Search Result

Results for "

mRNA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	mRNA (318) 5-HT Receptor (2) AAK1 (1) Acyltransferase (1) ADC Antibody (1) ADC Payload (5) Adrenergic Receptor (4) Akt (8) Aldehyde Dehydrogenase (ALDH) (1) Aldose Reductase (1) Amino Acid Derivatives (1) Amyloid-β (2) Anaplastic lymphoma kinase (ALK) (4) Androgen Receptor (3) Angiotensin Receptor (1) ANGPTL (1) Antibiotic (29) AP-1 (2) Apolipoprotein (5) Apoptosis (52) Aryl Hydrocarbon Receptor (4) ATTECs (1) Autophagy (13) Bacterial (34) Bcl-2 Family (12) Beclin1 (3) Biochemical Assay Reagents (34) Bradykinin Receptor (1) c-Myc (5) Calcium Channel (4) Cannabinoid Receptor (1) Caspase (7) Cathepsin (3) CD19 (2) CDK (13) Ceramidase (1) Cholecystokinin Receptor (2) ClpP (2) CMV (4) Constitutive Androstane Receptor (2) COX (15) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (7) Dihydroorotate Dehydrogenase (1) Dipeptidyl Peptidase (1) DNA Methyltransferase (2) DNA Stain (1) DNA/RNA Synthesis (101) Dopamine Receptor (2) Drug Derivative (1) Drug Intermediate (2) Drug Isomer (2) Drug Metabolite (2) Dystrophin (8) E1/E2/E3 Enzyme (2) EGFR (2) Endogenous Metabolite (54) Enterovirus (5) Epigenetic Reader Domain (3) ERK (5) Estrogen Receptor/ERR (6) Eukaryotic Initiation Factor (eIF) (8) Factor XI (1) Fat Mass and Obesity-associated Protein (FTO) (4) Fatty Acid Synthase (FASN) (4) FGFR (1) FKBP (3) Fluorescent Dye (33) Free Fatty Acid Receptor (1) Fungal (7) GABA Receptor (5) Galectin (2) GHR (2) Gli (2) Glucocorticoid Receptor (8) Glucosylceramide Synthase (GCS) (1) GnRH Receptor (2) GPR171 (1) GSK-3 (1) HCV (2) HDAC (2) Hedgehog (2) Heme Oxygenase (HO) (1) HIF/HIF Prolyl-Hydroxylase (15) Histamine Receptor (3) Histone Acetyltransferase (3) Histone Demethylase (1) Histone Methyltransferase (5) HIV (2) HMG-CoA Reductase (HMGCR) (2) HOXA (1) HSP (2) HSV (3) Huntingtin (5) HuR (4) Hydroxycarboxylic Acid Receptor (HCAR) (1) IFNAR (1) IGF-1R (3) iGluR (1) Indoleamine 2,3-Dioxygenase (IDO) (2) Influenza Virus (8) Insulin Receptor (3) Integrin (3) Interleukin Related (19) IRE1 (7) Isotope-Labeled Compounds (21) JAK (2) JNK (6) Keap1-Nrf2 (8) LDLR (1) Ligands for Target Protein for PROTAC (1) LIM Kinase (LIMK) (1) Lipase (1) Liposome (129) Lipoxygenase (1) LPL Receptor (1) LXR (7) LYTACs (1) MDM-2/p53 (6) MEK (2) Melanocortin Receptor (2) METTL3 (1) mGluR (2) MicroRNA (12) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) Mitosis (1) MMP (13) Molecular Glues (1) Monoamine Oxidase (2) mTOR (2) NEKs (1) NF-κB (22) NO Synthase (14) NOD-like Receptor (NLR) (4) Nuclear Hormone Receptor 4A/NR4A (1) Nucleoside Antimetabolite/Analog (24) Orthopoxvirus (1) Oxysterol-binding Protein-related Protein (ORP) (1) P-glycoprotein (1) p38 MAPK (2) PAI-1 (1) Parasite (8) PCSK9 (5) PD-1/PD-L1 (1) PEPCK (1) PGC-1α (1) Phosphatase (1) Phosphodiesterase (PDE) (7) PI3K (1) PKA (2) Potassium Channel (2) PPAR (6) Pregnane X Receptor (PXR) (2) Progesterone Receptor (6) Prolyl Endopeptidase (PREP) (1) Prostaglandin Receptor (1) PROTACs (7) Protease Activated Receptor (PAR) (2) Proteasome (2) Pyruvate Kinase (1) Quinone Reductase (2) RAR/RXR (3) Reactive Oxygen Species (ROS) (8) Reference Standards (42) RGS Protein (1) ROR (2) RSV (5) RUNX (1) Salt-inducible Kinase (SIK) (1) SARS-CoV (10) Separase (1) Ser/Thr Kinase (1) Serpin (1) SF3B1 (2) Sirtuin (2) Small Interfering RNA (siRNA) (7) Smo (1) Sodium Channel (3) Somatostatin Receptor (1) SphK (3) SRPK (3) STAT (4) Stearoyl-CoA Desaturase (SCD) (1) STING (1) Succinate Dehydrogenase (1) Tau Protein (1) Telomerase (1) Thyroid Hormone Receptor (2) Tie (1) TNF Receptor (8) Toll-like Receptor (TLR) (3) Topoisomerase (1) Transmembrane Glycoprotein (2) Transthyretin (TTR) (4) TRP Channel (3) TSH Receptor (2) Tyrosinase (2) VEGFR (8) Virus Protease (2) Wee1 (1) YAP (1) α-synuclein (1)
By Research Areas:	Cancer (331) Cardiovascular Disease (43) Endocrinology (26) Infection (94) Inflammation/Immunology (262) Metabolic Disease (81) Neurological Disease (89)
Click Chemistry:	Azide (2) Alkynes (1)
Oligonucleotides:	Nucleoside Phosphoramidites (2) saRNAs (2) Guanosine (1) Nucleotide Analogs (6) Adenine (2) mRNA (316) Phospholipids (5) siRNA drugs (8) Cap Analogs (29) Antisense Oligonucleotides (48) Adenine Nucleotide (1) Cytidine Nucleotide (2) siRNAs (8) Fluorescent Lipids (5) Pegylated Lipids (9) Nucleoside Analogs (5) Aptamers (3) CpG ODNs (2) Uridine (3) Inosine (1) Cationic Lipids (60)

1022

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

113

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

494

Oligonucleotides

Targets Recommended: mRNA

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E70081

mRNA Cap 2'-O-methyltransferase	Biochemical Assay Reagents	Others
mRNA Cap 2'-O-methyltransferase uses S-adenosylmethionine (SAM) as a methyl donor to add a methyl group at the 2'-O position of the first nucleotide at the 5’ end of Cap-0 mRNA, resulting in Cap-1 structure. Cap-1 structure promotes translation efficiency, increasing subsequent protein expression .

