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Aprindine hydrochloride-d<sub>10</sub>

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-A0236A
    Aprindine hydrochloride

    		Potassium Channel Cardiovascular Disease
    Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a hERG channel blocker with an IC50 of 0.23 μM. Aprindine hydrochloride has inhibitory effects on Na+/Ca2+ exchanger currents, which is partly responsible for their antiarrhythmic and cardioprotective effects. Aprindine hydrochloride is widely used for trial and ventricular tachyarrhythmias research research.
    Aprindine hydrochloride
  • HY-A0236
    Aprindine

    		Calmodulin Cardiovascular Disease
    Aprindine is an arrhythmia inhibitor that stabilizes the cell membranes of heart muscle cells, thereby preventing abnormal electrical impulses from causing irregular heartbeats. In hematological toxicity studies, aprindine showed potential inhibitory effects on the replicative capacity of mouse and human blood cells at certain concentrations .
    Aprindine
  • HY-103509
    NNC 05-2090 hydrochloride

    		GABA Receptor Neurological Disease
    NNC 05-2090 hydrochloride is a GABA uptake inhibitor and inhibitor of the β-GABA transporter (BGT-1) (IC50< /sub>: 10.6 μM). NNC 05-2090 hydrochloride also inhibits mGAT2 with a Ki value of 1.4 μM. NNC 05-2090 has anticonvulsant activity and can be used in the study of epilepsy and neurological diseases .
    NNC 05-2090 hydrochloride
  • HY-W710915
    Aprindine hydrochloride-d10

    		Isotope-Labeled Compounds Potassium Channel Cardiovascular Disease
    Aprindine hydrochloride-d10 is the deuterium labeled Aprindine hydrochloride (HY-A0236A). Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a hERG channel blocker with an IC50 of 0.23 μM. Aprindine hydrochloride has inhibitory effects on Na+/Ca2+ exchanger currents, which is partly responsible for their antiarrhythmic and cardioprotective effects. Aprindine hydrochloride is widely used for trial and ventricular tachyarrhythmias research research.
    Aprindine hydrochloride-d10
  • HY-A0236AR
    Aprindine hydrochloride (Standard)

    		Potassium Channel Cardiovascular Disease
    Aprindine (hydrochloride) (Standard) is the analytical standard of Aprindine (hydrochloride). This product is intended for research and analytical applications. Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a hERG channel blocker with an IC50 of 0.23 μM. Aprindine hydrochloride has inhibitory effects on Na+/Ca2+ exchanger currents, which is partly responsible for their antiarrhythmic and cardioprotective effects. Aprindine hydrochloride is widely used for trial and ventricular tachyarrhythmias research research.
    Aprindine hydrochloride (Standard)
  • HY-A0082S
    Diphenidol-d10 hydrochloride

    Difenidol hydrochloride-d<sub>10sub>

    		 Isotope-Labeled Compounds Sodium Channel mAChR Neurological Disease
    Diphenidol-d10 (hydrochloride) (Difenidol hydrochloride-d10) is deuterium labeled Diphenidol (hydrochloride). Diphenidol hydrochloride (Difenidol hydrochloride) is a non-selective muscarinic M1-M4 receptor antagonist, has anti-arrhythmic activity. Diphenidol hydrochloride is also a potent non-specific blocker of voltage-gated ion channels (Na +, K +, and Ca 2+) in neuronal cells. Diphenidol hydrochloride can be used in the study of antivertigo and antinausea .
    Diphenidol-d10 hydrochloride
  • HY-W726429
    Apomorphine hydrochloride-d4

    (-)-Apomorphine hydrochloride-d<sub>4sub>

    		 Isotope-Labeled Compounds Others
    Apomorphine hydrochloride-d4 ((-)-Apomorphine hydrochloride-d4) is the deuterium labeled Apomorphine hydrochloride.
    Apomorphine hydrochloride-d4
  • HY-W701551
    4-Hydrazinylbenzoic acid hydrochloride-d4

    p-Hydrazinobenzoic acid hydrochloride-d<sub>4sub>

    		 Isotope-Labeled Compounds Others
    4-Hydrazinylbenzoic acid hydrochloride-d4 (p-Hydrazinobenzoic acid hydrochloride-d4) is the deuterium labeled 4-Hydrazinylbenzoic acid hydrochloride (HY-W015269).
    4-Hydrazinylbenzoic acid hydrochloride-d4
  • HY-120146
    NNC 05-2090

