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Results for "

cytotoxicity of cells

" in MedChemExpress (MCE) Product Catalog:

1449

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3

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23

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15

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61

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3

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94

Inhibitory Antibodies

451

Natural
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18

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8

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7

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0750
    Monocrotaline
    30+ Cited Publications

    Crotaline

    		 Others Metabolic Disease Cancer
    Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid. Monocrotaline inhibits OCT-1 and OCT-2 with IC50s of 36.8 µM and 1.8 mM, respectively. Monocrotaline has antitumor activity and is cytotoxic to hepatocellular carcinoma cells. Monocrotaline is used to induce a model of pulmonary hypertension in rodents. [2][6][8].
    Monocrotaline
  • HY-119529
    Jineol

    3,8-Quinolinediol

    		 Tyrosinase Bacterial Cancer
    Jineol is a cytotoxic alkaloid from the centipede Scolopendra subspinipes. Jineol exhibits modest cytotoxic activity in vitro against the growth of human tumor cell lines .
    Jineol
  • HY-N0750R
    Monocrotaline (Standard)

    Crotaline (Standard)

    		 Others Metabolic Disease Cancer
    Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid. Monocrotaline inhibits OCT-1 and OCT-2 with IC50s of 36.8 µM and 1.8 mM, respectively. Monocrotaline has antitumor activity and is cytotoxic to hepatocellular carcinoma cells. Monocrotaline is used to induce a model of pulmonary hypertension in rodents. .
    Monocrotaline (Standard)
  • HY-N13938
    Azinomycin A

    		Others Cancer
    Azinomycin A is highly cytotoxic, and the cytotoxicity to L5178Y cell IC50 is 0.07 g/mL .
    Azinomycin A
  • HY-130995
    Agrochelin

    		Antibiotic ADC Payload Infection
    Agrochelin, an alkaloid cytotoxic antibiotic, is produced by the fermentation of a marine Agrobacterium sp. Agrochelin has cytotoxic activity in tumor cell lines .
    Agrochelin
  • HY-N9339
    Norglaucine

    (+)-Norglaucine

    		 Others Cancer
    Norglaucine ((+)-Norglaucine), a cytotoxic alkaloid, exhibits cytotoxicity towards the tumor cell lines B16-F10, HepG2, K562 and HL-60 cells .
    Norglaucine
  • HY-N15747
    Mycoleptodiscin A

    (-)-Mycoleptodiscin A

    		 Apoptosis Cancer
    Mycoleptodiscin A ((-)-Mycoleptodiscin A) is a cytotoxic indole alkaloid found in fungus. Mycoleptodiscin A exerts cytotoxic effects by inducing apoptosis or inhibiting cell cycle progression .
    Mycoleptodiscin A
  • HY-N10265
    Stephacidin B

    		Endogenous Metabolite Cancer
    Stephacidin B is a fungal metabolite. Stephacidin B shows in vitro cytotoxicity against a panel of human tumor cell lines. Stephacidin B shows the strongest cytotoxicity against testosterone-dependent prostate LNCaP cancer cells .
    Stephacidin B
  • HY-118327
    Maleuric acid

    N-carbamylmaleamic acid

    		 DNA/RNA Synthesis Mitosis Cancer
    Maleuric acid has cytotoxicity on Ehrlich ascites tumor cells by preventing the entry of preprophase cells into mitosis.
    Maleuric acid
  • HY-N1555
    Pseudotaraxasterol

    		Biochemical Assay Reagents Others
    Pseudotaraxasterol shows cytotoxic activity against MOLT-4 cells.
    Pseudotaraxasterol
  • HY-W028690
    DNMDP
    4 Publications Verification

    		 Phosphodiesterase (PDE) Cancer
    DNMDP, a phosphodiesterase 3A (PDE3A) inhibitor, is a potent and selective cancer cell cytotoxic agent. DNMDP binding to PDE3A promotes an interaction between PDE3A and Schlafen 12 (SLFN12). DNMDP shows clear cell-selective cytotoxicity .
    DNMDP
  • HY-133667
    Bromoiodoacetamide