HY-153229

*Firefly luciferase mRNA-LNP* 1 Publications Verification	mRNA Biochemical Assay Reagents	Others
Firefly luciferase mRNA-LNP is a lipid nanoparticle (LNP) containing firefly luciferase mRNA. Firefly luciferase mRNA-LNP exhibits a stable nanostructure, in which LNP plays a key role in effectively protecting and transporting mRNA to cells. Luciferase is a bioluminescent reporter gene for gene regulation and functional studies. Firefly Luciferase mRNA-LNP expresses firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Firefly luciferase mRNA-LNP is studied in research for RNA delivery, cell viability, and translation efficiency .

HY-153235

*COVID-19 Spike Protein mRNA-LNP*	mRNA SARS-CoV Liposome	Infection
COVID-19 Spike Protein mRNA-LNP is a lipid nanoparticle (LNP) containing *mRNA* encoding COVID-19 Spike Protein. COVID-19 Spike Protein undertakes the functions of virus binding with host cell receptors, thereby mediating the entry of COVID-19 virus into cells. COVID-19 Spike Protein is an important site of action for host neutralizing antibodies and a key target for vaccine design. COVID-19 Spike Protein mRNA-LNP can be used for RNA delivery, vaccine formulation and design targeting SARS-CoV-2 .

HY-153084

*CD19 CAR mRNA* (Mouse)**	CD19 mRNA	Inflammation/Immunology Cancer
CD19 CAR mRNA (Mouse) expresses mouse CD19 CAR protein. CD19 CAR mRNA can trigger transitory expression of CAR, allowing T cells to be targeted without permanent genetic modification. CD19 CAR mRNA targets CD19 which is a transmembrane glycoprotein primarily expressed on B lymphocytes and is important in B cell activation. CD19 CAR mRNA can be studied in cancer research such as lymphoma and leukemia .

HY-153084A

*CD19 CAR mRNA* (Human)** 1 Publications Verification	mRNA CD19	Cancer
CD19 CAR mRNA (Human) expresses Human CD19 CAR protein. CD19 CAR mRNA can trigger transitory expression of CAR, allowing T cells to be targeted without permanent genetic modification. CD19 CAR mRNA targets CD19 which is a transmembrane glycoprotein primarily expressed on B lymphocytes and is important in B cell activation. CD19 CAR mRNA can be studied in cancer research such as lymphoma and leukemia .

HY-153231A

*eGFP mRNA-LNP (500 ng/μL)*	Fluorescent Dye Liposome	Others
eGFP mRNA-LNP (500 ng/μL) is a lipid nanoparticle (LNP) containing eGFP mRNA. eGFP mRNA-LNP carries Enhanced Green Fluorescent Protein (eGFP), which will express green fluorescent protein after entering the cell. eGFP is commonly used as a reporter gene detectable by fluorescence microscopy or flow cytometry (excitation wavelength = 488 nm; emission wavelength = 535/40 bandpass). eGFP mRNA-LNP can be used for RNA delivery, translation efficiency and cell viability .

HY-153231

*eGFP mRNA-LNP*	mRNA Fluorescent Dye Liposome	Others
eGFP mRNA-LNP is a lipid nanoparticle (LNP) containing eGFP mRNA. eGFP mRNA-LNP carries Enhanced Green Fluorescent Protein (eGFP), which will express green fluorescent protein after entering the cell. eGFP is commonly used as a reporter gene detectable by fluorescence microscopy or flow cytometry (excitation wavelength = 488 nm; emission wavelength = 535/40 bandpass). eGFP mRNA-LNP can be used for RNA delivery, translation efficiency and cell viability .

HY-174495

Human EPO mRNA	mRNA	Others
Human EPO mRNA encodes the human erythropoietin (EPO) protein, a hormone that controls erythropoiesis, or red blood cell production. EPO also plays a role in wound healing and the brain’s response to neural injury. Kariko et al. showed that transfection of EPO mRNA in vivo resulted in significant increases of both reticulocyte counts and hematocrits.

HY-150361

Mouse Tert mRNA	mRNA	Cancer
Mouse Tert mRNA encodes the mouse telomerase reverse transcriptase (Tert) protein that plays important roles in aging and antiapoptosis.

HY-174722

Human DCT mRNA	mRNA	Cancer
Human DCT mRNA encodes the human dopachrome tautomerase (DCT) protein, which is involved in regulating eumelanin and phaeomelanin levels.

HY-174795

mCherry mRNA	mRNA	Others
mCherry mRNA encodes the mCherry fluorescent protein, which is derived from Anaplasma marginale. mCherry can be used as a fluorescent tracer in transfection and transgenic experiments or as a reporter of gene expression.

HY-174501

*β-galactosidase mRNA* (5moU)** Beta-galactosidase mRNA (5moU)	mRNA	Others
β-galactosidase mRNA (5moU) encodes β-galactosidase, a protein product of the bacterial LacZ gene. β-galactosidase catalyzes the conversion of β-galactosides into monosaccharides which could be used as a common marker to assess transfection efficiency. The incorporation of 5moU can reduce the immunogenicity of the resulting mRNA.

