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Exsiccated sodium phosphate-d<sub>1</sub>

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (1046) Cardiovascular Disease (350) Endocrinology (251) Infection (530) Inflammation/Immunology (475) Metabolic Disease (532) Neurological Disease (627)
Click Chemistry:	Labeling and Fluorescence Imaging (1) Azide (2) Alkynes (15)
Oligonucleotides:	Fillers (1) saRNAs (1) Aptamers (2) Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNA drugs (2) Antisense Oligonucleotides (4) siRNAs (5)

4029

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

3776

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Sodium Phosphate Cotransporter Sodium Channel Glucose-6-Phosphate Isomerase (GPI) Carbamoyl Phosphate Synthetase (CPS) Apical Sodium-Dependent Bile Acid Transporter Na+/H+ Exchanger (NHE) SGLT PIKfyve Na+/K+ ATPase Pyruvate Oxidase PI4P5K P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y0308S

Phosphate dibasic-d1(sodium) Exsiccated sodium phosphate-d<sub>1sub>	Isotope-Labeled Compounds	Others
Phosphate dibasic-d₂ (sodium) is the deuterium labeled Sodium phosphate dibasic ^[1].

HY-Y1322S

Triphenyl phosphate-d15 Celluflex TPP-d<sub>15sub>; DHPF 005-d<sub>15sub>; Disflamol TP-d<sub>15sub>; Disflamoll TP-d<sub>15sub>; NSC 57868-d<sub>15sub>; Phenyl phosphate ((PhO)3PO)-d<sub>15sub>; Phoscon FR 903N-d<sub>15sub>	Isotope-Labeled Compounds	Others
Triphenyl phosphate-d₁₅ is the deuterium labeled Triphenyl phosphate ^[1].

HY-W008954S

Tris(2-ethylhexyl) phosphate-d17 'TRIOCTYL' phosphate-d<sub>17sub>	Isotope-Labeled Compounds	Others
Tris(2-ethylhexyl) phosphate-d₁₇ ('TRIOCTYL' PHOSPHATE-d₁₇) is a deuterium labeled compound.

HY-RS13999

SUB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SUB1 Human Pre-designed siRNA Set A SUB1 Human Pre-designed siRNA Set A

HY-RS18793

Sub1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sub1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sub1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sub1 Mouse Pre-designed siRNA Set A Sub1 Mouse Pre-designed siRNA Set A

HY-RS25282

Sub1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sub1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sub1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sub1 Rat Pre-designed siRNA Set A Sub1 Rat Pre-designed siRNA Set A

HY-P10215

Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2	Parasite	Infection
Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent **Plasmodium subtilisin-like protease 1 (SUB1)** inhibitor. SUB1-IN-1 shows IC₅₀ values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively ^[1].

HY-146227

DNA topoisomerase II inhibitor 1	Topoisomerase Apoptosis	Cancer
DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase ^[1].

HY-10844S1

Pretomanid-d5 PA-824-d<sub>5sub>; (S)-PA 824-d<sub>5sub>	Antibiotic Bacterial Isotope-Labeled Compounds	Infection Cancer
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-146829S

1-Pentadecanoyl-2-oleoyl-sn-glycero-3-phosphate-d7 sodium 15:0-18:1-PA-d<sub>7sub>	Isotope-Labeled Compounds	Others
1-Pentadecanoyl-2-oleoyl-sn-glycero-3-phosphate-d₇ (sodium) is deuterium labeled 1-Pentadecanoyl-2-oleoyl-sn-glycero-3-phosphate (sodium).

HY-B1829S

Dexamethasone phosphate-d4 Dexamethasone 21-phosphate-d<sub>4sub>	Isotope-Labeled Compounds	Others
Dexamethasone phosphate-d₄ is the deuterium labeled Dexamethasone phosphate ^[1].

HY-W012351S

Tripropyl phosphate-d21 tris(1-propyl)phosphate-d<sub>21sub>	Isotope-Labeled Compounds	Others
Tripropyl phosphate-d₂₁ is the deuterium labeled Tripropyl phosphate ^[1].

HY-15381S

Fingolimod phosphate-d4 FTY720 phosphate-d<sub>4sub>	LPL Receptor Isotope-Labeled Compounds	Others
Fingolimod phosphate-d₄ is deuterium labeled FTY720 Phosphate.

