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  3. Hardwickiic acid

Hardwickiic acid  (Synonyms: (-)-Hardwickiic acid; (-)-Hardwikiic acid)

Cat. No.: HY-N3990 Purity: ≥98.0%
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Hardwickiic acid ((-)-Hardwickiic acid) is a diterpenoid compound. Hardwickiic acid can block tetrodotoxin-sensitive voltage-dependent sodium channels and possesses multiple activities such as insecticidal, antinociceptive, and neurotransmitter release-regulating effects. Hardwickiic acid can be used in the study of neurological diseases.

For research use only. We do not sell to patients.

Hardwickiic acid Chemical Structure

Hardwickiic acid Chemical Structure

CAS No. : 1782-65-6

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Based on 1 publication(s) in Google Scholar

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1 Publications Citing Use of MCE Hardwickiic acid

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Description

Hardwickiic acid ((-)-Hardwickiic acid) is a diterpenoid compound. Hardwickiic acid can block tetrodotoxin-sensitive voltage-dependent sodium channels and possesses multiple activities such as insecticidal, antinociceptive, and neurotransmitter release-regulating effects. Hardwickiic acid can be used in the study of neurological diseases[1][2][3].

In Vitro

Hardwickiic acid (0-100 nM; 90 s) promotes K+-evoked [3H]noradrenaline overflow in mouse hippocampal synaptosomes[1].
Hardwickiic acid (5 ppm; 24 h) causes 62% mortality in adult female Aphis craccivora aphids[2].
Hardwickiic acid (20 μM) inhibits tetrodotoxin-sensitive voltage-gated sodium channels in rat dorsal root ganglion neurons[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Hardwickiic acid (2 μg/5 μL; intrathecal injection; single dose) exhibits antinociceptive activity in both HIV-1 gp120-induced sensory neuropathy rat models and Paclitaxel (HY-B0015)-induced peripheral neuropathy rat models[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats (225-250 g) treated HIV-1 gp120 or Paclitaxel (HY-B0015)[3]
Dosage: 2 μg/5 μL
Administration: Intrathecal injection; single dose
Result: Significantly reversed mechanical allodynia 1-2 h post-injection, with the effect lasting for 2-3 additional hours in HIV-1 gp120-induced sensory neuropathy model.
Significantly relieved mechanical allodynia 0.5 h post-injection, with the effect lasting for 2-3 hours in paclitaxel-induced peripheral neuropathy model.
Molecular Weight

316.43

Formula

C20H28O3

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@@](CCC=C2C(O)=O)([H])[C@](C)([C@H](C)CC1)CCC3=COC=C3

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥98.0%

References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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