HY-174578

Human MYB mRNA	mRNA	Cancer
Human MYB mRNA encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. MYB plays an essential role in the regulation of hematopoiesis.

HY-174500

eSpCas9 mRNA	mRNA	Others
The eSpCas9 mRNA expresses enhanced-specificity SpCas9 protein, with sequence originally from Slaymaker et al Science. 2015 Dec 1.

HY-174485

OVA mRNA	mRNA	Others
OVA mRNA encodes the ovalbumin (OVA) protein, a member of the serpin superfamily and the predominant glycoprotein found in egg whites. It is a commonly used antigen for immunization and biochemical studies and is an established model allergen for airway hyper-responsiveness.

HY-174576

Human MYDGF mRNA	mRNA	Inflammation/Immunology
Human MYDGF mRNA encodes the human myeloid derived growth factor (MYDGF) protein. MYDGF was previously thought to support proliferation of lymphoid cells and was considered an interleukin.

HY-174656

Human IFNW1 mRNA	mRNA	Inflammation/Immunology
Human IFNW1 mRNA encodes the human interferon omega 1 (IFNW1) protein, an interferon that possesses antiviral activity.

HY-174585

Human MAFA mRNA	mRNA	Metabolic Disease
Human MAFA mRNA encodes the human MAF bZIP transcription factor A (MAFA) protein, a transcription factor that regulates pancreatic beta cell-specific expression of the insulin gene.

HY-174667

Human IFNA4 mRNA	mRNA	Cancer
Human IFNA4 mRNA encodes the human interferon alpha 4 (IFNA4) protein, which may have antiviral activities.

HY-174789

Gaussia luciferase mRNA	mRNA	Others
Gaussia luciferase (GLuc) mRNA will express a luciferase protein, derived from the Gaussia princeps. luciferases are widely used in biotechnology, for microscopy and as reporter genes, for many of the same applications as fluorescent proteins.

HY-174577

Human MYC mRNA	mRNA	Cancer
Human MYC mRNA encodes the human MYC proto-oncogene, bHLH transcription factor (MYC) protein, a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation.

HY-150358

β-galactosidase mRNA Beta-galactosidase mRNA	mRNA	Others
β-galactosidase mRNA encodes β-galactosidase, a protein product of the bacterial LacZ gene. β-galactosidase catalyzes the conversion of β-galactosides into monosaccharides which could be used as a common marker to assess transfection efficiency.

HY-174497

eGFP mRNA	mRNA	Others
eGFP mRNA expresses an enhanced version of the green fluorescent protein, originally isolated from the jellyfish, Aequorea victoria. EGFP is a commonly used direct detection reporter in mammalian cell culture, yielding bright green fluorescence with an emission peak at 509 nm.

HY-174590

Human LIN28A mRNA	mRNA	Cancer
Human Lin-28 homolog A (LIN28A) mRNA encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. LIN28A functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development.

HY-174773

Human BTC mRNA	mRNA	Metabolic Disease
Human BTC mRNA encodes the human betacellulin (BTC) protein, a member of the epidermal growth factor family. BTC promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability.

HY-174719

Human ELANE mRNA	mRNA	Inflammation/Immunology
Human ELANE mRNA encodes the human elastase (ELANE) protein, a member of serine proteases family. ELANE may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin.

HY-174655

Human IGF1 mRNA	mRNA	Metabolic Disease
Human IGF1 mRNA encodes the human insulin like growth factor 1 (IGF1) protein which is involved in mediating growth and development.

HY-174624

Human IL20 mRNA	mRNA	Inflammation/Immunology
Human IL20 mRNA encodes the human interleukin 20 (IL20) protein, a proinflammatory and angiogenic cytokine that may involves in epidermal function and psoriasis.

HY-174790

Firefly Luciferase mRNA	mRNA	Others
Firefly Luciferase (FLuc) mRNA will express a luciferase protein, originally isolated from the Photinus pyralis (Firefly). FLuc is commonly used in mammalian cell culture to measure both gene expression and cell viability.

HY-174682

Human FOS mRNA	mRNA	Cancer
Human FOS mRNA encodes the human Fos proto-oncogene, AP-1 transcription factor subunit (FOS) protein which has been implicated as regulators of cell proliferation, differentiation, and transformation.

HY-174717

Human ERAS mRNA	mRNA	Cancer
Human ERAS mRNA encodes the human ES cell expressed Ras (ERAS) protein, a constitutively active member of the small GTPase Ras protein family. ERAS may be involved in cancer and chemotherapy resistance.

HY-174535

Human TGFA mRNA	mRNA	Cancer
Human TGFA mRNA encodes the human transforming growth factor alpha (TGFA) protein. TGFA is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development.

HY-150144

Uracil-m7GpppAmpG ammonium	DNA/RNA Synthesis	Others
Uracil-m7GpppAmpG ammonium is a cap analog that can be used for mRNA synthesis.

HY-168380

Lipid C3	Biochemical Assay Reagents	Others
Lipid C3 can be used to synthesize lipid-like nanoparticles (LNPs) for delivery of mRNA .

HY-174780

Human AMHR2 mRNA	mRNA	Cancer
Human AMHR2 mRNA encodes the human anti-Mullerian hormone receptor type 2 (AMHR2) protein, a receptor for the anti-Mullerian hormone (AMH).

HY-174570

Human NEUROG3 mRNA	mRNA	Neurological Disease
Human NEUROG3 mRNA encodes the human neurogenin 3 (NEUROG3) protein, a basic helix-loop-helix (bHLH) transcription factor that involved in neurogenesis.

HY-150360

Renilla luciferase mRNA	mRNA	Others
Renilla luciferase (RLuc) mRNA will express a luciferase protein, originally isolated from the Renilla muelleri (Sea pansy). Luciferases are widely used in biotechnology, for microscopy and as reporter genes, for many of the same applications as fluorescent proteins.

HY-174537

Human TERT mRNA	mRNA	Cancer
Human TERT mRNA encodes the human telomerase reverse transcriptase (TERT) protein, a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex.