HY-N5034S

Phosphorylethanolamine-d4 Monoaminoethyl phosphate-d<sub>4sub>; NSC 254167-d<sub>4sub>; O-Phosphoethanolamine-d<sub>4sub>	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Phosphorylethanolamine-d₄ (Monoaminoethyl phosphate-d₄; NSC 254167-d₄) is a deuterium labeled Phosphorylethanolamine (HY-N5034). Phosphorylethanolamine is an endogenous metabolite.

HY-W700392

IMPDH-IN-2	IMPDH	Cancer
IMPDH-IN-2 (compound 2) is an inhibitor of inosine monophosphate dehydrogenase (IMPDH) with *IC_{50 for IMPDH I and IMPDH II >}*Values are 0.15 and 0.17 μM, respectively. IMPDH-IN-2 has antitumor activity ^[1].

HY-B0389S3

D-Glucose-d1-1 Glucose-d<sub>1sub>-1; D-(+)-Glucose-d<sub>1sub>-1; Dextrose-d<sub>1sub>-1	Endogenous Metabolite	Metabolic Disease
D-Glucose-d-11 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response ^[1].

HY-125833

Alpha-Naphthoflavone 5+ Cited Publications	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis	Cancer
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis ^[1] .

HY-W654319

Tri-p-tolyl phosphate-d21 Tricresyl phosphate-d<sub>21sub>	Isotope-Labeled Compounds	Others
Tri-p-tolyl phosphate-d21 is the deuterium labeled Tri-p-tolyl phosphate ^[1].

HY-W585980S

Bis(2-butoxyethyl) 2-hydroxyethyl phosphate-d4 Bis(2-butoxyethyl) 2-hydroxyethyl phosphate-d<sub>4sub>	Isotope-Labeled Compounds	Others
Bis(2-butoxyethyl) 2-hydroxyethyl phosphate-d₄ (Bis(2-butoxyethyl) 2-hydroxyethyl phosphate-d₄) is a deuterium labeled compound.

HY-W023144S

Tris(1-chloro-2-propyl) phosphate-d18 Tris(1-chloropropan-2-yl) phosphate-d<sub>18sub>	Isotope-Labeled Compounds	Others
Tris(1-chloro-2-propyl) phosphate-d₁₈ (Tris(1-chloropropan-2-yl) phosphate-d₁₈) is a deuterium labeled compound.

HY-165664S

β-Glycerophosphate-d5 sodium salt hydrate Glyceol 2-phosphate-d<sub>5sub> sodium salt hydrate	Isotope-Labeled Compounds	Others
β-Glycerophosphate-d₅ (Glyceol 2-Phosphate-d₅) sodium salt hydrateis deuterium labeled β-Glycerophosphate (sodium salt hydrate) ^[1].

HY-B0389S1

D-Glucose-d1 Glucose-d<sub>1sub>; D-(+)-Glucose-d<sub>1sub>; Dextrose-d<sub>1sub>	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease Cancer
D-Glucose-d is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molec

HY-W008151S

Diphenyl Phosphate-d10 DPhP-d<sub>10sub>	Isotope-Labeled Compounds	Metabolic Disease
Diphenyl Phosphate-d₁₀ (DPhP-d₁₀) is the deuterium labled Diphenyl Phosphate (HY-W008151). Diphenyl Phosphate inhibits growth and energy metabolism of zebrafish in a sex-specific manner.

HY-N0378S5

D-Mannitol-d1 Mannitol-d<sub>1sub>; Mannite-d<sub>1sub>	Isotope-Labeled Compounds Apoptosis Endogenous Metabolite	Metabolic Disease Cancer
D-Mannitol-d is the deuterium labeled D-Mannitol.

HY-41700S2

D-Alanine-d1 (R)-Alanine-d<sub>1sub>; Ba 2776-d<sub>1sub>; D-α-Alanine-d<sub>1sub>	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease
D-Alanine-d is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC₅₀ of 9 mM for GlyR ^[1].

HY-B0389S4

D-Glucose-d1-2 Glucose-d<sub>1sub>-2; D-(+)-Glucose-d<sub>1sub>-2; Dextrose-d<sub>1sub>-2	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
D-Glucose-d₁-2 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response ^[1].

HY-B0389S7

D-Glucose-d1-3 Glucose-d<sub>1sub>-3; D-(+)-Glucose-d<sub>1sub>-3; Dextrose-d<sub>1sub>-3	Endogenous Metabolite	Metabolic Disease
D-Glucose-d-33 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response ^[1].

