2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. BRI-50460

BRI-50460 is an inhibitor of cytosolic calcium-dependent phospholipase A2 (cPLA2) that has the ability to penetrate the blood-brain barrier, with an IC50 of 0.88 nM. BRI-50460 exerts the activities of regulating neuroinflammation and restoring lipid homeostasis by inhibiting cPLA2, regulating the downstream inflammatory lipid signaling pathway, and alleviating the effects of amyloid β42 oligomers on the activation of cPLA2, the hyperphosphorylation of tau protein, and the reduction of synapses and dendrites. BRI-50460 can be applied to the research in the fields of Alzheimer's disease and other neurodegenerative diseases.

For research use only. We do not sell to patients.

BRI-50460 Chemical Structure

BRI-50460 Chemical Structure

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BRI-50460 Related Antibodies

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Phospholipase A PLD Phospholipase C

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Description

BRI-50460 is an inhibitor of cytosolic calcium-dependent phospholipase A2 (cPLA2) that has the ability to penetrate the blood-brain barrier, with an IC50 of 0.88 nM. BRI-50460 exerts the activities of regulating neuroinflammation and restoring lipid homeostasis by inhibiting cPLA2, regulating the downstream inflammatory lipid signaling pathway, and alleviating the effects of amyloid β42 oligomers on the activation of cPLA2, the hyperphosphorylation of tau protein, and the reduction of synapses and dendrites. BRI-50460 can be applied to the research in the fields of Alzheimer's disease and other neurodegenerative diseases[1].

Molecular Weight

394.44

Formula

C21H18N2O4S
Appearance

Solid

Color

White to off-white

SMILES

O=C(CC1)NC2=C1C=CC(NS(C3=CC=CC(OC4=CC=CC=C4)=C3)(=O)=O)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (253.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5352 mL 12.6762 mL 25.3524 mL
5 mM 0.5070 mL 2.5352 mL 5.0705 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5352 mL 12.6762 mL 25.3524 mL 63.3810 mL
5 mM 0.5070 mL 2.5352 mL 5.0705 mL 12.6762 mL
10 mM 0.2535 mL 1.2676 mL 2.5352 mL 6.3381 mL
15 mM 0.1690 mL 0.8451 mL 1.6902 mL 4.2254 mL
20 mM 0.1268 mL 0.6338 mL 1.2676 mL 3.1690 mL
25 mM 0.1014 mL 0.5070 mL 1.0141 mL 2.5352 mL
30 mM 0.0845 mL 0.4225 mL 0.8451 mL 2.1127 mL
40 mM 0.0634 mL 0.3169 mL 0.6338 mL 1.5845 mL
50 mM 0.0507 mL 0.2535 mL 0.5070 mL 1.2676 mL
60 mM 0.0423 mL 0.2113 mL 0.4225 mL 1.0563 mL
80 mM 0.0317 mL 0.1585 mL 0.3169 mL 0.7923 mL
100 mM 0.0254 mL 0.1268 mL 0.2535 mL 0.6338 mL
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BRI-50460 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRI-50460BRI50460BRI 50460PhospholipaseInhibitorinhibitorinhibit

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