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type-2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (11) 5 alpha Reductase (2) 5-HT Receptor (2) Acyltransferase (3) Adenosine Receptor (1) Adenylate Cyclase (1) Adrenergic Receptor (2) Akt (11) Aldose Reductase (3) Amine N-methyltransferase (1) AMPK (23) Amylases (7) Amylin Receptor (3) Amyloid-β (3) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (3) Angiotensin Receptor (7) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (2) Apelin Receptor (APJ) (2) Apical Sodium-Dependent Bile Acid Transporter (1) Apolipoprotein (2) Apoptosis (42) Arrestin (4) ATP Citrate Lyase (1) Autophagy (24) Bacterial (9) Bcl-2 Family (8) Beta-secretase (1) Biochemical Assay Reagents (7) c-Met/HGFR (1) Calcium Channel (2) Cannabinoid Receptor (8) Caspase (6) Cathepsin (1) CCR (2) Ceramidase (2) CFTR (1) Cholinesterase (ChE) (1) Claudin (2) COX (3) CRFR (8) Cytochrome P450 (2) Dengue Virus (3) DGK (1) Dipeptidyl Peptidase (51) DNA/RNA Synthesis (1) Dopamine Receptor (11) Drug Derivative (1) Drug Intermediate (4) Drug Metabolite (5) Endogenous Metabolite (58) Enterovirus (1) Epigenetic Reader Domain (1) Epoxide Hydrolase (2) ERK (6) Estrogen Receptor/ERR (6) FAAH (1) FBPase (4) Ferroptosis (8) FGFR (1) Flavivirus (2) Formyl Peptide Receptor (FPR) (1) FOXO (2) Free Fatty Acid Receptor (17) FXR (4) G protein-coupled Bile Acid Receptor 1 (4) G Protein-coupled Receptor Kinase (GRK) (1) GCGR (35) GLP Receptor (33) Glucocorticoid Receptor (1) Glucokinase (16) GLUT (6) Glutaminase (1) Glycosidase (38) Glycosyltransferase (1) GlyT (5) GPR109A (2) GPR119 (12) GPR35 (1) GSK-3 (3) HBV (2) Hippo (MST) (1) Histone Acetyltransferase (2) HIV (1) HIV Protease (2) HSP (2) HSV (1) IFNAR (1) IKK (3) Influenza Virus (1) Insulin Receptor (20) Integrin (1) Interleukin Related (18) IPK Superfamily (1) IRE1 (1) Isotope-Labeled Compounds (32) JNK (3) Keap1-Nrf2 (1) Ketohexokinase (1) Leukotriene Receptor (2) Ligands for Target Protein for PROTAC (1) LOX-1 (1) LPL Receptor (2) LRRK2 (3) mAChR (1) MDM-2/p53 (1) Melanocortin Receptor (3) MetAP (2) Microtubule/Tubulin (2) Mineralocorticoid Receptor (6) Mitochondrial Metabolism (6) Mitophagy (7) MMP (2) Molecular Glues (1) mRNA (5) mTOR (9) NEKs (2) Neurokinin Receptor (4) Neuropeptide Y Receptor (7) Neurotensin Receptor (3) NF-κB (15) NO Synthase (1) NOD-like Receptor (NLR) (5) Nucleoside Antimetabolite/Analog (2) OAT (1) Orexin Receptor (OX Receptor) (9) Organoid (2) Orphan GPCR (1) Oxidative Phosphorylation (1) P-glycoprotein (5) P2X Receptor (2) P2Y Receptor (1) p38 MAPK (12) Parasite (2) PARP (2) PDHK (1) PDI (1) PEPCK (1) Phosphatase (24) Phosphorylase (4) PI3K (7) PKA (1) PKC (3) PKD (3) Potassium Channel (25) PPAR (32) Prolyl Endopeptidase (PREP) (1) Prostaglandin Receptor (2) Proton Pump (2) PTHR (1) Pyroptosis (1) RAR/RXR (2) Reactive Oxygen Species (ROS) (9) Reference Standards (42) Ribosomal S6 Kinase (RSK) (1) SGLT (12) SHP2 (1) Sirtuin (2) Sodium Channel (2) Somatostatin Receptor (7) Src (1) STAT (7) Stearoyl-CoA Desaturase (SCD) (1) Tau Protein (3) TGF-beta/Smad (1) TGF-β Receptor (2) TNF Receptor (8) Toll-like Receptor (TLR) (1) TRP Channel (1) VDAC (1) α-synuclein (7)
By Research Areas:	Cancer (72) Cardiovascular Disease (71) Endocrinology (43) Infection (22) Inflammation/Immunology (77) Metabolic Disease (488) Neurological Disease (80)
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633

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

*Adenylyl cyclase type 2* agonist-1**	Adenylate Cyclase	Inflammation/Immunology
Adenylyl cyclase type 2 agonist-1 (Compound 73) is a potent agonist of adenylyl cyclase type 2 (AC2) with the EC₅₀ of 90 nM. Adenylyl cyclase type 2 agonist-1 inhibits expression of Interleukin-6, making it a potential lead compound against respiratory diseases .

Repaglinide-d5 AG-EE 623ZW d₅	Isotope-Labeled Compounds Potassium Channel	Metabolic Disease
Repaglinide-d₅ is deuterium labeled Repaglinide. Repaglinide is an insulin secretagogue for the treatment of type-2 diabetes mellitus .

Repaglinide 1 Publications Verification AG-EE 623ZW	Potassium Channel	Metabolic Disease Cancer
Repaglinide is an insulin secretagogue for the treatment of type-2 diabetes mellitus .

Azaleatin	Dipeptidyl Peptidase	Metabolic Disease
Azaleatin is an O-methylated flavonol isolated from Rhododendron species. Azaleatin is a dipeptidyl peptidase-IV inhibitor. Azaleatin can be used for the research of type-2 diabetes and obesity ^[2].

AMG131 INT131	PPAR	Metabolic Disease
AMG131 (INT131) is a potent non-thiazolidinedione (TZD) selective peroxisome proliferator-activated receptor γ modulator (SPPARM). AMG131 binds to PPARγ within the same binding pocket as the TZDs, but occupies a unique space in the pocket and contacts the receptor at distinct points from the TZDs. AMG131 is promising for research of type-2 diabetes mellitus ^[2] .

Methylswertianin	Others	Metabolic Disease
Methylswertianin is an active constituent in Swertia punicea Hemsl, with anti-diabetic effect. Methylswertianin can abates type-2 diabetes, likely via the improvement of insulin resistance (IR) .

α-Glucosidase-IN-67	Amylases Glycosidase	Metabolic Disease
α-Glucosidase-IN-67 (compound 5k) is a potent α-Glucosidase inhibitor with IC₅₀ values of 0.31, 4.51 µM for alpha-glucosidase and alpha-amylase, respectively. α-Glucosidase-IN-67 has the potential for the research of type-2 diabetes .

Caulophyllogenin	PPAR	Metabolic Disease Inflammation/Immunology
Caulophyllogenin is a triterpene saponin extracted from M. polimorpha. Caulophyllogenin is a partial PPARγ agonist, with an EC₅₀ of 12.6 μM. Caulophyllogenin can be used for the research of type-2 diabetes, obesity, metabolic syndrome and inflammation ^[2].

Prunetin 5-O-β-D-glucopyranoside	Glycosidase	Metabolic Disease
Prunetin 5-O-β-D-glucopyranoside is an isoflavone isolated from extracts of Potentilla astracanica. Prunetin 5-O-β-D-glucopyranoside is a potent and uncompetitive inhibitor of α-glucosidase, with an IC₅₀ of 56.05 μg/mL. Prunetin 5-O-β-D-glucopyranoside can be used for the research of type-2 diabetes .

AMG131 benzenesulfonate INT131 benzenesulfonate	PPAR	Metabolic Disease
AMG131 (INT131) (benzenesulfonate) is a potent non-thiazolidinedione (TZD) selective peroxisome proliferator-activated receptor γ modulator (SPPARM). AMG131 (benzenesulfonate) binds to PPARγ within the same binding pocket as the TZDs, but occupies a unique space in the pocket and contacts the receptor at distinct points from the TZDs. AMG131 (benzenesulfonate) is promising for research of type-2 diabetes mellitus ^[2] .

SAR247799 2 Publications Verification S1P1 agonist 3	LPL Receptor	Cardiovascular Disease
SAR247799 (S1P1 agonist 3) is an oral activity, selective G-protein-biased sphingosine-1 phosphate receptor-1 (S1P1 ) agonist, with EC₅₀s rang from 12.6 to 493 nM in S1P1-overexpressing cells and HUVECs. SAR247799 can be used for the research of endothelial protection, including type-2 diabetes, metabolic syndrome ^[2] .

ZK-158252	Leukotriene Receptor	Inflammation/Immunology
ZK-158252 is a leukotriene B4 type-2 receptor (BLT2) antagonist .

Repaglinide (Standard) AG-EE 623ZW (Standard)	Reference Standards Potassium Channel	Metabolic Disease Cancer
Repaglinide (Standard) is the analytical standard of Repaglinide. This product is intended for research and analytical applications. Repaglinide is an insulin secretagogue for the treatment of type-2 diabetes mellitus .

Galbacin (3S)-Zuonin A	AMPK	Metabolic Disease Cancer
Galbacin ((3S)-Zuonin A), the epimer of (-)-Zuonin A (HY-N7394A), is a AMPK activator. Galbacin can be isolated from Myristica fragrans (nutmeg). Galbacin stimulates AMPK enzyme in differentiated C2C12 cells. Galbacin also has anticancer activity, and inhibits the proliferation of lymphocyte and tumor cells. Galbacin prevents weight gain in diet-induced mice model. Galbacin can be used for metabolic syndrome (including obesity and type-2 diabetes) and caners research ^[2].

Urocortin II, human	CRFR	Metabolic Disease Endocrinology
Urocortin II (human) is a selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor. For investigating the role of the CRF (2) receptor in ingestive behavior .

Urocortin II, human acetate	CRFR	Metabolic Disease Endocrinology
Urocortin II, human acetate is a selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor. For investigating the role of the CRF (2) receptor in ingestive behavior .

Urocortin II, human TFA	CRFR	Metabolic Disease Endocrinology
Urocortin II, human TFA is a selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor. For investigating the role of the CRF (2) receptor in ingestive behavior .

CB2R PAM	Cannabinoid Receptor	Neurological Disease
CB2R PAM is an orally active cannabinoid type-2 receptors (CB2Rs) positive allosteric modulator. CB2R PAM displays antinociceptive activity in vivo in an experimental mouse model of neuropathic pain .

ACLY-IN-2	ATP Citrate Lyase	Metabolic Disease Inflammation/Immunology Cancer
ACLY-IN-2 (Compound 7) has inhibitory effect against human ATP citrate lyase (hACLY), with an IC₅₀ of less than 1 nM. ACLY-IN-2 can be studied in research on liver-related diseases, type-2 diabetes, autoimmunity, and cancer .

YNT-185 1 Publications Verification	Orexin Receptor (OX Receptor)	Neurological Disease
YNT-185 is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC₅₀s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 ameliorates narcolepsy-cataplexy symptoms in mouse models ^[2].

YNT-185 dihydrochloride 1 Publications Verification	Orexin Receptor (OX Receptor)	Neurological Disease
YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC₅₀s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models ^[2].

NS-220	PPAR	Metabolic Disease
NS-220 is an orally active PPARα agonist with high subtype selectivity, with EC₅₀ values of 1.9×10 ^-8 M, 9.6×10 ^-6 M and >10 ^-4 M for PPARα, PPAR γ and PPARδ, respectively. NS-220 is used in the research for hyperlipidemia or metabolic disorders in type-2 diabetes .

Orexin 2 Receptor Agonist 3	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin 2 Receptor Agonist 3 (Compound 57) is an orally active and brain-penetrant orexin receptor type-2 (OX₂) agonist (EC₅₀: 2.5 nM). Orexin 2 Receptor Agonist 3 increases wakefulness in the orexin/ataxin-3 NT1 mouse model and healthy beagle dogs. Orexin 2 Receptor Agonist 3 can be used in the study of narcolepsy .

DIBA-Cy5	mAChR	Others
DIBA-Cy5 is a fluorescent DIBA antagonist made up be DIBA-alkyne binding Cyanine5 fluorophores (Cy5) and polyethylene glycol (PEG) biomolecules. DIBA-Cy5 can serve as a fluorescent ligand, suitable for probe attachment through click chemistry. DIBA-Cy5 exerts a high binding affinity to type-2 mAChR (M2R) with the K_d value of 1.80 nM, can directly stain M2R receptors in the sinoatrial node of a mouse heart .

