2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse IL-12 p40 Antibody (C17.8)

Anti-Mouse IL-12 p40 Antibody (C17.8) 

Cat. No.: HY-P990225 Purity: 95.00%
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Anti-Mouse IL-12 p40 Antibody (C17.8) is a rat-derived anti-mouse IL-12 p40 IgG2a κ type antibody inhibitor. Anti-Mouse IL-12 p40 Antibody (C17.8) binds p40 subunit of IL-12. Anti-Mouse IL-12 p40 Antibody (C17.8) can be used for the researches of inflammation, immunology and metabolic disease, such as diabetes and arthritis.

For research use only. We do not sell to patients.

Anti-Mouse IL-12 p40 Antibody (C17.8) Chemical Structure

Anti-Mouse IL-12 p40 Antibody (C17.8) Chemical Structure

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Based on 1 publication(s) in Google Scholar

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Description

Anti-Mouse IL-12 p40 Antibody (C17.8) is a rat-derived anti-mouse IL-12 p40 IgG2a κ type antibody inhibitor. Anti-Mouse IL-12 p40 Antibody (C17.8) binds p40 subunit of IL-12. Anti-Mouse IL-12 p40 Antibody (C17.8) can be used for the researches of inflammation, immunology and metabolic disease, such as diabetes and arthritis[1][2][3].

Isotype

Rat IgG2a kappa
Recommend Isotype Controls
IC50 & Target

IL-12 p40
In Vitro

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse IL-12 p40 Antibody (C17.8) Related Antibodies
In Vivo

Anti-Mouse IL-12 p40 Antibody (C17.8) (500 μg, i.p., twice a week during 5-30 weeks) exhibits suppression of both insulitis and diabetes in non-obese diabetic mice models [1].
Anti-Mouse IL-12 p40 Antibody (C17.8) (200 μg, i.p., for 6 consecutive days) results in the enhancement of diabetes in 2-week-old non-obese diabetic mice models[1].
Anti-Mouse IL-12 p40 Antibody (C17.8) (0.5 mg, i.p., 2 h before injection of SCW fragments) suppresses of murine streptococcal cell wall (SCW) arthritis[2].
Anti-Mouse IL-12 p40 Antibody (C17.8) (0.5 mg, i.p., once a week) prolongs survival in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis mice models[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Non-obese diabetic mice models[1]
Dosage: 500 μg
Administration: Intraperitoneally injection, twice a week during 5-30 weeks
Result: Completely prevented diabetes.
Significantly decreased the degree of insulitis.
Only 62% of NOD mice at 15 weeks of age.
Animal Model: 2-week-old non-obese diabetic mice models[1]
Dosage: 200 μg
Administration: Intraperitoneally injection, for 6 consecutive days
Result: Only 56% of NOD mice at 10 weeks of age.
Inhibited IL-2 and IFN-γ production at 4 weeks.
Enhanced production of IL-2 and IFN-γ and suppressed production of IL-4 and IL-10 at 8 weeks of age.
Increased CD25+ and CD44high cells in both CD4+ and CD8+ subsets at 8 days after the final injection.
Resulted in a rapid onset of overt diabetes when Splenic T-cells transferred to NOD-scid with spleen cells from diabetic NOD mice.
Animal Model: Streptococcal cell wall (SCW)-induced arthritis mice models[2]
Dosage: 0.5 mg
Administration: Intraperitoneally injection, 2 hours before injection of SCW fragments
Result: Increased the chondrocyte PG synthesis.
Reduced infiltration of synovial membrane with inflammatory cells.
Decreased mRNA levels for IL1β, IL12 and TNFα and increased IL1Ra and IL10 mRNA levels.
Animal Model: B6D2F1 mice were injected with 80 million B6 spleen cells[3]
Dosage: 0.5 mg
Administration: Intraperitoneally injection, every 7 days subsequently
Result: Significantly prolonged survival of mice.
Gene ID

16159  [NCBI] & 16160  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse IL-12 p40 Antibody (C17.8)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse IL-12 p40 Antibody (C17.8) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-12 p40 Antibody (C17.8)Interleukin RelatedILIL-12P40InflammationImmunologyDiabetesArthritisInhibitorinhibitorinhibit

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