2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. DNA/RNA Synthesis Dihydrofolate reductase (DHFR)
  4. D-156844 hydrochloride

D-156844 (Compound 11a) hydrochloride is a SMN2 promoter activator with an EC50 of 4 nM. D-156844 hydrochloride increases the mRNA expression of the mouse SMN in NSC-34 cells and human SMN2 promoter in severe type I spinal muscular atrophy (SMA) fibroblasts as well as full-length human SMN protein. D-156844 hydrochloride overcomes DHFR inhibition. D-156844 hydrochloride can be used for SMA research.

For research use only. We do not sell to patients.

D-156844 hydrochloride

D-156844 hydrochloride Chemical Structure

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D-156844 hydrochloride Related Antibodies

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Description

D-156844 (Compound 11a) hydrochloride is a SMN2 promoter activator with an EC50 of 4 nM. D-156844 hydrochloride increases the mRNA expression of the mouse SMN in NSC-34 cells and human SMN2 promoter in severe type I spinal muscular atrophy (SMA) fibroblasts as well as full-length human SMN protein. D-156844 hydrochloride overcomes DHFR inhibition. D-156844 hydrochloride can be used for SMA research[1].

Molecular Weight

454.37

Formula

C21H26Cl2FN5O
SMILES

NC1=NC(N)=C2C(OCC3CCN(CC4=CC=CC=C4F)CC3)=CC=CC2=N1.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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D-156844 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-156844D156844D 156844DNA/RNA SynthesisDihydrofolate reductase (DHFR)SMN2 promoterNSC-34 cellsFibroblastsDHFR inhibitionSpinal muscular atrophySMAInhibitorinhibitorinhibit

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