Urocortin II, mouse	CRFR	Metabolic Disease Endocrinology
Urocortin II, mouse is a potent and selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor with K_i values of 0.66 nM and ﹥100 nM for CRFR2 and CRFR1, respectively. Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca ²⁺/CaMKII-dependent manner.Urocortin II, mouse is expressed in discrete areas of the central nervous system, and activates central neurons involved in the processing of visceral sensory information, and in modulating autonomic outflow ^[2] .

IDE-IN-1	MMP	Metabolic Disease
IDE-IN-1 (compound 6bK) is an insulin-degrading enzyme (IDE) inhibitor with IC₅₀ value of 50 nM. IDE-IN-1 can be used to study type 2 diabetes .

Linerixibat 10+ Cited Publications GSK2330672	Apical Sodium-Dependent Bile Acid Transporter	Metabolic Disease Inflammation/Immunology
Linerixibat (GSK2330672) is a highly potent, nonabsorbable and orally active apical sodium-dependent bile acid transporter (ASBT) inhibitor with an IC₅₀ of 42 nM human ASBT. Linerixibat can be used as lipid-lowering agent. Linerixibat has the potential for type 2 diabetes and Primary Biliary Cholangitis treatment ^[2] .

Genipin 20+ Cited Publications (+)-Genipin	Autophagy	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research ^[2].

Genipin (Standard) (+)-Genipin (Standard)	Reference Standards Autophagy	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Genipin (Standard) is the analytical standard of Genipin. This product is intended for research and analytical applications. Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research ^[2].

α-Glucosidase-IN-8	Glycosidase	Metabolic Disease
α-Glucosidase-IN-8 (Compound 4k) is a competitive α-glucosidase inhibitor with an IC₅₀ of 0.18 µg/mL .

Peonidin 3-O-glucoside chloride 1 Publications Verification	Insulin Receptor	Metabolic Disease
Peonidin 3-O-glucoside chloride is an agonist of the free fatty acid receptor FFAR1 and Glucokinase. Peonidin 3-O-glucoside chloride enhances insulin secretion of pancreatic beta cells and increases glucose uptake by liver cells. Peonidin 3-O-glucoside chloride activates FFAR1, promotes the phosphorylation of related proteins in the insulin secretion pathway, and increases the expression of FFAR1. In liver cells, Peonidin 3-O-glucoside chloride activates GK and regulates proteins associated with carbohydrate metabolism. Peonidin 3-O-glucoside chloride can be used in diabetes research ^[2].

Onzigolide BIM-23A760; TBR-760	Dopamine Receptor Somatostatin Receptor	Neurological Disease Cancer
Onzigolide (BIM-23A760), a chimeric dopamine-somatostatin compound, shows potent agonist activity at both DA type 2 (D2R) and SST type 2 (SSTR2) receptors ^[2].

Chromium nicotinate	Others	Metabolic Disease
Chromium nicotinate is a nicotinate salt of trivalent chromium that is used as a supplement for type 2 diabetes .

Rivoglitazone R-106056	PPAR	Metabolic Disease
Rivoglitazone is a thiazolidinedione-derivative PPARγ agonist for the research of type 2 diabetes mellitus.

Utreglutide	GLP Receptor	Cardiovascular Disease Metabolic Disease
Utreglutide is an effective glucagon-like peptide 1 (GLP-1) receptor agonist. Utreglutide can lower blood pressure, blood lipids and body weight, and improve cardiovascular metabolism. Utreglutide can be used for research on type 2 diabetes or non-type 2 diabetes obesity ^[2].

N-Acetylornithine 1 Publications Verification	Others	Metabolic Disease
N-Acetylornithine is a precursor of ornithine. N-Acetylornithine is associated with type 2 diabetes ^[2].

(+/-)-Adomeglivant (+/-)-LY2409021	Endogenous Metabolite	Metabolic Disease
(+/-)-Adomeglivant ((+/-)-LY2409021) is a potent and selective glucagon receptor antagonist with hypoglycemic activity. (+/-)-Adomeglivant is effective in lowering blood sugar levels in both healthy people and people with type 2 diabetes. (+/-)-Adomeglivant is well tolerated by glucagon signaling blockade in patients with type 2 diabetes and significantly reduces fasting and postprandial blood glucose with a concomitant reversible elevation of aminotransferases. Glucagon signaling inhibition by (+/-)-Adomeglivant is a promising potential inhibitory approach for patients with type 2 diabetes and warrants further evaluation of its benefits and risks in longer clinical trials .

Insulin degludec	Insulin Receptor	Endocrinology
Insulin degludec is an ultra-long-acting form of insulin used for the research of hyperglycemia caused by type 1 and type 2 dabetes. Insulin degludec shows binding efficiency with an IC₅₀ value of 19.59 nM for insulin receptor. Insulin degludec can be used for the research of type 1 and type 2 diabetes ^[2].

Sodelglitazar GW 677954	Endogenous Metabolite	Metabolic Disease
Sodelglitazar (GW 677954) serves as a PPAR agonist with potential applications in the treatment of hyperlipidemia and type 2 diabetes.

Eloralintide 1 Publications Verification LY-3841136	Amylin Receptor	Metabolic Disease
Eloralintide (LY 3841136) is an AMYR agonist, which is promising for research of type 2 diabetes and obesity .

Farglitazar GI262570; GI262570X	PPAR	Metabolic Disease
Farglitazar is a PPARγ agonist that has significant therapeutic benefits such as glycemic control in type 2 diabetic patients.

SB756050 2 Publications Verification	G protein-coupled Bile Acid Receptor 1	Metabolic Disease
SB756050 is a selective TGR5 agonist. SB756050 has the potential for type 2 diabetes treatment.

Eloralintide sodium 1 Publications Verification LY-3841136 sodium	Amylin Receptor	Metabolic Disease
Eloralintide (LY 3841136) sodium is an AMYR agonist, which is promising for research of type 2 diabetes and obesity .

Ilepatril AVE 7688	Angiotensin-converting Enzyme (ACE)	Metabolic Disease
Ilepatril, a dual inhibitor of angiotensin-converting enzyme (ACE) and neutral endopeptidase, has inhibitory effects in the type 2 diabetic nephropathy model in obese Zucker diabetic fatty (ZDF) rats. Ilepatril significantly reduced albuminuria in a dose-dependent manner and may be a strategy distinct from metabolic control to inhibit type 2 diabetic nephropathy .

Tianagliflozin	SGLT	Metabolic Disease
Tianagliflozin is a sodium/glucose cotransporter 2 (SGLT-2) inhibitor with potential for investigation in type 2 diabetes .

(R,R)-Suntinorexton	Orexin Receptor (OX Receptor)	Neurological Disease
(R,R)-Suntinorexton is a isomeride of Suntinorexton (HY-137452). Suntinorexton is a *orexin type 2* receptor** agonist .

Cat. No.	Product Name

HY-L094

Food-Sourced Compound Library

1,998 compounds

The health benefits deriving from the consumption of certain foods have been common knowledge. All foods are made up of chemical substances. Chemicals in foods are largely harmless and often desirable. At present, numerous researchers have been focused on the beneficial role played by certain food components in the close relationship between food intake and health status. For example, polyphenols, a common class of compounds among foods, are well-known antioxidants, which may play a role in the prevention of several diseases including type 2 diabetes, cardiovascular diseases, and some types of cancer.

MCE supplies a unique collection of 1,998 compounds from variety of foods. All compounds are with specific food source(s). MCE Food-Sourced Compound Library is the useful tool to discover molecules with pharmaceutical activity from foods.

HY-L087

Anti-Obesity Compound Library

3,126 compounds

Obesity is widely recognized as the largest and fastest growing public health problem and is associated with numerous chronic disorders including osteoarthritis, obstructive sleep apnea, gallstones, fatty liver disease, reproductive and gastrointestinal cancers, dyslipidemia, hypertension, type 2 diabetes, heart failure, coronary artery disease, stroke, etc. Although obesity has long been associated with serious health issues, it has only recently been regarded as a disease in the sense of being a specific target for medical therapy. Obesity may be viewed as the dysregulation of two physiological functions, appetite regulation and energy metabolism, which combine to create disordered energy balance. Consequently, developing obesity treatments that target novel pathways is a growing focus for both biopharmaceutical industries.

MCE Anti-Obesity Compound Library owns a unique collection of 3,126 compounds, which mainly target signaling pathway of controlling appetite, fatty acid metabolism and energy expenditure, etc. This library is a useful tool for discovery anti-obesity drugs.

HY-L053

NMPA-Approved Drug Library

1,410 compounds

From target identification to clinical research, traditional drug discovery and development is a time-consuming and costly process, which also bears high risk. Compared with traditional drug discovery, drug repositioning or repurposing, also known as old drugs for new uses can greatly shorten the development cycle and reduce development cost, which has become a new trend of drug development. After undergoing clinical trials, approved drugs have identified bioactivities, good pharmacokinetic characteristics and safety, which can greatly improve the success rate of drug discovery. A number of successes have been achieved, such as metformin for type 2 diabetes and thalidomide for leprosy and multiple myeloma, etc.

MCE provides a unique collection of 1,410 China NMPA (National Medical Products Administration) approved compounds, which have undergone extensive preclinical and clinical studies and have well-characterized bioactivities, safety and bioavailability properties. MCE NMPA-Approved Drug Library is a good tool for drug repurposing which could dramatically accelerate drug development.

HY-L165

Dopamine Receptor Compound Library

244 compounds

Dopamine receptor (DAR), widely distributed in the brain, plays a key role in regulating motor function, motivation, driving force and cognition. The role of DA is mediated by D1-type (D1, D5) and D2-type receptors (D2S, D2L, D3, D4), which are distributed in presynaptic, postsynaptic and extrasynaptic, projection neurons and interneurons. Each receptor has a different function. D1 and D5 receptors couple with G stimulation sites and activate Adenylyl cyclase. The activation of Adenylyl cyclase leads to the production of the second messenger cAMP, which leads to the production of protein kinase A (PKA), which leads to further transcription in the nucleus. D2 to D4 receptors are coupled to G inhibitory sites to inhibit adenylyl cyclase and activate potassium Ion channel. These receptors utilize phosphorylation cascades or direct membrane interactions to affect the functions of voltage-gated and neurotransmitter-gated channels, cytoplasmic enzymes, and transcription factors. Dopamine receptor plays an important role in daily life.

MCE designs a unique collection of 244 small molecules related to dopamine receptor. It is a good tool for screening drugs from nervous system disease.

HY-L040

Anti-diabetic Compound Library

968 compounds

Diabetes mellitus, usually called diabetes, is a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time. The most common types are Type I and Type II. Type I diabetes (T1D), also called juvenile onset diabetes mellitus or insulin-dependent diabetes mellitus, is characterized by destruction of the β-cells of the pancreas and insulin is not produced, whereas type II diabetes (T2D), also called non-insulin-dependent diabetes mellitus, is characterized by a progressive impairment of insulin secretion and relative decreased sensitivity of target tissues to the action of this hormone. Type 2 diabetes accounts for the vast majority of all diabetes mellitus. Diabetes of all types can lead to complications in many parts of the body and can increase the overall risk of dying prematurely. Possible complications include kidney failure, leg amputation, vision loss and nerve damage.

The pathogenesis of diabetes is complicated, and development of the safe and effective drugs against diabetes is full of challenge. Increasing studies have confirmed that the pathogenesis of diabetes is related to various signaling pathways, such as insulin signaling pathway, AMPK pathway, PPAR regulation and chromatin modification pathways. These signaling pathways have thus become the major source of the promising novel drug targets to treat metabolic diseases and diabetes.

MCE Anti-diabetic Compound Library owns a unique collection of 968 compounds, which mainly target SGLT, PPAR, DPP-4, AMPK, Dipeptidyl Peptidase, Glucagon Receptor, etc. This library is a useful tool for discovery anti-diabetes drugs.

Cat. No.	Product Name	Type

HY-114118F

Semaglutide, FITC labeled

Fluorescent Dyes/Probes

Semaglutide, FITC labeled is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide, FITC labeled promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide, FITC labeled also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide, FITC labeled has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide, FITC labeled can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer ^[2] .

HY-151801

DIBA-Cy5

Fluorescent Dyes/Probes

DIBA-Cy5 is a fluorescent DIBA antagonist made up be DIBA-alkyne binding Cyanine5 fluorophores (Cy5) and polyethylene glycol (PEG) biomolecules. DIBA-Cy5 can serve as a fluorescent ligand, suitable for probe attachment through click chemistry. DIBA-Cy5 exerts a high binding affinity to type-2 mAChR (M2R) with the K_d value of 1.80 nM, can directly stain M2R receptors in the sinoatrial node of a mouse heart .

