Stearoylcarnitine 

Stearoylcarnitine, a fatty ester lipid molecule, is an endogenous metabolite. Stearoylcarnitine can be used as PKC inhibitor. Stearoylcarnitine accumulates in β cells, leading to arrest of insulin synthesis and energy deficiency in type 2 diabetes mouse. Stearoylcarnitine inhibits lecithin cholesterol acyltransferase (LCAT) in rat and rabbits plasma. Stearoylcarnitine acts as a metabolomics biomarker for Parkinson’s disease. Stearoylcarnitine is a less potent inhibitor of GlyT2^{[1][2][3][4][5]}.

Stearoylcarnitine (100 μM, 2 h) impairs mitochondrial energy metabolism in MIN6 cells^[1].
Stearoylcarnitine accumulates in β cells, leading to arrest of insulin synthesis and energy deficiency via excessive β-oxidation and depletion of tricarboxylic acid (TCA) cycle and oxidative phosphorylation metabolites in type 2 diabetes (T2D) mouse pancreatic tissues^[1].
Stearoylcarnitine (1 μM, 25 min) significantly abolishes the stimulatory effect of triterpene derivative on ⁴⁵Ca²⁺ influx in pancreatic islets of male Wistar rats^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Stearoylcarnitine increases in the cortex, striatum/thalamus, and cerebellum in CD1 mouse pups (postnatal day 9) with hypoxic-ischemic brain injury (HIBI) induced by carotid artery ligation^[2].
Stearoylcarnitine (500 μM, 0-40 min) shows inhibitory towards lecithin cholesterol acyltransferase (LCAT) in rat and rabbits plasma, but not in human plasma^[3].
Stearoylcarnitine is characterized as one of potential biomarkers involved in the pathogenesis of Parkinson’s disease (PD) ^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

427.66

C₂₅H₄₉NO₄

25597-09-5

Solid

White to off-white

CCCCCCCCCCCCCCCCCC(O[C@H](CC([O-])=O)C[N+](C)(C)C)=O

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

• [1]. Aichler M, et al. N-acyl Taurines and Acylcarnitines Cause an Imbalance in Insulin Synthesis and Secretion Provoking β Cell Dysfunction in Type 2 Diabetes. Cell Metab. 2017 Jun 6;25(6):1334-1347.e4.  [Content Brief]

  [2]. Dave AM, et al. Neonatal Hypoxic-Ischemic Brain Injury Alters Brain Acylcarnitine Levels in a Mouse Model. Metabolites. 2022 May 22;12(5):467.  [Content Brief]

  [3]. Bell FP. Carnitine esters: novel inhibitors of plasma lecithin: cholesterol acyltransferase in experimental animals but not in man (Homo sapiens). Int J Biochem. 1983;15(2):133-6.  [Content Brief]

  [4]. Li XZ, et al. Cerebral metabonomics study on Parkinson's disease mice treated with extract of Acanthopanax senticosus harms. Phytomedicine. 2013 Oct 15;20(13):1219-29.  [Content Brief]

  [5]. da Luz G, et al. Triterpene derivative: A potential signaling pathway for the fern-9(11)-ene-2α,3β-diol on insulin secretion in pancreatic islet. Life Sci. 2016 Jun 1;154:58-65.  [Content Brief]