2. Immunology/Inflammation Apoptosis
  3. CD28 Apoptosis
  4. Galiximab

Galiximab  (Synonyms: IDEC 114; Anti-Human CD80 Recombinant Antibody)

Cat. No.: HY-P99293 Purity: 99.23%
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Galiximab (IDEC-114) is a primatized monoclonal IgG1 antibody targeting CD80. Galiximab variable regions are primatized, and the constant regions are humanized. Galiximab induces antibody-dependent cellular cytotoxicity by blocking CD80-CD28 binding. Galiximab has antitumor activity and can induce apoptosis in tumor cells. Galiximab can be used in the research of relapsed Hodgkin lymphoma and solid tumors.

For research use only. We do not sell to patients.

CAS No. : 357613-77-5

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Description

Galiximab (IDEC-114) is a primatized monoclonal IgG1 antibody targeting CD80. Galiximab variable regions are primatized, and the constant regions are humanized. Galiximab induces antibody-dependent cellular cytotoxicity by blocking CD80-CD28 binding. Galiximab has antitumor activity and can induce apoptosis in tumor cells. Galiximab can be used in the research of relapsed Hodgkin lymphoma and solid tumors[1][2].

Isotype

Human IgG1 lambda1
Recommend Isotype Controls
IC50 & Target

CD28L/CD80
In Vitro

Galiximab (25-100 μg/mL; 36 h) in combination with Doxorubicin (HY-15142A) significantly enhances apoptosis in Raji cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Galiximab Related Antibodies

Apoptosis Analysis[1]

Cell Line: Raji cells treated Doxorubicin (HY-15142A) (0.05-1 µg/mL)
Concentration: 25, 50 and 100 μg/mL
Incubation Time: 36 h
Result: Enhanced cell apoptosis in a dose-dependent manner.
In Vivo

Galiximab (0.1-30 mg/kg; intraperitoneal injection; once a week; 3-4 times in total) shows antitumor activity in mouse Raji and SKW6.4 tumor models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CB17 SCID mice aged 6-8 weeks old treated Raji cells or SKW6.4 cells[1]
Dosage: Raji model: 0.1, 1, 3, 10, 30 mg/kg; once weekly; 3 times in total
SKW6.4 model: 5, 10, 30 mg/kg; once weekly; 4 times in total
Administration: Intraperitoneal injection
Result: Showed dose-dependent tumor growth inhibition and survival prolongation in both models.
Clinical Trial
Gene ID

941  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

145.24 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Galiximab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda
Purity & Documentation

Purity: 99.23%

SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Galiximab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Galiximab357613-77-5IDEC 114 Anti-Human CD80 Recombinant AntibodyIDEC114IDEC-114CD28ApoptosisB-cell lymphomamonoclonal antibody Raji cellsSKW6.4 cellsInhibitorinhibitorinhibit

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