2. Antibody-drug Conjugate/ADC Related Apoptosis
  3. Transferrin Receptor Antibody-Oligonucleotide Conjugates (AOCs)
  4. Delpacibart braxlosiran

Delpacibart braxlosiran  (Synonyms: Del-brax; AOC 1020)

Cat. No.: HY-177566
Handling Instructions Technical Support

Delpacibart braxlosiran (Del-brax), an antibody oligonucleotide conjugate (AOC), consists of a monoclonal antibody (Delpacibart) (HY-P990051) that binds to the transferrin receptor 1 (TfR1) conjugated with a siRNA targeting DUX4 (Double homeobox protein) mRNA. It is used for the study of Facioscapulohumeral Muscular Dystrophy (FSHD). The abnormal expression of DUX4 protein leads to changes in gene expression in muscle cells that are associated with the life-long, progressive loss of muscle function in patients with FSHD.

For research use only. We do not sell to patients.

Delpacibart braxlosiran

Delpacibart braxlosiran Chemical Structure

CAS No. : 2929261-85-6

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Delpacibart braxlosiran Related Antibodies

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Description

Delpacibart braxlosiran (Del-brax), an antibody oligonucleotide conjugate (AOC), consists of a monoclonal antibody (Delpacibart) (HY-P990051) that binds to the transferrin receptor 1 (TfR1) conjugated with a siRNA targeting DUX4 (Double homeobox protein) mRNA. It is used for the study of Facioscapulohumeral Muscular Dystrophy (FSHD). The abnormal expression of DUX4 protein leads to changes in gene expression in muscle cells that are associated with the life-long, progressive loss of muscle function in patients with FSHD[1].

CAS No.
SMILES

[Delpacibart braxlosiran]
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Delpacibart braxlosiran Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Delpacibart braxlosiran2929261-85-6Del-brax AOC 1020AOC1020AOC 1020AOC-1020Transferrin ReceptorAntibody-Oligonucleotide Conjugates (AOCs)TfRCD71Inhibitorinhibitorinhibit

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