    		Apoptosis Cancer
    Bromoiodoacetamide is a kind of iodinated haloacetamides (I-HAcAms), with cytotoxicity. Bromoiodoacetamide induces cytotoxicity by via reactive oxygen species (ROS) accumulation and apoptosis in HepG-2 cells .
    Bromoiodoacetamide
  • HY-N15414
    Demethoxykanugin

    Desmethoxykanugin

    		 Cholinesterase (ChE) Neurological Disease Cancer
    Demethoxykanugin (Desmethoxykanugin, compound 1) is a acetylcholine (AChE) inhibitor. Demethoxykanugin shows cell cytotoxicity agains Vero cells .
    Demethoxykanugin
  • HY-13767
    Tirapazamine
    10+ Cited Publications

    SR259075; SR4233; Win59075; SML 0552; SR 259075; Tirazone

    		 DNA/RNA Synthesis Cancer
    Tirapazamine (SR259075) is an anticancer agent that shows selective cytotoxicity for hypoxic cells in solid tumors, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. Tirapazamine is an anticancer and bioreductive agent.Tirapazamine (SR259075) can enhance the cytotoxic effects of ionizing radiation in hypoxic cells .
    Tirapazamine
  • HY-131058
    Muscotoxin A

    		ADC Payload Cancer
    Muscotoxin A is an ADC cytotoxin. Muscotoxin A is a cytotoxic lipopeptide that permeabilizes mammalian cell membranes and induces necrotic cell death .
    Muscotoxin A
  • HY-N14293
    4-Methylaeruginoic acid

    		Antibiotic Bacterial Infection Cancer
    4-Methylaeruginoic acid is an antibiotic and is cytotoxic to several human tumor cell lines .
    4-Methylaeruginoic acid
  • HY-N8198
    Ardisiacrispin B

    		Apoptosis Ferroptosis Cancer
    Ardisiacrispin B displays cytotoxic effects in multi-factorial agent resistant cancer cells via ferroptotic and apoptotic cell death .
    Ardisiacrispin B
  • HY-N2483
    Hydroprotopine

    		Others Cancer
    Hydroprotopine is a alkaloid from Hypecoum leptocarpumand. Leptopidine can suppress growth and induce cytotoxicity in breast cancer cells and that the cytotoxicity of leptopidine may be related to its inhibitory effect on fatty acid synthase expression .
    Hydroprotopine
  • HY-N8088
    Neolancerin

    		Others Cancer
    Neolancerin is a natural product with weak cytotoxic activity against HL-60 cells .
    Neolancerin
  • HY-139813
    Phenanthriplatin

    		DNA Alkylator/Crosslinker Cancer
    Phenanthriplatin is a monovalent platinum(II)-based complex with a large cytotoxicity against cancer cells .
    Phenanthriplatin
  • HY-N6622
    Tazettine

    		Others Others
    Tazettine is an alkaloid with low cytotoxicity to mammalian cell lines (CC50 >100 μg/mL) .
    Tazettine
  • HY-139705
    Anticancer agent 12

    		Others Cancer
    Anticancer agent 12 is unexpectedly devoids of hepatotoxicity while maintaining cytotoxic activity in malignant cells.
    Anticancer agent 12
  • HY-N14621
    Harzialacton A

    		Others Cancer
    Harzialacton A has weak cytotoxicity to P388 leukemia cells with ED50 of > 100 μg/mL .
    Harzialacton A
  • HY-113845
    (+)-Intermedine

    		Others Neurological Disease
    (+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs) .
    (+)-Intermedine
  • HY-N9651
    12a-Hydroxydalpanol

    		Others Cancer
    12a-Hydroxydalpanol is a rotenoid cytotoxic agent found in Amorpha fruticosa. 12a-Hydroxydalpanol exerts cytotoxic effects by inhibiting tumor cell proliferation. 12a-Hydroxydalpanol is promising for research of cancers .
    12a-Hydroxydalpanol
  • HY-129752
    Piperafizine B

