2. GPCR/G Protein Neuronal Signaling NF-κB JAK/STAT Signaling Stem Cell/Wnt
  3. Neurokinin Receptor NF-κB STAT
  4. Anti-Mouse NK1.1 Antibody (PK136)

Anti-Mouse NK1.1 Antibody (PK136) 

Cat. No.: HY-P99143 Purity: ≥95.0%
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Anti-Mouse NK1.1 Antibody (PK136) is an anti-mouse NK1.1 IgG2a monoclonal antibody. Anti-Mouse NK1.1 Antibody (PK136) can deplete natural killer (NK) cells. Anti-Mouse NK1.1 Antibody (PK136) inhibits the JAK-STAT and NF-κB signaling pathways. Anti-Mouse NK1.1 Antibody (PK136) can be used for research on inflammation conditions such as non-alcoholic steatohepatitis (NASH).

For research use only. We do not sell to patients.

Anti-Mouse NK1.1 Antibody (PK136) Chemical Structure

Anti-Mouse NK1.1 Antibody (PK136) Chemical Structure

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Description

Anti-Mouse NK1.1 Antibody (PK136) is an anti-mouse NK1.1 IgG2a monoclonal antibody. Anti-Mouse NK1.1 Antibody (PK136) can deplete natural killer (NK) cells. Anti-Mouse NK1.1 Antibody (PK136) inhibits the JAK-STAT and NF-κB signaling pathways. Anti-Mouse NK1.1 Antibody (PK136) can be used for research on inflammation conditions such as non-alcoholic steatohepatitis (NASH)[1][2].

Isotype

Mouse IgG2a kappa
Recommend Isotype Controls
IC50 & Target[2]

NF-κB

 

p-STAT3

 

STAT1

 

In Vivo

Anti-Mouse NK1.1 Antibody (PK136) (90 µg, on day 1 before tumor engraftment and on day 1, 4, 7, 14, 21 after Panc02 cells inoculation) can reduce the number of natural killer (NK) cells in male C57BL/6 mice bearing Panc02 tumors[1].
Anti-Mouse NK1.1 Antibody (PK136) (150 μg, i.p., once every 3 days, from week 7 to week 11) can improve non-alcoholic steatohepatitis (NASH) in male C57BL/6 mice fed with methionine- andcholine-deficient (MCD) diet[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5×105 Panc02 cells injected male C57BL/6 mice (6 weeks)[1]
Dosage: 90 µg
Administration: /, on day 1 before tumor engraftment and on day 1, 4, 7, 14, 21 after Panc02 cells inoculation
Result: Significantly reduced the number of NK cells.
Significantly increased tumor weight.
Animal Model: Male C57BL/6 mice (6-8 weeks) fed with MCD diet (4 weeks)[2]
Dosage: 150 μg
Administration: Intraperitoneal injection (i.p.), once every 3 days from week 7 to week 11
Result: Significantly reduced the number of NK cells.
Ruduced the level of p-STAT1, p-STAT3, and p-NF-κB p65.
Improved NASH inflammation in mice.
Gene ID

17057  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse NK1.1 Antibody (PK136)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: ≥95.0%

SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Anti-Mouse NK1.1 Antibody (PK136) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse NK1.1 Antibody (PK136)Neurokinin ReceptorNF-κBSTATNK receptorTachykinin receptorNuclear factor-κBNuclear factor-kappaBNK1.1NASHInhibitorinhibitorinhibit

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