Anti-Mouse PD-L2/B7-DC Antibody (TY25) 

Anti-Mouse PD-L2/B7-DC Antibody (TY25) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse PD-L2/B7-DC. Anti-Mouse PD-L2/B7-DC Antibody (TY25) blocks PD-L2 binding to PD-1 and blocks PD-1 signaling. Anti-Mouse PD-L2/B7-DC Antibody (TY25) can be used for the researches of inflammation and immunology, such as conjunctivitis and transplantation^[1][2][3].

Rat IgG2a kappa

Rat IgG2a kappa, Isotype Control

Mouse

PD-L2/B7-DC

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse PD-L2/B7-DC Antibody (TY25) (500 μg/mouse at day 0 and 250 μg/ mouse twice a week during 4 weeks, i.p.) slightly inhibits the induction of spontaneous tolerance in orthotopic liver transplantation mice models^[1].
Anti-Mouse PD-L2/B7-DC Antibody (TY25) (250 μg, i.p., 6 h before and 48 h following each allergen exposure) limits the severity of airway hyperresponsiveness in allergen-induced asthma mice models^[2].
Anti-Mouse PD-L2/B7-DC Antibody (TY25) (500 μg, i.p., at days 0, 2, 4, 6, and 8) significantly increases eosinophil infiltration into the conjunctivain in ragweed pollen-induced experimental allergic conjunctivitis mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

58205  [NCBI]

Q9WUL5

ELISA, FACS, Functional assay, Research in vivo

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

[Anti-Mouse PD-L2/B7-DC Antibody (TY25)]

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Morita M, et al. PD-1/B7-H1 interaction contribute to the spontaneous acceptance of mouse liver allograft. Am J Transplant. 2010 Jan;10(1):40-6.  [Content Brief]

  [2]. Lewkowich IP, et al. PD-L2 modulates asthma severity by directly decreasing dendritic cell IL-12 production. Mucosal Immunol. 2013 Jul;6(4):728-39.  [Content Brief]

  [3]. Fukushima A, et al. Involvement of programmed death-ligand 2 (PD-L2) in the development of experimental allergic conjunctivitis in mice. Br J Ophthalmol. 2006 Aug;90(8):1040-5.  [Content Brief]