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A2

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136466

A2ti-2 2 Publications Verification	Annexin A Virus Protease HPV	Infection
A2ti-2 is a selective and low-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC₅₀ of 230 μM . A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-2 prevents human papillomavirus type 16 (HPV16) infection ^[2].

HY-136465

A2ti-1 3 Publications Verification	Annexin A Virus Protease HPV	Infection
A2ti-1 is a selective and high-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC₅₀ of 24 μM . A2ti-1 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-1 prevents human papillomavirus type 16 (HPV16) infection ^[2].

HY-158494

A2 glycan (G0) A2 N-linked oligosaccharide	Biochemical Assay Reagents	Others
A2 glycan (G0) (A2 N-linked oligosaccharide) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158493

A2 glycan (G0), procainamide labelled A2 N-linked oligosaccharide, procainamide labelled	Biochemical Assay Reagents	Others
A2 glycan (G0), procainamide labelled (A2 N-linked oligosaccharide, procainamide labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158497

A2 glycan (G0), APTS labelled A2 N-linked oligosaccharide, APTS labelled	Biochemical Assay Reagents	Others
A2 glycan (G0), APTS labelled (A2 N-linked oligosaccharide, APTS labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158496

A2 glycan (G0), 2-AB labelled A2 N-linked oligosaccharide, 2-AB labelled	Biochemical Assay Reagents	Others
A2 glycan (G0), 2-AB labelled (A2 N-linked oligosaccharide, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158495

A2 glycan (G0), 2-AA labelled A2 N-linked oligosaccharide, 2-AA labelled	Biochemical Assay Reagents	Others
A2[3]G1 & A2[6]G1 glycan (G1), 2-AB labeled Lewis sugar. SLeX is a ligand for the cell adhesion molecule E-selectin (E-selectin), which is specifically expressed at sites of inflammatory lesions. Designing SLeX-polysaccharide conjugates to deliver drugs to inflammatory lesions .

HY-158523

A2[3]G1 & A2[6]G1 glycan (G1) A2[3]G1 & A2[6]G1 N-linked oligosaccharide	Biochemical Assay Reagents	Others
A2[3]G1 & A2[6]G1 glycan (G1) (A2[3]G1 & A2[6]G1 N-linked oligosaccharide) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158520

A2[3]G1 & A2[6]G1 glycan (G1), 2-AA labelled A2[3]G1 & A2[6]G1 N-linked oligosaccharide, 2-AA labelled	Biochemical Assay Reagents	Others
A2[3]G1 & A2[6]G1 glycan (G1), 2-AA labelled (A2[3]G1 & A2[6]G1 N-linked oligosaccharide, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-151510

A2-Iso5-4DC19	Liposome	Others
A2-Iso5-4DC19 is a lipidoid compound. A2-Iso5-4DC19 is an effective carrier for the delivery of an agent such as a polynucleotide to a cell .

HY-151509

A2-Iso5-2DC18	Liposome	Cancer
A2-Iso5-2DC18 is a dihydroimidazole-linked lipid, served as potent mRNA delivery vehicle. A2-Iso5-2DC18 can be used for antitumor research, including B16F10 melanoma. .

HY-158522

A2[3]G1 & A2[6]G1 glycan (G1), 2-AB labelled A2[3]G1 & A2[6]G1 N-linked oligosaccharide, 2-AB labelled	Biochemical Assay Reagents	Others
A2[3]G1 & A2[6]G1 glycan (G1), 2-AB labeled Lewis sugar. SLeX is a ligand for the cell adhesion molecule E-selectin (E-selectin), which is specifically expressed at sites of inflammatory lesions. Designing SLeX-polysaccharide conjugates to deliver drugs to inflammatory lesions .

HY-158458

A2[3]G1F1(α-1-3) glycan A2[3]G1F1(a1-3) glycan	Biochemical Assay Reagents	Others
A2[3]G1F1(α-1-3) glycan (A2[3]G1F1(a1-3) glycan) is an asymmetric Lewis X polysaccharide and N-glycan. SLeX is a ligand for the cell adhesion molecule E-selectin, which is specifically expressed at sites of inflammatory lesions. Designing SLeX-polysaccharide conjugates to deliver drugs to inflammatory lesions .

HY-158457

A2[3]G1 N-glycan N/A	Biochemical Assay Reagents	Others
A2[3]G1 N-glycan (N/A) is a Lewis sugar. SLeX is a ligand for the cell adhesion molecule E-selectin, which is specifically expressed at sites of inflammatory lesions. Designing SLeX-polysaccharide conjugates to deliver drugs to inflammatory lesions .

