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TCA cycle,Fatty acid β-oxidation

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3470

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553

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Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-F0001
    NADH disodium salt
    5+ Cited Publications

    Disodium NADH

    		 Endogenous Metabolite Metabolic Disease
    NADH disodium salt (Disodium NADH) is an orally active reduced coenzyme. NADH disodium salt is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. NADH disodium salt plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle .
    NADH disodium salt
  • HY-F0001R
    NADH disodium salt (Standard)

    Disodium NADH (Standard)

    		 Reference Standards Endogenous Metabolite Metabolic Disease
    NADH (disodium salt) (Standard) is the analytical standard of NADH (disodium salt). This product is intended for research and analytical applications. NADH disodium salt (Disodium NADH) is an orally active reduced coenzyme. NADH disodium salt is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. NADH disodium salt plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle .
    NADH disodium salt (Standard)
  • HY-W400421
    3-Hydroxyvalproic acid

    3-Hydroxy VPA

    		 Endogenous Metabolite Metabolic Disease
    3-Hydroxyvalproic acid (3-Hydroxy VPA) is a metabolite of valproic acid. 3-Hydroxyvalproic acid is a weak inhibitor of enzymes related to the mitochondrial β-oxidation pathway. 3-Hydroxyvalproic acid is promising for research of diseases related to abnormal valproic acid metabolism .
    3-Hydroxyvalproic acid
  • HY-12904
    TCA1
    1 Publications Verification

    		 Bacterial Infection
    TCA1 is a small molecule with activity against agent-susceptible and -resistant Mycobacterium tuberculosis (Mtb). TCA1 inhibits enzymes involved in cell wall and molybdenum cofactor biosynthesis, such as DprE1 and MoeW .
    TCA1
  • HY-134427
    Palmitoyl coenzyme A lithium
    1 Publications Verification

    Palmitoyl CoA lithium

    		 Endogenous Metabolite Metabolic Disease
    Palmitoyl coenzyme A lithium is an acyl-CoA thioester that can be transported into the mitochondrial matrix via the carnitine shuttle system and is involved in β-oxidation. Palmitoyl coenzyme A lithium can also be used as a substrate for sphingosine biosynthesis .
    Palmitoyl coenzyme A lithium
  • HY-50202A
    Etomoxir sodium salt
    110+ Cited Publications

    (R)-(+)-Etomoxir sodium salt

    		 Apoptosis Metabolic Disease Cancer
    Etomoxir((R)-(+)-Etomoxir) sodium salt is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig .
    Etomoxir sodium salt
  • HY-F0001A
    NADH disodium hydrate

    Disodium NADH hydrate

    		 Endogenous Metabolite Metabolic Disease
    NADH disodium salt (Disodium NADH) hydrate is an orally active reduced coenzyme. NADH disodium salt hydrate is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. NADH disodium salt hydrate plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle .
    NADH disodium hydrate
  • HY-175673
    LCB-2151

    		Apoptosis Oxidative Phosphorylation Mitochondrial Metabolism Reactive Oxygen Species (ROS) Cancer
    LCB-2151 (Compound 2), a nucleoside analogue, is an anticancer agent. LCB-2151 disrupts the two primary sources of ATP production (glycolysis and mitochondrial oxidative phosphorylation), reducing the bioenergetic capacity of KRAS-mutated pancreatic cancer cells and inducing ROS formation. LCB-2151 effectively inhibits key enzymes (such as CACT and CPT2) in glycolysis, the TCA cycle and fatty acid β-oxidation. LCB-2151 has significant cytotoxicity and induces cells apoptosis. LCB-2151 can be used for radiation therapy of cancers research .
    LCB-2151
  • HY-154922
    Palmitoyl coenzyme A

    Palmitoyl CoA

    		 Endogenous Metabolite Metabolic Disease
    Palmitoyl coenzyme A is an acyl-CoA thioester that can be transported into the mitochondrial matrix via the carnitine shuttle system and is involved in β-oxidation. Palmitoyl coenzyme A can also be used as a substrate for sphingosine biosynthesis .
    Palmitoyl coenzyme A
  • HY-113355
    NADH

    		Endogenous Metabolite Metabolic Disease
    NADH is an orally active reduced coenzyme. NADH is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. NADH plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle .
    NADH
  • HY-137782B
    Palmitoleoyl-CoA lithium