HY-B0389S2

D-Glucose-d12-1 Glucose-d<sub>12sub>-1; D-(+)-Glucose-d<sub>12sub>-1; Dextrose-d<sub>12sub>-1	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
D-Glucose-d₁₂-12 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response ^[1].

HY-B0389S23

D-Glucose-d2-1 Glucose-d<sub>2sub>-1; D-(+)-Glucose-d<sub>2sub>-1; Dextrose-d<sub>2sub>-1	Endogenous Metabolite	Metabolic Disease Cancer
D-Glucose-d₂-1 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling mol

HY-B0389S8

D-Glucose-d1-4 Glucose-d<sub>1sub>-4; D-(+)-Glucose-d<sub>1sub>-4; Dextrose-d<sub>1sub>-4	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
D-Glucose-d-44 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response ^[1].

HY-19696S2

Tauroursodeoxycholate-d4-1 Tauroursodeoxycholic acid-d<sub>4sub>-1; TUDCA-d<sub>4sub>-1; UR 906-d<sub>4sub>-1	Isotope-Labeled Compounds ERK Caspase Endogenous Metabolite Apoptosis	Cancer
Tauroursodeoxycholate-d₄-1 is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-109037S2

Mavacamten-d1 MYK461-d<sub>1sub>; SAR439152-d<sub>1sub>	Isotope-Labeled Compounds Myosin	Cardiovascular Disease
Mavacamten-d₁ (MYK461-d₁; SAR439152-d₁) is deuterium labeled Mavacamten (HY-109037). Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC₅₀s of 490, 711 nM for bovine cardiac and human cardiac, respectively.

HY-Y0001S1

Cyclopropylcarboxylic acid-d1 Carboxycyclopropane-d<sub>1sub>; Cyclopropionic acid-d<sub>1sub>	Isotope-Labeled Compounds	Others
Cyclopropane-1-carboxylic Acid-d₁ is the deuterium labeled Cyclopropane-1-carboxylic Acid ^[1].

HY-W392933S5

Thymidine 5'-monophosphate-d13 dilithium Thymidine-5'-phosphate-d<sub>13sub> dilithium	Isotope-Labeled Compounds	Others
Thymidine 5'-monophosphate-d₁₃ (Thymidine-5'-phosphate-d₁₃) dilithium is deuterium labeled Thymidine 5'-monophosphate (HY-W392933).

HY-B0763S2

Ibudilast-d7-1 KC-404-d<sub>7sub>-1; AV-411-d<sub>7sub>-1; MN-166-d<sub>7sub>-1	Phosphodiesterase (PDE)	Inflammation/Immunology
Ibudilast-d₇-1 is the deuterium labeled Ibudilast ^[1]. Ibudilast (KC-404;AV-411;MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia .

HY-B0141S6

Estradiol-d2-1 β-Estradiol-d<sub>2sub>-1; E2-d<sub>2sub>-1; 17β-Estradiol-d<sub>2sub>-1; 17β-Oestradiol-d<sub>2sub>-1	Isotope-Labeled Compounds Estrogen Receptor/ERR Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Estradiol-d₂-1 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway ^[1] .

HY-101417S1

Diethyl phosphate-d10-1 Diethyl phosphoric acid-d<sub>10sub>	Endogenous Metabolite	Others
Diethyl phosphate-d₁₀-1 is the deuterium labeled Diethyl phosphate. Diethylphosphate (Diethyl phosphoric acid) is an orally active organophosphorus pesticides metabolite. Diethylphosphate can interfere with thyroid hormone-related mechanisms and affect intestinal microbes in rats ^[1].

HY-157440

AChE/Aβ-IN-3	Amyloid-β Reactive Oxygen Species Cholinesterase (ChE)	Neurological Disease
AChE/Aβ-IN-3 (compound AM5) is a dual inhibitor of AChE and Amyloid-β aggregation with *IC_50<.sub>* values of 1.29 and 4.93 μM, respectively. AChE/Aβ-IN-3 has antioxidant properties that scavenge ROS and restore their normal levels. AChE/Aβ-IN-3 can be used in the study of neurological diseases, such as Alzheimer's disease ^[1].

HY-B1411S1

i-Inositol-d1 myo-Inositol-d<sub>1sub>; meso-Inositol-d<sub>1sub>	Isotope-Labeled Compounds Endogenous Metabolite	Others
i-Inositol-d is the deuterium labeled i-Inositol ^[1].

HY-B0152S

Adenine-d1 6-Aminopurine-d<sub>1sub>; Vitamin B4-d<sub>1sub>	DNA/RNA Synthesis Endogenous Metabolite	Cancer
Adenine-d is the deuterium labeled Adenine. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis ^[1] .