HY-134928

Pyridinium bisretinoid A2E A2E	Apoptosis Autophagy Reactive Oxygen Species (ROS)	Cancer
Pyridinium bisretinoid A2E (A2E) is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E can be used in the study of retinal degenerative diseases ^[2].

HY-158057

A2AR/A2BR antagonist 1	Adenosine Receptor	Cancer
A_2AR/A_2BR antagonist 1 (compound 7ai) has a dual antagonistic effect on *A_2AR/A_2BR, with the IC₅₀* values of 11.2 nM and 6.4 nM for *A_2AR* and *A_2BR, respectively. A_2AR/A_2BR* antagonist 1 promotes T cell-mediated cancer cell death .

HY-158442

A2G2 glycan (G2) A2G2 N-linked oligosaccharide; A2G(4)2 glycan	Biochemical Assay Reagents	Others
A2G2 glycan (G2) (A2G2 N-linked oligosaccharide; A2G(4)2 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-117442

A2B57	Sirtuin	Cancer
A2B57 is a selective inhibitor for SIRT 2 with an IC₅₀ of 6.3 µM .

HY-149916

A2AR-antagonist-1	Adenosine Receptor	Cancer
A2AR-antagonist-1 (compound 38) is an orally active adenosine A2A receptor (A2AR) antagonist (IC₅₀=29 nM). A2AR-antagonist-1 exhibits anti-tumor activity and mouse liver microsomal metabolic stability (t_1/2=86.1 min). A2AR-antagonist-1 is also a T cells activator, via inhibiting immunosuppressive molecules (LAG-3 and TIM-3) and enhancing effector molecules (GZMB, IFNG, and IL-2) .

HY-N10629

A2G0 Glycan	Biochemical Assay Reagents	Others
A2G0 Glycan is a glycan, and can be used for labeling and modification of proteins.

HY-18776

A2AR-agonist-1 1 Publications Verification	Adenosine Receptor	Neurological Disease
A2AR-agonist-1 is a potent A2AR and ENT1 agonist with Ki of 4.39 and 3.47 for A2AR and ENT1.

HY-170948

A2AR modulator-1	Adenosine Receptor	Cancer
A2AR modulator-1 (Compound 45) is a selective negative allosteric adenosine A_2a receptor (A_2aR) modulator with an IC₅₀ value of 9 nM. A2AR modulator-1 reduces the affinity of endogenous adenosine for the receptor and inhibits cAMP signaling pathway activation. A2AR modulator-1 potently restores pCREB phosphorylation in CD4 ⁺ T cells, reversing immunosuppression in the tumor microenvironment, and shows potential to suppress tumor growth and metastasis in triple-negative breast cancer models .

HY-134928A

Pyridinium bisretinoid A2E TFA A2E TFA; N-retinylidene-N-retinylethanolamine TFA	Apoptosis Autophagy Reactive Oxygen Species (ROS)	Cancer
Pyridinium bisretinoid A2E (A2E) TFA is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E TFA is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E TFA mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E TFA can be used in the study of retinal degenerative diseases ^[2].

HY-158447

A2G2 glycan (G2), procainamide labelled A2G2 N-linked oligosaccharide, procainamide labelled; A2G(4)2 glycan, procainamide labelled	Biochemical Assay Reagents	Others
A2G2 glycan (G2), procainamide labelled (A2G2 N-linked oligosaccharide, procainamide labelled; A2G(4)2 glycan, procainamide labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-134928AS

Pyridinium bisretinoid A2E-d4 TFA A2E-d₄ TFA	Isotope-Labeled Compounds	Cancer
Pyridinium bisretinoid A2E-d₄ TFA is the deuterium-labeled Pyridinium bisretinoid A2E (HY-134928). Pyridinium bisretinoid A2E (A2E)is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species ^[2] .

HY-143324

A2AAR/HDAC-IN-1	HDAC Adenosine Receptor	Cancer
A2AAR/HDAC-IN-1 (compound 14c) is an orally active, potent and balanced *A_2AAR/HDAC* dual inhibitor, with a K_i of 163.5 nM for A_2AAR and an IC₅₀ of 145.3 nM for HDAC1. A2AAR/HDAC-IN-1 shows anticancer activity .

