation and responses by forming a stable TIM-1 complex and bringing TIM-1 into the T-cell receptor (TCR)-CD3 complex. Anti-Mouse TIM-1/CD365 Antibody (3B3) can be used for the researches of cancer, inflammation and immunology, such as experimental autoimmune encephalomyelitis, B16 F10 tumor and transplant [2] .
Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) is an anti-mouse Thy1.1/CD90.1IgG2a monoclonal antibody. Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) can deplete CD90.1 + cells. Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) can clear Tregs. Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) can be used for researches on inflammation conditions and immune response such as airway inflammation and experimental autoimmune encephalomyelitis (EAE) [2] .
Anti-Mouse MHC class II (I-A) Antibody (Y-3P) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC class II. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) reacts with mouse MHC Class II haplotypes I-Ab, I-Af, I-Ap, I-Aq, I-Ar, I-As, I-Au, I-Av, and weakly with I-Ak. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) blocks MHC class II and inhibits expansion of regulate T cells. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) can be used for the immunology research .
Anti-Mouse CD80/B7-1 Antibody (RM80) is an anti-mouse CD80/B7-1IgG2a monoclonal antibody. Anti-Mouse CD80/B7-1 Antibody (RM80) can inhibit the number of tissue-resident memory (TRM) cells. Anti-Mouse CD80/B7-1 Antibody (RM80) can prolong the survival time of transplants combined with CD86 mAb. Anti-Mouse CD80/B7-1 Antibody (RM80) can be used for researches on inflammation conditions and immunology such as viral myocarditis and corneal transplant [2] .
Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IL-7Rα/CD127. Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) blocks IL-7 signaling. Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) can be used for the researches of cancer,infection, inflammation, immunology, cardiovascular and metabolic disease, such as abdominal aortic aneurysms, helicobacter felis-induced gastritis and diabetes [2] .
Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) is a rat-derived IgG2a κ antibody inhibitor, targeting to mouse 4-1BBL/CD137L. Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) can block 4-1BB ligand (4-1BBL) and inhibit CD4 + and CD8 + T cells. Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) can be used for the researches of cancer, infection, inflammation and immunology, such as MC38 tumor, lymphocytic choriomeningitis virus (LCMV) infection and herpetic stromal keratitis (HSK) [2] .
Anti-Mouse 4-1BB/CD137 (LALA-PG) Antibody (LOB12.3) is a mouse-derived IgG2a κ type antibody agonist, targeting to mouse 4-1BB/CD137. Anti-Mouse 4-1BB/CD137 (LALA-PG) Antibody (LOB12.3) is a chimeric antibody of the original LOB12.3 antibody (HY-P990809). Anti-Mouse 4-1BB/CD137 (LALA-PG) Antibody (LOB12.3) contains the LALA-PG mutation region. Anti-Mouse 4-1BB/CD137 (LALA-PG) Antibody (LOB12.3) can be used for the researches of cancer, infection, immunology and neurological disease.
Anti-Mouse MHC Class I (H-2Kk, H-2Dk) Antibody (15-3-1S (HB-13)) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC Class I. Anti-Mouse MHC Class I (H-2Kk, H-2Dk) Antibody (15-3-1S (HB-13)) reacts with the mouse H-2Kk and H-2Dk MHC class I alloantigens. Anti-Mouse MHC Class I (H-2Kk, H-2Dk) Antibody (15-3-1S (HB-13)) can be used for immunology research .
Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse ICOSL/CD275. Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) is a chimeric antibody of the original HK5.3 antibody (HY-P990123). Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) contains the LALA-PG mutation region. Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) can neutralize ICOSL. Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) can be used for researches of inflammation and infection.
Anti-Mouse IFNγR/CD119 Antibody (GR-20) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IFNγR/CD119.Anti-Mouse IFNγR/CD119 Antibody (GR-20) reacts with the mouse IFNγR (interferon gamma receptor) α chain also known as CD119 and IFNγ receptor 1. Anti-Mouse IFNγR/CD119 Antibody (GR-20) blocks the binding of IFNγ to CD119 therefore inhibiting IFNγ signaling. Anti-Mouse IFNγR/CD119 Antibody (GR-20) can be used for the researches of cancer, infection, inflammation and immunology, such as melanoma and C. trachomatis infected genital tract inflammation [2].
Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse/rat MHC Class II. Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) reacts with mouse MHC Class II alloantigen I-Ek and the rat MHC class II alloantigen RT1D. Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) blocks antigen presentation. Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) can be used for the research of immunology and cancer .
Anti-Influenza A virus NP Antibody (H16-L10-4R5 (HB-65)) is mouse-derived IgG2a κ type antibody inhibitor, targeting to influenza virus nucleoprotein. Anti-Influenza A virus NP Antibody (H16-L10-4R5 (HB-65)) reacts with influenza virus nucleoprotein (NP). Anti-Influenza A virus NP Antibody (H16-L10-4R5 (HB-65)) can induce passive immunity to influenza A virus. Anti-Influenza A virus NP Antibody (H16-L10-4R5 (HB-65)) can be used for the detections of western blot, flow cytometry and immunohistochemistry in Influenza A virus infection [2].
Anti-Mouse CD47/IAP Antibody (MIAP301) is an anti-mouse CD47/IAPIgG2a monoclonal antibody. Anti-Mouse CD47/IAP Antibody (MIAP301) can effectively block CD47 signaling and enhance macrophage phagocytic function. Anti-Mouse CD47/IAP Antibody (MIAP301) can increase the infiltration of immune cells. Anti-Mouse CD47/IAP Antibody (MIAP301) restores the phagocytic function of myeloid cells and alleviate B cell inhibition. Anti-Mouse CD47/IAP Antibody (MIAP301) may interfere with wound healing. Anti-Mouse CD47/IAP Antibody (MIAP301) can be used for researches on cancer, inflammation and infection conditions such as melanoma, intestinal mucosal repair and sepsis [2] .
Anti-Mouse CD16/CD32 (LALA-PG) Antibody (2.4G2) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse CD16/CD32. Anti-Mouse CD16/CD32 (LALA-PG) Antibody (2.4G2) is a chimeric antibody of the original 2.4G2 antibody (HY-P99125). Anti-Mouse CD16/CD32 (LALA-PG) Antibody (2.4G2) contains the LALA-PG mutation region. Anti-Mouse CD16/CD32 (LALA-PG) Antibody (2.4G2) can block the combination of CD16 and FcγRs. Anti-Mouse CD16/CD32 (LALA-PG) Antibody (2.4G2) can be used for the researches of immunology and cardiovascular disease.
Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) is a rat-derived anti-LPAM-1/Integrin α4β7 IgG2a, κ type antibody inhibitor. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) specifically reacts with both chains of the α4β7 heterodimer and blocks the adhesion to immobilized mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) suppresses the proliferation and cytokine secretion of CD8+ T cells. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) decreases Peyer’s patches and follicular B cells in mice. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) can be used for the researches of inflammation, such as ulcerative colitis [2] .
Anti-Mouse 4-1BBL/CD137L (D265A) Antibody (TKS-1) is a mouse-derived IgG1 κ antibody inhibitor that targets mouse 4-1BBL/CD137L. Anti-Mouse 4-1BBL/CD137L (D265A) Antibody (TKS-1) is a chimeric version of the original TKS-1 antibody (HY-P990304). The variable domain sequences are identical to the original TKS-1 but the constant region sequences have been switched from rat IgG2a to mouse IgG1. Anti-Mouse 4-1BBL/CD137L (D265A) Antibody (TKS-1) contains a D265A mutation in the Fc fragment rendering it unable to bind to endogenous Fcγ receptors. Anti-Mouse 4-1BBL/CD137L (D265A) Antibody (TKS-1) reacts with mouse 4-1BB ligand (4-1BBL). Anti-Mouse 4-1BBL/CD137L (D265A) Antibody (TKS-1) can be used for the researches of cancer, infection, inflammation and immunology.
