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  4. Apocynaceae

Apocynaceae

 

Apocynaceae (269):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0488
    Vincristine sulfate 2068-78-2 99.51%
    Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM.
    Vincristine sulfate
  • HY-13780
    Vinblastine sulfate 143-67-9 99.86%
    Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM.
    Vinblastine sulfate
  • HY-12053A
    Vinorelbine ditartrate 125317-39-7 99.94%
    Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.
    Vinorelbine ditartrate
  • HY-N1445
    Isoquercitrin 482-35-9 99.64%
    Isoquercetin (Quercetin 3-glucoside) is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties. Isoquercetin alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway. Isoquercetin regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. Isoquercetin has high bioavailability and low toxicity, is a promising candidate agent to prevent birth defects in diabetic pregnancies.
    Isoquercitrin
  • HY-N0768
    Quercetin 3-O-β-D-glucofuranoside 21637-25-2 99.95%
    Quercetin 3-O-β-D-glucofuranoside is an effective antioxidant and an eosinophilic inflammation suppressor.
    Quercetin 3-O-β-D-glucofuranoside
  • HY-N15632
    D-Sarmentose 90-56-2
    D-Sarmentose can be extracted from the leaves of Nerium oleander L.. D-Sarmentose can be isolated and purified by use of PVP- and charcoal treatment and further separated by paper chromatography and electrophoresis.
    D-Sarmentose
  • HY-N15753
    Tetrahydroellipticine 6538-51-8
    Tetrahydroellipticine is an alkaloid that can be isolated from the seeds and root-bark of Pterotaberna inconspicua.
    Tetrahydroellipticine
  • HY-N16416
    Dregamine 2299-26-5
    Dregamine is a monoterpene indole organism that can be isolated from methanol extracts of bamboo and rattan roots and can induce apoptosis. Dregamine has anti-tumor activity.
    Dregamine
  • HY-13295
    Vinpocetine 42971-09-5 99.57%
    Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels. The IC50 value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders.
    Vinpocetine
  • HY-N2331
    Proscillaridin A 466-06-8 99.74%
    Proscillaridin A is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively.
    Proscillaridin A
  • HY-15753
    Ellipticine 519-23-3 99.56%
    Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.
    Ellipticine
  • HY-129071
    Vindesine sulfate 59917-39-4 99.91%
    Vindesine sulfate is a potent tubulin inhibitor with an Ki of 0.110 μM. Vindesine sulfate shows anti-proliferation effect in vitro. Vindesine sulfate shows antitumor effect in vivo.
    Vindesine sulfate
  • HY-N2183
    Baimaside 18609-17-1 99.57%
    Baimaside (Quercetin 3-O-sophoroside) is isolated from the flowers of A. venetum, is a scavenger of superoxide anions.
    Baimaside
  • HY-13719
    Oleandrin 465-16-7 99.91%
    Oleandrin (PBI-05204) inhibits the Na+, K+-ATPase activity with an IC50 of 620 nM.
    Oleandrin
  • HY-15753A
    Ellipticine hydrochloride 5081-48-1 99.34%
    Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.
    Ellipticine hydrochloride
  • HY-N11692
    9-Hydroxyoctadecanoic acid 3384-24-5 98.0%
    9-Hydroxyoctadecanoic acid (9-HSA) is an HDAC1 inhibitor that inhibits ∼66.4% HDAC1 enzymatic activity at 5 μM. 9-Hydroxyoctadecanoic acid shows anticancer activity.
    9-Hydroxyoctadecanoic acid
  • HY-N0480A
    Reserpine hydrochloride 16994-56-2 99.87%
    Reserpine hydrochloride is an inhibitor of the vesicular monoamine transporter 2 (VMAT2).
    Reserpine hydrochloride
  • HY-N0252
    Catharanthine 2468-21-5 99.65%
    Catharanthine ((+)-3,4-Didehydrocoronaridine), a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca2+ channel (VOCC). Catharanthine has IC50s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine lowers blood pressure (BP), heart rate (HR). Catharanthine has anti-cancer activity.
    Catharanthine
  • HY-B1167
    Ajmaline 4360-12-7 99.73%
    Ajmaline (Cardiorythmine) is a sodium channel blocking, class 1A anti-arrhythmic agent. Ajmaline blocks HERG currents with an IC50 of 1 μM in HEK cells and 42.3 μM in Xenopus oocytes. Ajmaline can be used for the research of the ventricular tachyarrhythmia.
    Ajmaline
  • HY-W011151
    trans-Zeatinriboside 6025-53-2 99.28%
    trans-Zeatinriboside is a type of cytokinin precursor, acts as a major long-distance signalling form in xylem vessels, regulates leaf size and meristem activity-related traits.
    trans-Zeatinriboside