Phospholipase A

Phospholipase A Related Products (41):

By Type:	Pan (1) Selective (25)
By Effects:	Inhibitors (40) Antagonist (1)

Cat. No.	Product Name	Effect	Purity

HY-13402

Varespladib	Inhibitor	99.23%
Varespladib (LY315920) is a potent and selective group IIA, secretory phospholipase A₂ (sPLA₂) inhibitor with an IC₅₀ of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC₅₀s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively.

HY-111376

Pyrrophenone	Inhibitor	99.66%
Pyrrophenone is a potent and specific cytosolic phospholipase A₂α (cPLA₂α) inhibitor with an IC₅₀ value of 4.2 nM.

HY-107411

Bromoenol lactone	Inhibitor	99.59%
Bromoenol lactone ((6E)-Bromoenol lactone) is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A₂ (iPLA₂β) with an IC₅₀ value of approximately 7 μM, which inhibits antigen-stimulated mast cell exocytosis without blocking Ca²⁺ influx.

HY-18570

1-Naphthaleneacetic acid	Inhibitor	99.89%
1-Naphthaleneacetic acid (1-Naphthylacetic acid), a auxin, can promote plant growth. 1-Naphthaleneacetic acid is also an inhibitor of PLA₂, with an IC₅₀ of 13.16 μM.

HY-101015A

OBAA	Inhibitor	99.27%
OBAA is a potent phospholipase A2 (PLA2) inhibitor with an IC₅₀ of 70 nM. OBAA blocks Melittin-induced Ca²⁺ influx in Trypanosoma brucei with an IC₅₀ of 0.4 μM.

HY-168765

LY433771	Inhibitor
LY433771 (LSN433771) (Compound 8) is a type X secretory phospholipase A₂ (sPLA₂) inhibitor with an IC₅₀ value of 3 nM, which can be used in the study of cardiovascular diseases.

HY-108132

Ro 23-9358	Inhibitor
Ro 23-9358 is a potent secretory phospholipase A2 inhibitor with anti-inflammatory activity.

HY-N14104

Cinatrin C2	Inhibitor
Cinatrin C2 is a phospholipase A2 (PLA2) inhibitor with an IC₅₀ of 800 μM and can be extracted from Circinotrichum falcatisporum RF-641.

HY-108607

PACOCF3	Inhibitor	≥98.0%
PACOCF3 (Palmityltrifluoromethylketone) is a selective phospholipase A2 inhibitor with an IC₅₀ of 3.8 μM. PACOCF3 alters Ca²⁺ signaling in renal tubular cells.

HY-11059

KH064	Inhibitor	99.47%
KH064, a D-tyrosine derivative, is an orally active, potent secretory phospholipase A₂ (sPLA₂) inhibitor with an IC₅₀ of 29 nM for human nonpancreatic secretory PLA₂ isoform IIa (hnpsPLA₂-IIa). KH064 has anti-inflammatory activity.

HY-19415

SB-435495	Inhibitor	99.80%
SB-435495 is a potent, selective, reversible, non-covalent and orally active Lp-PLA₂ inhibitor with an IC₅₀ of 0.06 nM.

HY-N8213

Rapanone	Inhibitor	99.20%
Rapanone is a natural benzoquinone. Rapanone exhibits a broad spectrum of biological actions, including anti-tumor, antioxidant, anti-inflammatory, antibacterial and antiparasitic. Rapanone also is a potent and selective human synovial PLA₂ inhibitor, with an IC₅₀ of 2.6 μM.

HY-14952

Giripladib	Inhibitor	99.68%
Giripladib (PLA-695) is a indole-based inhibitor of cytosolic phospholipase A₂ (cPLA₂). Giripladib can be used for osteoarthritis and breast cancer research.

HY-120986

(S)-Bromoenol lactone	Inhibitor	≥99.0%
(S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase A₂β (iPLA₂β) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC₅₀ of 2 µM.

HY-17485

Alminoprofen	Inhibitor	99.91%
Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory agent (NSAID) of the phenylpropionic acid class. Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both secretory phospholipase A₂ (sPLA₂) and COX-2.

HY-W012595A

trans-Benzylideneacetone	Inhibitor	99.44%
trans-Benzylideneacetone (trans-Benzalacetone), a metabolite of gram-negative entomopathogenic bacterium Xenorhabdus nematophila, is an enzyme inhibitor against phospholipase A2 (PLA2). trans-Benzylideneacetone is an immunosuppressant.

HY-18570A

1-Naphthaleneacetic acid potassium salt	Inhibitor	99.64%
1-Naphthaleneacetic acid potassium salt (Potassium 1-Naphthaleneacetate), a synthetic auxin, can promote plant growth. 1-Naphthaleneacetic acid potassium salt is also an inhibitor of PLA₂, with an IC₅₀ of 13.16 μM.

HY-13402A

Varespladib sodium	Inhibitor	≥98.0%
Varespladib sodium (LY315920 sodium) is a potent and selective group IIA, secretory phospholipase A₂ (sPLA₂) inhibitor with an IC₅₀ of 9 nM. Varespladib sodium exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC₅₀s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively.

HY-19757

Lp-PLA2-IN-1	Inhibitor	99.18%
Lp-PLA2-IN-1 is a potent Lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor. Lp-PLA2-IN-1 has the potential for atherosclerosis, Alzheimer's disease research.

HY-134082A

(Z)-Oleyloxyethyl phosphorylcholine	Inhibitor
(Z)-Oleyloxyethyl phosphorylcholine ((Z)-OPC) is an isomer of Oleyloxyethyl phosphorylcholine (OPC). Oleyloxyethyl phosphorylcholine is an inhibitor of secreted Phospholipase A2 (sPLA2), which is involved in the biosynthesis of proinflammatory lipid media. Oleyloxyethyl phosphorylcholine can be used to study inflammatory diseases. Oleyloxyethyl phosphorylcholine also modified the red blood membrane and was used to bind the oxygen-carrying liquid perfluorocarbons as an antivenom agent to reduce toxin-induced hemolysis.

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