2. Metabolic Enzyme/Protease
  3. Liposome
  4. MK16

MK16 is a lipid material that can be used to construct blood-brain barrier penetrable lipid nanoparticles for mRNA delivery.

For research use only. We do not sell to patients.

MK16

MK16 Chemical Structure

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MK16 Related Antibodies

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  • Purity & Documentation

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Description

MK16 is a lipid material that can be used to construct blood-brain barrier penetrable lipid nanoparticles for mRNA delivery[1].

Molecular Weight

997.84

Formula

C55H91ClF2N2O7S
Appearance

Oil

Color

Colorless to off-white

SMILES

CC(OCCCCCC)OCCCCCCN(CCCCCCOC(C)OCCCCCC)CCCCCCNC(CC[C@H]1CC[C@@](C2=CC(F)=CC=C2F)(S(C3=CC=C(Cl)C=C3)(=O)=O)CC1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (100.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0022 mL 5.0108 mL 10.0216 mL
5 mM 0.2004 mL 1.0022 mL 2.0043 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0022 mL 5.0108 mL 10.0216 mL 25.0541 mL
5 mM 0.2004 mL 1.0022 mL 2.0043 mL 5.0108 mL
10 mM 0.1002 mL 0.5011 mL 1.0022 mL 2.5054 mL
15 mM 0.0668 mL 0.3341 mL 0.6681 mL 1.6703 mL
20 mM 0.0501 mL 0.2505 mL 0.5011 mL 1.2527 mL
25 mM 0.0401 mL 0.2004 mL 0.4009 mL 1.0022 mL
30 mM 0.0334 mL 0.1670 mL 0.3341 mL 0.8351 mL
40 mM 0.0251 mL 0.1253 mL 0.2505 mL 0.6264 mL
50 mM 0.0200 mL 0.1002 mL 0.2004 mL 0.5011 mL
60 mM 0.0167 mL 0.0835 mL 0.1670 mL 0.4176 mL
80 mM 0.0125 mL 0.0626 mL 0.1253 mL 0.3132 mL
100 mM 0.0100 mL 0.0501 mL 0.1002 mL 0.2505 mL
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MK16 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK16MK 16MK-16LiposomeBBBblood-brain barrierInhibitorinhibitorinhibit

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