    		Biochemical Assay Reagents Others
    Palmitoleoyl-CoA lithium is the lithium salt form of Palmitoleoyl-CoA (HY-137782). Palmitoleoyl-CoA lithium can be activated and transported into the mitochondria for metabolism, specifically for β-oxidation. Palmitoleoyl-CoA lithium induces the cardiac mitochondrial membrane permeability transition, which causes mitochondrial dysfunction. Palmitoleoyl-CoA lithium regulates metabolism via allosteric control of AMPK β1-isoforms .
    Palmitoleoyl-CoA lithium
  • HY-103266
    TC-A 2317 hydrochloride

    		Aurora Kinase Cancer
    TC-A 2317 hydrochloride is an orally active Aurora A kinase inhibitor (Ki=1.2 nM). TC-A 2317 hydrochloride exhibits excellent selectivity to Aurora B kinase (Ki=101 nM) and other 60 kinases, good cell permeability and good PK profile. Antitumor activity .
    TC-A 2317 hydrochloride
  • HY-B0399
    L-Carnitine
    15+ Cited Publications

    (R)-Carnitine; Levocarnitine

    		 Endogenous Metabolite Neurological Disease Cancer
    L-Carnitine ((R)-Carnitine), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine is an antioxidant. L-Carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism .
    L-Carnitine
  • HY-B2246
    L-Carnitine hydrochloride
    15+ Cited Publications

    (R)-Carnitine hydrochloride; Levocarnitine hydrochloride

    		 Endogenous Metabolite Metabolic Disease Cancer
    L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism .
    L-Carnitine hydrochloride
  • HY-B0399R
    L-Carnitine (Standard)

    (R)-Carnitine (Standard); Levocarnitine (Standard)

    		 Reference Standards Endogenous Metabolite Neurological Disease Cancer
    L-Carnitine (Standard) is the analytical standard of L-Carnitine. This product is intended for research and analytical applications. L-Carnitine ((R)-Carnitine), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine is an antioxidant. L-Carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism .
    L-Carnitine (Standard)
  • HY-108571
    CP-775146

    		PPAR Cardiovascular Disease Metabolic Disease
    CP-775146 is a selective PPARα agonist (Ki of 24.5 nM) that binds strongly to the PPARα ligand. CP-775146 has no observable affinity for PPARβ and PPARγ.CP-775146 shows hypolipidemic activity. CP-775146 efficiently alleviates obesity-induced liver damage, prevents lipid accumulation by activating the liver fatty acid β-oxidation pathway .
    CP-775146
  • HY-B2246R
    L-Carnitine hydrochloride (Standard)

    (R)-Carnitine hydrochloride (Standard); Levocarnitine hydrochloride (Standard)

    		 Reference Standards Endogenous Metabolite Metabolic Disease Cancer
    L-Carnitine (hydrochloride) (Standard) is the analytical standard of L-Carnitine (hydrochloride). This product is intended for research and analytical applications. L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism .
    L-Carnitine hydrochloride (Standard)
  • HY-113201
    Tetradecanoylcarnitine

    		Endogenous Metabolite Metabolic Disease
    Tetradecanoylcarnitine is a human carnitine involved in β-oxidation of long-chain fatty acids.
    Tetradecanoylcarnitine
  • HY-W008646R
    7,8-Dihydro-L-biopterin (Standard)

    		Reference Standards Endogenous Metabolite Others
    NADH (disodium salt) (Standard) is the analytical standard of NADH (disodium salt). This product is intended for research and analytical applications. NADH disodium salt (Disodium NADH) is an orally active reduced coenzyme. NADH disodium salt is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. NADH disodium salt plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle .
    7,8-Dihydro-L-biopterin (Standard)
  • HY-W250154
    β-Nicotinamide adenine dinucleotide reduced dipotassium

    		Endogenous Metabolite Metabolic Disease
    β-Nicotinamide adenine dinucleotide reduced dipotassium is an orally active reduced coenzyme. β-Nicotinamide adenine dinucleotide reduced dipotassium is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. β-Nicotinamide adenine dinucleotide reduced dipotassium plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle .
    β-Nicotinamide adenine dinucleotide reduced dipotassium
  • HY-113879
    18-Carboxy dinor Leukotriene B4