HY-174587

Human LTB mRNA	mRNA	Inflammation/Immunology
Human LTB mRNA encodes the human lymphotoxin beta (LTB) protein, a type II membrane protein of the TNF family. LTB is an inducer of the inflammatory response system and also involved in normal development of lymphoid tissue.

HY-174579

Human MNX1 mRNA	mRNA	Metabolic Disease
Human MNX1 mRNA encodes the human motor neuron and pancreas homeobox 1 (MNX1) protein, a putative transcription factor involved in pancreas development and function.

HY-174634

Human IL16 mRNA	mRNA	Inflammation/Immunology
Human IL16 mRNA encodes the human interleukin 16 (IL16) protein, a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication.

HY-174608

Human IL32 mRNA	mRNA	Inflammation/Immunology
Human IL32 mRNA encodes the human interleukin 32 (IL32) protein, a member of the cytokine family. IL32 induces the production of TNFalpha from macrophage cells.

HY-174581

Human MET mRNA	mRNA	Cancer
Human MET mRNA encodes the human MET proto-oncogene, receptor tyrosine kinase (MET) protein, a member of the receptor tyrosine kinase family. MET regulates many physiological processes including proliferation, scattering, morphogenesis and survival.

HY-174661

Human IFNK mRNA	mRNA	Inflammation/Immunology
Human IFNK mRNA encodes the human interferon kappa (IFNK) protein, a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections.

HY-174716

Human EREG mRNA	mRNA	Inflammation/Immunology
Human EREG mRNA encodes the human epiregulin (EREG) protein, a member of the epidermal growth factor family. EREG may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation.

HY-174718

Human EPGN mRNA	mRNA	Cancer
Human EPGN mRNA encodes the human epithelial mitogen (EPGN) protein, a member of the epidermal growth factor family. EPGN can promote the growth of epithelial cells and may stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.

HY-164875

Apt-A-FAM-AS	Biochemical Assay Reagents	Others
Apt-A-FAM-AS is a type of mRNA.

HY-174516

Human TNFRSF1A mRNA	mRNA	Cancer
Human TNFRSF1A mRNA encodes the human TNF receptor superfamily member 1A (TNFRSF1A) protein, a member of the TNF receptor superfamily.

HY-174715

Human ETV2 mRNA	mRNA	Cancer
Human ETS variant transcription factor 2 (ETV2) mRNA encodes a protein that can binds to DNA sequences containing the consensus pentanucleotide 5''-CGGA[AT]-3''.

HY-174609

Human IL31 mRNA	mRNA	Inflammation/Immunology
Human IL31 mRNA encodes the human interleukin 31 (IL31) protein, which may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-141472

7-Methylguanosine 5'-diphosphate sodium 7-Methyl-GDP sodium; m7GDP sodium	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
7-Methylguanosine 5'-diphosphate (7-Methyl-GDP) sodium, a cap analog, can be used in the synthesis of mRNA cap analogues .

HY-W510159

5-O-Methylembelin	Structural Classification Lysimachia vulgarisL. Source classification Coumarins Phenylpropanoids Plants Primulaceae	PCSK9
5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9, inducible degrader of the low-density lipoprotein receptor (IDLR), and sterol regulatory element binding protein 2 (SREBP2) mRNA expression .

HY-N0857

Deoxyandrographolide 1 Publications Verification	Andrographis paniculata (Burm. F.) Nees Acanthaceae Terpenoids Source classification Diterpenoids Plants	Interleukin Related
Deoxyandrographolide suppresses LPS induced increase in mRNA levels of iNOS as well as production of proinflammatory mediators TNF-α and IL-6. Deoxyandrographolide potentiates NGF-induced neurite outgrowth .

HY-139576B

Larsucosterol (trimethylamine) DUR-928 (trimethylamine)	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	LXR Endogenous Metabolite
Larsucosterol (DUR-928) trimethylamine, a cholesterol metabolite, is a potent liver X receptor (LXR) antagonist. Larsucosterol trimethylamine as a potent endogenous regulator decreases lipogenesis. Larsucosterol trimethylamine inhibits the cholesterol biosynthesis via decreasing mRNA levels and inhibiting the activation of SREBP-1 .

HY-113061R

Pseudouridine (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Other disease Source classification Disease markers Endogenous metabolite	Reference Standards Endogenous Metabolite Nucleoside Antimetabolite/Analog DNA/RNA Synthesis
Pseudouridine (Standard) is the analytical standard of Pseudouridine. This product is intended for research and analytical applications. Pseudouridine is an isomer of the nucleoside uridine, and the most abundant modified nucleoside in non-coding RNAs. Pseudouridine in rRNA and tRNA can fine-tune and stabilize the regional structure and help maintain their functions in mRNA decoding, ribosome assembly, processing and translation [4].

HY-113061

Pseudouridine	Structural Classification Natural Products Human Gut Microbiota Metabolites Other disease Classification of Application Fields Source classification Disease markers Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite Nucleoside Antimetabolite/Analog DNA/RNA Synthesis
Pseudouridine is an isomer of uridine and the most abundant modified nucleoside in non-coding RNA. It fine-tunes and stabilizes regional structures in rRNA and tRNA, maintaining their functions in mRNA decoding, ribosome assembly, processing, and translation. Pseudouridine-modified tRNA fragments can inhibit aberrant protein synthesis and hold promise for research on myelodysplastic syndrome (MDS)-related leukemia. .

HY-131081

γ-Amanitin	Structural Classification Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Source classification Disease Research Fields Cancer	DNA/RNA Synthesis ADC Payload
γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin. γ-Amanitin competitively binds to monoclonal antibody (mAb), with an IC₅₀ of 163.1 ng/mL. γ-Amanitin is toxic to a variety of cells .

HY-139576

Larsucosterol DUR-928	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	LXR Endogenous Metabolite
Larsucosterol (DUR-928), a cholesterol metabolite, is a potent liver X receptor (LXR) antagonist. Larsucosterol as a potent endogenous regulator decreases lipogenesis. Larsucosterol inhibits the cholesterol biosynthesis via decreasing mRNA levels and inhibiting the activation of SREBP-1 .

