2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse TSLP Antibody (28F12)

Anti-Mouse TSLP Antibody (28F12) 

Cat. No.: HY-P990150 Purity: 95.00%
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Anti-Mouse TSLP Antibody (28F12) is an anti-mouse TSLP IgG2a monoclonal antibody. Anti-Mouse TSLP Antibody (28F12) weakens skin inflammation and allergic reactions by reducing Treg cells and lymph node cells. Anti-Mouse TSLP Antibody (28F12) can be used for research on allergic conditions.

For research use only. We do not sell to patients.

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Description

Anti-Mouse TSLP Antibody (28F12) is an anti-mouse TSLP IgG2a monoclonal antibody. Anti-Mouse TSLP Antibody (28F12) weakens skin inflammation and allergic reactions by reducing Treg cells and lymph node cells. Anti-Mouse TSLP Antibody (28F12) can be used for research on allergic conditions[1][2][3].

Isotype

Rat IgG2a kappa
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

TSLP
In Vitro

Anti-Mouse TSLP Antibody (28F12) (1 μg/mL) inhibits TSLP dependent proliferation in NAG8/7 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse TSLP Antibody (28F12) Related Antibodies
In Vivo

Anti-Mouse TSLP Antibody (28F12) (200-400 μg, i.p., once every 3 days, for 7 days) significantly reduces skin inflammation and lymph node cells in female BALB/c mice induced by Triclosan (HY-B1119)[1].
Anti-Mouse TSLP Antibody (28F12) (200 μg, i.p., twice a week, for 4 weeks) significantly inhibits the expansion of Treg cells in C57BL/6 mice with an altered Schaedler flora (ASF) colonization[2].
Anti-Mouse TSLP Antibody (28F12) (250 μg, i.v., single dose, on day 0) significantly inhibits Th2 differentiation but does not affect the migration and maturation of eosinophils or dendritic cells in BALB/c or C57BL/6 mice induced by Papain (HY-P1645)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Triclosan induced female BALB/c mice (6-8 weeks)[1]
Dosage: 200-400 μg
Administration: Intraperitoneal injection (i.p.), once every 3 days, for 7 days
Result: Reduced the level of TSLP and IL-1β.
Reduced the numbers of B cells and dendritic cells (DCs).
Animal Model: C57BL/6 mice with an ASF colonization[2]
Dosage: 200 μg
Administration: Intraperitoneal injection (i.p.), twice a week, for 4 weeks
Result: Reduced the number of Treg cells.
Exacerbated Th17 and IFNγ responses.
Animal Model: Papain (50 μg) induced BALB/c or C57BL/6 mice[3]
Dosage: 250 μg
Administration: Intravenous injection (i.v.), single dose on day 0
Result: Significantly inhibited Th2 differentiation.
Gene ID

53603  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse TSLP Antibody (28F12)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Immobilized TSLP Protein, Mouse (HEK293, Fc, HY-P70626) can bind Anti-Mouse TSLP Antibody (28F12). The EC50 for this effect is 8.511 ng/mL.
Purity & Documentation

Purity: 95.00%

SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Anti-Mouse TSLP Antibody (28F12) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse TSLP Antibody (28F12)Interleukin RelatedILTSLPTregimmunologyallergicInhibitorinhibitorinhibit

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