Anti-Mouse PD-L1/B7-H1 (LALA-PG) Antibody (10F.9G2) is a recombinant chimeric version of the original 10F.9G2 antibody (HY-P99145). The variable domain sequences are identical to the original 10F.9G2 but the constant region sequences have been switched from rat IgG2b to mouse IgG2a. Anti-Mouse PD-L1/B7-H1 (LALA-PG) Antibody (10F.9G2) contains a LALA-PG mutation in the Fc fragment rendering it unable to bind to endogenous Fcγ receptors. Anti-Mouse PD-L1/B7-H1 (LALA-PG) Antibody (10F.9G2) blocks PD-1 signaling. Anti-Mouse PD-L1/B7-H1 (LALA-PG) Antibody (10F.9G2) can be used for the research of cancer.
MCE Protein G Agarose, a 4% highly cross-linked agarose reagent coupled with recombinant Protein G, effectively purifies mammalian monoclonal and polyclonal antibodies, such as human IgG3 and rat IgG2a.
Mouse IgG2a (D265A) kappa, isotype control is a mouse-derived IgG2a antibody inhibitor. Mouse IgG2a (D265A) kappa, isotype control reacts with hen egg lysozyme and has low or no specific binding to any mouse sample. Mouse IgG2a (D265A) kappa, isotype control is commonly used as an isotype control .
Rat IgG2a kappa, Isotype Control is a monoclonal antibody derived from rats, representing the immunoglobulin G2a (IgG2a) subclass with a kappa light chain. Rat IgG2a kappa, Isotype Control exhibits high efficiency in inducing K cell mediated cytotoxicity. Rat IgG2a kappa, Isotype Control is utilized in research investigating the roles of different immunoglobulin subclasses in tumor immunology .
Lecanemab (Mouse IGG2a) is a monoclonal antibody that targets soluble β-amyloid and has the potential to reduce cognitive decline. The variable region of Lecanemab (Mouse IGG2a) is consistent with that of Lecanemab, while the constant region is of Mouse IGG2a sequence. Lecanemab (Mouse IGG2a) holds promise for research in the field of Alzheimer's disease .
Anti-Rat IgG2a Antibody (RG7/1.30) is a mouse-derived IgG2b κ type antibody inhibitor, targeting to rat IgG2a. Anti-Rat IgG2a Antibody (RG7/1.30) reacts with the Fc region of rat IgG2a. Anti-Rat IgG2a Antibody (RG7/1.30) can be used for detections of immunofluorescence, flow cytometry and ELISA .
Vopratelimab (Mouse IgG2a) is a monoclonal antibody that selectively targets Inducible CO-Stimulator of T cells (ICOS). The variable region of Vopratelimab (Mouse IgG2a) is consistent with that of Vopratelimab (HY-P99382), while the constant region is of Mouse IgG2a sequence. Vopratelimab (Mouse IgG2a) has antitumor immune response and enhances combinatorial efficacy with anti-PD-1 (HY-P9902A) therapy .
Aducanumab (Mouse IGG2a) is a monoclonal antibody that selectively targets aggregated amyloid-beta (Aβ). The variable region of Aducanumab (Mouse IGG2a) is consistent with that of Aducanumab (HY-P9967), while the constant region is of Mouse IGG2a sequence. Aducanumab (Mouse IGG2a) has strong selectivity for Aβ fibrils with EC50s of >1 μM and 0.2 nM for monomeric Aβ1-40 and fibrillar Aβ1-42, respectively. Aducanumab (Mouse IGG2a) can be used for Alzheimer's disease (AD) research .
Anti-Mouse VEGFR-2 Antibody (DC101-Mouse IgG2a) is an anti-mouse VEGFR-2IgG2a monoclonal antibody. Anti-Mouse VEGFR-2 Antibody (DC101-Mouse IgG2a) is a chimeric antibody of the original DC101 antibody (HY-P990106). Anti-Mouse VEGFR-2 Antibody (DC101-Mouse IgG2a) can react with mouse VEGFR-2 .
Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1-Mouse IgG2a) is a mouse-derived IgG2a κ antibody inhibitor that targets mouse 4-1BBL/CD137L. Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1-Mouse IgG2a) is a chimeric version of the original TKS-1 antibody (HY-P990304). The variable domain sequences are identical to the original TKS-1 but the constant region sequences have been switched from rat IgG2a to mouse IgG2a. Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1-Mouse IgG2a) reacts with mouse 4-1BB ligand (4-1BBL). Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1-Mouse IgG2a) can be used for the researches of cancer, infection, inflammation and immunology.
Enlimomab (BI-RR 0001), a murine IgG2a monoclonal antibody to the human ICAM-1, inhibits leukocyte adhesion to the vascular endothelium, thereby decreasing leukocyte extravasation and inflammatory tissue injury. Enlimomab has anti-inflammatory effects, and can be used for stroke research [2] .
Fremanezumab (TEV-48125) is a humanized IgG2a monoclonal antibody that selectively and potently binds to calcitonin gene-related peptide (CGRP). CGRP is a 37-amino acid neuropeptide involved in central and peripheral pathophysiological events of migraine. Fremanezumab has the potential for chronic migraine research .
Anti-CD28 Antibody (9.3) is an anti-human CD28IgG2a monoclonal antibody. Anti-CD28 Antibody (9.3) can activate T cells. Anti-CD28 Antibody (9.3) can be used for research on immunology. The recommend isotype control of Anti-CD28 Antibody (9.3): Mouse IgG2a kappa, Isotype Control (HY-P99978) [2].
Donanemab (Mouse IgG2a) is a chimeric antibody composed of humanized variable regions and a mouse IgG2b backbone. Donanemab (Mouse IgG2b) is an anti-amyloid inhibitor used in Alzheimer's disease research.
Tositumomab (Anti-Human CD20 Recombinant Antibody) is a mouse-derived IgG2a monoclonal antibody, targeting to human CD20. Tositumomab can deplete B cells. Tositumomab can be used for the research of cancer, such as lymphoma [2].
Grisnilimab (WT1), a IgG2a monoclonal antibody anti-CD7, is a tumor suppressor involved in the etiology of Wilms' tumor. Grisnilimab regulates the transcription of multiple target genes and may participate in the post-transcriptional processing of RNA .
Anti-Mouse PD-1 Antibody (RMP1-14) is an anti-mouse PD-1IgG2a antibody. Anti-Mouse PD-1 Antibody (RMP1-14) can be used for the study of colon carcinoma .
Anti-Mouse GITR (LALA-PG) Antibody (DTA-1) is an anti-mouse GITRIgG2a monoclonal antibody. Anti-Mouse GITR (LALA-PG) Antibody (DTA-1) is a chimeric antibody of the original DTA-1 antibody (HY-P990124). Anti-Mouse GITR (LALA-PG) Antibody (DTA-1) contains the LALA-PG mutation region. Anti-Mouse GITR (LALA-PG) Antibody (DTA-1) can be used for research on cancer and allergic conditions. The recommed isotype control of Anti-Mouse GITR (LALA-PG) Antibody (DTA-1) is Mouse IgG2a kappa, Isotype Control (HY-P99978).
Anti-Mouse CD20 Antibody (AISB12) is an anti-mouse CD20IgG2a monoclonal antibody. Anti-Mouse CD20 Antibody (AISB12) can deplete B cells. Anti-Mouse CD20 Antibody (AISB12) can be used for research on immunology [2].
Anti-CD8α Antibody (OKT-8) is an anti-human CD8αIgG2a monoclonal antibody. Anti-CD8α Antibody (OKT-8) can reduce the secretion of IFNγ. Anti-CD8α Antibody (OKT-8) can deplete CD8 + T cells. Anti-CD8α Antibody (OKT-8) can be used for researches on inflammation conditions and cancer such as B non-Hodgkin lymphomas (B-NHLs). The recommend isotype control of Anti-CD8α Antibody (OKT-8): Mouse IgG2a kappa, Isotype Control (HY-P99978) [2].