HY-143325

A2AAR/HDAC-IN-2	HDAC Adenosine Receptor	Cancer
A2AAR/HDAC-IN-2 is a potent *A_2AAR/HDAC* dual inhibitor, with good binding affinity for *A_2AAR* (K_i=10.3 nM) and good inhibitory activity against HDAC1 (IC₅₀=18.5 nM). A2AAR/HDAC-IN-2 can be used in study of antitumor .

HY-158459

A2G2F2 glycan A2G2F2(a1-3) glycan	E-Selectin Biochemical Assay Reagents	Others
A2G2F2 glycan (A2G2F2(a1-3) glycan) is a Lewis X polysaccharide containing two Lewis X epitopes and is a symmetric N-glycan. SLeX is a ligand for the cell adhesion molecule E-selectin, which is specifically expressed at sites of inflammatory lesions. Designing SLeX-polysaccharide conjugates to deliver drugs to inflammatory lesions .

HY-158506

A2G2S2 glycan (G2S2) A2G2S2 N-linked oligosaccharide; A2G(4)2S(6)2 glycan	Biochemical Assay Reagents	Others
A2G2S2 glycan (G2S2) (A2G2S2 N-linked oligosaccharide; A2G(4)2S(6)2 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158475

A2G2S1 glycan (G2S1) A2G2S1 N-linked oligosaccharide; A2G(4)2S(6)1 glycan	Biochemical Assay Reagents	Others
A2G2S1 glycan (G2S1) (A2G2S1 N-linked oligosaccharide; A2G(4)2S(6)1 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158446

A2G2 glycan (G2), APTS labelled A2G2 N-linked oligosaccharide, APTS labelled	Biochemical Assay Reagents	Others
A2G2 glycan (G2), APTS labelled (A2G2 N-linked oligosaccharide, APTS labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-174413

A2AAR antagonist 3	Adenosine Receptor	Cancer
A2AAR antagonist 3 is a selective and potent A_2A adenosine receptor (A_2A AR) antagonist with an IC₅₀ of 1.57 nM. A2AAR antagonist 3 demonstrates high and selective binding affinities to the A_2A AR. A2AAR antagonist 3 demonstrates favorable stability in rat liver microsomes in vitro and acceptable pharmacokinetic profiles in vivo. A2AAR antagonist 3 can be used in cancer research.

HY-N12422

A2AAR antagonist 2	Adenosine Receptor	Inflammation/Immunology Cancer
3′-Methoxyfurano[4″,5″:3,4]chalcone (compound 2) is a selective *A_2AAR* antagonist (IC₅₀=33.5 nM) with high affinity. 3′-Methoxyfurano[4″,5″:3,4]chalcone is also a natural product obtained from the bark of Allium cepa L. 3′-Methoxyfurano[4″,5″:3,4]chalcone can promote T cell activation and can be used in cancer immunity research .

HY-151387

A2AAR antagonist 1	Adenosine Receptor	Neurological Disease
A2AAR antagonist 1 (compound 21a) is an *A2AAR* (adenosine A2A receptor) antagonist with a K_i value of 20 nM. A2AAR antagonist 1 shows high ligand efficiency, and it can be used for the research of neurodegenerative diseases .

HY-120826

A2AAR/hMAO-B-IN-1	Monoamine Oxidase Adenosine Receptor	Neurological Disease
A2AAR/hMAO-B-IN-1 (compoudn 17) is a non-xanthine dual-target inhibitor targeting the A2A adenosine receptor (A2AAR) (IC₅₀: 34.9 nM) andMAO-B (Ki: 39.5 nM, human). A2AAR/hMAO-B-IN-1 inhibits A2AAR-induced cAMP accumulation and exhibits competitive, reversible inhibition of MAO-B. A2AAR/hMAO-B-IN-1 can be used in the study of neurodegenerative diseases such as Parkinson's disease (PD) .

HY-158445

A2G2 glycan (G2), 2-AB labelled A2G2 N-linked oligosaccharide, 2-AB labelled	Biochemical Assay Reagents	Others
A2G2 glycan (G2), 2-AB labelled (A2G2 N-linked oligosaccharide, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158463

A2G2S2-KVANKT glycopeptide	Biochemical Assay Reagents	Others
A2G2S2-KVANKT glycopeptide is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-U00321

A2B receptor antagonist 1	Adenosine Receptor	Inflammation/Immunology Cancer
A2B receptor antagonist 1 is a potent A2B adenosine receptor antagonist extracted from patent WO 2009157938 A1 EXAMPLE 9B.

HY-145706

A2A/A1 AR antagonist-1	Adenosine Receptor	Neurological Disease
A2A/A1 AR antagonist-1 (compound 1a) is dual potent A_2A/A₁ AR antagonist with K_is of 5.58 and 24.2 nM, respectively. A2A/A1 AR antagonist-1 has the potential for the research of ischemic stroke .

