2. Metabolic Enzyme/Protease Epigenetics Cell Cycle/DNA Damage Apoptosis
  3. Phospholipase HDAC Apoptosis
  4. Rhamnetin

Rhamnetin is a quercetin derivative found in Coriandrum sativum, inhibits secretory phospholipase A2 and histone deacetylase 2 (HDAC2). Rhamnetin exhibits antitumor, antioxidant and anti-inflammatory activity.

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Rhamnetin Chemical Structure

Rhamnetin Chemical Structure

CAS No. : 90-19-7

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Based on 1 publication(s) in Google Scholar

Other Forms of Rhamnetin:

Rhamnetin Related Antibodies

Top Publications Citing Use of Products

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Phospholipase A PLD Phospholipase C

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Rhamnetin is a quercetin derivative found in Coriandrum sativum, inhibits secretory phospholipase A2 and histone deacetylase 2 (HDAC2). Rhamnetin exhibits antitumor, antioxidant and anti-inflammatory activity[1][2].

Cellular Effect
Cell Line Type Value Description References
HeLa IC50
7.8 μM
Compound: 3
Cytotoxicity against human HeLa cells by MTT assay
Cytotoxicity against human HeLa cells by MTT assay
[PMID: 19278239]
Monocyte IC50
22 μM
Compound: Rhamnetin
Inhibition of TNFalpha expression in LPS-stimulated human monocytes treated 30 mins before LPS challenge measured after 14 hrs by ELISA
Inhibition of TNFalpha expression in LPS-stimulated human monocytes treated 30 mins before LPS challenge measured after 14 hrs by ELISA
[PMID: 10096854]
In Vitro

Rhamnetin (0-10 μM, 24-48 h) inhibits the proliferation of cancer cell SKOV3 with an an IC50 of 1.22 μM (24 h)[2].
Rhamnetin (0-10 μM, 24 h) arrests the cell cycle of SKOV3 at G1 phase, and induces apoptosis[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Rhamnetin Related Antibodies

Cell Viability Assay[2]

Cell Line: SKOV3
Concentration: 0-10 μM
Incubation Time: 24-48 h
Result: Inhibited the cell viability of SKOV3.

Cell Cycle Analysis[2]

Cell Line: SKOV3
Concentration: 0-10 μM
Incubation Time: 24 h
Result: Arrested the cell cycle at G1 phase.
In Vivo

Rhamnetin (50-200 mg/kg, ip, once daily for 21 days) improves cognitive dysfunction after traumatic brain injury in rats and inhibits inflammatory response and oxidative stress in the hippocampus[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat traumatic brain injury model[3]
Dosage: 50-200 mg/kg
Administration: ip, once daily for 21 days
Result: Improved the spatial learning and memory ability of rats.
Reduced the levels of TNF-α, IL-1β, IL-6, IL-8, hs-CRP, MDA and H2O2 in the hippocampus.
Increased the levels of IL-10, SOD, GSH-Px in the hippocampus.
Molecular Weight

316.27

Formula

C16H12O7
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

OC1=C(C2=CC=C(O)C(O)=C2)OC3=C(C(O)=CC(OC)=C3)C1=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (632.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1619 mL 15.8093 mL 31.6186 mL
5 mM 0.6324 mL 3.1619 mL 6.3237 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.18%

SDS (419 KB)

COA (249 KB) HNMR (117 KB) RP-HPLC (76 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1619 mL 15.8093 mL 31.6186 mL 79.0464 mL
5 mM 0.6324 mL 3.1619 mL 6.3237 mL 15.8093 mL
10 mM 0.3162 mL 1.5809 mL 3.1619 mL 7.9046 mL
15 mM 0.2108 mL 1.0540 mL 2.1079 mL 5.2698 mL
20 mM 0.1581 mL 0.7905 mL 1.5809 mL 3.9523 mL
25 mM 0.1265 mL 0.6324 mL 1.2647 mL 3.1619 mL
30 mM 0.1054 mL 0.5270 mL 1.0540 mL 2.6349 mL
40 mM 0.0790 mL 0.3952 mL 0.7905 mL 1.9762 mL
50 mM 0.0632 mL 0.3162 mL 0.6324 mL 1.5809 mL
60 mM 0.0527 mL 0.2635 mL 0.5270 mL 1.3174 mL
80 mM 0.0395 mL 0.1976 mL 0.3952 mL 0.9881 mL
100 mM 0.0316 mL 0.1581 mL 0.3162 mL 0.7905 mL
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Rhamnetin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rhamnetin90-19-7PhospholipaseHDACApoptosisHistone deacetylasesInhibitorinhibitorinhibit

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