2. Metabolic Enzyme/Protease
  3. Liposome
  4. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE

1-Palmitoyl-2-oleoyl-sn-glycero-3-PE  (Synonyms: 1,2-POPE; 16:0-18:1 PE)

Cat. No.: HY-W583868 Purity: 99.46%
SDS
COA
Handling Instructions Technical Support

1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines.

For research use only. We do not sell to patients.

1-Palmitoyl-2-oleoyl-sn-glycero-3-PE Chemical Structure

1-Palmitoyl-2-oleoyl-sn-glycero-3-PE Chemical Structure

CAS No. : 26662-94-2

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1-Palmitoyl-2-oleoyl-sn-glycero-3-PE Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines[1][2].

In Vitro

1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (as a phospholipid component, molar ratio 30%) can significantly increase the expression level of luciferase mRNA in HEK293T and HeLa cells in the in vitro transfection experiment of lipid nanoparticles (LNPs)[2].
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (as a phospholipid component, molar ratio 30%) shows in vivo organ targeting experiments that the LNPs constructed with it mainly enriched in the liver, and the expression of luciferase activity in the liver is significantly higher than that in other organs such as the spleen[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1-Palmitoyl-2-oleoyl-sn-glycero-3-PE Related Antibodies
Molecular Weight

718.00

Formula

C39H76NO8P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCC/C=C\CCCCCCCC(O[C@@H](COP(O)(OCCN)=O)COC(CCCCCCCCCCCCCCC)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Methanol : 2.5 mg/mL (3.48 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3928 mL 6.9638 mL 13.9276 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.46%

SDS (585 KB)

COA (239 KB) HNMR (318 KB) RP-HPLC (213 KB) MS (69 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Methanol 1 mM 1.3928 mL 6.9638 mL 13.9276 mL 34.8189 mL
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1-Palmitoyl-2-oleoyl-sn-glycero-3-PE Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Palmitoyl-2-oleoyl-sn-glycero-3-PE26662-94-21,2-POPE 16:0-18:1 PELiposomephospholipiddrug deliveryInhibitorinhibitorinhibit

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