Anti-Mouse 4-1BBL/CD137L (LALA-PG) Antibody (TKS-1) is a mouse-derived IgG2a κ antibody inhibitor that targets mouse 4-1BBL/CD137L.Anti-Mouse 4-1BBL/CD137L (LALA-PG) Antibody (TKS-1) is a chimeric version of the original TKS-1 antibody (HY-P990304). The variable domain sequences are identical to the original TKS-1 but the constant region sequences have been switched from rat IgG2a to mouse IgG2a. Anti-Mouse 4-1BBL/CD137L (LALA-PG) Antibody (TKS-1) contains a LALA-PG mutation in the Fc fragment rendering it unable to bind to endogenous Fcγ receptors. Anti-Mouse 4-1BBL/CD137L (LALA-PG) Antibody (TKS-1) reacts with mouse 4-1BB ligand (4-1BBL). Anti-Mouse 4-1BBL/CD137L (LALA-PG) Antibody (TKS-1) can be used for the researches of cancer, infection, inflammation and immunology.
Anti-Mouse CD29 Antibody (KMI6) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD29. Anti-Mouse CD29 Antibody (KMI6) can neutralize CD29. Anti-Mouse CD29 Antibody (KMI6) can be used for the research of cancer, such as glioma .
Anti-CD133/PROM1 Antibody (CMab-43) is a human IgG2a monoclonal antibody (mAb) targeting PROM1/CD133. Anti-CD133/PROM1 Antibody (CMab-43) can be used in colon cancer research .
Anti-CD25/IL-2Rα Antibody (7G7B6) is an anti-human CD25/IL-2RαIgG2a monoclonal antibody. Anti-CD25/IL-2Rα Antibody (7G7B6) can inhibit the growth of tumors. Anti-CD25/IL-2Rα Antibody (7G7B6) can be used for research on leukemia. The recommend isotype control of Anti-CD25/IL-2Rα Antibody (7G7B6): Mouse IgG2a kappa, Isotype Control (HY-P99978) .
Anti-Mouse VEGF-A Antibody (2G11-2A05) is a rat-derived IgG2a κ type antibody inhibitor, tragrting to mouse VEGF-A with high affinity. Anti-Mouse VEGF-A Antibody (2G11-2A05) shows good anti-tumor effect in gastric cancer xenograft models .
Anti-Mouse TSLP Antibody (28F12) is an anti-mouse TSLPIgG2a monoclonal antibody. Anti-Mouse TSLP Antibody (28F12) weakens skin inflammation and allergic reactions by reducing Treg cells and lymph node cells. Anti-Mouse TSLP Antibody (28F12) can be used for research on allergic conditions [2] .
Anti-Mouse CD3ε Antibody (KT3) is a rat-derived IgG2a type antibody inhibitor, targeting to mouse CD3ε. Anti-Mouse CD3ε Antibody (KT3) increases thymocytes proliferation. Anti-Mouse CD3ε Antibody (KT3) can be used for the research of immunology [2] .
Anti-CD3 Antibody (OKT-3) is a kind of mouse IgG2a κ antibody inhibitor, targeting to human CD3. Anti-CD3 Antibody (OKT-3) decreases T cells. Anti-CD3 Antibody (OKT-3) can be used for the research of immunology, such as graft-versus-host disease [2] .
Bectumomab (IMMU-LL 2) is an humanized IgG2a mAb against human CD22 (antigen). Bectumomab is also an anti-lymphoma antibody fragment. Bectumomab can be used for imaging in combination with technetium 99 (Tc99m LL2 Fab). Moreover, Bectumomab examines in the staging of recurrent or newly diagnosed non-Hodgkin's lymphoma (NHL) and to assess targeting before radioimmunoresearch (RIT) .
Anti-Mouse CD200 Antibody (OX-90) is an anti-mouse CD200IgG2a monoclonal antibody. Anti-Mouse CD200 Antibody (OX-90) can reduce immune cell infiltration and T cell function by blocking CD200. Anti-Mouse CD200 Antibody (OX-90) can be used for research on immunology [2].
Anti-Mouse IL-2 Antibody (S4B6-1) is an anti-mouse IL-2IgG2a monoclonal antibody. Anti-Mouse IL-2 Antibody (S4B6-1) can reduce CD4 + T cells and increase Tregs. Anti-Mouse IL-2 Antibody (S4B6-1) can induce Th17 cell differentiation. Anti-Mouse IL-2 Antibody (S4B6-1) can be used for research on cancer such as melanoma. The recommend isotype control of Anti-Mouse IL-2 Antibody (S4B6-1): Rat IgG2a kappa, Isotype Control (HY-P990679) [2] .
Anti-Mouse CD8 beta Antibody (53-5.8) is an anti-mouse CD8 betaIgG2a monoclonal antibody. Anti-Mouse CD8 beta Antibody (53-5.8) can deplete CD8 + T cells and enhance cytotoxicity. Anti-Mouse CD8 beta Antibody (53-5.8) can be used for research on immunology [2].
Anti-Fy3 Antibody (MIMA-29) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human Fy3. Anti-Fy3 Antibody (MIMA-29) binds to erythrocytes and induces RBC (red blood cells) clearance. Anti-Fy3 Antibody (MIMA-29) can be used for the research of metabolic disease .
Anti-Ganglioside GD2 Antibody (14G2a) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human Ganglioside GD2. Anti-Ganglioside GD2 Antibody (14G2a) can induce neuroblastoma cells autophagy and lysis. Anti-Ganglioside GD2 Antibody (14G2a) can be used for the research of cancer, such as neuroblastoma [2].
Anti-Mouse Ly6G Antibody (1A8) is a rat-derived anti-mouse Ly6GIgG2a, κ type antibody inhibitor. Anti-Mouse Ly6G Antibody (1A8) can deplete neutrophil in various mice. Anti-Mouse Ly6G Antibody (1A8) can be used for the researches of inflammation, such as arthritis and peritonitis [2].
Anti-Rat CD4 Antibody (OX-38) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to rat CD4. Anti-Rat CD4 Antibody (OX-38) can deplete CD4+ cells. Anti-Rat CD4 Antibody (OX-38) can be used for the researches of immunology and infection, such as borna disease and transplantation [2] .
Anti-Mouse CD86/B7-2 Antibody (GL-1) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD86/B7-2. Anti-Mouse CD86/B7-2 Antibody (GL-1) can be used for the researches of inflammation and immunology, such as allergic pulmonary inflammation [2] .
Anti-Mouse CD103 Antibody (M290) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD103. Anti-Mouse CD103 Antibody (M290) can neutralize CD103. Anti-Mouse CD103 Antibody (M290) can be used for the researches of cancer, inflammation, immunology and metabolic disease, such as B16.gp33 tumor, colitis and diabetes [2] .
Anti-Mouse CD73 Antibody (TY/23) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD73. Anti-Mouse CD73 Antibody (TY/23) can neutralize CD73. Anti-Mouse CD73 Antibody (TY/23) can be used for the researches of cancer, infection and immunology, such as B16F10 tumor and murine cytomegalovirus infection [2].
Anti-Mouse CD18 Antibody (M18/2) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD18. Anti-Mouse CD18 Antibody (M18/2) can neutralize lymphocyte function-associated antigen 1 (LFA-1). Anti-Mouse CD18 Antibody (M18/2) can be used for the researches of immunology, such as heart transplantation [2] .
Anti-Mouse/Rat/Human v-H-Ras Antibody (Y13-238) is an anti-mouse/rat/human v-H-RasIgG2a monoclonal antibody. Anti-Mouse/Rat/Human v-H-Ras Antibody (Y13-238) can be used as a control antibody. Anti-Mouse/Rat/Human v-H-Ras Antibody (Y13-238) is often used for immunofluorescence and immunoprecipitation [2] .
Anti-Rat CD2 Antibody (OX-34) is mouse-derived IgG2a κ type antibody inhibitor, targeting to rat CD2. Anti-Rat CD2 Antibody (OX-34) can block CD2 and inhibit the mixed lymphocyte reaction. Anti-Rat CD2 Antibody (OX-34) can be used for the researches of cancer, inflammation and immunology, such as RNK-16 tumor and arthritis [2] .
Anti-Mouse Ly6C Antibody (Monts 1) is a rat-derived anti-mouse Ly6CIgG2a type antibody inhibitor. Anti-Mouse Ly6C Antibody (Monts 1) depletes monocytes, neutrophils, and some other granulocyte populations. Anti-Mouse Ly6C Antibody (Monts 1) can be used for the researches of cancer, immunology and infection, such as chikungunya (CHIKV) and aggressive tumor [2] .