    		GABA Receptor Neurological Disease
    NNC 05-2090 is aGABA uptake inhibitor and inhibitor of the β-GABA transporter (BGT-1) (IC50 sub>: 10.6 μM). NNC 05-2090 also inhibits mGAT2 with a Ki value of 1.4 μM. NNC 05-2090 has anticonvulsant activity and can be used in the study of epilepsy and neurological diseases .
    NNC 05-2090
  • HY-W744750
    TDHL-d10

    Tergurid-d<sub>10sub>; Terguride-d<sub>10sub>; trans-Dihydrolisuride-d<sub>10sub>

    		 Isotope-Labeled Compounds Dopamine Receptor 5-HT Receptor Neurological Disease
    TDHL-d10 (Tergurid-d10; Terguride-d10; trans-Dihydrolisuride-d10) is the deuterium labeled TDHL (HY-12714). TDHL (Tergurid) is a dopamine receptor agonist with a Kd of 0.39 nM for D2 receptor and an orally available 5-HT-2 receptor antagonist.
    TDHL-d10
  • HY-N7434S1
    N-Nitrosodiethylamine-d10

    Diethylnitrosamine-d<sub>10sub>; DEN-d<sub>10sub>; DENA-d<sub>10sub>

    		 DNA/RNA Synthesis Cancer
    N-Nitrosodiethylamine-d10 is the deuterium labeled N-Nitrosodiethylamine . N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.
    N-Nitrosodiethylamine-d10
  • HY-16562S
    Irinotecan-d10

    (+)-Irinotecan-d<sub>10sub>; CPT-11-d<sub>10sub>; VAL-413-d<sub>10sub>

    		 Topoisomerase Autophagy Cancer
    Irinotecan-d10 is a deuterium labeled Irinotecan ((+)-Irinotecan). Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .
    Irinotecan-d10
  • HY-100703S
    Pipamperone-d10 dihydrochloride

    Floropipamide-d<sub>10sub> dihydrochloride; McN-JR 3345-d<sub>10sub> dihydrochloride; R 3345-d<sub>10sub> dihydrochloride

    		 Isotope-Labeled Compounds Dopamine Receptor 5-HT Receptor Neurological Disease
    Pipamperone-d10 (Floropipamide-d10) dihydrochloride is a deuterated Pipamperone dihydrochloride (HY-100703A). Pipamperone dihydrochloride (Floropipamide dihydrochloride) is a butyrophenone derivative and high-affinity antagonist of 5-HT2A receptor (pKi=8.2) and D4 receptor (pKi=8.0). Pipamperone dihydrochloride is also a low-affinity antagonist of D2 receptor (pKi=6.7). Pipamperone dihydrochloride affects neurotransmitter functions and exerts antipsychotic activity. Pipamperone dihydrochloride is used in the research of mental disorders such as autism-related behavioral disorders and Alzheimer's disease .
    Pipamperone-d10 dihydrochloride
  • HY-Y0504S1
    Trimethylammonium chloride-d10

    Hegzadesil-d<sub>10sub>; Trimethylamine hydrochloric acid-d<sub>10sub>; Trimethylamine monohydrochloride-d<sub>10sub>

    		 Endogenous Metabolite Metabolic Disease
    Trimethylammonium chloride-d10 is the deuterium labeled Trimethylammonium chloride . Trimethylammonium chloride is an endogenous metabolite.
    Trimethylammonium chloride-d10
  • HY-13738S4
    Raloxifene-d10-1

    Keoxifene-d<sub>10sub>; LY156758(free base)-d<sub>10sub>; LY139481-d<sub>10sub>

    		 Estrogen Receptor/ERR Cancer
    Raloxifene-d10-1 is the deuterium labeled Raloxifene . Raloxifene (Keoxifene) is a benzothiophene-derived selective estrogen receptor modulator (SERM). Raloxifene has estrogen-agonistic effects on bone and lipids and estrogen-antagonistic effects on the breast and uterus. Raloxifene is used for breast cancer and osteoporosis research .
    Raloxifene-d10-1
  • HY-B1550S
    Benzoin-d10