HY-139314

A2B receptor antagonist 2	Adenosine Receptor	Metabolic Disease
A2B receptor antagonist 2 (compound 18) is an adenosine receptor A_2B antagonist, with K_i values of 2.30 μM, 6.8 μM and 3.44 μM for rA₁, rA_2A and hA_2B, respectively .

HY-148076

A2A receptor antagonist 3	Adenosine Receptor	Cancer
A2A receptor antagonist 3 (Example 92) is an adenosine A2a receptor antagonist with a K_i of 0.4 nM. A2A receptor antagonist 3 also binds to A2b, A1 and A3 receptor with K_is of 37, 107 and 1467 nM, respectively .

HY-144672

A2A receptor antagonist 2	Adenosine Receptor	Inflammation/Immunology Cancer
A2A receptor antagonist 2 (Compound 57) is a potent, highly selective *adenosine A_2A* receptor** (A_2AR) antagonist with an IC₅₀ of 8.3 nM .

HY-147541

A2A/A3 AR antagonist-1	Adenosine Receptor	Inflammation/Immunology
A2A/A3 AR antagonist-1 (compound 23) is a dual A_2A/A₃ adenosine receptor (AR) fluorescent ligand, with K_is of 90 nM and 31.8 nM for hA_2A AR and hA₃ AR, respectively .

HY-158510

A2G2S2 glycan (G2S2), APTS labelled A2G2S2 N-linked oligosaccharide, APTS labelled; A2G(4)2S(6)2 glycan, APTS labelled	Biochemical Assay Reagents	Others
A2G2S2 glycan (G2S2), APTS labelled (A2G2S2 N-linked oligosaccharide, APTS labelled; A2G(4)2S(6)2 glycan, APTS labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-RS00010

A2M Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
A2M Human Pre-designed siRNA Set A contains three designed siRNAs for A2M gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

A2M Human Pre-designed siRNA Set A A2M Human Pre-designed siRNA Set A

HY-RS18322

A2m Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
A2m Mouse Pre-designed siRNA Set A contains three designed siRNAs for A2m gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

A2m Mouse Pre-designed siRNA Set A A2m Mouse Pre-designed siRNA Set A

HY-RS24800

A2m Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
A2m Rat Pre-designed siRNA Set A contains three designed siRNAs for A2m gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

A2m Rat Pre-designed siRNA Set A A2m Rat Pre-designed siRNA Set A

HY-158508

A2G2S2 glycan (G2S2), 2-AA labelled A2G2S2 N-linked oligosaccharide, 2-AA labelled; A2G(4)2S(6)2 glycan, 2-AA labelled	Biochemical Assay Reagents	Others
A2G2S2 glycan (G2S2), 2-AA labelled (A2G2S2 N-linked oligosaccharide, 2-AA labelled; A2G(4)2S(6)2 glycan, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158512

A2G2S2 glycan (G2S2), 2-AB labelled A2G2S2 N-linked oligosaccharide, 2-AB labelled; A2G(4)2S(6)2 glycan, 2-AB labelled	Biochemical Assay Reagents	Others
A2G2S2 glycan (G2S2), 2-AB labelled (A2G2S2 N-linked oligosaccharide, 2-AB labelled; A2G(4)2S(6)2 glycan, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158474

A2G2S1 glycan (G2S1), APTS labelled A2G2S1 N-linked oligosaccharide, APTS labelled	Biochemical Assay Reagents	Others
A2G2S1 glycan (G2S1), APTS labelled (A2G2S1 N-linked oligosaccharide, APTS labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N12422

A2AAR antagonist 2	Structural Classification Natural Products Liliaceae Source classification Allium cepa L. Plants	Adenosine Receptor
3′-Methoxyfurano[4″,5″:3,4]chalcone (compound 2) is a selective *A_2AAR* antagonist (IC₅₀=33.5 nM) with high affinity. 3′-Methoxyfurano[4″,5″:3,4]chalcone is also a natural product obtained from the bark of Allium cepa L. 3′-Methoxyfurano[4″,5″:3,4]chalcone can promote T cell activation and can be used in cancer immunity research .

