2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Anti-Mouse CD86/B7-2 Antibody (GL-1)

Anti-Mouse CD86/B7-2 Antibody (GL-1) 

Cat. No.: HY-P990260 Purity: 99.17%
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Anti-Mouse CD86/B7-2 Antibody (GL-1) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD86/B7-2. Anti-Mouse CD86/B7-2 Antibody (GL-1) can be used for the researches of inflammation and immunology, such as allergic pulmonary inflammation.

For research use only. We do not sell to patients.

Anti-Mouse CD86/B7-2 Antibody (GL-1) Chemical Structure

Anti-Mouse CD86/B7-2 Antibody (GL-1) Chemical Structure

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Description

Anti-Mouse CD86/B7-2 Antibody (GL-1) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD86/B7-2. Anti-Mouse CD86/B7-2 Antibody (GL-1) can be used for the researches of inflammation and immunology, such as allergic pulmonary inflammation[1][2][3][4].

Isotype

Rat IgG2a kappa
Recommend Isotype Controls
IC50 & Target

CD86/B7-2
In Vitro

Anti-Mouse CD86/B7-2 Antibody (GL-1) (7 days) induces immunomodulatory cells production in splenocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD86/B7-2 Antibody (GL-1) Related Antibodies
In Vivo

Anti-Mouse CD86/B7-2 Antibody (GL-1) (100 μg, i.p., a single dose) suppresses the development of IL-2-secreting cells and enhances TNF-α secretion in experimental allergic encephalomyelitis mice models[2].
Anti-Mouse CD86/B7-2 Antibody (GL-1) (400 μg, i.p., every other day for 4 times) alleviates inflammation in ovalbumin-induced allergic pulmonary inflammation mice models[3].
Anti-Mouse CD86/B7-2 Antibody (GL-1) (200 μg, i.p., a single dose) prolongs survival in cardiac allografts mice models[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ovalbumin-induced allergic pulmonary inflammation mice models[3]
Dosage: 400 μg
Administration: Intraperitoneally injection (the first doses via tail vein), every other day for 4 times
Result: Decreased expression of CD25 on CD4+ T cells.
Decreased allergen-induced AHR and the expansion of eosinophil subset in the BAL.
Showed slightly attenuated inflammation.
Animal Model: Cardiac allografts mice models[4]
Dosage: 200 μg
Administration: Intraperitoneally injection
Result: Led to more than 2 months allograft survival in all mice.
Gene ID

12524  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CD86/B7-2 Antibody (GL-1)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse CD86/B7-2 Antibody (GL-1) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD86/B7-2 Antibody (GL-1)Transmembrane GlycoproteinCD86B7-2Allergic pulmonary inflammationExperimental allergic encephalomyelitisOvalbuminInhibitorinhibitorinhibit

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