Cat. No.	Product Name	Type

HY-77642

4-(Methylsulfonyl)phenylboronic acid	Biochemical Assay Reagents
4-(Methylsulfonyl)phenylboronic acid is an intermediate. 4-(Methylsulfonyl)phenylboronic acid can be used to synthesize GPR119 agonists via Suzuki coupling reaction. 4-(Methylsulfonyl)phenylboronic acid can be used in the research of type 2 diabetes .

HY-W134326

Polydextrose	Biochemical Assay Reagents
Polydextrose is an orally active prebiotic. Polydextrose promotes the growth of Pediococcus pentosaceus ATCC 43200. Polydextrose reduces cholesterol and synergistically lowers blood sugar with Sitagliptin (HY-13749). Currently, it is mainly used in the research of diseases such as hyperlipidemia, type 2 diabetes, and postoperative iron deficiency anemia ^[2] .

HY-E70147

ST3 β-Gal α-2,3-Sialyltransferase 6

EC:2.4.99.; ST3GAL6; type 2 lactosamine α-2,3-sialyltransferase

Enzyme Substrates

ST3 beta-Gal alpha-2,3-Sialyltransferase 6 (EC:2.4.99., ST3GAL6; SIAT10, Type 2 lactosamine alpha-2,3-sialyltransferase) transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. ST3 beta-Gal alpha-2,3-Sialyltransferase 6 play an important role in cancer .

HY-W584173

D-Glyceric acid calcium hydrate	Cell Assay Reagents
D-Glyceric acid calcium hydrate is an endogenous metabolite present in urine that can be used for the research of primary hyperoxaluria type I and glutaric acidemia type 2 .

HY-W587977

3-Hydroxypalmitoylcarnitine 3-Hydroxyhexadecanoylcarnitine	Biochemical Assay Reagents
3-Hydroxypalmitoylcarnitine (3-Hydroxyhexadecanoylcarnitine) is an acylcarnitine. Elevated levels of 3-Hydroxypalmitoylcarnitine are associated with cardiovascular disease (CVD) in type 2 diabetes mellitus (T2DM) .

HY-E70141

β-1,3-N-Acetylglucosaminyltransferase 4 EC:2.4.1.149; B3GNT4	Enzyme Substrates
β-1,3-N-Acetylglucosaminyltransferase 4 (EC:2.4.1.149, B3GNT4) is involved in the synthesis of poly-N-acetyllactosamine and has activity for type 2 oligosaccharides .

HY-NP0214

human Cystatin-C protein	Native Proteins
Cystatin C is an endogenous cysteine proteinase inhibitor belonging to the type 2 cystatin superfamily. Human Cystatin-C protein is encoded by the CST3 gene, ubiquitously expressed at moderate levels. Human Cystatin-C protein is an important endogenous marker of renal function .

Cat. No.	Product Name	Target	Research Area

HY-P1752

Urocortin II, human	CRFR	Metabolic Disease Endocrinology
Urocortin II (human) is a selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor. For investigating the role of the CRF (2) receptor in ingestive behavior .

HY-P1752B

Urocortin II, human acetate	CRFR	Metabolic Disease Endocrinology
Urocortin II, human acetate is a selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor. For investigating the role of the CRF (2) receptor in ingestive behavior .

HY-P2847

Urocortin II, mouse	CRFR	Metabolic Disease Endocrinology
Urocortin II, mouse is a potent and selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor with K_i values of 0.66 nM and ﹥100 nM for CRFR2 and CRFR1, respectively. Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca ²⁺/CaMKII-dependent manner.Urocortin II, mouse is expressed in discrete areas of the central nervous system, and activates central neurons involved in the processing of visceral sensory information, and in modulating autonomic outflow ^[2] .

HY-P3388

Utreglutide	GLP Receptor	Cardiovascular Disease Metabolic Disease
Utreglutide is an effective glucagon-like peptide 1 (GLP-1) receptor agonist. Utreglutide can lower blood pressure, blood lipids and body weight, and improve cardiovascular metabolism. Utreglutide can be used for research on type 2 diabetes or non-type 2 diabetes obesity ^[2].

HY-108743

Insulin degludec	Insulin Receptor	Endocrinology
Insulin degludec is an ultra-long-acting form of insulin used for the research of hyperglycemia caused by type 1 and type 2 dabetes. Insulin degludec shows binding efficiency with an IC₅₀ value of 19.59 nM for insulin receptor. Insulin degludec can be used for the research of type 1 and type 2 diabetes ^[2].

HY-P10798

Eloralintide 1 Publications Verification LY-3841136	Amylin Receptor	Metabolic Disease
Eloralintide (LY 3841136) is an AMYR agonist, which is promising for research of type 2 diabetes and obesity .

HY-P10798A

Eloralintide sodium 1 Publications Verification LY-3841136 sodium	Amylin Receptor	Metabolic Disease
Eloralintide (LY 3841136) sodium is an AMYR agonist, which is promising for research of type 2 diabetes and obesity .

HY-P1752A

Urocortin II, human TFA	CRFR	Metabolic Disease Endocrinology
Urocortin II, human TFA is a selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor. For investigating the role of the CRF (2) receptor in ingestive behavior .

HY-P3294

Onzigolide BIM-23A760; TBR-760	Dopamine Receptor Somatostatin Receptor	Neurological Disease Cancer
Onzigolide (BIM-23A760), a chimeric dopamine-somatostatin compound, shows potent agonist activity at both DA type 2 (D2R) and SST type 2 (SSTR2) receptors ^[2].

HY-109552

Pramlintide acetate hydrate	Peptides	Metabolic Disease
Pramlintide acetate hydrate is the acetate hydrate of Pramlintide (HY-P0058). Pramlintide acetate hydrate can be used for the stufy of type 1 and type 2 diabetes .

HY-P0014

Liraglutide 30+ Cited Publications	GCGR GLP Receptor	Metabolic Disease Cancer
Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus.

HY-P2829

Stresscopin (human)	CRFR	Endocrinology
Stresscopin (human) is a selective ligand of type 2 adrenocorticotropin-releasing hormone (CRH) receptors and can be used in the research of stress-related diseases .

HY-P0165

Taspoglutide ITM077; R1583; BIM51077	GCGR	Metabolic Disease
Taspoglutide is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist developed for treatment of type 2 diabetes, with an EC₅₀ value of 0.06 nM.

HY-P1160

Bay 55-9837	GCGR	Metabolic Disease
Bay 55-9837 is a potent and highly selective agonist of *VPAC2, with a K_d* of 0.65 nM. Bay 55-9837 may be a useful therapy for the research of type 2 diabetes .

HY-P0014A

Liraglutide acetate	GLP Receptor	Metabolic Disease
Liraglutide acetate is the acetate form of Liraglutide (HY-P0014), a glucagon-like peptide-1 (GLP-1) receptor agonist studied in type 2 diabetes .

HY-P1160A

Bay 55-9837 TFA	GCGR	Metabolic Disease
Bay 55-9837 TFA is a potent and highly selective agonist of *VPAC2, with a K_d* of 0.65 nM. Bay 55-9837 TFA may be a useful therapy for the research of type 2 diabetes .

HY-P4633

γ-Glu-Tyr 1 Publications Verification	Dipeptidyl Peptidase	Metabolic Disease
γ-Glu-Tyr, a competitive inhibitor of dipeptidyl peptidase-IV (DPP-IV) (IC₅₀=6.77 mM), is a potentially functional component of the type 2 diabetes diet .

HY-P10758

Alkyne-βAG-TOCA	Somatostatin Receptor	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Alkyne-βAG-TOCA, an octreotide derivative, targets somatostatin receptor type 2 (SST2) . Alkyne-βAG-TOCA can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

HY-P0120

Dulaglutide 1 Publications Verification LY2189265	GCGR	Metabolic Disease
Dulaglutide (LY2189265) is a glucagon-like peptide-1 (GLP-1) receptor agonist. Dulaglutide can be uesd for the research of type 2 diabetes (T2D) ^[2].

HY-P4070

Insulin icodec	Peptides	Metabolic Disease
Insulin icodec is an Insulin (HY-P0035) analog that strongly but reversibly binds to albumin. Insulin icodec has long plasma half-life. Insulin icodec can be used for the research of type 2 diabetes .

HY-P5161

FC382K10W15	GLP Receptor GCGR	Metabolic Disease
FC382K10W15 is a glucagon analogue and GLP-1R/GCGR agonist. FC382K10W15 can be used in type 2 diabetes research .

HY-P10305

Visepegenatide PB-119	Insulin Receptor	Metabolic Disease
PB-119 is a PEGylated Exenatide. PB-119 decreases glycemic levels by improving beta-cell function and insulin resistance. PB-119 can be used for research of type 2 diabetes .

HY-P1540

Angiotensin III, human, mouse	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT₂R) agonist, with IC₅₀s of 0.648 nM and 21.1 nM for AT₂R and AT₁R, respectively.

HY-P5161A

FC382K10W15 TFA	GLP Receptor GCGR	Metabolic Disease
FC382K10W15 TFA is a glucagon analogue and GLP-1R/GCGR agonist. FC382K10W15 TFA can be used in type 2 diabetes research .

HY-P0014AS

Liraglutide-d8 tetraTFA	Isotope-Labeled Compounds GLP Receptor	Metabolic Disease
Liraglutide-d₈ tetraTFA is deuterium labeled Liraglutide (HY-P0014). Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for the study of type 2 diabetes mellitus .

HY-P10269

Bofanglutide GZR18	GLP Receptor	Metabolic Disease
Bofanglutide (GZR18) is an analog of glucagon-like peptide-1 (GLP-1), which exhibits agonistic activity for GLP-1 receptor, with an EC₅₀ of 0.677 nM. GZR18 ameliorates type 2 diabetes .

HY-P11285

LAGIPRA peptide Long acting GIPRA-1	Insulin Receptor	Metabolic Disease
LAGIPRA peptide is a long-acting GIP1R agonist. LAGIPRA peptide enhances insulin sensitivity by augmenting glucose disposal and reduces branched-chain amino acids (BCAAs) and ketoacids. LAGIPRA peptide has the potential for the research of type 2 diabetes .

HY-P10809

VAMP	Dipeptidyl Peptidase	Metabolic Disease
VAMP, a tetrapeptide, is a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 1.00 μM and a K_d of 6.89 μM. VAMP effectively targets the DPP-IV-GLP-1 axis and can be used for the study of type 2 diabetes .

HY-P0014S2

Liraglutide-13C6,15N TFA	Isotope-Labeled Compounds	Others
Liraglutide- ¹³C₆, ¹⁵N (TFA)is the ¹³C and ¹⁵N labeledLiraglutide(HY-P0014). Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus .

HY-P10767

MD01-67	Neurotensin Receptor	Neurological Disease
MD01-67 is a selective macrocyclic compound targeting the neurotensin receptor type 2 (NTS2), with K_i of 2.9 nM. MD01-67 exhibits analgesic and tactile hypersensitivity reducing activity in rats acute/persistent/chronic inflammatory pain models .

HY-P11285A

LAGIPRA peptide TFA Long acting GIPRA-1 TFA	Insulin Receptor	Metabolic Disease
LAGIPRA peptide TFA is a long-acting GIP1R agonist. LAGIPRA peptide TFA enhances insulin sensitivity by augmenting glucose disposal and reduces branched-chain amino acids (BCAAs) and ketoacids. LAGIPRA peptide TFA has the potential for the research of type 2 diabetes .

HY-P5878

RG33 Peptide	Biochemical Assay Reagents	Metabolic Disease
RG33 Peptide is a diabetes inhibitor that significantly improves glucose clearance in insulin-resistant mice. RG33 Peptide effectively solubilizes lipid vesicles and promotes cholesterol efflux in cultured macrophages. RG33 Peptide is used in research into type 2 diabetes (T2D) .

HY-P0014S1

Liraglutide-13C5,15N TFA	Isotope-Labeled Compounds GLP Receptor GCGR	Others
Liraglutide- ¹³C₅, ¹⁵N (tetraTFA) is the ¹³C and ¹⁵N labeled Liraglutide (HY-P0014) . Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus ^[2].

HY-P3959

(Tyr0)-Urocortin, rat	CRFR	Endocrinology
(Tyr0)-Urocortin, rat is a high-affinity agonist of *corticotropin-releasing factor receptor type* 1 (CRF-R1) and type 2** (CRF-R2). (Tyr0)-Urocortin, rat shows inhibitory binding constants (Ki) of 1-2 nM .