    18-Carboxy dinor LTB4

    		 Drug Metabolite Metabolic Disease
    18-Carboxy dinor Leukotriene B4 (18-carboxy dinor LTB4) is a β-oxidation metabolite of LTB4. In the liver, LTB4 is rapidly metabolized to 20-carboxy LTB4, which then undergoes β-oxidation to 18-carboxy dinor LTB4.
    18-Carboxy dinor Leukotriene B4
  • HY-N0458
    Pedunculoside
    1 Publications Verification

    		 Fatty Acid Synthase (FASN) Metabolic Disease
    Pedunculoside exerts lipid-lowering effects partly through the regulation of?lipogenesis?and?fatty acid β-oxidation .
    Pedunculoside
  • HY-120556
    tetranor-12(R)-HETE

    8(R)-HHxTrE; tetranor-12(R)-Hydroxyeicosatetraenoic acid; 2,3,4,5-Tetranor 12(R)-HETE

    		 Drug Metabolite Metabolic Disease
    tetranor-12(R)-HETE is a metabolite of 12(R)-HETE formed via β-oxidation.
    tetranor-12(R)-HETE
  • HY-113261
    Oleoylcarnitine

    		Endogenous Metabolite Metabolic Disease Cancer
    Oleoylcarnitine, the metabolite which accumulates through suppression of fatty acid β-oxidation, can enhance hepatocarcinogenesis via STAT3 activation .
    Oleoylcarnitine
  • HY-W587877
    Triundecanoin

    		Biochemical Assay Reagents Others
    Triundecanoin is a triacylglycerol. Triundecanoin maintain the glucose supplement during fasting through β-oxidation and acetyl-CoA production in rat models .
    Triundecanoin
  • HY-W105518
    L-Carnitine tartrate
    15+ Cited Publications

    		 Endogenous Metabolite Neurological Disease
    L-Carnitine tartrate is a highly polar, small zwitterion. L-Carnitine tartrate is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine tartrate functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine tartrate is an antioxidant. L-Carnitine tartrate can ameliorate metabolic imbalances in many inborn errors of metabolism [3] .
    L-Carnitine tartrate
  • HY-152012S
    Tetradecanoylcarnitine-d3 hydrochloride

    		Isotope-Labeled Compounds Metabolic Disease
    Tetradecanoylcarnitine-d3 (hydrochloride) is deuterium labeled Tetradecanoylcarnitine. Tetradecanoylcarnitine is a human carnitine involved in β-oxidation of long-chain fatty acids .
    Tetradecanoylcarnitine-d3 hydrochloride
  • HY-113201S
    Tetradecanoylcarnitine-d9

    		Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    Tetradecanoylcarnitine-d9 is deuterium labeled Tetradecanoylcarnitine. Tetradecanoylcarnitine is a human carnitine involved in β-oxidation of long-chain fatty acids .
    Tetradecanoylcarnitine-d9
  • HY-B2246S
    L-Carnitine-d9 chloride

    (R)-Carnitine-d9 chloride; Levocarnitine-d9 chloride

    		 Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    L-Carnitine-d9 (chloride)e is the deuterium labeled L-Carnitine chloride. L-Carnitine chloride, a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine chloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine chloride is an antioxidant. L-Carnitine chloride can ameliorate metabolic imbalances in many inborn errors of metabolism .
    L-Carnitine-d9 chloride
  • HY-113201R
    Tetradecanoylcarnitine (Standard)

    		Reference Standards Endogenous Metabolite Metabolic Disease
    Tetradecanoylcarnitine (Standard) is the analytical standard of Tetradecanoylcarnitine. This product is intended for research and analytical applications. Tetradecanoylcarnitine is a human carnitine involved in β-oxidation of long-chain fatty acids.
    Tetradecanoylcarnitine (Standard)
  • HY-B1453
    (±)-Carnitine chloride
    2 Publications Verification

    DL-Carnitine chloride

    		 Reactive Oxygen Species (ROS) Metabolic Disease
    (±)-Carnitine chloride exists in two isomers, known as D and L. L-carnitine plays an essential role in the β-oxidation of fatty acids and also shows antioxidant, and anti-inflammatory activities.
    (±)-Carnitine chloride
  • HY-W353470
    2,3-Dinor-8-iso prostaglandin F 2α

    2,3-Dinor-8-isoPGF2α

    		 Drug Metabolite Metabolic Disease
    2,3-Dinor-8-iso prostaglandin F₂α (2,3-Dinor-8-isoPGF2α) is the major β-oxidation metabolite of 8-iso-prostaglandin F₂α. 2,3-Dinor-8-iso prostaglandin F₂α serves as a biomarker to evaluate the in vivo production of 8-iso-prostaglandin F₂α and the level of lipid peroxidation. 2,3-Dinor-8-iso prostaglandin F₂α is promising for research of oxidative stress-related diseases such as arteriosclerosis and diabetes .
    2,3-Dinor-8-iso prostaglandin F 2α
  • HY-168397
    tetranor-Prostaglandin E1

    		Prostaglandin Receptor Endocrinology
    tetranor-Prostaglandin E1 is metabolite of Prostaglandin E1 (HY-B0131) and Prostaglandin E2 (HY-101952) that is formed by β-oxidation .
    tetranor-Prostaglandin E1
  • HY-W754236
    (R)-Carnitine Hydrochloride-13C3

    		Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    (R)-Carnitine Hydrochloride- 13C3 is the 13C-labeled L-Carnitine hydrochloride (HY-B2246). L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism .
    (R)-Carnitine Hydrochloride-13C3
  • HY-N0458R
    Pedunculoside (Standard)

    		Reference Standards Fatty Acid Synthase (FASN) Metabolic Disease
    Pedunculoside (Standard) is the analytical standard of Pedunculoside. This product is intended for research and analytical applications. Pedunculoside exerts lipid-lowering effects partly through the regulation of lipogenesis and fatty acid β-oxidation .
    Pedunculoside (Standard)
  • HY-19109
    RG-7152

    		Leukotriene Receptor Others
    RG-7152 is a tetrazolyl-substituted leukotriene D4 receptor antagonist that can induce peroxisomal β-oxidation and peroxisome bifunctional enzymes (PBEs) in hepatocytes in various animal models. It has been shown to significantly increase PBE levels and β-oxidation activity in rat and mouse liver homogenates, while smaller effects were observed in guinea pigs and monkeys and no effect in dogs. In vitro studies have also shown that it can induce PBEs comparable to clofibric acid, indicating its potential as a peroxisome proliferator .
    RG-7152
  • HY-B0399G
    L-Carnitine

    (R)-Carnitine; Levocarnitine

    		 Endogenous Metabolite Neurological Disease Cancer
    L-Carnitine (GMP) is L-Carnitine (HY-B0399) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. L-Carnitine, a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine is an antioxidant. L-Carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism .
    L-Carnitine
  • HY-B0399S2
    L-Carnitine-13C3

    (R)-Carnitine-13C3; Levocarnitine-13C3

    		 Isotope-Labeled Compounds Endogenous Metabolite Neurological Disease Cancer
    L-Carnitine- 13C3 ((R)-Carnitine- 13C3) is the 13C--labeled L-Carnitine (HY-B0399). L-Carnitine ((R)-Carnitine), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine is an antioxidant. L-Carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism .
    L-Carnitine-13C3
  • HY-W105518R
    L-Carnitine tartrate (Standard)

    		Reference Standards Endogenous Metabolite Neurological Disease
    L-Carnitine (tartrate) (Standard) is the analytical standard of L-Carnitine (tartrate). This product is intended for research and analytical applications. L-Carnitine tartrate is a highly polar, small zwitterion. L-Carnitine tartrate is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine tartrate functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine tartrate is an antioxidant. L-Carnitine tartrate can ameliorate metabolic imbalances in many inborn errors of metabolism [3] .
    L-Carnitine tartrate (Standard)
  • HY-W747072
    3-Sulfo-taurocholic Acid Disodium Salt

    3-Sulfocholyl Taurine; TCA3S

    		 Drug Metabolite Metabolic Disease
    3-Sulfo-taurocholic Acid Disodium Salt (3-Sulfocholyl Taurine; TCA3S) is a metabolite of the conjugated bile acid taurocholic acid. Plasma levels of 3-Sulfo-taurocholic Acid Disodium Salt are elevated in wild-type and Sortilin 1 (Sort1) knockout mice at 6 hours following bile duct ligation (BDL) and are further elevated in Sort1 knockout mice at 24 hours post-BDL.
    3-Sulfo-taurocholic Acid Disodium Salt
  • HY-E70262
    Acetoyl-CoA triammonium

    		Oxidative Phosphorylation Endogenous Metabolite Metabolic Disease
    Acetoyl-CoA (triammonium) is a triammonium derivative of Acetoyl-CoA (HY-114293), Acetyl-CoA is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A is also a key precursor of lipid synthesis .
    Acetoyl-CoA triammonium
  • HY-113261S
    Oleoylcarnitine-d9

    		Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease Cancer
    Oleoylcarnitine-d9 is deuterium labeled Oleoylcarnitine. Oleoylcarnitine, the metabolite which accumulates through suppression of fatty acid β-oxidation, can enhance hepatocarcinogenesis via STAT3 activation .
    Oleoylcarnitine-d9
  • HY-126718
    Methylenecyclopropylpyruvate

    Ketohypoglycin

    		 Mitochondrial Metabolism Metabolic Disease
    Methylenecyclopropylpyruvate (Ketohypoglycin) is an inhibitor for gluconeogenesis. Methylenecyclopropylpyruvate inhibits ketogenesis and affects the fatty acids metabolism. Methylenecyclopropylpyruvate may interfere with the mitochondrial β-oxidation pathway, affects the contents and composition of coenzyme A, and affects the glucose homeostasis .
    Methylenecyclopropylpyruvate
  • HY-113261R
    Oleoylcarnitine (Standard)

    		Reference Standards Endogenous Metabolite Metabolic Disease Cancer
    Oleoylcarnitine (Standard) is the analytical standard of Oleoylcarnitine. This product is intended for research and analytical applications. Oleoylcarnitine, the metabolite which accumulates through suppression of fatty acid β-oxidation, can enhance hepatocarcinogenesis via STAT3 activation .
    Oleoylcarnitine (Standard)
  • HY-139172
    MD001

    		PPAR Metabolic Disease
    MD001 is a PPARα/γ dual agonist and can increase the transcriptional activity of PPARα and PPARγ. MD001 enhances the expression of genes related to β-oxidation and fatty acid and glucose uptake .
    MD001
  • HY-B1453S1
    (±)-Carnitine-d9 chloride

    DL-Carnitine-d9 (chloride)

    		 Reactive Oxygen Species (ROS) Metabolic Disease
    (±)-Carnitine-d9 (chloride) is the deuterium labeled (±)-Carnitine chloride. (±)-Carnitine chloride exists in two isomers, known as D and L. L-carnitine plays an essential role in the β-oxidation of fatty acids and also shows antioxidant, and anti-inflammatory activities.
    (±)-Carnitine-d9 chloride
  • HY-50202
    Etomoxir
    110+ Cited Publications

    (R)-(+)-Etomoxir

    		 Apoptosis Metabolic Disease Cancer
    Etomoxir ((R)-(+)-Etomoxir) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.
    Etomoxir
  • HY-114333
    Octyl-α-ketoglutarate

    1-Octyl 2-oxopentanedioate

    		 HIF/HIF Prolyl-Hydroxylase Metabolic Disease Cancer
    Octyl-α-ketoglutarate (1-Octyl 2-oxopentanedioate) is a stable, cell-permeable form of α-ketoglutarate which accumulates rapidly in HEK293 cells with a dysfunctional tricarboxylic acid (TCA) cycle, stimulating prolyl hydroxylase (PHD) activity. In addition, Octyl-α-ketoglutarate competitively blocks succinate- or fumarate-mediated inhibition of PHD .
    Octyl-α-ketoglutarate
  • HY-P10876
    mcK6A1

    		Amyloid-β Neurological Disease
    mcK6A1 is an inhibitor for the aggregation of amyloid-β (Aβ), that selectively binds to the 16KLVFFA21 segment of Aβ42, forms an extended β-folded structure, and inhibits the formation of Aβ42 oligomers. mcK6A1 can be used in research of Alzheimer's disease and other amyloid-related diseases .
    mcK6A1
  • HY-W420033
    (S)-(+)-Etomoxir

    		Acyltransferase Others
    (S)-(+)-Etomoxir is the S enantiomer of Etomoxir (HY-50202). Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig .
    (S)-(+)-Etomoxir

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