HY-139576A

Larsucosterol sodium DUR-928 sodium	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	LXR Endogenous Metabolite
Larsucosterol (DUR-928) sodium, a cholesterol metabolite, is a potent liver X receptor (LXR) antagonist. Larsucosterol sodium as a potent endogenous regulator decreases lipogenesis. Larsucosterol sodium inhibits the cholesterol biosynthesis via decreasing mRNA levels and inhibiting the activation of SREBP-1 .

HY-N7661

4β-Hydroxywithanolide E	Source classification Plants Solanaceae Steroids	PPAR
4β-Hydroxywithanolide E, isolated from Physalis peruviana L., inhibits adipocyte differentiation of 3T3-L1 cells through modulation of mitotic clonal expansion. 4β-Hydroxywithanolide E is an adipogenesis inhibitor and inhibits PPARγ, C/EBPα, and the adipocyte-specific molecule aP2 mRNA expression .

HY-N10295

Flavipin	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Inflammation/Immunology Disease Research Fields	Aryl Hydrocarbon Receptor
Flavipin is an aryl hydrocarbon receptor (Ahr) agonist that induces the expression of Ahr downstream genes in mouse CD4 ⁺ T cells and CD11b ⁺ macrophages. Flavipin inhibits the stabilizing function of Arid5a on Il23a 3′UTR, a newly identified target mRNA . Flavipin exhibits the DPPH free radical scavenging ability with IC₅₀ value of 7.2 μM, and has potent α-glucosidase inhibition with IC₅₀ value of 33.8 μM .

HY-103248

Toyocamycin 5+ Cited Publications Vengicide	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	IRE1 Fungal Antibiotic Apoptosis CDK
Toyocamycin (Vengicide) is an adenosine analog produced by Streptomyces diastatochromogenes, acts as an XBP1 inhibitor. Toyocamycin blocks RNA synthesis and ribosome function, and induces apoptosis. Toyocamycin affects IRE1α-XBP1 pathway, and inhibits XBP1 mRNA cleavage with an IC₅₀ value of 80 nM with affecting IRE1α auto-phosphorylation. Toyocamycin specifically inhibits CDK9 with an IC₅₀ value of 79 nM .

HY-N6675

Gardenia yellow	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Lridaceae Plants Crocus sativus L. Disease Research Fields Cancer	Sirtuin
Gardenia yellow is an active member of crocin, increases mRNA expression of SIRT3, and acts as an orally active antidepressant agent .

HY-N5118

Chimonanthine (-)-Chimonanthine	Alkaloids Classification of Application Fields Source classification Chimonanthus nitens Oliv. Plants Disease Research Fields Alkaloid Dimers Cancer Calycanthaceae	Tyrosinase
Chimonanthine is an alkaloid of Chimonanthus praecox, inhibits tyrosinase and tyrosine-related protein-1 mRNA expression, amd inhibits melanogenesis .

HY-139103

Thailanstatin C	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	DNA/RNA Synthesis
Thailanstatin C is a *pre-mRNA* splicing inhibitor (IC₅₀*= 6.84 μM) and antiproliferative agent from Burkholderia thailandensis* MSMB43 .

HY-N1125

Triptobenzene H Hypoglic acid	Structural Classification Ketones, Aldehydes, Acids Terpenoids Source classification Celastraceae Diterpenoids Tripterygium wilfordii Hook. f. Plants	TNF Receptor
Triptobenzene H (Hypoglic acid) significantly increases TNF-α and IL-1β mRNA levels in macrophages, causing indirect liver damage .

HY-N0023

Cistanoside A	Classification of Application Fields Simple Phenylpropanols Source classification Cistanche deserticola Ma Phenols Polyphenols Orobanchaceae Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology	NO Synthase
Cistanoside A is a phenylethanoid isolated from Cistanche deserticola, reduces NO accumulation, but shows no effect on iNOS mRNA, iNOS protein levels or iNOS activity. Anti-inflammatory effect .

HY-N3720

Demethoxycapillarisin 6-Demethoxycapillarisin	Source classification Artemisia dracunculus L. Plants Compositae	PEPCK
Demethoxycapillarisin (6-Demethoxycapillarisin) inhibits PEPCK mRNA levels (IC₅₀: 43 μM) by activation of the PI3K pathway. Demethoxycapillarisin decreases glucose production .

HY-W014410

Mucic acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Others
Mucic acid (Galactaric acid) is a building block for polymers. Mucic acid stimulates Runx2 mRNA expression. Mucic acid can be used in polymer synthesis and bone tissue engineering research .

HY-N1949

Homoplantaginin 4 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Labiatae Source classification Cassia Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	TNF Receptor NF-κB
Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia with antiinflammatory and antioxidant properties. Homoplantaginin could inhibit TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation.

HY-N0637A

(±)-Eriodictyol (±)-Huazhongilexone; Dihydroluteolin	Structural Classification Flavonoids Lythraceae Lawsonia inermis L. Flavones Source classification Plants	Melanocortin Receptor
(±)-Eriodictyol ((±)-Huazhongilexone), a flavonoid, is a potent melanogenesis inhibitor with an IC₅₀ of 48 μM. (±)-Eriodictyol suppresses tyrosinase, TRP-1, and TRP-2 mRNA expression. (±)-Eriodictyol has strong anti-plasmin activities .

HY-B2230

Hinokitiol 5+ Cited Publications β-Thujaplicin	Infection Structural Classification Cupressaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Chamaecyparis obtusa	Keap1-Nrf2 DNA Methyltransferase Virus Protease
Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.

HY-113447

11-Dehydrocorticosterone 2 Publications Verification	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
11-Dehydrocorticosterone is a endogenous corticosteroid. 11-Dehydrocorticosterone can be a source of transcriptionally active glucocorticoid in cardiac myocytes and fibroblasts. 11-Dehydrocorticosterone can increase SGK mRNA expression in cardiac fibroblast .