HY-B0479S1

Thiamphenicol-d3-1 Thiophenicol-d<sub>3sub>-1; Dextrosulphenidol-d<sub>3sub>-1	Isotope-Labeled Compounds	Infection
Thiamphenicol-d₃-1 (Thiophenicol-d₃-1; Dextrosulphenidol-d₃-1) is the deuterium-labeled Thiamphenicol (HY-B0479) ^[1]. Thiamphenicol (Thiophenicol)，a methyl-sulfonyl derivative of Chloramphenicol，is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit，leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative，Gram-positive aerobic and anaerobic bacteria) .

HY-B0511S

Biotin-d2-1 Vitamin B7 d<sub>2sub>-1; Vitamin H d<sub>2sub>-1; D-Biotin d<sub>2sub>-1	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Biotin-d₂-1 is the deuterium labeled Biotin. Biotin is an enzyme co-factor present in minute amounts in every living cell.

HY-144290

ARN25068	GSK-3 DYRK	Neurological Disease
ARN25068 is a sub-micromolar inhibitor of the three protein kinases, GSK-3β, FYN and *DYRK1A* to tackle tau hyperphosphorylation ^[1].

HY-N7118

Clindamycin hydrochloride monohydrate	Bacterial Antibiotic	Infection Cancer
Clindamycin hydrochloride monohydrate is an oral protein synthesis inhibitory agent that has the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin hydrochloride monohydrate resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin hydrochloride monohydrate decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla) ^[1].

HY-N2037AS1

Higenamine-d4-1 hydrochloride Norcoclaurine-d<sub>4sub>-1 hydrochloride; Demethyl-Coclaurine-d<sub>4sub>-1 hydrochloride	Isotope-Labeled Compounds MAP3K MDM-2/p53 Apoptosis ROS Kinase	Infection Cardiovascular Disease Endocrinology Cancer
Higenamine-d₄-1 (Norcoclaurine-d₄-1) hydrochloride is deuterium labeled Higenamine (hydrochloride). Higenamine hydrochloride is a selective *LSD1* inhibitor (IC₅₀=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine (Norcoclaurine) can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine hydrochloride protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine hydrochloride can be used to study cancer, inflammation, cardiorenal syndrome and other diseases ^[1] .

HY-B0234S4

Estrone-d2-1 E1-d<sub>2sub>-1; Oestrone-d<sub>2sub>-1	Isotope-Labeled Compounds Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology
Estrone-d₂-1 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells ^[1] .

HY-17043S2

Loratadine-d4-1 Loratidine-d<sub>4sub>-1; SCH 29851-d<sub>4sub>-1	Isotope-Labeled Compounds Histamine Receptor Dengue Virus Flavivirus	Infection Inflammation/Immunology Endocrinology Cancer
Loratadine-d₄-1 (Loratidine-d₄-1) is deuterium labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators ^[1].

HY-14648S5

Dexamethasone-d3-1 Hexadecadrol-d<sub>3sub>-1; Prednisolone F-d<sub>3sub>-1	Isotope-Labeled Compounds Antibiotic Autophagy Glucocorticoid Receptor SARS-CoV ADC Cytotoxin Mitophagy Complement System Bacterial	Cancer
Dexamethasone-d₃-1 (Hexadecadrol-d₃-1; Prednisolone F-d₃-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-23188

Loratadine-d5-1 Loratidine-d<sub>5sub>-1; SCH 29851-d<sub>5sub>-1	Isotope-Labeled Compounds	Others
Loratadine-d₅-1 is a deuterated labeled Loratadine (HY-17043). Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC₅₀ of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.

HY-14648S1

Dexamethasone-d5-1 Hexadecadrol-d<sub>5sub>-1; Prednisolone F-d<sub>5sub>-1	Isotope-Labeled Compounds Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic	Infection Inflammation/Immunology Endocrinology Cancer
Dexamethasone-d₅-1 is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125833

Alpha-Naphthoflavone 5+ Cited Publications	Flavonoids Flavones Source classification Indigofera heterantha Wall. ex Brand. Plants Compositae Disease Research Fields Cancer	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis ^[1] .

HY-W011474

Geranylgeraniol	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model ^[1] .

HY-P2274

Argifin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Parasite
Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC₅₀s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively ^[1].

HY-W011474R

Geranylgeraniol (Standard)	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol (Standard) is the analytical standard of Geranylgeraniol. This product is intended for research and analytical applications. Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model ^[1] [4].