Luspatercept (mIgG2a) (RAP-536) is a fusion protein, consisting of a modified extracellular domain of human ActRIIB linked to the murine IgG2a Fc domain. Luspatercept (mIgG2a) inhibits Smad2/3 signaling, promotes differentiation of late-stage erythroid precursors and mitigates ineffective erythropoiesis (IE) in murine β-thalassemia. Luspatercept (mIgG2a) reduces anemia, α-globin aggregates, hemolysis, and disease complications of IE such as iron overload, splenomegaly, and bone defects .
Anti-LCMV Nucleoprotein Antibody (VL-4) is rat-derived IgG2a κ type antibody inhibitor, targeting to LCMV nucleoprotein. Anti-LCMV Nucleoprotein Antibody (VL-4) reacts with lymphocytic choriomeningitis virus (LCMV) nucleoprotein. Anti-LCMV Nucleoprotein Antibody (VL-4) stain LCMV-infected cell internally with no surface staining. Anti-LCMV Nucleoprotein Antibody (VL-4) can be used for the detections of immunofluorescence and flow cytometry in LCMV infection .
Anti-Mouse/Human Integrin β7 Antibody (FIB504) is an anti-mouse/human Integrin β7IgG2a monoclonal antibody. Anti-Mouse/Human Integrin β7 Antibody (FIB504) can reduce the residence of type 2 innate lymphoid cells (ILC2s). Anti-Mouse/Human Integrin β7 Antibody (FIB504) can be used for researches on inflammation conditions and cancer such as lupus nephritis and glioma [2].
Anti-Mouse CD45.2 Antibody (104.2) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse CD45.2. Anti-Mouse CD45.2 Antibody (104.2) can inhibit B Cell differentiation. Anti-Mouse CD45.2 Antibody (104.2) can be used for the researches of inflammation and immunology, such as LPS (HY-D1056)-induced inflammation and autoimmunity [2] .
Anti-Mouse CD11a/LFA-1α Antibody (M17/4) is an anti-mouse CD11a/LFA-1αIgG2a monoclonal antibody. Anti-Mouse CD11a/LFA-1α Antibody (M17/4) can reduce the recruitment of effector memory CD8 T cells. Anti-Mouse CD11a/LFA-1α Antibody (M17/4) promotes the formation of xenograft tumors by reducing immune rejection reactions. Anti-Mouse CD11a/LFA-1α Antibody (M17/4) can be used for researches on cancer, infection conditions and immunology such as glioblastoma, parasitic and bacterial infections. The recommend isotype control of Anti-Mouse CD11a/LFA-1α Antibody (M17/4): Rat IgG2a kappa, Isotype Control (HY-P990679) [2].
Anti-Mouse RGMb Antibody (307.9D1) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse RGMb. Anti-Mouse RGMb Antibody (307.9D1) blocks RGMb binding to PD-L2. Anti-Mouse RGMb Antibody (307.9D1) can be used for the researches of cancer inflammation and immunology, such as acute myeloid leukemia (AML) and graft versus-host disease (GVHD) [2] .
Anti-Mouse IL-21R Antibody (4A9) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IL-21R. Anti-Mouse IL-21R Antibody (4A9) blocks IL-21 signaling. Anti-Mouse IL-21R Antibody (4A9) can be used for the researches of cancer, infection immunology and inflammation, such as psoriasis, hepatocellular carcinoma and C. rodentium infection [2] .
Anti-Mouse CD27 Antibody (RM27-3E5) is an agonistic rat-derived IgG2a κ type antibody, targeting to mouse CD27. Anti-Mouse CD27 Antibody (RM27-3E5) stimulates CD 27. Anti-Mouse CD27 Antibody (RM27-3E5) can be used for the researches of cancer and immunology, such as B16cOVA tumor [2].
Anti-Mouse/Human TYRP1 Antibody (TA99) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse/human TYRP1. Anti-Mouse/Human TYRP1 Antibody (TA99) binds to Tyrp1 (tyrosinase related protein-1) on tumor. Anti-Mouse/Human TYRP1 Antibody (TA99) enhances infiltration of the tumor by CD8+ T cells. Anti-Mouse/Human TYRP1 Antibody (TA99) can be used for the research of melanoma .
Anti-Mouse Pan-endothelial Cell Antigen/MECA-32 Antibody (MECA-32) is an anti-mouse Pan-endothelial Cell Antigen/MECA-32IgG2a monoclonal antibody. Anti-Mouse Pan-endothelial Cell Antigen/MECA-32 Antibody (MECA-32) can label endothelial cells. Anti-Mouse Pan-endothelial Cell Antigen/MECA-32 Antibody (MECA-32) is often used for immunohistochemistry, delivery of siRNA and immunofluorescence [2] .
Anti-Mouse CD8 Antibody (HB-129) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse CD8. Anti-Mouse CD8 Antibody (HB-129) can deplete CD8 + T cells. Anti-Mouse CD8 Antibody (HB-129) can be used for the researches of cancer, inflammation, immunology and metabolic disease, such as P815 tumor, experimental autoimmune thyroiditis (EAT) and graft versus host disease (GVHD) [2] .
Anti-Mouse/Human PrP/prion protein Antibody (TW1) is a mouse-derived IgG2a type antibody inhibitor, targeting to mouse/human PrP/prion protein. Anti-Mouse/Human PrP/prion protein Antibody (TW1) binds to both PrPc (cellular prion protein) and PrPSc (Scrapie Prion Protein) and blocks the interaction of prion protein with tau protein. Anti-Mouse/Human PrP/prion protein Antibody (TW1) can be used for the researches of Alzheimer’s disease (AD) .
Anti-West Nile/dengue virus E protein Antibody (E60) is mouse-derived IgG2a κ type antibody inhibitor, targeting to West Nile/dengue virus E protein. Anti-West Nile/dengue virus E protein Antibody (E60) can cross-neutralize West Nile virus (WNV) and dengue virus (DENV) envelope (E) protein. Anti-West Nile/dengue virus E protein Antibody (E60) can be used for the researches of WNV and DENV infection [2].
Anti-Mouse CD205 Antibody (NLDC-145) is a rat-derived IgG2aκ type antibody inhibitor, targeting to mouse CD205. Anti-Mouse CD205 Antibody (NLDC-145) reacts with CD205 also known as DEC-205. Anti-Mouse CD205 Antibody (NLDC-145) can be used for the researches of cancer, inflammation, immunology and metabolic disease, such as colitis, D2F2/E2 tumor and diabetes [2] .
Anti-Mouse CD45RB Antibody (MB23G2) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD45RB. Anti-Mouse CD45RB Antibody (MB23G2) blocks CD45RB and induces transplantation tolerance. Anti-Mouse CD45RB Antibody (MB23G2) can be used for the researches of infection, immunology and metabolic disease, such as diabetes and Mem71 (H3N1) virus-infection [2].
Anti-Mouse/Human phosphorylated PD-1/CD279 Antibody (407.6G12) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse/human phosphorylated PD-1/CD279. Anti-Mouse/Human phosphorylated PD-1/CD279 Antibody (407.6G12) can detect the phosphorylated form of the PD-1 ITSM by both western blot and flow cytometry .
Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC Class I. Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) reacts with the mouse H-2Kd MHC class I alloantigen. Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) can be used for immunology research, such as cardiac graft .
Anti-Mouse IL-12 p40 Antibody (C17.8) is a rat-derived anti-mouse IL-12 p40IgG2a κ type antibody inhibitor. Anti-Mouse IL-12 p40 Antibody (C17.8) binds p40 subunit of IL-12. Anti-Mouse IL-12 p40 Antibody (C17.8) can be used for the researches of inflammation, immunology and metabolic disease, such as diabetes and arthritis [2] .
Anti-Mouse NK1.1 Antibody (PK136) is an anti-mouse NK1.1IgG2a monoclonal antibody. Anti-Mouse NK1.1 Antibody (PK136) can deplete natural killer (NK) cells. Anti-Mouse NK1.1 Antibody (PK136) inhibits the JAK-STAT and NF-κB signaling pathways. Anti-Mouse NK1.1 Antibody (PK136) can be used for research on inflammation conditions such as non-alcoholic steatohepatitis (NASH) [2].