    		Antibiotic Cancer
    Piperafizine B exhibits slightly cytotoxicity in moser cells, P388 cells and Vincristine (VCR) (HY-N0488)-resistant P388 cells (IC50s is 23.8, 22.6 and 23.7 μg/mL, respectively). Piperafizine B exhibits synergistic effects with Vincristine, enhances the VCR-induced cytotoxicity and ameliorates the leukemia in mouse model .
    Piperafizine B
  • HY-114939
    Phelorphan

    		DNA/RNA Synthesis Others
    Phelorphan is a purine MTH1 inhibitor identified through chemical array screening. Although it targets cellular MTH1, its cytotoxicity to cancer cells is weaker than that of other reported inhibitors. The cytotoxicity of MTH1 inhibitors may be attributed to off-target effects, and MTH1 is not essential for cancer cell survival.
    Phelorphan
  • HY-P991555
    XmAb5485

    		TNF Receptor Apoptosis Cancer
    XmAb5485 is an Fc-engineered humanized anti-CD40 monoclonal antibody with high affinity to Fc-γ receptors. XmAb5485 induces potent antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) against tumor cells. XmAb5485 inhibits proliferation and induces apoptosis of tumor cells. XmAb5485 shows highly cytotoxic against lymphoma, leukemia and multiple myeloma cell lines as well as primary cancer cells .
    XmAb5485
  • HY-N10304
    Isodispar B

    		Apoptosis Cancer
    Isodispar B is an anticancer agent that inhibits the proliferation of nasopharyngeal carcinoma and breast cancer cells and induces cell apoptosis. Isodispar B is cytotoxic to a wide range of cancer cell lines .
    Isodispar B
  • HY-141425
    NSC73306

    		P-glycoprotein Cancer
    NSC73306, a thiosemicarbazone, is a cell penetrant, cytotoxic agent that exhibits greater toxicity against cells expressing functional P-gp (P-glycoprotein) than against other cells .
    NSC73306
  • HY-N12122
    Dehydropipernonaline

    		Fungal Neurological Disease
    Dehydropipernonaline (Compound 24) is an amide compound. Dehydropipernonaline shows considerable cytotoxicity to L5178Y mouse lymphoma cells (IC508.9μM). Dehydropipernonaline can be used for screening antifungal and cytotoxicity .
    Dehydropipernonaline
  • HY-N13878
    Anguinomycin B

    		Antibiotic Bacterial Infection
    Anguinomycin B is an antitumor antibiotic that shows highly cytotoxic to murine P388 leukemia cells .
    Anguinomycin B
  • HY-N7199
    (Rac)-Hydnocarpin

    		Drug Isomer Cancer
    (Rac)-Hydnocarpin is a flavonoid isolated from Hydnocarpus anthelminthica, and exhibits moderate cytotoxic on cancer cells .
    (Rac)-Hydnocarpin
  • HY-N14995
    Frenolicin

    		Antibiotic Bacterial Fungal Infection Cancer
    Frenolicin is an antibiotic with antibacterial activity. Frenolicin also exhibits cytotoxicity against tumor cells .
    Frenolicin
  • HY-125131
    Buddlejasaponin IV

    		NO Synthase COX Inflammation/Immunology Cancer
    Buddlejasaponin IV (BS‐IV) exerts anti-inflammatory and cytotoxic effects against cancer cells .
    Buddlejasaponin IV
  • HY-147971
    Anticancer agent 75

    		Parasite Topoisomerase Infection Cancer
    Anticancer agent 75 is a potent anticancer agent. Anticancer agent 75 shows cytotoxicity and selectivity in cancer cell lines. Anticancer agent 75 shows cytotoxicity to normal human kidney cell lines is at least 35 times lower than that of the Doxorubicin standard. Anticancer agent 75 shows good activity of antiplasmodial .
    Anticancer agent 75
  • HY-120190
    Citreoindole

