SirT2 Antibody (YA5213)

SirT2 Antibody (YA5213) is a mouse-derived and non-conjugated monoclonal antibody, targeting to SirT2. It can be applicated for WB, ICC/IF assays, in the background of human, mouse, rat.

SIRT2 is an NAD-dependent protein deacetylase that targets histones (e.g., H4K16ac, H3K56ac), α-tubulin (e.g., Lys-40), and key transcription factors (e.g., FOXO1, FOXO3, HIF1A, RELA, p53/TP53). It regulates diverse processes including cell cycle control (e.g., G2/M transition, APC/C activation), genomic stability, microtubule dynamics, metabolic pathways (e.g., PPP, gluconeogenesis), autophagy, and epigenetic modifications (e.g., H4K20me1 deposition). During bacterial infection (e.g., Listeria monocytogenes) or oxidative stress, SIRT2 modulates transcriptional activity and stress responses via deacetylation. It also exhibits demyristoylation (e.g., ARF6) and depalmitoylation (e.g., KRAS) activities, influencing membrane localization. by similar: SIRT2 promotes FOXO3 ubiquitination and degradation through deacetylation.

Q8IXJ6

Observed band size: 43 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Rat

WB: 1:1000; ICC/IF: 1:50-200

WB, ICC/IF

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant human SirT2 protein expressed in E.coli.