2. Anti-infection Cell Cycle/DNA Damage
  3. Antibiotic Fungal Bacterial DNA/RNA Synthesis
  4. Merulidial

Merulidial (Compound 1) is an antibiotic and cytotoxic agent with a sesquiterpene dialdehyde structure. Merulidial significantly inhibits the germination of spores and the hyphal growth of the wood-roting basidiomycete Heterobasidion annosum (H. annosum) and the saprophytic mould Cladosporium cucumerinum (C.cucumerinum). Merulidial also inhibits a variety of bacteria, algae and DNA synthesis of ECA cells. Merulidial shows a strong anticancer activity with IC50 s of 20 and 10 μg/mL for ECA and L1210 cells, respectively .

For research use only. We do not sell to patients.

Merulidial Chemical Structure

Merulidial Chemical Structure

CAS No. : 68053-32-7

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Merulidial Related Antibodies

Top Publications Citing Use of Products

View All Antibiotic Isoform Specific Products:

View All Isoforms
Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Merulidial (Compound 1) is an antibiotic and cytotoxic agent with a sesquiterpene dialdehyde structure. Merulidial significantly inhibits the germination of spores and the hyphal growth of the wood-roting basidiomycete Heterobasidion annosum (H. annosum) and the saprophytic mould Cladosporium cucumerinum (C.cucumerinum). Merulidial also inhibits a variety of bacteria, algae and DNA synthesis of ECA cells. Merulidial shows a strong anticancer activity with IC50 s of 20 and 10 μg/mL for ECA and L1210 cells, respectively [1][2][3].

In Vitro

Merulidial (Compound 1) (25 mg/mL, 3-5 days)significantly prevents the hyphal growth, with the clear zones from the edge of the well of 4-7 mm (C. cucumerinum) and 15-19 mm (H. annosum), respectively[1].
Merulidial (6.3-25 μg/mL, 24 h) strongly inhibits germination of H. annosum spores at both 12.5 and 25 μg/mL with delay germination at 6.3 ug/mL, and shows a weak effect on C. cucumerinum spore germination, delaying by at least 48 h[1].
Merulidial (50 μg/plate) has a mutagenic activity in the Ames' Salmonella assay for mutant strains TA98, TA2637 and TA100 with mutagenic rate of 0.62、0.28 and 1.5 revertants/nmol[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Merulidial Related Antibodies
Molecular Weight

248.32

Synonyms

(-)-Merulidial

Formula

C15H20O3
CAS No.
SMILES

O=C[C@@]12[C@@](C1)([C@H]([C@@]3([H])C(CC(C)(C3)C)=C2C=O)O)C
Structure Classification
Initial Source

Physisporinus sanguinolentus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Merulidial Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Merulidial68053-32-7(-)-MerulidialAntibioticFungalBacterialDNA/RNA SynthesisAnticancerCytotoxic AgentMutagenSesquiterpene dialdehydePhysisporinus sanguinolentusECA cellsL1210 cellsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Merulidial
Cat. No.:
HY-N15600
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.