HY-N3312

Matairesinol	Infection Structural Classification other families Classification of Application Fields Anti-aging Source classification Lignans Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields	Endogenous Metabolite
Matairesinol confers anti-allergic effects in an allergic dermatitis mouse model. DfE-induced changes in IL-4 and IFN-γ mRNA expression in the ears of NC/Nga mice were reversed by matairesinol application .

HY-N2117

Isoginkgetin Maximum Cited Publications 17 Publications Verification	Structural Classification Flavonoids Ginkgoaceae Classification of Application Fields Source classification Phenols Polyphenols Plants Biflavones Ginkgo biloba Disease Research Fields Cancer	MMP Akt NF-κB Proteasome Apoptosis Autophagy
Isoginkgetin is a *pre-mRNA* splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy** .

HY-134046

(-)-Isodocarpin Isodocarpin	Labiatae Source classification Ambrosia camphorata (Greene) W.W.Payne Plants	Melanocortin Receptor
(-)-Isodocarpin (Isodocarpin), a diterpenoid, is a potent melanogenesis inhibitor with an IC₅₀ of 0.19 μM in B16 4A5 cells. (-)-Isodocarpin inhibits the expression of tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA .

HY-N0086

N6-Methyladenosine 5+ Cited Publications 6-Methyladenosine; N-Methyladenosine	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Influenza Virus Endogenous Metabolite
N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities.

HY-N11772

Mutanocyclin	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Fungal
Mutanocyclin is a potent antifungal agent. Mutanocyclin inhibits Candida albicans (C. albicans) filamentation. Mutanocyclin decreases the mRNA expression of HWP1, ECE1, FLO8, TEC1. Mutanocyclin inhibits yeast-form in ex vivo mouse .

HY-122524

7-Methylguanosine 1 Publications Verification	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Nucleoside Antimetabolite/Analog Endogenous Metabolite DNA/RNA Synthesis
7-Methylguanosine is a modified nucleoside widely present in various RNAs and a key metabolite of the 5'-cap structure of eukaryotic mRNA. 7-Methylguanosine plays important roles in stabilizing RNA structures, regulating translation, and other aspects .

HY-N0698

Crocin II	Structural Classification Neurological Disease Classification of Application Fields Terpenoids Source classification Rubiaceae Diterpenoids Plants Gardenia jasminoides Ellis Inflammation/Immunology Disease Research Fields	NO Synthase COX Endogenous Metabolite
Crocin II is isolated from the fruit of Gardenia jasminoides with antioxidant, anticancer, and antidepressant activity. Crocin II inhibits NO production with an IC₅₀ value of 31.1 μM. Crocin II suppresses the expressions of protein and m-RNA of iNOS and COX-2 .

HY-137957

Longiferone B	Structural Classification Terpenoids Sesquiterpenes Source classification Boesenbergia longiflora (Wallich) Kuntze Plants Zingiberaceae	NO Synthase COX
Longiferone B is a daucane sesquiterpene, that can be isolated from Boesenbergia longiflora rhizomes. Longiferone B shows anti-inflammatory activity against NO release with an IC₅₀ of 21.0 μM. Longiferone B also suppresses the iNOS and COX-2 mRNA expression .

HY-B0652

Etonogestrel 3-Oxodesogestrel; 3-keto-Desogestrel	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Drug Metabolite Estrogen Receptor/ERR Progesterone Receptor Endogenous Metabolite FKBP
Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs . Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs) .

HY-N0582

Otophylloside B	Structural Classification Neurological Disease Classification of Application Fields Anti-aging Source classification Asclepiadaceae Cynanchum otophyllum Schneid． Plants Disease Research Fields Steroids	Amyloid-β
Otophylloside B, a C-21 steroidal glycoside isolated from Qingyangshen. Otophylloside B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mRNA level. Otophylloside B has antiepileptic activity .

HY-N9371

Crocin IV Dicrocin	Classification of Application Fields Terpenoids Source classification Other Diseases Pigments Diterpenoids Lridaceae Plants Crocus sativus L. Disease Research Fields Food Research	Endogenous Metabolite
Crocin IV (Dicrocin), a crocetin glycoside, is a carotenoid pigment. Crocin IV has potent antioxidant activity .

HY-131083

ε-Amanitin	Structural Classification Natural Products Monophenols Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields Cancer	DNA/RNA Synthesis ADC Payload
ε-Amanitin, a cyclic peptide isolated from a variety of mushroom species, potently binds to and inhibits the activity of RNA polymerase II .

HY-N9371R

Crocin IV (Standard) Dicrocin (Standard)	Structural Classification Terpenoids Source classification Diterpenoids Lridaceae Plants Crocus sativus L.	Reference Standards Endogenous Metabolite
Crocin IV (Standard) is the analytical standard of Crocin IV. This product is intended for research and analytical applications. Crocin IV (Dicrocin), a crocetin glycoside, is a carotenoid pigment. Crocin IV has potent antioxidant activity .

HY-N2160

6'''-Feruloylspinosin	Structural Classification Flavonoids other families Flavones Source classification Phenols Polyphenols Plants	GABA Receptor
6'''-Feruloylspinosin is a flavonoid isolated from seeds of Ziziphus jujuba. 6'''-Feruloylspinosin can across the blood-brain barrier and enhance the expression of GABAAα1, GABAAα5, and GABABR1 mRNA in rat hippocampal neurons .

HY-B1614

Clenbuterol hydrochloride 4 Publications Verification NAB-365 hydrochloride	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology	Adrenergic Receptor
Clenbuterol (NAB-365) hydrochloride, a selective β2-adrenergic agonist, enhances skeletal muscle strength and hypertrophy. Clenbuterol hydrochloride induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage .

HY-129461

Dibenzyl trisulfide DTS	Structural Classification Natural Products Petiveriaceae Source classification Plants Petiveria alliacea	Cathepsin
Dibenzyl trisulfide (DTS) is an active ingredient that can be isolated from Petiveria alliacea L.. Dibenzyl trisulfide inhibits cell proliferation and migration. Dibenzyl trisulfide decreased the mRNA and protein expression of BAK-1 and LTA. Dibenzyl trisulfide induces lysosomal membrane permeabilization and cathepsin B release .