HY-N9536

Cinnamtannin A2	Structural Classification Cinnamomum cassia (L.) D. Don Classification of Application Fields Source classification Metabolic Disease Plants Flavanonols Flavonoids Phenols Polyphenols Lauraceae Biflavones Disease Research Fields	GLP Receptor
Cinnamtannin A2, a tetrameric procyanidin, can increases GLP-1 and insulin secretion in mice. Cinnamtannin A2 could upregulate the expression of corticotrophin releasing hormone. Cinnamtannin A2 exhibits antioxidant, anti-diabetic and nephroprotective effect ^[2].

HY-N14458

Pluracidomycin A2 PLM A2	Structural Classification Microorganisms Antibiotics Source classification Beta-lactam Antibiotics	Antibiotic Bacterial
Pluracidomycin A2 (PLM A2) is a carbapenem antibiotic and has anti-Gram-positive bacteria and Gram-negative bacteria activities .

HY-N14275

Miyakamide A2	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Miyakamide A2 is an antibiotic with insecticidal effect. Miyakamide A2 inhibits the growth of Artemia salina. Miyakamide A2 has a weak antixanthomonas activity. Miyakamide A2 inhibits P388 cells with an IC₅₀ of 12.2 μg/mL .

HY-N15075

Espinomycin A2	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Bacterial
Espinomycin A2 is a sixteen-membered macrolide antibiotic. Espinomycin A2 is active against Gram-positive bacteria .

HY-N14097

Pyloricidin A2	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Bacterial
Pyloricidin A2 is an antibiotic against Helicobacter pylori found in Bacillus sp. HC-70. Pyloricidin A2 has strong anti-Helicobacter pylori activity. Pyloricidin A2 has no activity against other bacteria and yeast .

HY-N14465

Pneumocandin A2	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Bacterial
Pneumocandin A2 is a lipopeptide antibiotic. Pneumocandin A2 has a strong anti-Candida effect. Pneumocandin A2 has the effect of inhibiting the synthesis of 1,3 early-glucan in vitro, with an IC₅₀ of 0.07-0.5 μg/mL .

HY-156198

Bottromycin A2	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Bottromycin A2 is a natural antibiotic. Bottromycin A2 is active against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) .

HY-N10502

Colletofragarone A2	Other Terpenoids Structural Classification Microorganisms Terpenoids	MDM-2/p53 HSP
Colletofragarone A2 can be be isolated from the fungus Colletotrichum sp. (13S020). Colletofragarone A2 inhibits mutant p53 and HSP90 with anti-cancer activity. Colletofragarone A2 promotes degradation and aggregation of mutant p53 and suppressing tumor growth in vivo .

HY-125653

Kapurimycin A2	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Kapurimycin A2 is an antitumor antibiotic that can be found in the culture of Streptomyces sp.. Kapurimycin A2 is an active against bacteria, particularly Gram-positive organisms .

HY-N14269

Ezomycin A2	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Fungal
Ezomycin A2 is an antifungal antibiotic. Ezomycin A2 is mainly active against phytopathogens such as Sclerotinia sclerotiorum and Botrytis, and has a control effect on Sclerotinia, Botrytis and Candidiasis of crops .

HY-N2343R

Procyanidin A2 (Standard)	Structural Classification Flavonoids other families Source classification Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae Biflavones	Reference Standards Bacterial
Procyanidin A2 (Standard) is the analytical standard of Procyanidin A2. This product is intended for research and analytical applications. Procyanidin A2 is a flavonoid found in grapes, with anti-cancer, antioxidant, antimicrobial and anti-inflammation activity ^[2].

HY-W748013

Cervinomycin A2	Structural Classification Antibiotics Other Antibiotics	Antibiotic Bacterial
Cervinomycin A2 is an anti-anaerobic antibiotic that can be isolated from Streptomyces cervicalis. Cervinomycin A2 has a strong inhibitory effect on Clostridium perfringens, Gastrococcus prophylacticus, and Bacteroides fragilis .

HY-N9373

Bacoside A2	Triterpenes Terpenoids Source classification Scrophulariaceae Plants Bacopa monnieri (Linn.) Wettst.	Others
Bacoside A2 is a triterpenoid saponin .

HY-N8041

Mogroside III A2	Infection Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields	HSV
Mogroside III A2 is a cucurbitane glycoside. Mogroside III A2 can inhibit Epstein-Barr virus early antigen (EBV-EA) activation. Mogroside III A2 shows weak inhibitory effects on activation of NOR 1 .

HY-N14533

Quinolactacin A2	Structural Classification Alkaloids Microorganisms Source classification Quinoline Alkaloids	Cholinesterase (ChE)
Quinolactacin A2 inhibits acetylcholinesterase and TNF production .