    		Drug Metabolite Infection
    Citreoindole is a diketopiperazine metabolite isolated from a hybrid cell fusion of two strains of P. citreovirde that is cytotoxic in vitro against HeLa cells at 8.4 μM.
    Citreoindole
  • HY-N9534
    Xylopine

    		Reactive Oxygen Species (ROS) Apoptosis Cancer
    Xylopine is an aporphine alkaloid with cytotoxic activity on cancer cells. Xylopine induces oxidative stress, causes G2/M cell cycle arrest and apoptosis in cancer cells .
    Xylopine
  • HY-162068
    Auristatin23

    		Drug Derivative Cancer
    Auristatin23, a conjugate of Auristatin F (HY-15583), is a cytotoxin. Auristatin23 exhibit cytotoxic activities towards targeted cells, including abnormal cells such as cancer cells, that are MDR+ .
    Auristatin23
  • HY-126989
    19-O-Acetylchaetoglobosin A

    		Arp2/3 Complex Cancer
    19-O-Acetylchaetoglobosin A, a cytochalasan alkaloid, is a fungal metabolite originally isolated from C. globosum that has actin polymerization inhibitory and cytotoxic activities. 19-O-Acetylchaetoglobosin A is cytotoxic to HeLa cervical cancer cells .
    19-O-Acetylchaetoglobosin A
  • HY-N10127
    Lepidiline C

    		Others Cancer
    Lepidiline C shows cytotoxic activity against HL-60 cells with an IC50 of 27.7 μM.
    Lepidiline C
  • HY-15276
    4-Aminonaphthalimide

    		PARP Cancer
    4-Aminonaphthalimide is a potent PARP inhibitor and potentiates the cytotoxicity of γ-radiation in cancer cells .
    4-Aminonaphthalimide
  • HY-N7287
    (+)-Matairesinol

    		Others Others
    (+)-Matairesinol is a lignan. (+)-Matairesinol has no cytotoxic activity for human pancreatic PANC-1 cancer cells .
    (+)-Matairesinol
  • HY-100861
    C-11

    		ADC Payload Microtubule/Tubulin Cancer
    C-11 is a tubulin inhibitor and acts as an ADC cytotoxin, displays cytotoxicity for carcinoma cell lines .
    C-11
  • HY-N3800
    Eichlerialactone

    		Others Cancer
    Eichlerialactone is a sesquiterpene compound isolated from Chisocheton penduliflorus. Eichlerialactone is weakly cytotoxic to breast cancer cells .
    Eichlerialactone
  • HY-117125
    Longifolin

    		Others Cancer
    Longifolin is an anticancer agent that exhibits significant cytotoxicity against HeLa cell lines (IC50: 0.21 μg/mL).
    Longifolin
  • HY-N1039A
    Manool

    		Others Cancer
    Manool is a diterpene from Salvia officinalis. Manool induces selective cytotoxicity in cancer cells. Manool arrests the cancer cells at the G(2)/M phase of the cell cycle .
    Manool
  • HY-121087
    BCI-215
    3 Publications Verification

    		 Phosphatase Cancer
    BCI-215 is a potent and tumor cell-selective dual specificity MAPK phosphatase (DUSP-MKP) inhibitor. BCI-215 has cytotoxicity for tumor cells but not normal cells .
    BCI-215
  • HY-158336
    E/Z-FETPY

    		Ferroptosis Cancer
    E/Z-FETPY is an organo-diiron(I) complex with strong cytotoxicity in cancer cell lines. E/Z-FETPY induces ferroptosis in low-differentiated cell lines, such as A2780 cells .
    E/Z-FETPY
  • HY-N7230
    Rabdosin A

    		Others Cancer
    Rabdosin A is an ent-kaurane diterpene isolated from the leaves of Isodon grandiflora with anticancer activity and cytotoxicity. Rabdosin A is also cytotoxic against DU145 and LoVo human tumor cells with IC50 values of 5.90 mM and 14.20 mM, respectively .
    Rabdosin A

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