Anti-Human/Rat HER2 (neu) Antibody (7.16.4) is an anti-mouse HER2IgG2a monoclonal antibody. Anti-Human/Rat HER2 (neu) Antibody (7.16.4) reduces tumor cell proliferation by inhibiting the HER2 signaling pathway. Anti-Human/Rat HER2 (neu) Antibody (7.16.4) can activate CD8 + T cells. Anti-Human/Rat HER2 (neu) Antibody (7.16.4) can be used for research on cancer such as breast cancer [2].
Anti-CD44 Antibody (Hermes-1) is a kind of rat IgG2a κ chimeric antibody, targeting to human CD44. Anti-CD44 Antibody (Hermes-1) blocks the binding of hyaluronan to CD44. Anti-CD44 Antibody (Hermes-1) restores (Platelet-derived Growth Factor-BB)-induced β-receptor activation and motility in fibroblasts. Anti-CD44 Antibody (Hermes-1) causes partial loss of the anti-aging effect of hyaluronic [2] .
Anti-Mouse IL-12 p35 Antibody (C18.2) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IL-12 p35. Anti-Mouse IL-12 p35 Antibody (C18.2) can neutralize IL-12. Anti-Mouse IL-12 p35 Antibody (C18.2) can be used for the researches of infection, inflammation and immunology, such as airway inflammation and F. tularensis infection [2].
Anti-Mouse FGL-1 Antibody (177R4) is an anti-mouse FGL-1IgG2a monoclonal antibody. Anti-Mouse FGL-1 Antibody (177R4) can increase CD8 + T cell infiltration. Anti-Mouse FGL-1 Antibody (177R4) enhances the anti-tumor immune effect by blocking FGL1. Anti-Mouse FGL-1 Antibody (177R4) can be used for research on cancer such as lung cancer and breast cancer [2].
Anti-Mouse GM-CSF Antibody (MP1-22E9) is a rat-derived anti-mouse GM-CSFIgG2a antibody inhibitor. Anti-Mouse GM-CSF Antibody (MP1-22E9) can neutralize GM-CSF. Anti-Mouse GM-CSF Antibody (MP1-22E9) can be used for the researches of cancer, infection inflammation and immunology, such as cholangiocarcinoma and arthritis [2] .
Anti-Mouse IL-12 Antibody (R1-5D9) is a rat-derived IgG2a type antibody inhibitor, targeting to mouse IL-12. Anti-Mouse IL-12 Antibody (R1-5D9) can neutralize IL-12. Anti-Mouse IL-12 Antibody (R1-5D9) can be used for the researches of infection, inflammation and immunology, such as Leishmania infection and skin inflammation [2].
Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse CD40L/CD154. Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1) is a chimeric version of the original MR-1 antibody (HY-P990134). The variable domain sequences are identical to the original MR-1 but the constant region sequences have been switched from Armenian hamster IgG to mouse IgG2a. Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1) contains a LALA-PG mutation in the Fc fragment rendering it unable to bind to endogenous Fcγ receptors. Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1) blocks CD40/CD40L signaling. Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1) can be used for researches of cancer, inflammation and immunology.
Anti-Mouse IL-18 Antibody (YIGIF74-1G7) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IL-18. Anti-Mouse IL-18 Antibody (YIGIF74-1G7) can neutralize IL-18. Anti-Mouse IL-18 Antibody (YIGIF74-1G7) can be used for the researches of cancer, infection, inflammation and immunology, such as hepatocellular carcinoma and eosinophilic esophagitis [2] .
Anti-E-Selectin Antibody (CL2) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human E-Selectin. Anti-E-Selectin Antibody (CL2) reacts with human E-selectin also known as CD62E, endothelial-leukocyte adhesion molecule 1 (ELAM-1), and leukocyte-endothelial cell adhesion molecule 2 (LECAM2). Anti-E-Selectin Antibody (CL2) directly blocks the binding of E selectin to carbohydrate ligands. Anti-E-Selectin Antibody (CL2) can be used for the detection of flow cytometry [2].
Anti-Mouse 4-1BB/CD137 Antibody (3H3) is an anti-mouse 4-1BB/CD137IgG2a monoclonal antibody. Anti-Mouse 4-1BB/CD137 Antibody (3H3) can effectively activate memory T cells and inhibit tumors by increasing Bcl-xL and granzyme B levels. Anti-Mouse 4-1BB/CD137 Antibody (3H3) can be used for research on cancer such as lymphoma and colon cancer [2].
Anti-c-Kit/CD117 Antibody (SR-1) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human c-Kit/CD117. Anti-c-Kit/CD117 Antibody (SR-1) binds to the extracellular domain of human c-Kit (also known as CD117) and blocks stem cell factor (SCF) binding to CD117. Anti-c-Kit/CD117 Antibody (SR-1) can be used for the researches of cancer and immunology, such as gastrointestinal stromal tumor (GIST) and xenograft [2].
Anti-CTLA-4/CD152 Antibody (BN13) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human CTLA-4/CD152. Anti-CTLA-4/CD152 Antibody (BN13) can neutralize CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152. Anti-CTLA-4/CD152 Antibody (BN13) can be used for the researches of infection and immunology, such as human immunodeficiency virus (HIV) .
Anti-MHC Class I Antibody (W6/32) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human MHC Class I. Anti-MHC Class I Antibody (W6/32) reacts with the human major histocompatibility complex (MHC) class I, HLA-A, B, and C. Anti-MHC Class I Antibody (W6/32) increases adherence of monocytes to human endothelial cells. Anti-MHC Class I Antibody (W6/32) can be used for the research of immunology [2].
Anti-Monkey/Human CD40L/CD154 Antibody (5C8) is a mouse-derived IgG2a type antibody inhibitor, targeting to monkey/human CD40L/CD154. Anti-Monkey/Human CD40L/CD154 Antibody (5C8) blocks the interactionbetween CD154 and CD40. Anti-Monkey/Human CD40L/CD154 Antibody (5C8) can be used for the researches of inflammation and immunology, such as colitis and transplant [2].
Anti-Mouse CD71/TfR1 Antibody (8D3) is a rat-derived anti-mouse CD71/TfR1 IgG2a type antibody inhibitor. Anti-Mouse CD71/TfR1 Antibody (8D3) depletes of CD71+ erythroid cells but does not change percentages of Tregs in neonatal mice. Anti-Mouse CD71/TfR1 Antibody (8D3) enhances neonatal mice defence against infection [2].
Anti-Mouse MAdCAM-1 Antibody (MECA-367) is an anti-mouse MAdCAM-1IgG2a monoclonal antibody. Anti-Mouse MAdCAM-1 Antibody (MECA-367) significantly inhibits the migration of pig peripheral blood lymphocytes (PBL) by blocking the function of MAdCAM-1. Anti-Mouse MAdCAM-1 Antibody (MECA-367) selectively inhibits B cell migration to exacerbate inflammation. Anti-Mouse MAdCAM-1 Antibody (MECA-367) can be used for researches on inflammation, metabolic conditions and xenotransplantation such as colitis and diabetes [2] .
Anti-Mouse Thy1/CD90 Antibody (M5/49.4.1) is an anti-mouse Thy1/CD90IgG2a monoclonal antibody. Anti-Mouse Thy1/CD90 Antibody (M5/49.4.1) can clear T cells from the spleen and bone marrow. Anti-Mouse Thy1/CD90 Antibody (M5/49.4.1) can be used for researches on immunology and inflammation conditions such as colitis [2] .
Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) is a mouse-derived IgG2a κ type antibody, targeting to mouse/rat CD71/TfR1. Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) targets the transferrin receptor and binds to an extracellular domain for the transferrin receptor. Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) can be used for the research in drug delivery, especially for drug delivery to the brain .
Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC Class I. Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8) reacts with the mouse H-2 MHC class I alloantigen (all haplotypes). Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8) can be used for the flow cytometry and immunofluorescence experiments .
