2. Metabolic Enzyme/Protease
  3. 17β-HSD
  4. Rapirosiran

Rapirosiran  (Synonyms: ALN-HSD; ALN-288996; AD-288996)

Cat. No.: HY-164221
Handling Instructions Technical Support

Rapirosiran is a N-acetylgalactosamine-conjugated small-interfering RNA targeting liver-expressed hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13) mRNA. Loss-of-function variants in the HSD17B13 associated with reduced risk of chronic liver disease. Rapirosiran can be used for the study of Non-alcoholic steatohepatitis.

For research use only. We do not sell to patients.

Gene Regulation Tool

RNA, (Am-sp-(2′-deoxy-2′-fluoro)G-sp-Am-Um-Am-Gm-(3′→3′)-[1-de-β-D-ribofuranosyl-1-[(2S)-2,3-dihydroxypropyl]]m5U-(2′→5′)-Cm-Cm-Am-Um-Gm-Cm-(2′-deoxy-2′-fluoro)A-Am-(2′-deoxy-2′-fluoro)A-Am-Gm-Cm-Am-Um-sp-Um-sp-Cm), complex with RNA (Am-sp-Um-sp-Gm-Cm-Um-Um-(2′-deoxy-2′-fluoro)U-Um-(2′-deoxy-2′-fluoro)G-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)A-Um-Gm-Gm-Am-Cm-Um-Am-Um-Cm-Um) 3′-[[(2S,4R)-1-[29-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl]-4-hydroxy-2-pyrrolidinyl]methyl hydrogen phosphate] (1:1)

Rapirosiran Chemical Structure

CAS No. : 2755196-97-3

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Other Forms of Rapirosiran:

Rapirosiran Related Antibodies

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Description

Rapirosiran is a N-acetylgalactosamine-conjugated small-interfering RNA targeting liver-expressed hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13) mRNA. Loss-of-function variants in the HSD17B13 associated with reduced risk of chronic liver disease. Rapirosiran can be used for the study of Non-alcoholic steatohepatitis.

Molecular Weight

16307.22

CAS No.
SMILES

[Rapirosiran]
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Rapirosiran Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rapirosiran2755196-97-3ALN-HSD ALN-288996 AD-288996ALN288996ALN 288996ALN-288996AD288996AD 288996AD-28899617β-HSD17beta-HSD17β-hydroxysteroid dehydrogenases17 beta-hydroxysteroid dehydrogenaseInhibitorinhibitorinhibit

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