HY-N0662

Amentoflavone Maximum Cited Publications 9 Publications Verification Didemethyl-ginkgetin	Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Cancer	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase ^[1] .

HY-W011370

Pelargonidin chloride	Structural Classification Anthocyans Flavonoids Classification of Application Fields Leguminosae Source classification Other Diseases Phenols Polyphenols Plants Phaseolus vulgaris Linn. Disease Research Fields	Reactive Oxygen Species
Pelargonidin chloride is an anthocyanidin and also is a scavenger of nitric oxide radical and has antioxidant activities. Pelargonidin inhibits cell viability and induces cell cycle arrest at sub-G1 phase. Pelargonidin chloride increases the mRNA and protein expression of HO-1, NQO1, Nrf2. Pelargonidin chloride improves Aβ-induced memory and learning impairment ^[1] .

HY-N11799

Neochilenin 3-O-Methylquercetin 4′-O-glucoside	Structural Classification Flavonoids Source classification Plants Compositae Other Flavonoids	Others
Neochilenin (3-O-Methylquercetin 4 '-O-glucoside) is a glycoside of 3-O-methylquercetin, which can be isolated from the sub-family Cereoideae (Cactaceae). ^[1].

HY-N15356

9-Oxooctadecanedioic acid	Structural Classification Ketones, Aldehydes, Acids Source classification Plants Quercus suber L. Fagaceae	Bacterial
9-Oxooctadecanedioic acid is an α,ω-dicarboxylic fatty acid monomer found in the cork suberin of Quercus suber. It contributes to the formation of the hydrophobic barrier structure in plant cell walls and may play an important role in functions such as water resistance and protection against microbial penetration ^[1].

HY-N10192

Aculene D	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Endogenous Metabolite Bacterial
Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations ^[1].

HY-N15496

Fusaproliferin FUS	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Reactive Oxygen Species NO Synthase Interleukin Related TNF Receptor p38 MAPK ERK IKK NF-κB
Fusaproliferin is a sesterterpene mycotoxin isolated from Fusarium solani. Fusaproliferin reverse Lipopolysaccharides (HY-D1056) stimulation and the NF-κB and MAPKs signaling pathways contribute to the anti-inflammatory process. Fusaproliferin exhibits affinity for the TLR4 protein with K_D values of 28.6 μM. Fusaproliferin shows cytotoxicity against pancreatic cancer cell with rapid and sub-micromolar IC₅₀ ^[1] .

HY-P2274R

Argifin (Standard)	Structural Classification Natural Products Microorganisms Source classification	Parasite
Argifin (Standard) is the analytical standard of Argifin. This product is intended for research and analytical applications. Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC50s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively[1].

HY-N0662R

Amentoflavone (Standard)	Structural Classification Flavonoids Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Standard) is the analytical standard of Amentoflavone. This product is intended for research and analytical applications. Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase ^[1] .

HY-B0504S

Creatinine-d3 4 Publications Verification NSC13123-d<sub>3sub>	Classification of Application Fields Metabolic Disease Disease Research Fields	Isotope-Labeled Compounds Endogenous Metabolite
Creatinine-d₃ is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle ^[1].

HY-113511

Glycogen, Mussel	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides	Endogenous Metabolite
Glycogen, Mussel is a glycolytic intermediates and high-energy phosphates that can serve as a form of energy storage in humans, animals, fungi, and bacteria ^[1].

HY-145781

β-L-Fucopyranosyl phosphate	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Drug Intermediate
β-L-Fucopyranosyl phosphate can be used for the research of carbohydrate metabolism. Glycosyl phosphates play crucial roles in carbohydrate metabolism as metabolic regulators or ubiquitous intermediates for glycoconjugate biosynthesis ^[1].

HY-113511A

Glycogen, Oysters	Structural Classification Human Gut Microbiota Metabolites Animals Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides	Endogenous Metabolite Amylases
Glycogen, Oysters is a polysaccharide extracted from oysters and serves as the storage form of glucose in oysters. Glycogen, Oysters belongs to the intermediate products of glycolysis and high-energy phosphates, and is also an endogenous metabolite ^[1] .