Anti-Mouse CD40 Antibody (FGK4.5/FGK45) is an agonistic rat-derived IgG2a monoclonal antibody targeting mouse CD40. Anti-Mouse CD40 Antibody (FGK4.5/FGK45) enhances T cells responses, dendritic cells maturation and NK cells activation. Anti-Mouse CD40 Antibody (FGK4.5/FGK45) can be used for the researches of cancer, infection, inflammation and immunology, such as CT26 tumor, vesicular stomatitis virus (VSV) infection and transplantation [2] .
Anti-Mouse/Human Mac-2/Galectin-3 Antibody (TIB-166) is a rat-derived anti-mouse/human Mac-2/Galectin-3IgG2a monoclonal antibody. Anti-Mouse/Human Mac-2/Galectin-3 Antibody (TIB-166) significantly inhibits IL-6 expression (inhibition rates 34.7% and 55.3%). Anti-Mouse/Human Mac-2/Galectin-3 Antibody (TIB-166) is often used for immunoprecipitation, western blot, immunofluorescence, and flow cytometry [2] .
Anti-Mouse Vβ8 TCR Antibody (F23.1) is an anti-mouse Vβ8 TCRIgG2a monoclonal antibody. Anti-Mouse Vβ8 TCR Antibody (F23.1) can clear Vβ8 + T cells to alleviate immune conditions. Anti-Mouse Vβ8 TCR Antibody (F23.1) can be used for research on autoimmune conditions. Anti-Mouse Vβ8 TCR Antibody (F23.1) is often used in flow cytometry [2].
Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) is a mouse-derived IgG2a κ type antibody inhibitor targeting to mouse CTLA-4/CD152. Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) contains a LALA-PG mutation in the Fc fragment rendering it unable to bind to endogenous Fcγ receptors. Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) can be used for the researches of cancer and immunology, such as colon [2].
Anti-Mouse TIM-4 Antibody (RMT4-54) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse TIM-4. Anti-Mouse TIM-4 Antibody (RMT4-54) reacts with mouse T cell immunoglobulin and mucin domain 4 (TIM-4) and blocks TIM-4 signaling. Anti-Mouse TIM-4 Antibody (RMT4-54) inhibits phagocytosis of apoptotic cells. Anti-Mouse TIM-4 Antibody (RMT4-54) can be used for the researches of immunology and metabolic disease [2].
Anti-Mouse PD-1 Antibody (29F.1A12) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse PD-1. Anti-Mouse PD-1 Antibody (29F.1A12) blocks the binding of PD-1 to its two ligands, PD-L1 and PD-L2. Anti-Mouse PD-1 Antibody (29F.1A12) can be used for the researches of cancer and immunology, such as CT26 tumor and pancreatic cancer [2] .
Anti-Mouse L-Selectin/CD62L Antibody (Mel-14) is an anti-mouse L-Selectin/CD62LIgG2a monoclonal antibody. Anti-Mouse L-Selectin/CD62L Antibody (Mel-14) can significantly inhibit the migration of T cells and B cells. Anti-Mouse L-Selectin/CD62L Antibody (Mel-14) can block initial lymphocyte homing. Anti-Mouse L-Selectin/CD62L Antibody (Mel-14) can be used for researches on inflammation, metabolic and infection conditions such as diabetes and parasitic infections [2] .
Anti-Mouse (CSF1R/CD115) Antibody (AFS98) is an anti-mouse CSF1RIgG2a antibody inhibitor derived from rats. Anti-Mouse (CSF1R/CD115) Antibody (AFS98) inhibits M-CSF-dependent colony formation and cell growth by blocking the binding of M-CSF to its receptor. Anti-Mouse (CSF1R/CD115) Antibody (AFS98) can be used for the researches of inflammation, metabolic disease, cardiovascular disease and neurological disease, such as such as stroke, diabetes and arthritis [2] .
Anti-Mouse CD122/IL-2Rβ Antibody (5H4) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD122/IL-2Rβ. Anti-Mouse CD122/IL-2Rβ Antibody (5H4) can inhibit IL-2. Anti-Mouse CD122/IL-2Rβ Antibody (5H4) can be used for the researches of cancer and immunology, such as hepatocellular carcinoma [2].
Anti-Mouse CD8a Antibody (53-6.7) is an anti-mouse CD8a IgG2a antibody inhibitor derived from host Rat. Anti-Mouse CD8a Antibody (53-6.7) binds to CD8αβ stabilizes a conformation with a higher affinity for interaction with MHC class I. Anti-Mouse CD8a Antibody (53-6.7) induces the phosphorylation and activation of TCR proximal signaling pathway components Lck and ZAP70 in polyclonal memory T cells. Anti-Mouse CD8a Antibody (53-6.7) depletes CD8+ T cells and neutralizes cytokine in mice [2] .
Anti-Rat Kappa Immunoglobulin Light Chain Antibody (MAR 18.5) is an anti-rat Kappa Immunoglobulin Light ChainIgG2a monoclonal antibody. Anti-Rat Kappa Immunoglobulin Light Chain Antibody (MAR 18.5) can enhance B cell depletion. Anti-Rat Kappa Immunoglobulin Light Chain Antibody (MAR 18.5) can enhance T cell exhaustion after the injection of CD4 mAb (HY-P990792) and CD8 mAb (HY-P99129). Anti-Rat Kappa Immunoglobulin Light Chain Antibody (MAR 18.5) can be used for research on immunology [2].
Anti-Mouse CD38 Antibody (NIMR5) is an anti-mouse CD38IgG2a monoclonal antibody. Anti-Mouse CD38 Antibody (NIMR5) can activate the ERK signaling pathway and promote cell apoptosis. Anti-Mouse CD38 Antibody (NIMR5) can restore T cell function. Anti-Mouse CD38 Antibody (NIMR5) upregulates the expression of CD1d protein and enhances spleen cell proliferation, dendritic cell (DC) and natural killer T cell (NKT) expansion. Anti-Mouse CD38 Antibody (NIMR5) can be used for researches on cancer and immunology such as melanoma and colon cancer [2] .
Anti-Mouse TIM-3 Antibody (RMT3-23) is a kind of rat-derived anti-mouse TIM-3IgG2a antibody inhibitor. Anti-Mouse TIM-3 Antibody (RMT3-23) blocks Tim-3 binding to phosphatidylserine (PtdSer) and carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1). Anti-Mouse TIM-3 Antibody (RMT3-23) inhibits phagocytosis of apoptotic cells in peritoneal exudate Mac1+ cells. Anti-Mouse TIM-3 Antibody (RMT3-23) can be used for the researches of inflammation and immunology, such as rheumatoid arthritis [2] .
Anti-Mouse CD28 (LALA-PG) Antibody (D665) is an anti-mouse CD28IgG2a monoclonal antibody. Anti-Mouse CD28 (LALA-PG) Antibody (D665) is a chimeric antibody of the original D665 antibody (HY-P990793). Anti-Mouse CD28 (LALA-PG) Antibody (D665) contains the LALA-PG mutation region. Anti-Mouse CD28 Antibody (D665) induces the activation of T cells. Anti-Mouse CD28 Antibody (D665) can be used for research on neurological conditions, inflammation, immunology and cancer, such as Parkinson disease (PD), arthritis and graft-versus-host disease (GVHD).
Anti-Mouse NKG2A/C/E Antibody (20D5) is an anti-mouse NKG2A/C/EIgG2a monoclonal antibody. Anti-Mouse NKG2A/C/E Antibody (20D5) can activate natural killer (NK) and CD8 + T cells. Anti-Mouse NKG2A/C/E Antibody (20D5) can exacerbate liver pathological damage by enhancing the activation of iNKT cells. Anti-Mouse NKG2A/C/E Antibody (20D5) can be used for researches on cancer and immunology such as lymphoma [2].
Anti-Mouse IL-9 Antibody (9C1) is an anti-mouse IL-9IgG2a monoclonal antibody. Anti-Mouse IL-9 Antibody (9C1) can reduce the activation of NF-κB signaling pathway and decrease the infiltration of inflammatory cells. Anti-Mouse IL-9 Antibody (9C1) effectively reduces Th9 cell-mediated allergic reactions and anti-tumor effects. Anti-Mouse IL-9 Antibody (9C1) can be used for researches on inflammation, infection conditions and cancer such as parasitic infections, allergic reactions, breast cancer and osteosarcoma [2] .
Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to monkey/human MHC class II. Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243) can inhibits tumor cells proliferation and induce apoptosis. Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243) increases cellular reactive oxygen species (ROS) and loss of mitochondrial membrane potential in human endothelial cells. Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243) can be used for the researches of cancer and infection, such as lymphoma [2] .
Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) is an anti-monkey/human MDR-1/CD243IgG2a monoclonal antibody. Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) can efficiently inhibit P-glycoprotein. Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) enhances the inhibitory effect on multidrug resistance (MDR) by suppressing drug efflux. Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) can be used for research on cancer [2].
Anti-Mouse CD31/PECAM-1 Antibody (390) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD31/PECAM-1. Anti-Mouse CD31/PECAM-1 Antibody (390) reacts with mouse CD31, also known as PECAM-1 (platelet endothelial cell adhesion molecule). Anti-Mouse CD31/PECAM-1 Antibody (390) inhibits angiogenesis. Anti-Mouse CD31/PECAM-1 Antibody (390) can be used for the research of cancer, such as A549 tumor [2].
Anti-Mouse RANKL/CD254 Antibody (IK22/5) is an anti-mouse RANKL/CD254IgG2a monoclonal antibody. Anti-Mouse RANKL/CD254 Antibody (IK22/5) inhibits osteoclast formation and activity by specifically blocking the binding of RANKL and RANK. Anti-Mouse RANKL/CD254 Antibody (IK22/5) can inhibit the expression of MuRF1/Trogin-1 and activation of NF-κB. Anti-Mouse RANKL/CD254 Antibody (IK22/5) can be used for research on cancer such as melanoma or colon cancer and osteoporosis [2] .
Anti-Mouse ICOSL/CD275 Antibody (HK5.3) is an anti-mouse ICOSL/CD275IgG2a monoclonal antibody. Anti-Mouse ICOSL/CD275 Antibody (HK5.3) can inhibit the adhesion between T cells and endothelial cells. Anti-Mouse ICOSL/CD275 Antibody (HK5.3) can reduce the expansion of tissue resident (TR) Treg cells. Anti-Mouse ICOSL/CD275 Antibody (HK5.3) can be used for researches on inflammation and infection conditions such as influenza virus infection and arthritis [2] .
Anti-MAGEC2/CT10 Antibody (LX-CT10.5) is a kind of mouse IgG2a κ chimeric antibody, targeting to human MAGEC2/CT10. Anti-MAGEC2/CT10 Antibody (LX-CT10.5) reacts with human melanoma-associated antigen C2 (MAGEC2), also known as CT10. Anti-MAGEC2/CT10 Antibody (LX-CT10.5) can be used for identifying MAGEC2 expressing cells in immunohistochemistry, immunofluorescence and western blot studies .
Anti-Mouse OX40/CD134 (LALA-PG) Antibody (OX86) is an anti-mouse OX40/CD134 (LALA-PG)IgG2a monoclonal antibody. Anti-Mouse OX40/CD134 (LALA-PG) Antibody (OX86) is a chimeric antibody of the original OX86 antibody (HY-P990115). Anti-Mouse OX40/CD134 (LALA-PG) Antibody (OX86) can significantly enhance the generation of antigen-specific effector T cells. Anti-Mouse OX40/CD134 (LALA-PG) Antibody (OX86) can be used for research on cancer .
Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) is an anti-mouse MHC Class I (H-2Kd, H-2Dd)IgG2a monoclonal antibody. Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) can block the interaction between Ly49 and MHC-I. Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) can be used for the construction of acute lung injury models [2].
Anti-Mouse CD326/EpCAM Antibody (G8.8) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD326/EpCAM. Anti-Mouse CD326/EpCAM Antibody (G8.8) reacts with CD326 also known as EpCAM (Epithelial Cell Adhesion Molecule). Anti-Mouse CD326/EpCAM Antibody (G8.8) can be used for cancer research, such as lung carcinoma and colorectal carcinoma. Anti-Mouse CD326/EpCAM Antibody (G8.8) can be used for detections of western blot, immunohistochemistry, immunofluorescence and flow cytometry [2].
Anti-Mouse PD-L2/B7-DC Antibody (TY25) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse PD-L2/B7-DC. Anti-Mouse PD-L2/B7-DC Antibody (TY25) blocks PD-L2 binding to PD-1 and blocks PD-1 signaling. Anti-Mouse PD-L2/B7-DC Antibody (TY25) can be used for the researches of inflammation and immunology, such as conjunctivitis and transplantation [2] .
Anti-CD54/ICAM-1 Antibody (R6-5-D6) is a kind of mouse IgG2a chimeric antibody inhibitor, targeting to human CD54/ICAM-1. Anti-CD54/ICAM-1 Antibody (R6-5-D6) can block CD54 binding to its ligand Lymphocyte Function-Associated Antigen 1 (LFA-1). Anti-CD54/ICAM-1 Antibody (R6-5-D6) can be used for the researches of inflammation and immunology [2].
Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD71/TfR1. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can deplete CD71 + cells and inhibit transferrin receptor. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can be used for the researches of cancer, infection, inflammation and immunology, such as lung cancer, lymphocytic choriomeningitis virus (LCMV) infection and Cardiac allograft [2] .
Anti-Mouse TIM-1/CD365 Antibody (3B3) is a rat-derived IgG2a κ type agonistic antibody, targeting to mouse TIM-1/CD365. Anti-Mouse TIM-1/CD365 Antibody (3B3) enhances T-cell proliferation and responses by forming a stable TIM-1 complex and bringing TIM-1 into the T-cell receptor (TCR)-CD3 complex. Anti-Mouse TIM-1/CD365 Antibody (3B3) can be used for the researches of cancer, inflammation and immunology, such as experimental autoimmune encephalomyelitis, B16 F10 tumor and transplant [2] .
Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) is an anti-mouse Thy1.1/CD90.1IgG2a monoclonal antibody. Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) can deplete CD90.1 + cells. Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) can clear Tregs. Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) can be used for researches on inflammation conditions and immune response such as airway inflammation and experimental autoimmune encephalomyelitis (EAE) [2] .
Anti-Mouse MHC class II (I-A) Antibody (Y-3P) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC class II. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) reacts with mouse MHC Class II haplotypes I-Ab, I-Af, I-Ap, I-Aq, I-Ar, I-As, I-Au, I-Av, and weakly with I-Ak. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) blocks MHC class II and inhibits expansion of regulate T cells. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) can be used for the immunology research .
Anti-Mouse CD80/B7-1 Antibody (RM80) is an anti-mouse CD80/B7-1IgG2a monoclonal antibody. Anti-Mouse CD80/B7-1 Antibody (RM80) can inhibit the number of tissue-resident memory (TRM) cells. Anti-Mouse CD80/B7-1 Antibody (RM80) can prolong the survival time of transplants combined with CD86 mAb. Anti-Mouse CD80/B7-1 Antibody (RM80) can be used for researches on inflammation conditions and immunology such as viral myocarditis and corneal transplant [2] .
Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IL-7Rα/CD127. Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) blocks IL-7 signaling. Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) can be used for the researches of cancer,infection, inflammation, immunology, cardiovascular and metabolic disease, such as abdominal aortic aneurysms, helicobacter felis-induced gastritis and diabetes [2] .
Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) is a rat-derived IgG2a κ antibody inhibitor, targeting to mouse 4-1BBL/CD137L. Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) can block 4-1BB ligand (4-1BBL) and inhibit CD4 + and CD8 + T cells. Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) can be used for the researches of cancer, infection, inflammation and immunology, such as MC38 tumor, lymphocytic choriomeningitis virus (LCMV) infection and herpetic stromal keratitis (HSK) [2] .
Anti-Mouse 4-1BB/CD137 (LALA-PG) Antibody (LOB12.3) is a mouse-derived IgG2a κ type antibody agonist, targeting to mouse 4-1BB/CD137. Anti-Mouse 4-1BB/CD137 (LALA-PG) Antibody (LOB12.3) is a chimeric antibody of the original LOB12.3 antibody (HY-P990809). Anti-Mouse 4-1BB/CD137 (LALA-PG) Antibody (LOB12.3) contains the LALA-PG mutation region. Anti-Mouse 4-1BB/CD137 (LALA-PG) Antibody (LOB12.3) can be used for the researches of cancer, infection, immunology and neurological disease.