HY-N1949R

Homoplantaginin (Standard)	Structural Classification Flavonoids Flavones Labiatae Source classification Cassia Phenols Polyphenols Plants	Reference Standards TNF Receptor NF-κB
Homoplantaginin (Standard) is the analytical standard of Homoplantaginin. This product is intended for research and analytical applications. Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia with antiinflammatory and antioxidant properties. Homoplantaginin could inhibit TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation.

HY-B2230R

Hinokitiol (Standard)	Structural Classification Cupressaceae Ketones, Aldehydes, Acids Source classification Plants Chamaecyparis obtusa	Keap1-Nrf2 DNA Methyltransferase Virus Protease
Hinokitiol (Standard) is the analytical standard of Hinokitiol. This product is intended for research and analytical applications. Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.

HY-W014410R

Mucic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Biochemical Assay Reagents RUNX
Mucic acid (Standard) is the analytical standard of Mucic acid (HY-W014410). This product is intended for research and analytical applications. Mucic acid (Galactaric acid) is a building block for polymers. Mucic acid stimulates Runx2 mRNA expression. Mucic acid can be used in polymer synthesis and bone tissue engineering research .

HY-N3312R

Matairesinol (Standard)	Structural Classification other families Source classification Lignans Phenols Polyphenols Phenylpropanoids Plants	Reference Standards Endogenous Metabolite
Matairesinol (Standard) is the analytical standard of Matairesinol. This product is intended for research and analytical applications. Matairesinol confers anti-allergic effects in an allergic dermatitis mouse model. DfE-induced changes in IL-4 and IFN-γ mRNA expression in the ears of NC/Nga mice were reversed by matairesinol application .

HY-N15226

Butyrolactone Ia	Structural Classification Microorganisms Source classification Phenols	NO Synthase Interleukin Related Autophagy
Butyrolactone Ia is the inhibitor for the NO production with an IC₅₀ of 18 μM. Butyrolactone Ia inhibits LPS (HY-D1056)-induced mRNA expression of iNOS and the inflammatory cytokine IL-1β. Butyrolactone Ia modulates autophagy in HeLa cells, and exhibits immune suppressive activity .

HY-N1356

Reticuline 1 Publications Verification	Cardiovascular Disease Alkaloids Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Plants Lauraceae Isoquinoline Alkaloids Lindera aggregata (Sims) Kosterm. Disease Research Fields	JAK STAT NF-κB Endogenous Metabolite
Reticuline shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3 . Reticuline exhibits cardiovascular effects .

HY-N7151R

Aurachin D (Standard)	Structural Classification Alkaloids Microorganisms Source classification Quinoline Alkaloids	Antibiotic Bacterial Fungal Reference Standards
Kasugamycin (hydrochloride) (Standard) is the analytical standard of Kasugamycin (hydrochloride). This product is intended for research and analytical applications. Kasugamycin hydrochloride (Ksg hydrochloride) is an antibiotic which binds both the 30S and 70S ribosome but not isolated 50S subunits. Kasugamycin hydrochloride (Ksg hydrochloride) mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation .

HY-N2117R

Isoginkgetin (Standard)	Structural Classification Flavonoids Ginkgoaceae Source classification Phenols Polyphenols Plants Biflavones Ginkgo biloba	Reference Standards MMP Akt NF-κB Proteasome Apoptosis Autophagy
Isoginkgetin (Standard) is the analytical standard of Isoginkgetin. This product is intended for research and analytical applications. Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy .

HY-N2426R

Clerodendrin (Standard)	Clerodendrum trichotomum Thunb. Structural Classification Flavonoids Verbenaceae Plants Isoflavones	Reference Standards Interleukin Related
Desvenlafaxine (Standard) is the analytical standard of Desvenlafaxine. This product is intended for research and analytical applications. Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter .

HY-N2426

Clerodendrin	Clerodendrum trichotomum Thunb. Structural Classification Flavonoids Verbenaceae Plants Isoflavones	Interleukin Related
Clerodendrin is a nature product could be isolated from Lobelia chinensis. Clerodendrin is a potent dual Interleukin-4 (IL-4) inhibitor and β-hexosaminidase (Hex) inhibitor .

HY-19828

Herboxidiene GEX1A	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	DNA/RNA Synthesis
Herboxidiene (GEX1A) is a potent phytotoxic polyketide from Streptomyces sp. A7847 with a diverse range of activities, including herbicidal, anti-cholesterol, anti-tumor effects. Herboxidiene inhibits the *pre-mRNA* splicing** process by binding to spliceosome-associated protein (SAP) 155, a subunit of SF3b, in the splicesome .

Cat. No.	Product Name	Chemical Structure

HY-109101S

Risdiplam-d4
Risdiplam-d₄ is deuterium labeled Risdiplam. Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels .

HY-138622S1

24:0 Lyso PC-d4
24:0 Lyso PC-d₄4 is the deuterium labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery .

HY-138622S

24:0 Lyso PC-13C6
24:0 Lyso PC- ¹³C₆ is the ¹³C labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery .

HY-13580S

Budesonide-d8
Budesonide-d₈ is the deuterium labeled Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma .

HY-147338S

5-Methylcytidine 5′-triphosphate-d3 trisodium

5-Methylcytidine 5′-triphosphate-d₃ trisodium is the deuterium labeled 5-Methylcytidine 5’-triphosphate trisodium (HY-147338A). 5-Methylcytidine 5′-triphosphate (5-Methyl-CTP) trisodium is a modified nucleoside triphosphate. 5-Methylcytidine 5′-triphosphate trisodium can apply in replacing unmodified mRNA, resulting in the increase of translational properties and stability, as well as the reduction of innate immune responses in human and other mammalian cells .

