2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 2,3-Diphospho-D-glyceric acid pentasodium salt

2,3-Diphospho-D-glyceric acid pentasodium salt  (Synonyms: 2,3-DPG pentasodium salt)

Cat. No.: HY-138822 Purity: ≥95.0%
COA
SDS
Handling Instructions Technical Support

2,3-Diphospho-D-glyceric acid pentasodium salt is a highly anionic polyphosphorus compound. 2,3-Diphospho-D-glyceric acid is present in the concave center of red blood cells, it binds hemoglobin to reduce its oxygen affinity. 2,3-Diphospho-D-glyceric acid is an endogenous, selective inhibitor of vascular calcification (VC) and significantly delays the formation of crystalline calpain particles (CPP). 2,3-Diphospho-D-glyceric acid also inhibits calcification in mouse vascular smooth muscle cell line (MOVAS) without cytotoxic effects.

For research use only. We do not sell to patients.

2,3-Diphospho-D-glyceric acid pentasodium salt Chemical Structure

2,3-Diphospho-D-glyceric acid pentasodium salt Chemical Structure

CAS No. : 102783-53-9

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2,3-Diphospho-D-glyceric acid pentasodium salt Related Antibodies

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Description

2,3-Diphospho-D-glyceric acid pentasodium salt is a highly anionic polyphosphorus compound. 2,3-Diphospho-D-glyceric acid is present in the concave center of red blood cells, it binds hemoglobin to reduce its oxygen affinity. 2,3-Diphospho-D-glyceric acid is an endogenous, selective inhibitor of vascular calcification (VC) and significantly delays the formation of crystalline calpain particles (CPP). 2,3-Diphospho-D-glyceric acid also inhibits calcification in mouse vascular smooth muscle cell line (MOVAS) without cytotoxic effects[1].

Molecular Weight

375.95

Formula

C3H3Na5O10P2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=P(O[Na])(O[Na])OC[C@H](C(O[Na])=O)OP(O[Na])(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (133.00 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6599 mL 13.2996 mL 26.5993 mL
5 mM 0.5320 mL 2.6599 mL 5.3199 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥95.0%

SDS (252 KB)

COA (253 KB) HNMR (269 KB) CNMR (261 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.6599 mL 13.2996 mL 26.5993 mL 66.4982 mL
5 mM 0.5320 mL 2.6599 mL 5.3199 mL 13.2996 mL
10 mM 0.2660 mL 1.3300 mL 2.6599 mL 6.6498 mL
15 mM 0.1773 mL 0.8866 mL 1.7733 mL 4.4332 mL
20 mM 0.1330 mL 0.6650 mL 1.3300 mL 3.3249 mL
25 mM 0.1064 mL 0.5320 mL 1.0640 mL 2.6599 mL
30 mM 0.0887 mL 0.4433 mL 0.8866 mL 2.2166 mL
40 mM 0.0665 mL 0.3325 mL 0.6650 mL 1.6625 mL
50 mM 0.0532 mL 0.2660 mL 0.5320 mL 1.3300 mL
60 mM 0.0443 mL 0.2217 mL 0.4433 mL 1.1083 mL
80 mM 0.0332 mL 0.1662 mL 0.3325 mL 0.8312 mL
100 mM 0.0266 mL 0.1330 mL 0.2660 mL 0.6650 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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2,3-Diphospho-D-glyceric acid pentasodium salt Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2,3-Diphospho-D-glyceric acid pentasodium102783-53-92,3-DPG pentasodiumEndogenous Metabolitevascular calcificationmouse vascular smooth muscle cell linecrystalline calpain particlesCPPInhibitorinhibitorinhibit

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