Anti-Mouse MHC Class I (H-2Kk, H-2Dk) Antibody (15-3-1S (HB-13)) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC Class I. Anti-Mouse MHC Class I (H-2Kk, H-2Dk) Antibody (15-3-1S (HB-13)) reacts with the mouse H-2Kk and H-2Dk MHC class I alloantigens. Anti-Mouse MHC Class I (H-2Kk, H-2Dk) Antibody (15-3-1S (HB-13)) can be used for immunology research .
Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse ICOSL/CD275. Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) is a chimeric antibody of the original HK5.3 antibody (HY-P990123). Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) contains the LALA-PG mutation region. Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) can neutralize ICOSL. Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) can be used for researches of inflammation and infection.
Anti-Mouse IFNγR/CD119 Antibody (GR-20) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IFNγR/CD119.Anti-Mouse IFNγR/CD119 Antibody (GR-20) reacts with the mouse IFNγR (interferon gamma receptor) α chain also known as CD119 and IFNγ receptor 1. Anti-Mouse IFNγR/CD119 Antibody (GR-20) blocks the binding of IFNγ to CD119 therefore inhibiting IFNγ signaling. Anti-Mouse IFNγR/CD119 Antibody (GR-20) can be used for the researches of cancer, infection, inflammation and immunology, such as melanoma and C. trachomatis infected genital tract inflammation [2].
Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse/rat MHC Class II. Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) reacts with mouse MHC Class II alloantigen I-Ek and the rat MHC class II alloantigen RT1D. Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) blocks antigen presentation. Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) can be used for the research of immunology and cancer .
Anti-Influenza A virus NP Antibody (H16-L10-4R5 (HB-65)) is mouse-derived IgG2a κ type antibody inhibitor, targeting to influenza virus nucleoprotein. Anti-Influenza A virus NP Antibody (H16-L10-4R5 (HB-65)) reacts with influenza virus nucleoprotein (NP). Anti-Influenza A virus NP Antibody (H16-L10-4R5 (HB-65)) can induce passive immunity to influenza A virus. Anti-Influenza A virus NP Antibody (H16-L10-4R5 (HB-65)) can be used for the detections of western blot, flow cytometry and immunohistochemistry in Influenza A virus infection [2].
Anti-Mouse CD47/IAP Antibody (MIAP301) is an anti-mouse CD47/IAPIgG2a monoclonal antibody. Anti-Mouse CD47/IAP Antibody (MIAP301) can effectively block CD47 signaling and enhance macrophage phagocytic function. Anti-Mouse CD47/IAP Antibody (MIAP301) can increase the infiltration of immune cells. Anti-Mouse CD47/IAP Antibody (MIAP301) restores the phagocytic function of myeloid cells and alleviate B cell inhibition. Anti-Mouse CD47/IAP Antibody (MIAP301) may interfere with wound healing. Anti-Mouse CD47/IAP Antibody (MIAP301) can be used for researches on cancer, inflammation and infection conditions such as melanoma, intestinal mucosal repair and sepsis [2] .
Anti-Mouse CD16/CD32 (LALA-PG) Antibody (2.4G2) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse CD16/CD32. Anti-Mouse CD16/CD32 (LALA-PG) Antibody (2.4G2) is a chimeric antibody of the original 2.4G2 antibody (HY-P99125). Anti-Mouse CD16/CD32 (LALA-PG) Antibody (2.4G2) contains the LALA-PG mutation region. Anti-Mouse CD16/CD32 (LALA-PG) Antibody (2.4G2) can block the combination of CD16 and FcγRs. Anti-Mouse CD16/CD32 (LALA-PG) Antibody (2.4G2) can be used for the researches of immunology and cardiovascular disease.
Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) is a rat-derived anti-LPAM-1/Integrin α4β7 IgG2a, κ type antibody inhibitor. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) specifically reacts with both chains of the α4β7 heterodimer and blocks the adhesion to immobilized mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) suppresses the proliferation and cytokine secretion of CD8+ T cells. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) decreases Peyer’s patches and follicular B cells in mice. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) can be used for the researches of inflammation, such as ulcerative colitis [2] .
Anti-Mouse 4-1BBL/CD137L (D265A) Antibody (TKS-1) is a mouse-derived IgG1 κ antibody inhibitor that targets mouse 4-1BBL/CD137L. Anti-Mouse 4-1BBL/CD137L (D265A) Antibody (TKS-1) is a chimeric version of the original TKS-1 antibody (HY-P990304). The variable domain sequences are identical to the original TKS-1 but the constant region sequences have been switched from rat IgG2a to mouse IgG1. Anti-Mouse 4-1BBL/CD137L (D265A) Antibody (TKS-1) contains a D265A mutation in the Fc fragment rendering it unable to bind to endogenous Fcγ receptors. Anti-Mouse 4-1BBL/CD137L (D265A) Antibody (TKS-1) reacts with mouse 4-1BB ligand (4-1BBL). Anti-Mouse 4-1BBL/CD137L (D265A) Antibody (TKS-1) can be used for the researches of cancer, infection, inflammation and immunology.
Anti-Mouse PD-L1/B7-H1 (LALA-PG) Antibody (10F.9G2) is a recombinant chimeric version of the original 10F.9G2 antibody (HY-P99145). The variable domain sequences are identical to the original 10F.9G2 but the constant region sequences have been switched from rat IgG2b to mouse IgG2a. Anti-Mouse PD-L1/B7-H1 (LALA-PG) Antibody (10F.9G2) contains a LALA-PG mutation in the Fc fragment rendering it unable to bind to endogenous Fcγ receptors. Anti-Mouse PD-L1/B7-H1 (LALA-PG) Antibody (10F.9G2) blocks PD-1 signaling. Anti-Mouse PD-L1/B7-H1 (LALA-PG) Antibody (10F.9G2) can be used for the research of cancer.
Platycoside E is a platycodigenin-type saponin isolated from the root of Platycodon grandiflorum with haemolytic activity and adjuvant potential. Platycoside E promotes the production of the sera OVA-specific IgG2a and IgG2b antibody in the ovalbumin (OVA)-immunized mice .
VSA 2, a saponin-based vaccine adjuvant, is a derivative of Momordica saponin (MS) II. VSA 2 is an immunostimulant, shows consistent enhancement of immunoglobulin G2a (IgG2a) production when it was in formulation with either ovalbumin or recombinant hemagglutinin B (rHagB) antigen .
VSA 1, a semisynthetic QS-21 (HY-101092) analog, is a saponin adjuvant. VSA 1 potentiates antigen-specific IgG1 and IgG2a immune responses in BALB/c mice, indicating a mixed Th1/Th2 immune response. VSA 1 significantly improves vaccine efficacy after primary immunization and enhances homologous protection .
Ig gamma-2A chain C region (Immunoglobulin heavy chain gamma polypeptide) is one of the five types of mammalian immunoglobulin heavy chain: γ, δ, α, μ and ε. Heavy chain γ defines the classes of immunoglobulins IgG. IgG2A Fc Protein, Mouse (HEK293) is the recombinant mouse-derived IgG2A Fc protein, expressed by HEK293 , with tag free.
Ig gamma-2A chain C region (IgG2a) is one of the IgG antibodies subclasses and responses to an antigen. IgG2a plays a crucial role in the adaptive immune response. IgG2A Fc Protein, Rat (HEK293) is the recombinant rat-derived IgG2A Fc protein, expressed by HEK293 , with tag free.
Ig gamma-2A chain C region (Immunoglobulin heavy chain gamma polypeptide) is one of the five types of mammalian immunoglobulin heavy chain: γ, δ, α, μ and ε. Heavy chain γ defines the classes of immunoglobulins IgG. IgG2A Fc Protein, Mouse (Biotinylated, HEK293) is the recombinant mouse-derived IgG2A Fc protein, expressed by HEK293 , with tag free.