HY-113061S

Pseudouridine-O18
Pseudouridine- ¹⁸O is the ¹⁸O labeled Pseudouridine (HY-113061). Pseudouridine is an isomer of the nucleoside uridine, and the most abundant modified nucleoside in non-coding RNAs. Pseudouridine in rRNA and tRNA can fine-tune and stabilize the regional structure and help maintain their functions in mRNA decoding, ribosome assembly, processing and translation.

HY-109101AS2

Risdiplam-hydroxylate-d6
Risdiplam-hydroxylate-d₆ is a Risdiplam-hydroxylate tritium substitute. Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels .

HY-109101AS1

Risdiplam-hydroxylate-d3
Risdiplam-hydroxylate-d₃ is a Risdiplam-hydroxylate tritium substitute. Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels .

HY-163712S

17-Epiestriol-d5-1

17-Epiestriol-d₅-1 is the deuterium labeled 17-Epiestriol (HY-163712). 17-Epiestriol is an estrogen metabolite and a selective estrogen receptor (ER) β agonist. 17-epiestriol inhibits the mRNA and protein expression of the vascular cell adhesion molecule VCAM-1 induced by tumor necrosis factor α (TNFα). 17-epiestriol also inhibits TNFα-induced VCAM-1 expression and prevents NF-κB migration to the nucleus. 17-Epiestriol also induces the mRNA and protein expression of endothelial nitric oxide synthase .

HY-N3312S

Matairesinol-d6
Matairesinol-d₆ is the deuterium labeled Matairesinol. Matairesinol confers anti-allergic effects in an allergic dermatitis mouse model. DfE-induced changes in IL-4 and IFN-γ mRNA expression in the ears of NC/Nga mice were reversed by matairesinol application .

HY-W742981

Budesonide-d6
Budesonide-d₆ is deuterium labeled Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma .

HY-B0652S1

Etonogestrel-d6
Etonogestrel-d₆ is deuterium labeled Etonogestrel. Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs . Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs) .

HY-N0086S2

N6-Methyladenosine-13C4
N6-Methyladenosine- ¹³C₄ (6-Methyladenosine- ¹³C₄; N-Methyladenosine- ¹³C₄) is ¹³C-labeled N6-Methyladenosine (HY-N0086). N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities.

HY-N0086S3

N6-Methyladenosine-13C3
N6-Methyladenosine- ¹³C₃ (6-Methyladenosine- ¹³C₃) is ¹³C-labeled N6-Methyladenosine (HY-N0086). N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities .

HY-W768571

Pseudouridine-13C,15N2

Pseudouridine- ¹³C, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled Pseudouridine (HY-113061). Pseudouridine is an isomer of uridine and the most abundant modified nucleoside in non-coding RNA. It fine-tunes and stabilizes regional structures in rRNA and tRNA, maintaining their functions in mRNA decoding, ribosome assembly, processing, and translation. Pseudouridine-modified tRNA fragments can inhibit aberrant protein synthesis and hold promise for research on myelodysplastic syndrome (MDS)-related leukemia. .

HY-N0086S

N6-Methyladenosine-d3
N6-Methyladenosine-d₃ (6-Methyladenosine-d₃; N-Methyladenosine-d₃) is a deuterium labeled N6-Methyladenosine (HY-N0086). N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities.

HY-147338S2

5-Methylcytidine 5′-triphosphate-d8 trisodium

5-Methylcytidine 5'-triphosphate-d₈ trisodium is the deuterium-labeled form of 5-Methylcytidine 5'-triphosphate trisodium (HY-147338A). 5-Methylcytidine 5'-triphosphate (5-Methyl-CTP) trisodium is a modified nucleoside triphosphate. 5-Methylcytidine 5'-triphosphate trisodium can be used to replace unmodified mRNA, resulting in the increase of translational properties and stability, as well as the reduction of innate immune responses in human and other mammalian cells .

HY-W008091S

5-Methylcytosine-d4

5-Methylcytosine-d₄ is the deuterium labeled 5-Methylcytosine (HY-W008091). 5-Methylcytosine is a well-characterized DNA modification in prokaryotes and eukaryotes. 5-Methylcytosine forms symmetrical methylation on CpG dinucleotides in DNA, stabilizes tRNA/rRNA structure in RNA, and affects mRNA translation. 5-Methylcytosine can be oxidized to generate 5hmC, 5fC, and 5caC. 5-Methylcytosine can be used in epigenetics, developmental biology, and the study of diseases such as colorectal cancer and hepatocellular carcinoma .

HY-B0239S2

Threo-Chloramphenicol-d6

Threo-Chloramphenicol-d₆ is the deuterium labeled Chloramphenicol . Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research .

HY-B0268S2

Enoxacin-d8 hydrate

Enoxacin-d₈ (hydrate) is deuterium labeled Enoxacin. Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC₅₀=126 μg/ml) and topoisomerase IV (IC₅₀=26.5 μg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin has potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing .

HY-B0268S1

Enoxacin-d8 hydrochloride

Enoxacin-d₈ (hydrochloride) is deuterium labeled Enoxacin. Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC₅₀=126 μg/ml) and topoisomerase IV (IC₅₀=26.5 μg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin has potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing .

HY-B0084S4

Dienogest-13C,15N,d4

Dienogest-13C,15N,d4 (STS 557-13C,15N,d4) is the ¹³C, ¹⁵N and deuterium labeled isotope of Dienogest (HY-B0084). Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .

HY-W753593

N4-Acetylcytidine-13C5

N4-Acetylcytidine- ¹³C₅ is the ¹³C-labeled N4-Acetylcytidine (HY-W019670). N4-acetylcytidine (N4A) is an endogenous nucleoside metabolite from the degradation of tRNA. N4-Acetylcytidine is formed by N-acetyltransferase 10 and other enzymes. N4-acetylcytidine might sustain NLRP3 inflammasome activation via induction of HMGB1 expression and releasee. N4-Acetylcytidine modifies mRNA, tRNA and rRNA, affecting their stability, translation efficiency (such as enterovirus 71 RNA). N4-Acetylcytidine is used in the study of cancer, neuroinflammatory diseases, viral infections and obesity .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks