2. Epigenetics Anti-infection
  3. MicroRNA Parasite
  4. LIN28 inhibitor LI71

LIN28 inhibitor LI71 is a LIN28 inhibitor that effectively inhibits LIN28:let-7 binding (IC50: 7 μM). LIN28 inhibitor LI71 can abolish LIN28-mediated oligouridylation of let-7 precursor (IC50: 27 μM). LIN28 inhibitor LI71 has potential application value in LIN28-driven cancer research. LIN28 inhibitor LI71 inhibits the interaction of cold shock protein of Plasmodium falciparum (PfCoSP) with DNA and α/β tubulin and has an inhibitory effect on Plasmodium falciparum.

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LIN28 inhibitor LI71 Chemical Structure

LIN28 inhibitor LI71 Chemical Structure

CAS No. : 1357248-83-9

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

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LIN28 inhibitor LI71 Related Antibodies

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Description

LIN28 inhibitor LI71 is a LIN28 inhibitor that effectively inhibits LIN28:let-7 binding (IC50: 7 μM). LIN28 inhibitor LI71 can abolish LIN28-mediated oligouridylation of let-7 precursor (IC50: 27 μM). LIN28 inhibitor LI71 has potential application value in LIN28-driven cancer research. LIN28 inhibitor LI71 inhibits the interaction of cold shock protein of Plasmodium falciparum (PfCoSP) with DNA and α/β tubulin and has an inhibitory effect on Plasmodium falciparum[1][2].

IC50 & Target

IC50: 7 uM (LIN28)[1]
In Vitro

LIN28 inhibitor LI71 competitively blocks the interaction between LIN28 and let-7 precursor by directly binding to the cold shock domain (CSD) of LIN28 (IC50: 7 μM)[1].
LIN28 inhibitor LI71 (40 μM, 40 minutes) can effectively inhibit LIN28-mediated oligouridylation of let-7 precursor, thereby preventing the degradation of let-7 and restoring the level of mature let-7 (IC50: 27 μM)[1].
LIN28 inhibitor LI71 (100 μM) shows that it directly binds to CSD rather than zinc joint domain (ZKD) or let-7 RNA in saturation transfer difference (STD) spectroscopy experiments[1]
LIN28 inhibitor LI71 (50-100 μM) can effectively inhibit cell viability in HeLa cells expressing LIN28A and LIN28B without significant cytotoxicity[1].
LIN28 inhibitor LI71 (100 μM, 48 hours) significantly increases the expression level of mature let-7 in leukemia cells (K562) and embryonic stem cells (mESCs), thereby inhibiting cell viability[1].
LIN28 inhibitor LI71 inhibits the interaction of PfCoSP with DNA and α/β tubulin by competitively binding to PfCoSP[2].
LIN28 inhibitor LI71 (1.95-250 nM, 72 hours) has IC50s of 1.35 nM and 6.3 nM in 3D7 and RKL-9 strains of Plasmodium falciparum, respectively[2].
LIN28 inhibitor LI71 (10-500 nM, 30 minutes) affects the gametogenesis of Plasmodium falciparum and inhibits the deflagellation of male gametes in vitro[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LIN28 inhibitor LI71 Related Antibodies
Molecular Weight

335.40

Formula

C21H21NO3
CAS No.
Appearance

Solid

Color

Yellow to green

SMILES

O=C(O)C1=CC=C([C@@H]2NC3=C(C=CC=C3OCC)[C@@]4([H])[C@]2([H])CC=C4)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (298.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9815 mL 14.9076 mL 29.8151 mL
5 mM 0.5963 mL 2.9815 mL 5.9630 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9815 mL 14.9076 mL 29.8151 mL 74.5379 mL
5 mM 0.5963 mL 2.9815 mL 5.9630 mL 14.9076 mL
10 mM 0.2982 mL 1.4908 mL 2.9815 mL 7.4538 mL
15 mM 0.1988 mL 0.9938 mL 1.9877 mL 4.9692 mL
20 mM 0.1491 mL 0.7454 mL 1.4908 mL 3.7269 mL
25 mM 0.1193 mL 0.5963 mL 1.1926 mL 2.9815 mL
30 mM 0.0994 mL 0.4969 mL 0.9938 mL 2.4846 mL
40 mM 0.0745 mL 0.3727 mL 0.7454 mL 1.8634 mL
50 mM 0.0596 mL 0.2982 mL 0.5963 mL 1.4908 mL
60 mM 0.0497 mL 0.2485 mL 0.4969 mL 1.2423 mL
80 mM 0.0373 mL 0.1863 mL 0.3727 mL 0.9317 mL
100 mM 0.0298 mL 0.1491 mL 0.2982 mL 0.7454 mL
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LIN28 inhibitor LI71 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LIN28 inhibitor LI711357248-83-9MicroRNAParasitemiRNALIN28CSDZKDmRNAHeLa cellsPlasmodium falciparumInhibitorinhibitorinhibit

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