2. Metabolic Enzyme/Protease
  3. Dipeptidyl Peptidase
  4. VAMP

VAMP, a tetrapeptide, is a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 1.00 μM and a Kd of 6.89 μM. VAMP effectively targets the DPP-IV-GLP-1 axis and can be used for the study of type 2 diabetes.

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Custom Peptide Synthesis

VAMP

VAMP Chemical Structure

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Based on 1 publication(s) in Google Scholar

VAMP Related Antibodies

Top Publications Citing Use of Products

View All Dipeptidyl Peptidase Isoform Specific Products:

View All Isoforms
DPP-1 DPP-2 DPP-4 DPP-8 DPP-9

  • Biological Activity

  • Purity & Documentation

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Description

VAMP, a tetrapeptide, is a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 1.00 μM and a Kd of 6.89 μM. VAMP effectively targets the DPP-IV-GLP-1 axis and can be used for the study of type 2 diabetes[1].

IC50 & Target[1]

DPP-4

1 μM (IC50)

DPP-4

6.89 μM (Kd)

Clinical Trial
Molecular Weight

416.54

Formula

C18H32N4O5S
Sequence

Val-Ala-Met-Pro
Sequence Shortening

VAMP
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (240.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4007 mL 12.0036 mL 24.0073 mL
5 mM 0.4801 mL 2.4007 mL 4.8015 mL
View the Complete Stock Solution Preparation Table

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4007 mL 12.0036 mL 24.0073 mL 60.0182 mL
5 mM 0.4801 mL 2.4007 mL 4.8015 mL 12.0036 mL
10 mM 0.2401 mL 1.2004 mL 2.4007 mL 6.0018 mL
15 mM 0.1600 mL 0.8002 mL 1.6005 mL 4.0012 mL
20 mM 0.1200 mL 0.6002 mL 1.2004 mL 3.0009 mL
25 mM 0.0960 mL 0.4801 mL 0.9603 mL 2.4007 mL
30 mM 0.0800 mL 0.4001 mL 0.8002 mL 2.0006 mL
40 mM 0.0600 mL 0.3001 mL 0.6002 mL 1.5005 mL
50 mM 0.0480 mL 0.2401 mL 0.4801 mL 1.2004 mL
60 mM 0.0400 mL 0.2001 mL 0.4001 mL 1.0003 mL
80 mM 0.0300 mL 0.1500 mL 0.3001 mL 0.7502 mL
100 mM 0.0240 mL 0.1200 mL 0.2401 mL 0.6002 mL
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VAMP Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VAMPDipeptidyl PeptidaseDPPDPP-IV Inhibitortetrapeptidetype 2 diabetesInhibitorinhibitorinhibit

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