Anti-Mouse IL-12 p35 Antibody (C18.2) 

Anti-Mouse IL-12 p35 Antibody (C18.2) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IL-12 p35. Anti-Mouse IL-12 p35 Antibody (C18.2) can neutralize IL-12. Anti-Mouse IL-12 p35 Antibody (C18.2) can be used for the researches of infection, inflammation and immunology, such as airway inflammation and F. tularensis infection^[1][2].

Rat IgG2a kappa

Rat IgG2a kappa, Isotype Control

Mouse

IL-12 p35

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse IL-12 p35 Antibody (C18.2) (250 μg, i.p., at days 33 and 37, 2 h before the ovalbumin challenges) attenuates airway reactivity and Th2-type airway inflammation in ovalbumin-induced allergic airway inflammation mice models^[1].
Anti-Mouse IL-12 p35 Antibody (C18.2) (500 μg, i.p., twice at days -1, 0, and 1 after infection) reduces the frequency and number of effector memory CD4+ T cells in both the lungs and spleens in F. tularensis live vaccine strain infected mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

16159  [NCBI] & 16160  [NCBI]

P43431 & P43432

ELISA, FACS, Functional assay, Research in vivo

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

[Anti-Mouse IL-12 p35 Antibody (C18.2)]

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Meyts I, et al. IL-12 contributes to allergen-induced airway inflammation in experimental asthma. J Immunol. 2006 Nov 1;177(9):6460-70.  [Content Brief]

  [2]. Bitsaktsis C, et al. In vivo mechanisms involved in enhanced protection utilizing an Fc receptor-targeted mucosal vaccine platform in a bacterial vaccine and challenge model. Infect Immun. 2015 Jan;83(1):77-89.  [Content Brief]