HY-N14295

Fluvirucin A2	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Influenza Virus
Fluvirucin A2 is an antibiotic against influenza A virus .

HY-113350

Thromboxane A2 TXA2	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology Cancer	Prostaglandin Receptor Endogenous Metabolite
Thromboxane A2 (TXA2) is a prostanoid mediator produced by the metabolism of Arachidonic acid (HY-109590) through the cyclooxygenase pathway. Thromboxane A2 activates the thromboxane-prostanoid (TP) receptors. Thromboxane A2 is a potent vasoconstrictor eicosanoid. Thromboxane A2 (TXA2) leads to potent vasoconstriction by stimulation of smooth muscle cells. Thromboxane A2 acts as s tonic immunoregulator to regulate adaptive immune responses ^[2] .

HY-N14041

Arizonin A2	Quinones Structural Classification Microorganisms Source classification Naphthalene Quinones	Bacterial
Arizonin A2 is a microbial metabolite with anti-Gram-positive bacterial activities .

HY-N14412

Napyradiomycin A2	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Napyradiomycin A2 is an antibiotic with anti-Gram-positive bacteria and mycobacterial activity .

HY-135533

Chromomycin A2 Aburamycin A	Microorganisms Source classification	Autophagy
Chromomycin A2 (Aburamycin A) has cytotoxicity and induces autophagy. Chromomycin A2 has anti-tumor activity and can be used in cancer research .

HY-N14755

Juvenimicin A2	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification	Bacterial
Juvenimicin A2 can resist Gram-positive bacteria and individual Gram-negative bacteria .

HY-N14609

Respinomycin A2	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Bacterial
Respinomycin A2 is an anthracycline antibiotic that causes the differentiation of leukemic K-562 cells .

HY-N14492

Coumermycin A2	Structural Classification Natural Products Microorganisms Source classification	Bacterial
Coumermycin A2 has anti-Gram positive bacteria, negative bacteria, mycobacterium (weak) activity .

HY-N2343

Procyanidin A2 2 Publications Verification	Structural Classification Classification of Application Fields Source classification Vitis vinifera cv. Zalema Plants Vitaceae Infection Flavonoids other families Functional Molecules Research of Health Products Phenols Polyphenols Biflavones Inflammation/Immunology Disease Research Fields	Bacterial
Procyanidin A2 is a flavonoid found in grapes, with anti-cancer, antioxidant, antimicrobial and anti-inflammation activity ^[2].

HY-N14741

Lanopylin A2	Structural Classification Natural Products Microorganisms Source classification	Others
Lanopylin A2 can inhibit recombinant human lanosterol synthase (EC 5.4.99.7) with an IC₅₀ of 18 μM .

HY-N14862

Midecamycin A2	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification	Bacterial
Midecamycin A2 is a macrolide compound with strong anti-Gram-positive bacteria and weak anti-Gram-negative bacteria, mycobacteria and fungi activity .

HY-N14657

Paulomycin A2	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Bacterial
Paulomycin A2 has anti-Gram-positive bacteria effect, and it has inhibitory effect on Staphylococcus aureus resistant to penicillin, Streptomycin, Neomycin and Macrolide antibiotics .

HY-N12257

Antimycin A2	Structural Classification Monophenols Microorganisms Source classification Phenols	Fungal Cytochrome P450
Antimycin A2 is the component of the antibiotic antimycin A. Antimycin A is an antibiotic, that exhibits inhibitory activity against fungi and some insects through inhibition of respiration and cytochrome b reoxidation .

HY-N15099

Polymyxin A2	Structural Classification Natural Products Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Polymyxin A2 is a heteropeptide antibiotic found in different strains of Bacillus polymyxa, and its effect against Gram-negative bacteria is greater than that against Gram-positive bacteria .

HY-152909

Nystatin A2	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Fungal
Nystatin A2 is an active component of antifungal agent, Nystatin (HY-17409). Nystatin is an orally active polyene antifungal antibiotic effective against yeast and mycoplasma ^[2].

HY-N7614

Anemarrhenasaponin A2 Schidigerasaponin F2; Timosaponin AII	Cardiovascular Disease Liliaceae Classification of Application Fields Source classification Anemarrhena asphodeloides Bunge Plants Disease Research Fields Steroids	Others
Anemarrhenasaponin A2 (Schidigerasaponin F2) is a steroidal saponin isolated from the rhizomes of Anemarrhena asphodeloides. Anemarrhenasaponin A2 inhibits ADP-induced platelet aggregation .

