12a-Hydroxydalpanol

Cat. No.: HY-N9651: Data Sheet Handling Instructions
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12a-Hydroxydalpanol is a rotenoid cytotoxic agent found in Amorpha fruticosa. 12a-Hydroxydalpanol exerts cytotoxic effects by inhibiting tumor cell proliferation. 12a-Hydroxydalpanol is promising for research of cancers.

For research use only. We do not sell to patients.

12a-Hydroxydalpanol Chemical Structure

CAS No. : 85042-77-9

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	ED₅₀	9.28 μg/mL Compound: 8	Cytotoxicity against human A549 cells Cytotoxicity against human A549 cells	[PMID: 8326318]
HCT-8	ED₅₀	0.56 μg/mL Compound: 8	Cytotoxicity against human HCT8 cells Cytotoxicity against human HCT8 cells	[PMID: 8326318]
KB	ED₅₀	3.67 μg/mL Compound: 8	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 8326318]
P388	ED₅₀	0.59 μg/mL Compound: 8	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 8326318]
RPMI-7951	ED₅₀	0.73 μg/mL Compound: 8	Cytotoxicity against human RPMI7951 cells Cytotoxicity against human RPMI7951 cells	[PMID: 8326318]
TE-671	ED₅₀	0.12 μg/mL Compound: 8	Cytotoxicity against human TE671 cells Cytotoxicity against human TE671 cells	[PMID: 8326318]

Molecular Weight

428.43

Formula

C₂₃H₂₄O₈

CAS No.

85042-77-9

SMILES

O[C@@]1([C@](CO2)([H])OC3=C(C[C@@H]4C(C)(O)C)C(O4)=CC=C3C1=O)C(C2=C5)=CC(OC)=C5OC

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li L, et al. Antitumor agents, 138. Rotenoids and isoflavones as cytotoxic constitutents from Amorpha fruticosa. J Nat Prod. 1993 May;56(5):690-8. [Content Brief]

[2]. Terada H, et al. Structural elucidation and chemical conversion of amorphispironone, a novel spironone form Amorpha fruticosa, to rotenoids[J]. Chemical and pharmaceutical bulletin, 1993, 41(1): 187-190.