HY-P3130

Stresscopin-related peptide (human)	CRFR	Neurological Disease Inflammation/Immunology
Stresscopin-related peptide (human) is a specific ligand for the type 2 CRH receptor. Stresscopin-related peptide (human) suppresses food intake, delayed gastric emptying and decreases heat-induced edema. Stresscopin-related peptide (human) maintains homeostasis after stress, and can be used in the research of stress-related diseases .

HY-P4790

Acetyl-Exenatide	PI3K Akt	Metabolic Disease
Acetyl-Exenatideyes is an acetylated derivative of Exenatide. Exenatide has the function similar to insulin, which can be used for research of type 2 diabetes. Exenatide can promote Th17 differentiation, inhibits Tregs differentiation, downregulates PI3K/Akt/FoxO1 phosphorylation .

HY-P1434

[Pro3]-GIP (mouse)	Insulin Receptor	Metabolic Disease
[Pro3]-GIP (mouse) is a GIP receptor antagonist (IC₅₀: 2.6 μM). [Pro3]-GIP (mouse) improves glucose tolerance and insulin sensitivity in ob/ob mice. [Pro3]-GIP (mouse) can be used for research of type 2 diabetes ^[2].

HY-W003222

N-tert-Boc-cis-4-fluoro-L-proline	Drug Intermediate	Metabolic Disease
N-tert-Boc-cis-4-fluoro-L-proline (Compound 11) is a drug intermediate for the synthesis of 4-fluoropyrrolidine-2-carbonitrile DPP-4 inhibitor. N-tert-Boc-cis-4-fluoro-L-proline can be used to study type 2 diabetes .

HY-P10571

GPS1573	Melanocortin Receptor	Endocrinology
GPS1573 is a noncompetitive antagonist of melanocortin type 2 receptor (MC2R) that dose-dependently antagonizes ACTH-stimulated *MC2R* activity (IC₅₀=66 nM). GPS1573 can be used in the study of Cushing's disease due to its highly selective antagonism of *MC2R* .

HY-P1194

Spantide I	Neurokinin Receptor	Inflammation/Immunology
Spantide I, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation ^[2] .

HY-P0014B

Liraglutide TFA 30+ Cited Publications	GLP Receptor	Metabolic Disease
Liraglutide (TFA) is an agonist of glucagon-like peptide 1 receptor (GLP-1). Liraglutide (TFA) can activate GLP-1, leading to the release of insulin in the presence of increased glucose concentration. Liraglutide (TFA) also reduces glucagon secretion in a glucose-dependent manner. Liraglutide (TFA) can be studied in research on type 2 diabetes .

HY-P1194A

Spantide I TFA	Neurokinin Receptor	Inflammation/Immunology
Spantide I TFA, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation ^[2] .

HY-P10836

DN59	Dengue Virus	Infection
DN59 is a 33 amino acid peptide that mimics the dengue virus type 2 E stem region. DN59 inhibits all four serotypes of dengue virus (IC₅₀: 2-5 μM) as well as other flaviviruses. N59 causes the release of genomic RNA by interacting directly with viral particles. DN59 has antiviral activity .

HY-P1131A

M617 TFA	Neuropeptide Y Receptor	Cardiovascular Disease
M617 TFA is a selective galanin receptor 1 (GAL1) agonist, with K_is of 0.23 and 5.71 nM for GAL1 and GAL2, respectively. M617 TFA, acting through its central GAL1, can promote GLUT4 expression and enhance GLUT4 content in the cardiac muscle of type 2 diabetic rats ^[2].

HY-109556

Insulin Detemir	Akt ERK	Metabolic Disease
Insulin Detemir is an artificial insulin, shows effect on controlling blood sugar levels. Insulin Detemir stimulates GLP-1 secretion as a consequence of enhanced Gcg expression by a mechanism involving activation of Akt- and/or extracellular signal-regulated kinase (ERK)-dependent-cat and CREB signaling pathways. Insulin Detemir can be used for type 2 diabetes research ^[2].

HY-P2231

Cotadutide 1 Publications Verification MEDI0382	GCGR	Metabolic Disease
Cotadutide (MEDI0382) is a potent dual agonist of glucagon-like peptide-1 (GLP-1) and GCGR with EC₅₀ values of 6.9 pM and 10.2 pM, respectively. Cotadutide exhibits ability to facilitate both weight loss and glycaemic control, and alleviate fibrosis. Cotadutide can be used in the research of obesity and type 2 diabetes (T2D) ^[2] .

HY-P2231A

Cotadutide acetate 1 Publications Verification MEDI0382 acetate	GCGR	Metabolic Disease
Cotadutide (MEDI0382) acetate is a potent dual agonist of glucagon-like peptide-1 (GLP-1) and GCGR with EC₅₀ values of 6.9 pM and 10.2 pM, respectively. Cotadutide acetate exhibits ability to facilitate both weight loss and glycaemic control, and alleviate fibrosis. Cotadutide acetate can be used in the research of obesity and type 2 diabetes (T2D) ^[2] .

HY-P1944A

Apelin-13 TFA 5+ Cited Publications	Apelin Receptor (APJ)	Cardiovascular Disease Metabolic Disease
Apelin-13 TFA is an endogenous ligand for the G-protein coupled receptor angiotensin II protein J (APJ), activating this G protein-coupled receptor with an EC₅₀ value of 0.37 nM. Apelin-13 TFA has vasodilatory and antihypertensive effects. Apelin-13 TFA also can be used for researching type 2 diabetes and metabolic syndrome ^[2] .

HY-P10746

EB1002	Neurokinin Receptor	Metabolic Disease
EB1002 is a selective *NK2R* agonist. EB1002 significantly raises the expression levels of mitochondrial biosynthesis-related genes (like PGC-1α) in obese mice, indicating that it promotes energy expenditure by boosting mitochondrial activity. EB1002 also increases the insulin sensitivity and improves glycolipid metabolism of the mice. EB1002 is promising for research of obesity and type 2 diabetes .

HY-P10018

Bamadutide SAR425899	GLP Receptor GCGR	Metabolic Disease
Bamadutide (SAR425899) is a potent dual glucagon-like peptide-1 receptor/glucagon receptor (GLP-1R/GCGR) agonist. Bamadutide improves post-meal blood glucose control by significantly enhancing β-cell function and slowing down the rate of glucose absorption in the body. Bamadutide can be used for the research of metabolic diseases such as type 2 diabetes ^[2] .

Cat. No.	Product Name	Target	Research Area

HY-P99646

Golocdacimab 1 Publications Verification MEDI6570	LOX-1	Metabolic Disease
Golocdacimab (MEDI6570) is a fully human anti-LOX-1 monoclonal antibody. Golocdacimab (MEDI6570) has the potential to be used in the treatment of type 2 diabetes .

HY-P99614

Fazpilodemab BFKB8488A; RG-7992; RO-7040551	FGFR	Metabolic Disease
Fazpilodemab (BFKB8488A) is a humanized bispecific IgG1 antibody that selectively targets and activates fibroblast growth factor receptor 1c (FGFR1c) and Klothoβ. Fazpilodemab can be used for the research of type 2 diabetes mellitus (T2DM) or nonalcoholic fatty liver disease (NAFLD) .

HY-P990748

Lunsekimig SAR443765	Interleukin Related	Inflammation/Immunology
Lunsekimig (SAR443765) is an anti-TSLP/IL13/ALB nonobody composed of 5 sequentially linked variable region heavy chains. Lunsekimig decreases blood eosinophils and lowers plasma levels of IL-5, eotaxin-3, and IgE. Lunsekimig also improves lung function. Lunsekimig can be used for the study and treatment of type 2 inflammatory asthma ^[2].

HY-P991249

NI-203	Amylin Receptor	Metabolic Disease
NI-203 is a monoclonal antibody inhibitor that targets amylin. NI-203 is promising for research of type 2 diabetes .

HY-P991670

Abdakibart	Interleukin Related	Inflammation/Immunology
Abdakibart is a humanized IgG4 monoclonal antibody inhibitor targeting IL-1β. Abdakibart can be used for inflammatory disease like type 2 diabetes research ^[2].

HY-P991269

LY2189102	Interleukin Related	Metabolic Disease
LY2189102 is a humanized monoclonal antibody inhibitor targeting interleukin-1β (IL-1β). LY2189102 is promising for research of type 2 diabetes .

HY-P991258

CNTO-5825	Interleukin Related	Inflammation/Immunology
CNTO-5825 is a humanized monoclonal antibody inhibitor targeting interleukin-13 (IL-13). CNTO-5825 is promising for research of Th2-type inflammatory related diseases such as asthma and atopic dermatitis .

HY-P990207

Anti-Mouse/Human Integrin β7 Antibody (FIB504)	Integrin	Neurological Disease Inflammation/Immunology Cancer
Anti-Mouse/Human Integrin β7 Antibody (FIB504) is an anti-mouse/human Integrin β7 IgG2a monoclonal antibody. Anti-Mouse/Human Integrin β7 Antibody (FIB504) can reduce the residence of type 2 innate lymphoid cells (ILC2s). Anti-Mouse/Human Integrin β7 Antibody (FIB504) can be used for researches on inflammation conditions and cancer such as lupus nephritis and glioma ^[2].

Species:	Human (50) Virus (5) Rhesus Macaque (2) Mouse (14) Rat (4) Cynomolgus (13) Canine (2)
Tag:	GFP (1) His (53) SUMO (1) Tag Free (10) Avi (3) Myc (1) GST (4) Fc (19) Flag (1)
Source:	HEK293 (53) E. coli Cell-free (3) Sf9 insect cells (1) Sf9 insect cells (11) P. pastoris (5) E. coli (9)

Cat. No.	Compare	Product Name	Species	Source

HY-P76669

	TCPTP Protein, Mouse (sf9, His) 4 Publications Verification Tyrosine-protein phosphatase non-receptor type 2; MPTP; PTPN2	Mouse	Sf9 insect cells
	TCPTP is a non-receptor tyrosine-specific phosphatase that regulates multiple signaling pathways by dephosphorylating proteins such as INSR, EGFR, CSF1R, PDGFR, JAK, Src kinase and STAT.TCPTP acts in the nucleus and cytoplasm to regulate hematopoiesis, inflammation, cell proliferation, differentiation, and glucose homeostasis.TCPTP Protein, Mouse (sf9, His) is the recombinant mouse-derived TCPTP protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P76103A

	TCPTP Protein, Human (sf9) Tyrosine-protein phosphatase non-receptor type 2; TCPTP; PTPN2; PTPT	Human	Sf9 insect cells
	TCPTP is a non-receptor tyrosine-specific phosphatase that critically regulates various kinases (INSR, EGFR, JAK, Src) affecting hematopoiesis, inflammation, cell proliferation, and glucose homeostasis. In the immune system, TCPTP regulates T cell receptor signaling and inhibits cytokine pathways (IL2, interferon). TCPTP Protein, Human (sf9) is the recombinant human-derived TCPTP protein, expressed by Sf9 insect cells , with tag free.

HY-P7659

	BDH2 Protein, Human (His) rHuBDH2, His; 3-Hydroxybutyrate Dehydrogenase type 2; Oxidoreductase UCPA; BDH2	Human	E. coli
	BDH2 Protein, Human (His) expresses in E. coli with a His tag. BDH2 is a cytosolic-type 2-hydroxybutyrate dehydrogenase and has a physiological role in the utilization of cytosolic ketone bodies, which can subsequently enter mitochondria and the tricarboxylic acid cycle.

HY-P76103

	TCPTP Protein, Human (sf9, solution) Tyrosine-protein phosphatase non-receptor type 2; TCPTP; PTPN2; PTPT	Human	Sf9 insect cells
	TCPTP is a non-receptor tyrosine-specific phosphatase that critically regulates various kinases (INSR, EGFR, JAK, Src) affecting hematopoiesis, inflammation, cell proliferation, and glucose homeostasis. In the immune system, TCPTP regulates T cell receptor signaling and inhibits cytokine pathways (IL2, interferon). TCPTP Protein, Human (sf9, solution) is the recombinant human-derived TCPTP protein, expressed by Sf9 insect cells, with tag free.

HY-P77377

	Hemojuvelin Protein, Cynomolgus (sf9, His) hemochromatosis type 2 (juvenile)	Cynomolgus	Sf9 insect cells
	The Hemojuvelin protein is a membrane-bound and soluble protein in mammals, also known as rejection directing Molecule C (RGMc) or hemochromatosis type 2 protein (HFE2). Hemojuvelin works by inhibiting the MAPK-JNK pathway that inhibits the growth, adhesion, migration, and invasion of prostate cancer cells. Hemojuvelin Protein, Cynomolgus (sf9, His) is the recombinant cynomolgus-derived Hemojuvelin protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P700874

	MRC2 Protein, Canine (HEK293, His) Mannose receptor C type 2	Canine	HEK293
	The MRC2 protein may function as an endocytic lectin receptor with calcium-dependent lectin activity. It internalizes glycosylated ligands via clathrin-mediated endocytosis and releases them in endosomes. MRC2 Protein, Canine (HEK293, His) is the recombinant canine-derived MRC2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77304

	BLOT1 Protein, Blomia tropicalis (P.pastoris, His) type 2 allergen Blo t 2.047	Others	P. pastoris
	BLOT1 Protein, Blomia tropicalis (P.pastoris, His) is the recombinant BLOT1 protein, expressed by P. pastoris, with N-6*His labeled tag.

HY-P77305

	BLOT2 Protein, Blomia tropicalis (HEK293, His) type 2 allergen Blo t 2.047	Others	HEK293
	BLOT1 Protein is a Blomia tropicalis allergen and is highly homologous to cysteine proteases. BLOT1 may play a major role as an immunodominant allergen involved in dust mite-specific IgE-mediated hypersensitivity. BLOT1, like the other group 1 HDM allergens, is a digestive enzyme associated with mite fecal pellets. BLOT2 Protein, Blomia tropicalis (HEK293, His) is the recombinant BLOT2 protein, expressed by HEK293 , with N-6*His labeled tag.

HY-P76104

	TCPTP Protein, Human (sf9, His-GST) Tyrosine-protein phosphatase non-receptor type 2; TCPTP; PTPN2; PTPT	Human	Sf9 insect cells
	TCPTP is a non-receptor tyrosine-specific phosphatase that critically regulates various kinases (INSR, EGFR, JAK, Src) affecting hematopoiesis, inflammation, cell proliferation, and glucose homeostasis. In the immune system, TCPTP regulates T cell receptor signaling and inhibits cytokine pathways (IL2, interferon). TCPTP Protein, Human (sf9, His-GST) is the recombinant human-derived TCPTP protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P77140

	PILR-alpha Protein, Human (HEK293) Paired immunoglobulin-like type 2 receptor alpha; Cell surface receptor FDF03; PILRA	Human	HEK293
	Paired immunoglobulin-like type 2 receptor alpha (PILRA) is a immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing member of the paired receptor which consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction such as SH1 through dephosphorylation of signaling molecules. PILR-alpha Protein, Human (HEK293) is the recombinant human-derived PILR-alpha protein, expressed by HEK293 , with tag free.

HY-P72890

	CD21 Protein, Human (HEK293, His) Complement receptor type 2; Cr2; EBV receptor; CD21; C3DR	Human	HEK293
	CD21 Protein, a receptor for complement C3, Epstein-Barr virus, and HNRNPU, activates B lymphocytes and aids Epstein-Barr virus entry in microbial infection. Its engagement with these ligands highlights its vital role in immune responses and interactions, regulating B-cell activation and host defense against infections. CD21 Protein, Human (HEK293, His) is the recombinant human-derived CD21 protein, expressed by HEK293 , with C-His, C-10*His labeled tag.

HY-P76545

	PILR-alpha Protein, Mouse (HEK293, His) Paired immunoglobulin-like type 2 receptor alpha; Cell surface receptor FDF03; PILRA	Mouse	HEK293
	PILR-alpha Protein, a key member of paired immune system regulators, acts as a receptor for CD99 and PIANP. Its interactions with CD99 highlight its role in cellular recognition and immune response modulation. Paired receptors, featuring activating and inhibitory forms, finely tune immune system regulation. PILR-alpha's observed ligand interactions underscore its importance in mediating immune responses and cellular recognition processes. PILR-alpha Protein, Mouse (HEK293, His) is the recombinant mouse-derived PILR-alpha protein, expressed by HEK293 , with C-His labeled tag.

HY-P77141

	PILR-alpha Protein, Human (HEK293, Fc) Paired immunoglobulin-like type 2 receptor alpha; Cell surface receptor FDF03; PILRA	Human	HEK293
	Paired immunoglobulin-like type 2 receptor alpha (PILRA) is a immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing member of the paired receptor which consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction such as SH1 through dephosphorylation of signaling molecules. PILR-alpha Protein, Human (HEK293, Fc) is the recombinant human-derived PILR-alpha protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P702389

	NPY2R Protein, Human (Cell-Free, His) Neuropeptide Y receptor type 2; NPY-Y2 receptor; Y2 receptor	Human	E. coli Cell-free
	NPY2R, the neuropeptide Y (NPY) and peptide YY (PYY) receptors, exhibit different affinities for pancreatic peptides. Preferences in descending order include PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [ Pro -34] PYY and NPY free acids. NPY2R Protein, Human (Cell-Free, His) is the recombinant human-derived NPY2R protein, expressed by E. coli Cell-free , with N-10*His labeled tag.

HY-P77143

	PILR-beta Protein, Mouse (HEK293, Fc) Paired immunoglobulin-like type 2 receptor beta; Activating receptor PILR-beta; FDFACT; Pilrb1	Mouse	HEK293
	The PILR-β protein is a paired immune system modulator and is considered a signal-activated receptor that associates with cell surface ITAM adapters such as DAP12. It interacts with CD99 and may help natural killer cells recognize target cells and activate dendritic cells. PILR-beta Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived PILR-beta protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P77463

	PILR-beta Protein, Human (HEK293, His) Paired immunoglobulin-like type 2 receptor beta; Activating receptor PILR-beta; FDFACT; PP1551	Human	HEK293
	PILR-β is part of a family of paired receptors that play a critical regulatory role in the immune system. PILR-β functions as an activating receptor and is thought to participate in cell signaling by binding to ITAM-bearing adapter molecules, suggesting its role in transmitting immune response signals. PILR-beta Protein, Human (HEK293, His) is the recombinant human-derived PILR-beta protein, expressed by HEK293 , with N-His labeled tag.

HY-P7698

	Cadherin-11 Protein, Human (HEK293, His) 1 Publications Verification rHuCadherin-11, His; Cadherin 11 type 2 OB-cadherin (Osteoblast); CDH11; Cadherin-11	Human	HEK293
	Cadherin-11 Protein, Human (HEK293, His) is a recombinant human Cadherin-11 produced in HEK293 cells, with His tag. Cadherin-11 is a classical cadherin adhesion molecule that mediates homophilic cell-to-cell adhesion.

HY-P77142

	PILR-alpha Protein, Human (178a.a, HEK293, His) Paired immunoglobulin-like type 2 receptor alpha; Cell surface receptor FDF03; PILRA	Human	HEK293
	Paired immunoglobulin-like type 2 receptor alpha (PILRA) is a immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing member of the paired receptor which consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction such as SH1 through dephosphorylation of signaling molecules. PILR-alpha Protein, Human (178a.a, HEK293, His) is the recombinant human-derived PILR-alpha protein, expressed by HEK293 , with C-His labeled tag.

HY-P7426

	TGFBR2/TGF-beta RII Protein, Human (HEK293, Fc) TGFR-2; TGF-beta type II receptor; TGF-beta receptor type 2; TbetaR-II	Human	HEK293
	TGF-beta receptor 2 Protein, Human (HEK293, Fc), a fragment of transforming growth factor-beta receptor type 2 (TβRII), consists of amino acid of Thr23-Asp159 with an Fc tag at the C-terminus.

HY-P7427

	TGFBR2/TGF-beta RII Protein, Mouse (HEK293, Fc) TGFR-2; TGF-beta type II receptor; TGF-beta receptor type 2; TbetaR-II	Mouse	HEK293
	TGFBR2/TGF-beta RII Protein, Mouse (HEK293, Fc), a fragment of transforming growth factor-beta receptor type 2 (TβRII), with a 6His tag at the C-terminus.

HY-P7428

	TGFBR2/TGF-beta RII Protein, Mouse (HEK293, His) TGFR-2; TGF-beta type II receptor; TGF-beta receptor type 2; TbetaR-II	Mouse	HEK293
	TGFBR2/TGF-beta RII Protein, Mouse (HEK293, His), His consists of N-terminal ectodomain and C-terminal protein kinase domain with his tag.TGF-beta receptor type-2 is the ligand-binding receptor for all members of the TGF-β family.

HY-P73428

	TGFBR2/TGF-beta RII Protein, Human (sf9, His) TGFR-2; TGF-beta type II receptor; TGF-beta receptor type 2; TbetaR-II	Human	Sf9 insect cells
	The TGFBR2/TGF-β RII protein cooperates with TGFBR1 to form dedicated receptors for TGFB1, TGFB2, and TGFB3. It serves as a signal transducer that coordinates diverse physiological and pathological processes, including cell cycle regulation, mesenchymal cell dynamics, wound healing, matrix production, immunosuppression, and carcinogenesis. TGFBR2/TGF-beta RII Protein, Human (sf9, His) is the recombinant human-derived TGFBR2/TGF-beta RII protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P73430

	TGFBR2/TGF-beta RII Protein, Rat (HEK293, Fc) TGFR-2; TGF-beta type II receptor; TGF-beta receptor type 2; TbetaR-II	Rat	HEK293
	TGFBR2 is a transmembrane kinase that forms the TGF-β receptor complex with TGFBR1 and regulates various processes. Upon binding to cytokines, this complex activates TGFBR2, initiating SMAD-dependent signaling through phosphorylation of TGFBR1, SMAD2, and SMAD4. TGFBR2/TGF-beta RII Protein, Rat (HEK293, Fc) is the recombinant rat-derived TGFBR2/TGF-beta RII protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P704919

	TGFBR2/TGF-beta RII Protein, Human (HEK293, His) TGFR-2; TGF-beta type II receptor; TGF-beta receptor type 2; TbetaR-II	Human	HEK293

HY-P72855

	BMPR-II Protein, Human (HEK293, His-Fc) Bone morphogenetic protein receptor type-2; BMPR-2; BMPR-II; PPH1	Human	HEK293
	BMP Type II Receptor (BMPR2) is a type II member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. BMPR2 is highly expressed in the heart and liver, and involves in osteogenesis and cell differentiation, essential for embryogenesis, development, and adult tissue homeostasis. BMPR2 is associated with tubulin stability, the inhibition of BMPR2 destabilizes the microtubules promoting cell death of cancer cells that involves the activation of the lysosomes. Human BMPR2 protein contains 1038 amino acids and a transmembrane domain (151-171 a.a.). BMPR-II Protein, Human (HEK293, His-Fc) is the extracellular part of the complete BMPR2 protein, produced by HEK293 cells (M1-I151) with C-terminal hFc- and His-tag.

HY-P77229

	TGFBR2/TGF-beta RII Protein, Rhesus Macaque (HEK293, Fc) TGFR-2; TGF-beta type II receptor; TGF-beta receptor type 2; TbetaR-II	Rhesus Macaque	HEK293
	TGFBR2/TGF-beta RII Protein collaborates with TGFBR1 to form a dedicated receptor for TGFB1, TGFB2, and TGFB3. It serves as a signal transducer, orchestrating diverse physiological and pathological processes, including cell cycle regulation, mesenchymal cell dynamics, wound healing, matrix production, immunosuppression, and carcinogenesis. Upon cytokine binding, the receptor complex activates TGFBR1 through TGFBR2 phosphorylation, initiating the canonical SMAD-dependent TGF-beta signaling cascade. Additionally, TGFBR2 participates in non-canonical, SMAD-independent pathways. TGFBR2/TGF-beta RII Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived TGFBR2/TGF-beta RII protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P704897

	SSTR2 Protein-VLP, Human (HEK293) SSTR2; somatostatin receptor 2; somatostatin receptor type 2; SS2R; SRIF-1; SS-2-R	Human	HEK293

HY-P7669

	BMPR-II Protein, Human (HEK293, His) rHuBMPR-II, His; BMP type-2 Receptor; BMP type II Receptor; BMPR-II; BMPR2	Human	HEK293
	BMP Type II Receptor (BMPR2) is a type II member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. BMPR2 is highly expressed in the heart and liver, and involves in osteogenesis and cell differentiation, essential for embryogenesis, development, and adult tissue homeostasis. BMPR2 is associated with tubulin stability, the inhibition of BMPR2 destabilizes the microtubules promoting cell death of cancer cells that involves the activation of the lysosomes. Human BMPR2 protein contains 1038 amino acids and a transmembrane domain (151-171 a.a.). BMPR-II Protein, Human (HEK293, His) is the extracellular part of the complete BMPR2 protein, produced by HEK293 cells (S27-I151) with C-terminal 6*His-tag.

HY-P73740

	NS1 Protein, Dengue virus 2 (HEK293, His) DEN-2; Dengue NS1 protein; Dengue virus type 2; DENV2; DENV2-NS1	Virus	HEK293
	The NS1 protein plays a key role in viral budding, association with cell membranes, and facilitating the assembly of viral RNA into nucleocapsids to form mature viral particles. During entry, NS1 induces genome penetration into the host cytoplasm. NS1 Protein, Dengue virus 2 (HEK293, His) is the recombinant Virus-derived NS1 protein, expressed by HEK293 , with N-His labeled tag.

HY-P700430

	SSTR2 Protein-VLP, Human (HEK293, His) SSTR2; somatostatin receptor 2; somatostatin receptor type 2; SS2R; SRIF-1; SS-2-R	Human	HEK293
	SSTR2 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA, FACS. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

HY-P704898

	SSTR2 Protein-VLP, Human (HEK293, GFP) SSTR2; somatostatin receptor 2; somatostatin receptor type 2; SS2R; SRIF-1; SS-2-R	Human	HEK293

HY-P72436

	TrkB Protein, Mouse (HEK293, His) BDNF/NT-3 Growth Factors Receptor; GP145-TrkB; Trk-B; Neurotrophic Tyrosine Kinase Receptor type 2; TrkB Tyrosine Kinase; NTRK2; TRKB	Mouse	HEK293
	TrkB protein, also known as tropomyosin receptor kinase B, consists of a non-catalytic isoform. Unlike its catalytic isoform, the noncatalytic isoform of TrkB lacks intrinsic kinase activity. TrkB Protein, Mouse (HEK293, His) is the recombinant mouse-derived TrkB protein, expressed by HEK293 , with C-His labeled tag.

HY-P702257

	CXCR2 Protein, Mouse (Cell-Free, His) C-X-C chemokine receptor type 2; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; CD182	Mouse	E. coli Cell-free
	CXCR2 protein acts as a receptor for interleukin-8 and induces neutrophil activation through the G protein-mediated phosphatidylinositol-calcium second messenger system. In addition to IL-8, CXCR2 also exhibits high-affinity binding to ligands such as CXCL3, GRO/MGSA, and NAP-2. CXCR2 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived CXCR2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag.

HY-P701006

	IFN-gamma Protein, Cynomolgus (HEK293, His) IFN-gamma-R1; CDw119; CD119; IFNGR1; IFNGR; AVP; FLJ45734; IFN-gamma R1; IFN-gR1; type 2	Cynomolgus	HEK293
	IFN-gamma (interferon-gamma) is a type II interferon derived from immune cells such as T cells and NK cells, which can significantly activate effector immune cells and enhance antigen presentation. It affects gene regulation through the JAK-STAT pathway and its receptor IFNGR1. IFN-gamma Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IFN-gamma protein, expressed by HEK293 , with C-His labeled tag.

HY-P704829

	TrkB Protein, Human (HEK293, Fc) BDNF/NT-3 growth factors receptor; GP145-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Tropomyosin-related kinase B	Human	HEK293
	TrkB Protein, Human (HEK293, Fc) is the recombinant human-derived TrkB protein, expressed by HEK293, with C-hFc tag.

HY-P75667

	Cadherin-12/CDH12 Protein, Human (HEK293, His) CDH12; cadherin 12, type 2 (N-cadherin 2); cadherin-12; Br cadherin; CDHB; Br-cadherin; N-cadherin 2; brain cadherin; brain-cadherin; neuronal cadherin 2; neural type cadherin 2; cadherin, neural type, 2; FLJ34857;	Human	HEK293
	Cadherin-12/CDH12 is a calcium-dependent cell adhesion protein in the cadherin family known for its preferential homophilic interactions (binding to itself between connecting cells). This interaction is shown to play a crucial role in mediating cell adhesion and may play a key role in sorting heterogeneous cell types. Cadherin-12/CDH12 Protein, Human (HEK293, His) is the recombinant human-derived Cadherin-12/CDH12 protein, expressed by HEK293 , with C-His labeled tag.

HY-P70793

	TrkB Protein, Human (HEK293, His) BDNF/NT-3 Growth Factors Receptor; GP145-TrkB; Trk-B; Neurotrophic Tyrosine Kinase Receptor type 2; TrkB Tyrosine Kinase; Tropomyosin-Related Kinase B; NTRK2; TRKB	Human	HEK293
	The TrkB protein is a key receptor tyrosine kinase that plays a key role in central and peripheral nervous system development. It regulates neuronal survival, proliferation, migration, differentiation, synapse formation, and plasticity. TrkB Protein, Human (HEK293, His) is the recombinant human-derived TrkB protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P75849

	IL-1R2 Protein, Human (HEK293) Interleukin-1 receptor type 2; IL-1R-2; CDw121b; IL-1R-beta; CD121b; mIL-1R2; sIL-1R2	Human	HEK293
	IL-1R2 is a competitive endogenous inhibitor of IL-1 signaling. IL-1R2 serves as a decoy receptor and competes with IL-1R1 for IL-1, it can also form a complex with IL-1RAP once it binds IL-1. IL-1R2 is implicated in various IL-1-mediated inflammatory diseases. IL-1R2 Protein, Human (HEK293) is a recombinant human IL-1R2 protein and is expressed in HEK293 cells. It consists of 343 amino acids (M1-E343).

HY-P700536

	CXCR2 Protein, Human (His-SUMO) C-X-C motif chemokine receptor 2; IL8RB, interleukin 8 receptor, beta; C-X-C chemokine receptor type 2; CD182; CMKAR2;	Human	E. coli
	CXCR2, the receptor for interleukin-8 (IL-8), orchestrates neutrophil activation through a G-protein-mediated phosphatidylinositol-calcium second messenger system upon IL-8 binding. Exhibiting high-affinity binding to IL-8, CXCR2 also interacts with other ligands like CXCL3, GRO/MGSA, and NAP-2. The involvement of GNAI2 underscores the intricate signaling mechanisms regulating neutrophil function through CXCR2. CXCR2 Protein, Human (His-SUMO) is the recombinant human-derived CXCR2 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

HY-P790083

	CXCR2 Protein, Human (Cell-Free, His) CXC-R2; CXCR-2; GRO/MGSA receptor; High affinity interleukin-8 receptor B (IL-8R B); IL-8 receptor type 2; CXCR2; IL8RB	Human	E. coli Cell-free
	CXCR2, the receptor for interleukin-8 (IL-8), orchestrates neutrophil activation through a G-protein-mediated phosphatidylinositol-calcium second messenger system upon IL-8 binding. Exhibiting high-affinity binding to IL-8, CXCR2 also interacts with other ligands like CXCL3, GRO/MGSA, and NAP-2. The involvement of GNAI2 underscores the intricate signaling mechanisms regulating neutrophil function through CXCR2. CXCR2 Protein, Human (Cell-Free, His) is the recombinant human-derived CXCR2, expressed by E. coli Cell-free, with N-10His labeled tag. The total length of CXCR2 Protein, Human (Cell-Free, His) is 360 a.a.*.

HY-P72567

	IL-1R2 Protein, Human (HEK293, His) Interleukin-1 receptor type 2; IL-1R-2; CDw121b; IL-1R-beta; CD121b; mIL-1R2; sIL-1R2	Human	HEK293
	IL-1R2 is a competitive endogenous inhibitor of IL-1 signaling. IL-1R2 serves as a decoy receptor and competes with IL-1R1 for IL-1, it can also form a complex with IL-1RAP once it binds IL-1. IL-1R2 is implicated in various IL-1-mediated inflammatory diseases. IL-1R2 Protein, Human (HEK293, His) is a recombinant human IL-1R2 protein with a His tag at the C-terminus and is expressed in HEK293 cells. It consists of 330 amino acids (F14-E343).

HY-P72568

	IL-1R2 Protein, Mouse (HEK293, His) Interleukin-1 receptor type 2; IL-1R-2; CDw121b; IL-1R-beta; CD121b; mIL-1R2; sIL-1R2	Mouse	HEK293
	IL-1R2 is a competitive endogenous inhibitor of IL-1 signaling. IL-1R2 serves as a decoy receptor and competes with IL-1R1 for IL-1, it can also form a complex with IL-1RAP once it binds IL-1. IL-1R2 is implicated in various IL-1-mediated inflammatory diseases. IL-1R2 Protein, Mouse (HEK293, His) is a recombinant mouse IL-1R2 protein with a His tag at the C-terminus and is expressed in HEK293 cells. It consists of 342 amino acids (F14-E355).

HY-P74820

	IL-1R2 Protein, Mouse (HEK293, hFc) Interleukin-1 receptor type 2; IL-1R-2; CDw121b; IL-1R-beta; CD121b; mIL-1R2; sIL-1R2	Mouse	HEK293
	IL-1R2 is a competitive endogenous inhibitor of IL-1 signaling. IL-1R2 serves as a decoy receptor and competes with IL-1R1 for IL-1, it can also form a complex with IL-1RAP once it binds IL-1. IL-1R2 is implicated in various IL-1-mediated inflammatory diseases. IL-1R2 Protein, Mouse (HEK293, hFc) is a recombinant mouse IL-1R2 protein with an hFc tag at the C-terminus and is expressed in HEK293 cells. It consists of 355 amino acids (M1-E355).

HY-P75852

	IL-1R2 Protein, Rat (HEK293, His) Interleukin-1 receptor type 2; IL-1R-2; CDw121b; IL-1R-beta; CD121b; mIL-1R2; sIL-1R2	Rat	HEK293
	IL-1R2 is a competitive endogenous inhibitor of IL-1 signaling. IL-1R2 serves as a decoy receptor and competes with IL-1R1 for IL-1, it can also form a complex with IL-1RAP once it binds IL-1. IL-1R2 is implicated in various IL-1-mediated inflammatory diseases. IL-1R2 Protein, Rat (HEK293, His) is a recombinant rat IL-1R2 protein with a His tag at the C-terminus and is expressed in HEK293 cells. It consists of 355 amino acids (M1-E355).

HY-P76997

	IL-1R2 Protein, Canine (HEK293, Fc) Interleukin-1 receptor type 2; IL-1R-2; CDw121b; IL-1R-beta; CD121b; mIL-1R2; sIL-1R2	Canine	HEK293
	IL-1R2 Protein, Canine (HEK293, Fc) is the recombinant canine-derived IL-1R2 protein, expressed by HEK293, with C-hFc labeled tag.

HY-P77410

	IL-1R2 Protein, Cynomolgus (HEK293, Fc) Interleukin-1 receptor type 2; IL-1R-2; CDw121b; IL-1R-beta; CD121b; mIL-1R2; sIL-1R2	Cynomolgus	HEK293
	IL-1R2 is a competitive endogenous inhibitor of IL-1 signaling. IL-1R2 serves as a decoy receptor and competes with IL-1R1 for IL-1, it can also form a complex with IL-1RAP once it binds IL-1. IL-1R2 is implicated in various IL-1-mediated inflammatory diseases. IL-1R2 Protein, Cynomolgus (HEK293, Fc) is a recombinant cynomolgus IL-1R2 protein with an hFc tag at the C-terminus and is expressed in HEK293 cells. It consists of 343 amino acids (M1-E343).

HY-P70202

	HAI-2 Protein, Human (HEK293, His) rHuKunitz-type protease inhibitor 2/HAI-2, His; Kunitz-type Protease Inhibitor 2; Hepatocyte Growth Factor Activator Inhibitor type 2; HAI-2; Placental Bikunin; SPINT2; HAI2; KOP	Human	HEK293
	HAI-2 protein is a multifunctional inhibitor that regulates multiple cellular processes by potently inhibiting HGFAC and reducing serine protease activity, specifically TMPRSS13 and ST14/matriptase. HAI-2 is good at inhibiting plasmin, plasma and tissue kallikrein, with broad-spectrum inhibitory capabilities. HAI-2 Protein, Human (HEK293, His) is the recombinant human-derived HAI-2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P702864

	FOS Protein, Human (His, Myc) Peroxisomal multifunctional enzyme type 2; MFE-2; 17-beta-hydroxysteroid dehydrogenase 4; 17-beta-HSD 4; D-bifunctional protein; DBP; Multifunctional protein 2; MFP-2	Human	E. coli
	FOS Protein, Human (His, Myc) is the recombinant human-derived FOS, expressed by E. coli , with N-10*His, C-Myc labeled tag.

HY-P702863

	HSD17B4 Protein, Human (P.pastoris, His) Peroxisomal multifunctional enzyme type 2; MFE-2; 17-beta-hydroxysteroid dehydrogenase 4; 17-beta-HSD 4; D-bifunctional protein; DBP; Multifunctional protein 2; MFP-2	Human	P. pastoris
	HSD17B4 Protein, Human (P.pastoris, His) is the recombinant human-derived HSD17B4, expressed by P. pastoris , with N-6*His labeled tag. ,

HY-P702763

	TrkB Protein, Human (Biotinylated, sf9, Flag, Avi) NTRK2; neurotrophic tyrosine kinase, receptor, type 2; BDNF/NT-3 growth factors receptor; trk-B; GP145-TrkB/GP95-TrkB; trkB tyrosine kinase; Neural receptor protein-tyrosine kinase (trkB); Tkrb; trkB; TRKB1; RATTRKB1	Human	Sf9 insect cells
	The TrkB protein is a key receptor tyrosine kinase that plays a key role in central and peripheral nervous system development. It regulates neuronal survival, proliferation, migration, differentiation, synapse formation, and plasticity. TrkB Protein, Human (Biotinylated, sf9, Flag, Avi) is the recombinant human-derived NTRK2/TrkB, expressed by Sf9 insect cells, with Avi, Flag labeled tag.

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HY-P80862

	Phospho-TrkA/B (Tyr490/Tyr516) Antibody (YA139) NTRK2; TRKB; BDNF/NT-3 growth factors receptor; GP145-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Tropomyosin-related kinase B	WB	Human, Mouse, Rat
	Phospho-TrkA/B (Tyr490/Tyr516) Antibody (YA139) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-TrkA/B (Tyr490/Tyr516).

HY-P86928

	Junctophilin-2 Antibody (YA6621) FLJ40969 antibody; JP-2 antibody; JP2 antibody; Jph2 antibody; JPH2_HUMAN antibody; Junctophilin 2 antibody; Junctophilin type 2 antibody; Junctophilin-2 antibody; OTTHUMP00000031651 antibody; OTTHUMP00000031652 antibody;	WB, IHC-P	Human, Mouse, Rat
	Junctophilin-2 Antibody (YA6621) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Junctophilin-2.

HY-P83345

	AGTR2 Antibody (YA3090) AGTR2; Angiotensin ii receptor type 2; Angiotensin II type-2 receptor; AT2 receptor; AT2; At2r; MRX88; Angiotensin ii at2; Angiotensin receptor 2; type-2 angiotensin II receptor; ATGR2	WB, IP	Human, Mouse, Rat
	AGTR2 Antibody (YA3090) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AGTR2.

HY-P85062

	BMPR2 Antibody (YA4754) BMPR2; PPH1; Bone morphogenetic protein receptor type-2; BMP type-2 receptor; BMPR-2; Bone morphogenetic protein receptor type II; BMP type II receptor; BMPR-II	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat, Monkey
	BMPR2 Antibody (YA4754) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to BMPR2.

HY-P87102

	TCPTP Antibody (YA6795) Protein tyrosine phosphatase non receptor type 2 antibody; PTN2 antibody; PTN2_HUMAN antibody; PTPN 2 antibody; Ptpn2 antibody; PTPT antibody; T cell protein tyrosine phosphatase antibody; T-cell protein-tyrosine phosphatase antibody; TC PTP antibody; TCELLPTP antibody; Protein tyrosine phosphatase non receptor type 2 antibody; PTN2 antibody; PTN2_HUMAN antibody; PTPN 2 antibody; Ptpn2 antibody; PTPT antibody; T cell protein tyrosine phosphatase antibody; T-cell protein-tyrosine phosphatase antibody; TC PTP antibody; TCELLPTP antibody; TCPTP antibody; Tyrosine protein phosphatase non receptor type 2 antibody; Tyrosine-protein phosphatase non-receptor type 2 antibody;	WB, FC	Human, Mouse, Rat
	TCPTP Antibody (YA6795) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TCPTP.

HY-P83765

	K Cadherin Antibody(YA3564) CAD6 antibody; CADH6_HUMAN antibody; Cadherin 6 antibody; Cadherin 6 type 2 antibody; Cadherin 6 type 2 K cadherin (fetal kidney) antibody; Cadherin fetal kidney antibody; Cadherin-6 antibody; Cadherin6 antibody; CDH 6 antibody; Cdh6 antibody; K-cadherin antibody; KCAD antibody; Kidney cadherin antibody	WB, IHC-P, IF-Tissue	Human, Mouse, Rat
	K Cadherin Antibody(YA3564) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to K Cadherin.

HY-P86464

	CD21 Antibody (YA6156) CR2; C3DR; Complement receptor type 2; Cr2; Complement C3d receptor; Epstein-Barr virus receptor; EBV receptor; CD21	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	CD21 Antibody (YA6156) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD21.

HY-P82924

	Glucose Transporter GLUT2 Antibody (YA2669) liver; Glucose Transporter 2; Glucose Transporter GLUT2; Glucose transporter type 2; Glucose transporter; liver/islet; GLUT2; GTT2; SLC2A2	WB	Human
	Glucose Transporter GLUT2 Antibody (YA2669) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glucose Transporter GLUT2.

HY-P81724

	ALDH1A2 Antibody (YA1469) ALDH1A2; RALDH2; Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II)	WB	Human, Mouse, Rat
	ALDH1A2 Antibody (YA1469) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ALDH1A2.

HY-P86481

	TGF beta Receptor II Antibody (YA6173) TGFBR2; TGF-beta receptor type-2; TGFR-2; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	TGF beta Receptor II Antibody (YA6173) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TGF beta Receptor II.

HY-P81131

	TGF beta Receptor II Antibody TGF-beta receptor type-2; TGF beta R2; TGFBR2; AAT 3; AAT3; FAA 3; FAA3; HNPCC6; MFS 2; MFS2; RIIC; TAAD 2; TAAD2; TbetaR II; TGF beta receptor type 2; TGF beta receptor type II; TGF beta type II receptor; TGFB R2; TGFbeta RII; TGFBR 2; TGFR 2; TGFR2; Transforming growth factor beta receptor II; Transforming growth factor beta receptor type II. TGF-βRⅡ; TGFβRⅡ; TGF βRⅡ; TGFβ RⅡ.	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	TGF beta Receptor II Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to TGF beta Receptor II.

HY-P87015

	PSMB2 Antibody (YA6708) HC7 I antibody; Macropain subunit C7 I antibody; Macropain subunit C7-I antibody; Multicatalytic endopeptidase complex subunit C7 1 antibody; Multicatalytic endopeptidase complex subunit C7 I antibody; Multicatalytic endopeptidase complex subunit C7-I antibody; Proteasome (prosome, macropain) subunit beta type 2 antibody; Proteasome beta 2 subunit antibody; Proteasome component C7 I antibody; Proteasome component C7-I antibody; HC7 I antibody; Macropain subunit C7 I antibody; Macropain subunit C7-I antibody; Multicatalytic endopeptidase complex subunit C7 1 antibody; Multicatalytic endopeptidase complex subunit C7 I antibody; Multicatalytic endopeptidase complex subunit C7-I antibody; Proteasome (prosome, macropain) subunit beta type 2 antibody; Proteasome beta 2 subunit antibody; Proteasome component C7 I antibody; Proteasome component C7-I antibody; Proteasome subunit beta type-2 antibody; PSB2_HUMAN antibody; Psmb2 antibody;	WB	Human
	PSMB2 Antibody (YA6708) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PSMB2.

HY-P80385

	CCR2 Antibody (YA548) 1 Publications Verification C C chemokine receptor type 2 antibody; C C CKR 2 antibody; C-C chemokine receptor type 2 antibody; C-C CKR-2 antibody; CC chemokine receptor type 2 antibody; CC CKR 2 antibody; CC-CKR-2 antibody; CCCKR2 antibody; CCR 2 antibody; CCR-2 antibody; CCR1L antibody; CCR2 antibody; CCR2_HUMAN antibody; CCR2A antibody; CCR2B antibody; CCR5L antibody; CD192 antibody; CD192 antigen antibody; Chemokine C C motif receptor 2 antibody; Chemokine CC Motif Receptor 2 antibody; CKR 2 antibody; CKR2 antibody; CKR2A antibody; CKR2B antibody; CMKBR2 antibody; MCP 1 R antibody; MCP-1-R antibody; MCP1 RECEPTOR antibody; MCP1R antibody; Monocyte chemoattractant protein 1 receptor antibody; Monocyte Chemotactic Protein 1 Receptor antibody; Monocyte Chemotactic Protein 1 Receptor antibody	WB, IHC-P, IP, FC	Human
	CCR2 Antibody (YA548) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CCR2.

HY-P81435

	SLC1A5/ASCT2 Antibody (YA1180) SLC1A5 ; ASCT2; M7V1, RDR, RDRC; Neutral amino acid transporter B(0); ATB(0); Baboon M7 virus receptor; RD114/simian type D retrovirus receptor; Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 member 5	IHC-P	Human
	SLC1A5/ASCT2 Antibody (YA1180) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLC1A5/ASCT2.

HY-P81158

	CXCR2 Antibody CXC-chemokine receptor 2; CD 182; CD182; CD182 antigen; CDw128b; Chemokine (CXC) receptor 2; CMKAR2; CXCR 2; CXC R2; CXC-R2; CXCR2_HUMAN; C-X-C chemokine receptor type 2; CXCR-2; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; IL-8 receptor type 2.	WB, IHC-P, ELISA	Human
	CXCR2 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to CXCR2.

HY-P83598

	ERAB Antibody (YA3343) HSD17B10; ERAB; HADH2; MRPP2; SCHAD; XH98G2; 3-hydroxyacyl-CoA dehydrogenase type-2; 17-beta-hydroxysteroid dehydrogenase 10; 17-beta-HSD 10; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase type II; Endoplasmic	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	ERAB Antibody (YA3343) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ERAB.

HY-P81097

	VE-Cadherin Antibody (YA3491) 2 Publications Verification VE-cadherin; 7B4 antigen; VECD; Vascular endothelial cell cadherin; 7B 4; 7B4; 7B4 antigen; Cadherin 5; Cadherin 5 type 2; Cadherin-5; Cadherin5; CD 144; CD144 antigen; CDH 5; CDH5; CDH5 protein; Vascular endothelial cadherin; VE Cad antibody VEC; CADH5_HUMAN.	WB, ICC/IF, FC	Human
	VE-Cadherin Antibody (YA3491) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VE-Cadherin.

HY-P85521

	SirT2 Antibody (YA5213) FLJ35621; FLJ37491; NAD dependent deacetylase sirtuin 2; NAD-dependent deacetylase sirtuin-2; NAD-dependent protein deacetylase sirtuin-2; Regulatory protein SIR2 homolog 2; Silencing information regulator 2 like; Silent information regulator 2; Silent mating type information regulation 2; Silent mating type information regulation 2 homolog; SIR 2; SIR2; SIR2 like; SIR2 like protein 2; Sir2 related protein type 2; SIR2, S. cerevisiae, homolog-loke 2; SIR2-like protein 2; SIR2L; SIR2L2; SIRT 2; SIRT2; SIRT2_HUMAN; Sirtuin; silent mating type information regulation 2 homolog; 2; S.cerevisiae; Sirtuin 2; Sirtuin type 2; Sirtuin2.	WB, ICC/IF	Human, Mouse, Rat
	SirT2 Antibody (YA5213) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SirT2.

HY-P81562

	CD21 Antibody (YA1307) C3DR antibody; CD 21 antibody; CD21 antibody; Complement C3d receptor antibody; Complement component (3d/Epstein Barr virus) receptor 2 antibody; Complement receptor type 2 antibody; CR antibody; Cr2 antibody; CR2_HUMAN antibody; CVID7 antibody; EBV receptor antibody; EBV-R antibody; Epstein Barr virus receptor antibody; Epstein-Barr virus receptor antibody; EVBR antibody; SLEB9 antibody;	WB, IHC-P, ICC/IF, IP, FC, IF-Tissue	Human, Mouse, Rat
	CD21 Antibody (YA1307) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD21.

HY-P82974

	Cardiac Troponin T Antibody (YA2719) TNNT2; Cardiac muscle troponin T; Troponin T; cardiac muscle; troponin T type 2 (cardiac); Cardiac muscle troponin T antibody Cardiomyopathy dilated 1D (autosomal dominant) antibody; Cardiomyopathy hypertrophic 2 antibody; CMD1D antibody; CMH2 antibody; CMPD2 antibody; cTnT antibody; LVNC6 antibody; MGC3889 antibody; OTTHUMP00000033864 antibody; RCM3 antibody; TNNT 2 antibody; TNNT2 antibody; TNNT2_HUMAN antibody; TnTc antibody; Troponin T cardiac muscle antibody; Troponin T2 cardiac antibody	WB, IHC-P, IF-Tissue	Human, Mouse, Rat
	Cardiac Troponin T Antibody (YA2719) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cardiac Troponin T.

HY-P81206

	SRD5A2 Antibody (YA3540) 3 oxo 5 alpha steroid 4 dehydrogenase 2 antibody; 3-oxo-5-alpha-steroid 4-dehydrogenase 2 antibody; 5 alpha SR2 antibody; 5 alpha-SR2 antibody; 5ART2 antibody; e II 5 alpha reductase antibody; EC antibody; MGC138457 antibody; Micropenis, included antibody; S5A2_HUMAN antibody; S5AR 2 antibody; SR type 2 antibody; SRD5A2 antibody; Steroid 5 alpha reductase 2 antibody; Steroid 5-alpha-reductase 2 antibody; Steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) antibody; type II 5-alpha reductase antibody;	WB, IP	Human, Rat
	SRD5A2 Antibody (YA3540) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SRD5A2.

HY-P87139

	VGLUT2 Antibody (YA6832) Differentiation associated BNPI antibody; Differentiation associated Na dependent inorganic phosphate cotransporter antibody; Differentiation associated Na(+) dependent inorganic phosphate cotransporter antibody; Differentiation-associated BNPI antibody; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter antibody; DNPI antibody; SLC17A6 antibody; Sodium dependent inorganic phosphate cotransporter antibody; Solute carrier family 17 (Sodium dependent inorganic phosphate cotransporter) member 6 antibody; Solute carrier family 17 member 6 antibody; Differentiation associated BNPI antibody; Differentiation associated Na dependent inorganic phosphate cotransporter antibody; Differentiation associated Na(+) dependent inorganic phosphate cotransporter antibody; Differentiation-associated BNPI antibody; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter antibody; DNPI antibody; SLC17A6 antibody; Sodium dependent inorganic phosphate cotransporter antibody; Solute carrier family 17 (Sodium dependent inorganic phosphate cotransporter) member 6 antibody; Solute carrier family 17 member 6 antibody; Vesicular glutamate transporter 2 antibody; Vesicular glutamate transporter type 2 antibody; VGLU2_HUMAN antibody; VGLUT 2 antibody; VGluT2 antibody;	WB, IHC-F, IHC-P	Mouse, Rat
	VGLUT2 Antibody (YA6832) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VGLUT2.

HY-P86790

	BRCA2 Antibody (YA6483) BRCA 2 antibody; BRCA1/BRCA2 containing complex subunit 2 antibody; Brca2 antibody; BRCA2, DNA repair associated antibody; BRCA2_HUMAN antibody; BRCC 2 antibody; BRCC2 antibody; Breast and ovarian cancer susceptibility gene early onset antibody; breast and ovarian cancer susceptibility protein 2 antibody; Breast cancer 2 early onset antibody; BRCA 2 antibody; BRCA1/BRCA2 containing complex subunit 2 antibody; Brca2 antibody; BRCA2, DNA repair associated antibody; BRCA2_HUMAN antibody; BRCC 2 antibody; BRCC2 antibody; Breast and ovarian cancer susceptibility gene early onset antibody; breast and ovarian cancer susceptibility protein 2 antibody; Breast cancer 2 early onset antibody; Breast Cancer 2 tumor suppressor antibody; Breast cancer susceptibility protein BRCA2 antibody; Breast cancer type 2 susceptibility protein antibody; BROVCA2 antibody; FACD antibody; FAD 1 antibody; FAD antibody; FAD1 antibody; FANCB antibody; FANCD 1 antibody; FANCD antibody; FANCD1 antibody; FANCD1 gene antibody; Fanconi anemia complementation group D1 antibody; Fanconi anemia group D1 protein antibody; GLM3 antibody; mutant BRCA2 antibody; OTTHUMP00000018803 antibody; OTTHUMP00000042401 antibody; PNCA2 antibody; XRCC11 antibody;	WB, FC	Human
	BRCA2 Antibody (YA6483) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BRCA2.

HY-P80163

	Histone H2B Antibody (YA378) H2B GL105 antibody; H2B histone family member O antibody; H2B histone family member S antibody; H2B.1 antibody; H2B.1 B antibody; H2B.b antibody; H2B.c antibody; H2B.d antibody; H2B.e antibody; H2B.f antibody; H2B.j antibody; H2B.q antibody; H2B/b antibody; H2B/c antibody; H2B/d antibody; H2B/e antibody; H2B/f antibody; H2B/j antibody; H2B/o antibody; H2B/q antibody; H2BFB antibody; H2BFC antibody; H2BFD antibody; H2BFE antibody; H2BFF antibody; H2BFJ antibody; H2BFO antibody; H2BFQ antibody; H2BFS antibody; HIRIP2 antibody; HIST1H2BB antibody; HIST1H2BD antibody; HIST1H2BH antibody; HIST1H2BL antibody; HIST1H2BM antibody; HIST1H2BN antibody; HIST2H2BE antibody; Histone H2B antibody; Histone H2B type 1 B antibody; Histone H2B type 1 D antibody; Histone H2B type 1 H antibody; Histone H2B type 1 L antibody; Histone H2B type 1 M antibody; Histone H2B type 1 N antibody; Histone H2B type 2 E antibody; histone protein antibody	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse, Rat
	Histone H2B Antibody (YA378) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Histone H2B.

HY-P80706

	Histone H2B Antibody (YA737) H2BK5ac; H2B 1A; H2B; H2B histone family; H2B2f; H2Ba; H2Bf; HIST2H2BF; histone H2B; histone H2B type 1; Histone H2B type 2-F	WB, IHC-P	Human, Mouse, Rat
	Histone H2B Antibody (YA737) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Histone H2B.

HY-P85517

	PP2A alpha + beta Antibody (YA5209) PP2A beta; PP2A-beta; PP2AB_HUMAN; PP2Abeta; PP2CB; Ppp2cb; Protein phosphatase 2; formerly 2A; , catalytic subunit, beta isoform; Protein phosphatase 2 catalytic subunit beta isozyme; Protein phosphatase 2, catalytic subunit, beta isoform; Protein phosphatase 2A catalytic subunit beta isoform; Protein phosphatase type 2A catalytic subunit; Serine/threonine protein phosphatase 2A catalytic subunit beta; Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform.	WB, IP	Human, Mouse, Rat
	PP2A alpha + beta Antibody (YA5209) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PP2A alpha + beta.

HY-P86411

	PP2A alpha/beta Antibody (YA6103) PP2A A; PP2A alpha; PP2A B; PP2A beta; PP2A-alpha; PP2A-beta; PP2AA_HUMAN; PP2Aalpha; PP2AB_HUMAN; PP2Abeta; PP2Ac; PP2CA; PP2Calpha; PP2CB; PPP2CA; PPP2CB; Protein phosphatase 2 catalytic subunit alpha isoform; Protein phosphatase 2 catalytic subunit beta isoform; Protein phosphatase type 2A catalytic subunit; Replication protein C; RP C; RP-C; RPC; Serine/threonine protein phosphatase 2A catalytic subunit alpha isoform; Serine/threonine protein phosphatase 2A catalytic subunit beta isoform; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	PP2A alpha/beta Antibody (YA6103) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PP2A alpha/beta.

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Cat. No.	Product Name		Classification

HY-P10758

Alkyne-βAG-TOCA		Alkynes
Alkyne-βAG-TOCA, an octreotide derivative, targets somatostatin receptor type 2 (SST2) . Alkyne-βAG-TOCA can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

HY-12957

NITD008 10+ Cited Publications 7-Deaza-2'-C-acetylene-adenosine		Alkynes
NITD008 is a potent and selective flaviviruse inhibitor which can inhibit Dengue Virus Type 2 (DENV-2) with an EC₅₀ of 0.64 μM. NITD008 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-145727

Volanesorsen ISIS 304801		Antisense Oligonucleotides
Volanesorsen (ISIS 304801) is an antisense oligonucleotide inhibitor of apolipoprotein CIII (apo-CIII) mRNA that reduces triglyceride levels and improves insulin resistance. Volanesorsen is being studied in the treatment of hypertriglyceridemia, familial chylosiderosis syndrome, and type 2 diabetes ^[2] .

HY-145727A

Volanesorsen sodium ISIS 304801 sodium		Antisense Oligonucleotides
Volanesorsen (ISIS 304801) sodium is an antisense oligonucleotide inhibitor of apolipoprotein CIII (apo-CIII) mRNA that reduces triglyceride levels and improves insulin resistance. Volanesorsen sodium is being studied in the treatment of hypertriglyceridemia, familial chylosiderosis syndrome, and type 2 diabetes ^[2] .

HY-W134326

Polydextrose		Fillers
Polydextrose is an orally active prebiotic. Polydextrose promotes the growth of Pediococcus pentosaceus ATCC 43200. Polydextrose reduces cholesterol and synergistically lowers blood sugar with Sitagliptin (HY-13749). Currently, it is mainly used in the research of diseases such as hyperlipidemia, type 2 diabetes, and postoperative iron deficiency anemia ^[2] .

HY-174780

Human AMHR2 mRNA		mRNA
Human AMHR2 mRNA encodes the human anti-Mullerian hormone receptor type 2 (AMHR2) protein, a receptor for the anti-Mullerian hormone (AMH).

HY-159696

ISIS 449884		Antisense Oligonucleotides
ISIS 449884 is a 2'-O-methoxyethyl antisense oligonucleotide that targets GCGR. ISIS 449884 has an ability to reduce hepatic glucose output and lower the blood glucose level. ISIS 449884 can be used for the study of type 2 diabetes mellitus (T2DM) .

HY-159696A

ISIS 449884 sodium		Antisense Oligonucleotides
ISIS 449884 sodium is a 2'-O-methoxyethyl antisense oligonucleotide that targets GCGR. ISIS 449884 sodium has an ability to reduce hepatic glucose output and lower the blood glucose level. ISIS 449884 sodium can be used for the study of type 2 diabetes mellitus (T2DM) .

HY-159694

IONIS PTP1BRx ISIS 404173		Antisense Oligonucleotides
IONIS PTP1BRx (ISIS 404173) is an antisense inhibitor of protein tyrosine phosphatase 1B (PTP-1B). IONIS PTP1BRx shows antidiabetic activity, and can be used for the study of insulin resistance and type 2 diabetes mellitus associated with obesity .

HY-159694A

IONIS PTP1BRx sodium ISIS 404173 sodium		Antisense Oligonucleotides
IONIS PTP1BRx (ISIS 404173) sodium is an antisense inhibitor of protein tyrosine phosphatase 1B (PTP-1B). IONIS PTP1BRx sodium shows antidiabetic activity, and can be used for the study of insulin resistance and type 2 diabetes mellitus associated with obesity .

HY-174504

Human ZIC1 mRNA		mRNA
Human ZIC1 mRNA encodes the human Zic family member 1 (ZIC1) protein, a member of the ZIC family of C2H2-type zinc finger proteins. ZIC1 plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum.

HY-174547

Human PDX1 mRNA		mRNA
Human PDX1 mRNA encodes the human pancreatic and duodenal homeobox 1 (PDX1) protein, a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. PDX1 may be involved in the early development of the pancreas. It also plays a major role in glucose-dependent regulation of insulin gene expression.

HY-174783

Human ACVR2A mRNA		mRNA
Human ACVR2A mRNA encodes the human activin A receptor type 2A (ACVR2A) protein, a member of the TGFB family. ACVR2A mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. It may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality.

HY-174782

Human ACVR2B mRNA		mRNA
Human ACVR2B mRNA encodes the human activin A receptor type 2B (ACVR2B) protein, a receptor that transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis.

HY-W011527

Xanthosine 3 Publications Verification		Nucleoside Analogs
Xanthosine is a nucleoside derived from xanthine and ribose. Xanthosine activates the AMPK/FoxO1/AKT/GSK3β signaling cascade. Xanthosine promotes cell proliferation and regulates blood glucose metabolism. Xanthosine increases milk production in cows and goats. Xanthosine is used in mammary stem cell and type 2 diabetes research ^[2] .

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