2. Metabolic Enzyme/Protease
  3. PCSK9
  4. SPC5001

SPC5001 is a locked nucleic acid (LNA)-modifed antisense oligonucleotide (ASO) complementary to human PCSK9 (proprotein convertase subtilisin/kexin type 9) mRNA. SPC5001 can be used for the research of hypercholesterolemia. SPC5001 sequence: 5′-TGmCTACAAAACmCmCA-3′.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (SPC5001 sodium) that retains the same biological activity.

For research use only. We do not sell to patients.

5′-TGmCTACAAAACmCmCA-3′

SPC5001 Chemical Structure

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SPC5001 Related Antibodies

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Description

SPC5001 is a locked nucleic acid (LNA)-modifed antisense oligonucleotide (ASO) complementary to human PCSK9 (proprotein convertase subtilisin/kexin type 9) mRNA. SPC5001 can be used for the research of hypercholesterolemia. SPC5001 sequence: 5′-TGmCTACAAAACmCmCA-3′[1].

In Vitro

SPC5001 (0.16-40 μM; 72 h) induces the downregulation of PCSK9 mRNA targets but cytotoxicity is not observed at any concentration in 2D human renal proximal tubule epithelial cells (HRPTEC) cultures[1].
SPC5001 (5 μM; 48 h or 20 d) downregulates PCSK9 mRNA in chip-cultured HRPTEC, with 74.1% and 93.7% for 48 h and 20 days, respectively[1].
SPC5001 (5 μM; 20 d) induces cytotoxicity and increases perfusate levels of biomarkers KIM-1, NGAL, clusterin, osteopontin and VEGF in chip-cultured HRPTEC[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SPC5001 Related Antibodies
Clinical Trial
Molecular Weight

4689.85 (1mg=213nmol;5mg=1066nmol)

Appearance

Solid

Color

White to off-white

SMILES

[SPC5001]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL

*"≥" means soluble, but saturation unknown.

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
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SPC5001 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SPC5001SPC 5001SPC-5001PCSK9Proprotein convertase subtilisin/kexin type 9ntisense oligonucleotideASOmRNAhypercholesterolemia5′-TGmCTACAAAACmCmCA-3′Inhibitorinhibitorinhibit

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