HY-N2581R

Phytic acid sodium salt (Standard)	Structural Classification Natural Products Zea mays L. Gramineae Source classification Plants	Endogenous Metabolite
Phytic acid (sodium salt) (Standard) is the analytical standard of Phytic acid (sodium salt). This product is intended for research and analytical applications. Phytic acid sodium salt (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphat) is often present in legume seeds with antinutritional effects. Phytic acid sodium salt is a [PO4]3- storage depot and precursor for other inositol phosphates and pyrophosphates. phytic acid is hydrolyzed by phytases in a stepwise manner in the plant ^[1].

HY-N2581

Phytic acid sodium salt 1 Publications Verification myo-Inositol, hexakis(dihydrogen phosphate) sodium salt; Inositol hexaphosphate sodium salt	Structural Classification Natural Products Zea mays L. Classification of Application Fields Gramineae Source classification Other Diseases Plants Disease Research Fields	Endogenous Metabolite Amyloid-β Autophagy
Phytic acid sodium salt (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphate) is an orally active compound derived from the seeds of legumes. Phytic acid sodium salt is a [PO4] ³- storage depot and precursor for other inositol phosphates and pyrophosphates. phytic acid is hydrolyzed by phytases in a stepwise manner in the plant. Phytic acid sodium salt attenuates Aβ oligomers and upregulates autophagy protein. Phytic acid sodium salt can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research ^[1] .

HY-N3990

Hardwickiic acid 1 Publications Verification (-)-Hardwikiic acid	Classification of Application Fields Neurological Disease Pueraria tuberosa (Roxb. ex Willd.) DC. Source classification Plants Compositae Infection other families Terpenoids Croton tiglium Linn. Diterpenoids Euphorbiaceae Disease Research Fields	Sodium Channel
Hardwickiic acid ((-)-Hardwikiic acid) is an antinociceptive compound that blocks Tetrodotoxin-sensitive voltage-dependent sodium channels. Hardwickiic acid shows insecticidal activity ^[1] .

HY-N6691R

Veratridine (Standard)	Alkaloids Structural Classification Veratrum nigrum Linn. Liliaceae Source classification Plants Isoquinoline Alkaloids	Sodium Channel
Veratridine (Standard) is the analytical standard of Veratridine. This product is intended for research and analytical applications. Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) agonist. Veratridine inhibits the peak current of Nav1.7, with an IC₅₀ of 18.39?μM. Veratridine regulates sodium ion channels mainly by activating sodium ion channels, preventing channel inactivation and increasing sodium ion flow ^[1] .

HY-N6691

Veratridine 3 Publications Verification 3-Veratroylveracevine	Alkaloids Structural Classification Veratrum nigrum Linn. Liliaceae Source classification Plants Isoquinoline Alkaloids	Sodium Channel
Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) agonist. Veratridine inhibits the peak current of Nav1.7, with an IC₅₀ of 18.39 µM. Veratridine regulates sodium ion channels mainly by activating sodium ion channels, preventing channel inactivation and increasing sodium ion flow ^[1] .

HY-N2877

Annonacin	Structural Classification Natural Products Neurological Disease Classification of Application Fields Annona muricata Linn. Source classification Plants Annonaceae Disease Research Fields	Potassium Channel Sodium Channel Na+/K+ ATPase Calcium Channel Apoptosis
Annonacin is an acetylgenin that is toxic by inhibiting the pathway of the mitochondrial complex. Annonacin increases tau phosphorylation in R406W ^+/+ mice. Annonacin acts as an inhibitor of the sodium/potassium and sarcoplasmic reticulum (SERCA) ATPase pumps. Annonacin has significant killing effect on ovarian cancer cell, cervical cancer cell, breast cancer cell, bladder cancer cell and skin cancer cell. Annonacin induces apoptosis through Bax and Caspase-3-related pathways ^[1] .

HY-W016562

Hippuric acid Benzoylglycine	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields	Endogenous Metabolite Keap1-Nrf2 MMP Reactive Oxygen Species TGF-beta/Smad
Hippuric Acid is an orally active metabolite. Hippuric Acid can be produced by intestinal microorganisms from the metabolism of polyphenols, benzoic acid. Hippuric Acid decreases NRF2, MMP9 and leads to ROS accumulation. Hippuric Acid activates TGFβ/SMAD signaling. Hippuric Acid improves hyperuricemia and colitis. Hippuric Acid can also be used in cardiovascular disease research ^[1] . .

Cat. No.	Product Name	Chemical Structure

HY-Y0308S

Phosphate dibasic-d1(sodium)
Phosphate dibasic-d₂ (sodium) is the deuterium labeled Sodium phosphate dibasic ^[1].

HY-Y1322S

Triphenyl phosphate-d15
Triphenyl phosphate-d₁₅ is the deuterium labeled Triphenyl phosphate ^[1].

HY-W008954S

Tris(2-ethylhexyl) phosphate-d17
Tris(2-ethylhexyl) phosphate-d₁₇ ('TRIOCTYL' PHOSPHATE-d₁₇) is a deuterium labeled compound.

HY-W012351S

Tripropyl phosphate-d21
Tripropyl phosphate-d₂₁ is the deuterium labeled Tripropyl phosphate ^[1].

HY-10844S1

Pretomanid-d5
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-146829S

1-Pentadecanoyl-2-oleoyl-sn-glycero-3-phosphate-d7 sodium
1-Pentadecanoyl-2-oleoyl-sn-glycero-3-phosphate-d₇ (sodium) is deuterium labeled 1-Pentadecanoyl-2-oleoyl-sn-glycero-3-phosphate (sodium).

HY-B1829S

Dexamethasone phosphate-d4
Dexamethasone phosphate-d₄ is the deuterium labeled Dexamethasone phosphate ^[1].

HY-15381S

Fingolimod phosphate-d4
Fingolimod phosphate-d₄ is deuterium labeled FTY720 Phosphate.

HY-N5034S

Phosphorylethanolamine-d4
Phosphorylethanolamine-d₄ (Monoaminoethyl phosphate-d₄; NSC 254167-d₄) is a deuterium labeled Phosphorylethanolamine (HY-N5034). Phosphorylethanolamine is an endogenous metabolite.

HY-B0389S3

D-Glucose-d1-1
D-Glucose-d-11 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response ^[1].

HY-W654319

Tri-p-tolyl phosphate-d21
Tri-p-tolyl phosphate-d21 is the deuterium labeled Tri-p-tolyl phosphate ^[1].

HY-W585980S

Bis(2-butoxyethyl) 2-hydroxyethyl phosphate-d4
Bis(2-butoxyethyl) 2-hydroxyethyl phosphate-d₄ (Bis(2-butoxyethyl) 2-hydroxyethyl phosphate-d₄) is a deuterium labeled compound.

HY-W023144S

Tris(1-chloro-2-propyl) phosphate-d18
Tris(1-chloro-2-propyl) phosphate-d₁₈ (Tris(1-chloropropan-2-yl) phosphate-d₁₈) is a deuterium labeled compound.

HY-165664S

β-Glycerophosphate-d5 sodium salt hydrate
β-Glycerophosphate-d₅ (Glyceol 2-Phosphate-d₅) sodium salt hydrateis deuterium labeled β-Glycerophosphate (sodium salt hydrate) ^[1].

HY-B0389S1

D-Glucose-d1
D-Glucose-d is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molec

HY-W008151S

Diphenyl Phosphate-d10
Diphenyl Phosphate-d₁₀ (DPhP-d₁₀) is the deuterium labled Diphenyl Phosphate (HY-W008151). Diphenyl Phosphate inhibits growth and energy metabolism of zebrafish in a sex-specific manner.

HY-N0378S5

D-Mannitol-d1
D-Mannitol-d is the deuterium labeled D-Mannitol.

HY-41700S2

D-Alanine-d1
D-Alanine-d is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC₅₀ of 9 mM for GlyR ^[1].

HY-B0389S4

D-Glucose-d1-2
D-Glucose-d₁-2 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response ^[1].

HY-B0389S7

D-Glucose-d1-3
D-Glucose-d-33 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response ^[1].

HY-B0389S2

D-Glucose-d12-1
D-Glucose-d₁₂-12 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response ^[1].

HY-B0389S23

D-Glucose-d2-1
D-Glucose-d₂-1 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling mol

HY-B0389S8

D-Glucose-d1-4
D-Glucose-d-44 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response ^[1].

HY-19696S2

Tauroursodeoxycholate-d4-1
Tauroursodeoxycholate-d₄-1 is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-109037S2

Mavacamten-d1
Mavacamten-d₁ (MYK461-d₁; SAR439152-d₁) is deuterium labeled Mavacamten (HY-109037). Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC₅₀s of 490, 711 nM for bovine cardiac and human cardiac, respectively.

HY-Y0001S1

Cyclopropylcarboxylic acid-d1
Cyclopropane-1-carboxylic Acid-d₁ is the deuterium labeled Cyclopropane-1-carboxylic Acid ^[1].

