2. Immunology/Inflammation Anti-infection
  3. Transmembrane Glycoprotein CHIKV
  4. Anti-Mouse Ly6C Antibody (Monts 1)

Anti-Mouse Ly6C Antibody (Monts 1) 

Cat. No.: HY-P990200 Purity: 95.00%
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Anti-Mouse Ly6C Antibody (Monts 1) is a rat-derived anti-mouse Ly6C IgG2a type antibody inhibitor. Anti-Mouse Ly6C Antibody (Monts 1) depletes monocytes, neutrophils, and some other granulocyte populations. Anti-Mouse Ly6C Antibody (Monts 1) can be used for the researches of cancer, immunology and infection, such as chikungunya (CHIKV) and aggressive tumor.

For research use only. We do not sell to patients.

Anti-Mouse Ly6C Antibody (Monts 1)

Anti-Mouse Ly6C Antibody (Monts 1) Chemical Structure

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Description

Anti-Mouse Ly6C Antibody (Monts 1) is a rat-derived anti-mouse Ly6C IgG2a type antibody inhibitor. Anti-Mouse Ly6C Antibody (Monts 1) depletes monocytes, neutrophils, and some other granulocyte populations. Anti-Mouse Ly6C Antibody (Monts 1) can be used for the researches of cancer, immunology and infection, such as chikungunya (CHIKV) and aggressive tumor[1][2][3].

Isotype

Rat IgG2a kappa
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

Ly6C
In Vitro

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse Ly6C Antibody (Monts 1) Related Antibodies
In Vivo

Anti-Mouse Ly6C Antibody (Monts 1) (200 μg, i.p., once a week for 4 weeks) reverses anti-PD-1/CTLA-4 immunotherapy resistance in aggressive KP 344SQ tumor mice models[1].
Anti-Mouse Ly6C Antibody (Monts 1) (700 μg, i.p., 24 h prior to infection) reduces chikungunya (CHIKV) infection in the skin and subsequent dissemination in CHIKV mice models[2].
Anti-Mouse Ly6C Antibody (Monts 1) (70 μg, Subconjuctivally administration, 7 days before infection) depletes macrophages in Herpes Simplex Virus-1-induced subclinical corneal inflammation[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Aggressive KP 344SQ tumor mice models treated with PD-1/CTLA-4[1]
Dosage: 200 μg
Administration: Intraperitoneally injection, once a week for 4 weeks
Result: Reversed the resistance to anti-PD-1/CTLA-4 treatment.
Restored the levels of classical, non-classical monocytes and immune cell responses.
Animal Model: Mice were inoculated with chikungunya-LR in footpad[2]
Dosage: 700 μg
Administration: Intraperitoneally injection, 24 h prior to inoculation
Result: Reduced viral RNA levels.
Depleted monocytes, neutrophils, and some other granulocyte populations.
Significantly reduced in viral RNA levels in the skin, DLN, serum, spleen, and contralateral foot.
Animal Model: Mice with HSV-1(Herpes Simplex Virus-1)-induced subclinical corneal inflammation[3]
Dosage: 70 μg
Administration: Subconjuctivally administration, 7 days before infection
Result: Effectively depleted macrophages from HSV-1 infected.
Gene ID

17067  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse Ly6C Antibody (Monts 1)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse Ly6C Antibody (Monts 1) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse Ly6C Antibody (Monts 1)Transmembrane GlycoproteinCHIKVChikungunya virusLy6CMonocytesCancerImmunologyInfectionTumorInhibitorinhibitorinhibit

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