HY-N12272

Soyasaponin Af Acetyl-soyasaponin A2	Structural Classification Polysaccharides Leguminosae Source classification Plants Phaseolus vulgaris Linn. Saccharides	Others
Soyasaponin Af (Acetyl-soyasaponin A2) is a saponin isolated from Black bean (Phaseolus vulgaris L.) seed coats .

HY-N12555

6,6′-Didemethyl-7-methyl dragonbloodin A2	Structural Classification Natural Products Flavonoids Dracaena draco (L.) L. Source classification Agavaceae Plants Other Flavonoids	Others
6,6′-Didemethyl-7-methyl dragonbloodin A2 is isolated from the dragon’s blood of Daemonorops draco fruits and is a osteoclastogenesis inhibitor with IC₅₀ value of 36.8 μM_[1].

HY-N0604

Ginsenoside Rh1 4 Publications Verification Prosapogenin A2; Sanchinoside B2; Sanchinoside Rh1	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Araliaceae	Interleukin Related PPAR TNF Receptor Endogenous Metabolite
Ginsenoside Rh1 (Prosapogenin A2) inhibits the expression of PPAR-γ, TNF-α, IL-6, and IL-1β.

HY-N12012

11-Oxomogroside II A2 11-Dehydroxy-mogroside IIA2 O-rhamnoside	Triterpenes Structural Classification Polysaccharides Terpenoids Source classification Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Saccharides	Others
11-Oxomogroside II A2 (11-Dehydroxy-mogroside IIA2 O-rhamnoside) (compound 101) is a mogroside isolated from the fruit of Luo Han Guo .

HY-N0604R

Ginsenoside Rh1 (Standard) Prosapogenin A2 (Standard); Sanchinoside B2 (Standard); Sanchinoside Rh1 (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Araliaceae	Interleukin Related Reference Standards PPAR TNF Receptor Endogenous Metabolite
Ginsenoside Rh1 (Standard) is the analytical standard of Ginsenoside Rh1. This product is intended for research and analytical applications. Ginsenoside Rh1 (Prosapogenin A2) inhibits the expression of PPAR-γ, TNF-α, IL-6, and IL-1β.

HY-116671

Folipastatin	Monophenols Microorganisms Classification of Application Fields Source classification Other Diseases Phenols Disease Research Fields	Phospholipase
Folipastatin is a potent inhibitor of phospholipase A2 with an IC₅₀ of 39 μM. Folipastatin is a new depsidone compound from Aspergillus unguis .

HY-N13866

Cucumarioside A2-2	Triterpenes Structural Classification Animals Terpenoids Source classification	Others
Cucumarioside A2-2 is a triterpene glycoside with antitumor activity. Cucumarioside A2-2 can induce mouse macrophage polarization toward the M1 phenotype. Cucumarioside A2-2 pretreated macrophages can effectively and selectively target and kill multiple types of cancer cells. Cucumarioside A2-2-induced M1 macrophages can effectively target and penetrate tumor tissues and improve the survival rate of mice in an allogeneic model. Exogenous activation of Cucumarioside A2-2 provides a useful model for the subsequent development of antitumor cell immunosuppression .

HY-W782485

Anhydrolutein III Deoxylutein I; Provitamin A2	Structural Classification Natural Products Polygonaceae Source classification Rumex rugosus Campd. Plants	Drug Derivative
Anhydrolutein III (Deoxylutein I) is a dehydration product of Lutein (HY-N6947) .

HY-108993

Fujianmycin B SNA-8073A; Rubiginone A2	Quinones Structural Classification Microorganisms Anthraquinones Source classification	Others
Fujianmycin B (SNA-8073A) is found in the strain of Streptomyces sp .

HY-Z16212

Neomycin F Paromomycin Ⅱ; Aminosidine II; Zygomycin A2	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Paromomycin II is an aminoglycoside antibiotic. Paromomycin II has activity against Gram-positive, negative bacteria, mycobacterium and protozoa. Paromomycin II has good curative effect for amebic dysentery and a few bacillary dysentery .

HY-118725

Luffariellolide	Natural Products Classification of Application Fields Animals Source classification Disease Research Fields Inflammation/Immunology	Phospholipase
Luffariellolide is an inhibitor of human synovial fluid phospholipase A2 (HSF-PLA2) (IC₅₀=5 μM). Luffariellolide effectively inhibits phorbol ester (PMA)-induced ear edema (ED₅₀=50 μg/ear) .