HY-W392933S5

Thymidine 5'-monophosphate-d13 dilithium
Thymidine 5'-monophosphate-d₁₃ (Thymidine-5'-phosphate-d₁₃) dilithium is deuterium labeled Thymidine 5'-monophosphate (HY-W392933).

HY-B0763S2

Ibudilast-d7-1

Ibudilast-d₇-1 is the deuterium labeled Ibudilast ^[1]. Ibudilast (KC-404;AV-411;MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia .

HY-B0141S6

Estradiol-d2-1
Estradiol-d₂-1 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway ^[1] .

HY-101417S1

Diethyl phosphate-d10-1
Diethyl phosphate-d₁₀-1 is the deuterium labeled Diethyl phosphate. Diethylphosphate (Diethyl phosphoric acid) is an orally active organophosphorus pesticides metabolite. Diethylphosphate can interfere with thyroid hormone-related mechanisms and affect intestinal microbes in rats ^[1].

HY-B1411S1

i-Inositol-d1
i-Inositol-d is the deuterium labeled i-Inositol ^[1].

HY-B0152S

Adenine-d1
Adenine-d is the deuterium labeled Adenine. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis ^[1] .

HY-B0479S1

Thiamphenicol-d3-1

Thiamphenicol-d₃-1 (Thiophenicol-d₃-1; Dextrosulphenidol-d₃-1) is the deuterium-labeled Thiamphenicol (HY-B0479) ^[1]. Thiamphenicol (Thiophenicol)，a methyl-sulfonyl derivative of Chloramphenicol，is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit，leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative，Gram-positive aerobic and anaerobic bacteria) .

HY-B0511S

Biotin-d2-1
Biotin-d₂-1 is the deuterium labeled Biotin. Biotin is an enzyme co-factor present in minute amounts in every living cell.

HY-N2037AS1

Higenamine-d4-1 hydrochloride

Higenamine-d₄-1 (Norcoclaurine-d₄-1) hydrochloride is deuterium labeled Higenamine (hydrochloride). Higenamine hydrochloride is a selective LSD1 inhibitor (IC₅₀=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine (Norcoclaurine) can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine hydrochloride protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine hydrochloride can be used to study cancer, inflammation, cardiorenal syndrome and other diseases ^[1] .

HY-B0234S4

Estrone-d2-1
Estrone-d₂-1 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells ^[1] .

HY-17043S2

Loratadine-d4-1
Loratadine-d₄-1 (Loratidine-d₄-1) is deuterium labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators ^[1].

HY-14648S5

Dexamethasone-d3-1

Dexamethasone-d₃-1 (Hexadecadrol-d₃-1; Prednisolone F-d₃-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-23188

Loratadine-d5-1
Loratadine-d₅-1 is a deuterated labeled Loratadine (HY-17043). Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC₅₀ of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.

HY-14648S1

Dexamethasone-d5-1

Dexamethasone-d₅-1 is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-14649S6

Retinoic acid-d3-1

Retinoic acid-d₃-1 is the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha ^[1] .

HY-W016577S4

1-Bromoheptane-d1
1-Bromoheptane-d₁ is the deuterium labeled 1-Bromoheptane ^[1].

HY-W099504S2

1-Heptanol-d1
1-Heptanol-d₁ is the deuterium labeled 1-Heptanol ^[1].

HY-100442S1

Paquinimod-d5-1
Paquinimod-d5-1 is a deuterated analog of Paquinimod (HY-100442). Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice ^[1] .

HY-50898S3

Lapatinib-d4-1
Lapatinib-d₄-1 is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively ^[1].

HY-B0400S7

D-Sorbitol-d1-2
D-Sorbitol-d-2 is the deuterium labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and di

HY-G0016S1

N-Acetyl dapsone-d4-1
N-acetyl Dapsone-d₄-1 is the deuterium labeled N-acetyl Dapsone, which is a metabolite of Dapsone.

HY-B0400S8

D-Sorbitol-d2-1
D-Sorbitol-d₂-1 is the deuterium labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and di

HY-10162S3

Olaparib-d4-1
Olaparib-d₄-1 (AZD2281-d₄-1) is the deuterium labeled Olaparib (HY-10162). Olaparib is a potent and orally active PARP inhibitor with IC₅₀s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator ^[1] .

HY-70057S1

Safinamide-d4-1

Safinamide-d₄-1 is deuterium labeled Safinamide. Safinamide is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC₅₀=0.098 μM) over MAO-A (IC₅₀=580 μM) ^[1]. Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC₅₀=8?μM) than at resting (IC₅₀=262?μM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al .

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