Anti-Rat CD4 Antibody (OX-38) 

Anti-Rat CD4 Antibody (OX-38) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to rat CD4. Anti-Rat CD4 Antibody (OX-38) can deplete CD4⁺ cells. Anti-Rat CD4 Antibody (OX-38) can be used for the researches of immunology and infection, such as borna disease and transplantation^[1][2][3][4].

CD4

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Rat CD4 Antibody (OX-38) (2 mg, i.p., at days -1, 1, 14 and 21 of infection) inhibits encephalitis and borna disease in borna disease virus-infected rats models^[1].
Anti-Rat CD4 Antibody (OX-38) (0.4 mL, 3 days before organ transplantation) causes marked prolongation of liver and heart allografts in Lewis rats^[2].
Anti-Rat CD4 Antibody (OX-38) (1 mg/rat, i.p., weekly for 8 weeks) increases infection susceptibility in pneumocystis-infected pneumonia rats models^[3].
Anti-Rat CD4 Antibody (OX-38) (5 mg/kg, a single dose) induces unresporusiveness in DA recipienta of PVG grafts^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

Liquid

Colorless to light yellow

[Anti-Rat CD4 Antibody (OX-38)]

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Stitz L, et al. Preventive effects of early anti-CD4 or anti-CD8 treatment on Borna disease in rats. J Virol. 1992 Jun;66(6):3316-23.  [Content Brief]

  [2]. Sumimoto R, et al. Studies on the participation of different T cell subsets in rat liver allograft rejection. Comparison of liver with heart graft. Transpl Int. 1992;5 Suppl 1:S636-8.  [Content Brief]

  [3]. Thullen TD, et al. New rat model of Pneumocystis pneumonia induced by anti-CD4(+) T-lymphocyte antibodies. Infect Immun. 2003 Nov;71(11):6292-7.  [Content Brief]

  [4]. Qi Z, et al. Single dose anti-CD4 monoclonal antibody for induction of tolerance to cardiac allograft in high- and low-responder rat strain combinations. Transpl Immunol. 1997 Sep;5(3):204-11.  [Content Brief]