HY-108272

Mogroside II-A2	Triterpenes Classification of Application Fields Terpenoids Source classification Cucurbitaceae Metabolic Disease Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields Sweeteners Food Research	Others
Mogroside II-A2 is a triterpenoid glycoside and a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities .

HY-103183

CV1808 2-Phenylaminoadenosine	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Adenosine Receptor Endogenous Metabolite
CV1808 (2-Phenylaminoadenosine) is a non-selective A2 adenosine receptor (A2 AR) agonist with K_is of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively .

HY-N14050

Cinatrin A	Structural Classification Natural Products Microorganisms Source classification	Phospholipase
Cinatrin A has the activity of inhibiting phospholipase A2 .

HY-N14101

Cinatrin B	Structural Classification Natural Products Microorganisms Source classification	Phospholipase
Cinatrin B has the activity of inhibiting phospholipase A2 .

HY-103183R

CV1808 (Standard) 2-Phenylaminoadenosine (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Reference Standards Adenosine Receptor Endogenous Metabolite
CV1808 (Standard) is the analytical standard of CV1808. This product is intended for research and analytical applications. CV1808?(2-Phenylaminoadenosine) is a non-selective A2?adenosine receptor (A2 AR) agonist with Kis of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively .

HY-W612338

9-Oxononanoic acid 9-ONA	Structural Classification Arachis hypogaea L. Leguminosae Ketones, Aldehydes, Acids Source classification Plants	Phospholipase Prostaglandin Receptor
9-Oxononanoic acid (9-ONA) is secondary reaction product of lipid peroxidation. 9-Oxononanoic acid induces phospholipase A2 (PLA2) activity and thromboxane A2 (HY-113350) production (TXA2). 9-Oxononanoic acid induces the platelet aggregation in human blood. 9-Oxononanoic acid is orally active .

HY-N14103

Cinatrin C1	Structural Classification Natural Products Microorganisms Source classification	Phospholipase
Cinatrin C1 is a phospholipase A2 (PLA2) inhibitor that can be extracted from Circinotrichum falcatisporum RF-641 .

Cat. No.	Product Name	Chemical Structure

HY-134928AS

Pyridinium bisretinoid A2E-d4 TFA
Pyridinium bisretinoid A2E-d₄ TFA is the deuterium-labeled Pyridinium bisretinoid A2E (HY-134928). Pyridinium bisretinoid A2E (A2E)is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species ^[2] .

HY-113041S

Prostaglandin A2-d4
Prostaglandin A2-d₄ is the deuterium labeled Prostaglandin A2 .

HY-B0745S

Ramatroban-d4
Ramatroban-d₄ is deuterium labeled Ramatroban. Ramatroban is a selective thromboxane A2 (TxA2, IC50=14 nM) antagonist, which also antagonizes CRTH2 (IC50=113 nM) by inhibiting PGD2 binding.

HY-18763S

Indobufen-d5
Indobufen-d₅ is deuterium labeled Indobufen. Indobufen is a platelet aggregation inhibitor. Indobufen is a reversible platelet cyclooxygenase (Cox) activity inhibitor. Indobufen suppresses thromboxane A2 (TxA2) synthesis. Indobufen down-regulates tissue factor (TF) in monocytes .

HY-13402S

Varespladib-d7

Varespladib-d₇ (LY315920-d₇) is a deuterated labeled Varespladib (HY-13402). Varespladib is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC₅₀ of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC₅₀s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .

HY-130304S

8-Isoprostaglandin E2-d4

8-Isoprostaglandin E2-d₄ (iPE2-III-d₄) is deuterium labeled 8-Isoprostaglandin E2. 8-Isoprostaglandin E2 (iPE2-III) is a member of the isoprostane class of prostanoids. 8-Isoprostaglandin E2 acts at the receptor for thromboxane A₂ (the TP) in vivo to induce vasoconstriction and platelet aggregation. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway ^[2].

HY-W699983

Imidazole-15N2

Imidazole- ¹⁵N₂ (Glyoxaline- ¹⁵N₂) is ¹⁵N labeled Imidazole. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG₂ and PGH₂) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL ^Pro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease ^[2] .

HY-173108S

Haemoglobin HbA2 (a2d2), U-15N
Haemoglobin HbA2 (a2d2), U- ¹⁵N is the ¹⁵N-labeled Haemoglobin HbA2 (a2d2), U.

HY-173107S

Haemoglobin HbA0 (a2b2), U-15N
Haemoglobin HbA0 (a2b2), U- ¹⁵N is the ¹⁵N-labeled Haemoglobin Haemoglobin HbA0 (a2b2), U.

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