    DL-Benzoin-d<sub>10sub>; Desyl alcohol-d<sub>10sub>; (±)-2-Hydroxy-2-phenylacetophenone-d<sub>10sub>

    		 Isotope-Labeled Compounds PI3K Cancer
    Benzoin-d10 (DL-Benzoin-d10) is the deuterium labeled Benzoin (HY-B1550). Benzoin (DL-Benzoin), a natural balsamic resin, is a PI3Kα inhibitor with anticancer effects. Benzoin inihits the growth of colon cancer cell line (HCT-116). Benzoin can be used as a food additive .
    Benzoin-d10
  • HY-B0246S
    Carbamazepine-d10

    CBZ-d<sub>10sub>; NSC 169864-d<sub>10sub>

    		 Sodium Channel Autophagy Mitophagy Neurological Disease Cancer
    Carbamazepine-d10 is the deuterium labeled Carbamazepine. Carbamazepine (CBZ), a sodium channel blocker, is an anticonvulsant agent .
    Carbamazepine-d10
  • HY-W654320
    Piperin-d10

    Bioperine-d<sub>10sub>; 1-Piperoylpiperidine-d<sub>10sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite P-glycoprotein Autophagy Cancer
    Piperin-d10 is deuterium labeled Piperine. Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC50 of 61.94±0.054 μg/mL .
    Piperin-d10
  • HY-W709448
    Oxaprozin-d10

    Oxaprozinum-d<sub>10sub>; Wy21743-d<sub>10sub>

    		 Isotope-Labeled Compounds Apoptosis COX Akt IKK NF-κB Inflammation/Immunology
    Oxaprozin-d10 (Oxaprozinum-d10; Wy21743-d10) is the deuterium labeled Oxaprozin (HY-B0808). Oxaprozin is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB. Oxaprozin induces cell apoptosis. Oxaprozin shows anti-inflammatory activity. Oxaprozin-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties .
    Oxaprozin-d10
  • HY-Y0727S1
    1,5-Dibromopentane-d10

    1,5-Pentanedibromide-d<sub>10sub>; Pentamethylene bromide-d<sub>10sub>; Pentamethylene dibromide-d<sub>10sub>

    		 Isotope-Labeled Compounds Others
    1,5-Dibromopentane-d10 is the deuterium labeled 1,5-Dibromopentane .
    1,5-Dibromopentane-d10
  • HY-B1674S
    (±)-Leucine-d10

    DL-Leucine-d<sub>10sub>; (RS)-Leucine-d<sub>10sub>

    		 Endogenous Metabolite Bacterial Metabolic Disease
    (±)-Leucine-d10 is the deuterium labeled (±)-Leucine. (±)-Leucine (DL-Leucine), an isomer of Leucine, chemosterilant and dietary additive. (±)-Leucine inhibits growth of Escherichia coli HfrH by 92.08% .
    (±)-Leucine-d10
  • HY-13272S3
    Dacomitinib-d10

    PF-00299804-d<sub>10sub>; PF-299804-d<sub>10sub>

    		 Isotope-Labeled Compounds EGFR Apoptosis Cancer
    Dacomitinib-d10 is deuterium labeled Dacomitinib. Dacomitinib (PF-00299804) is a specific and irreversible inhibitor of the ERBB family of kinases with IC50s of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively .
    Dacomitinib-d10
  • HY-B0801AS
    Fexofenadine-d10 hydrochloride

    MDL-16455-d<sub>10sub> hydrochloride; Terfenadine carboxylate-d<sub>10sub> hydrochloride

    		 Isotope-Labeled Compounds Histamine Receptor Inflammation/Immunology Endocrinology
    Fexofenadine-d10 (hydrochloride) is deuterium labeled Fexofenadine (hydrochloride). Fexofenadine hydrochloride (MDL-16455 hydrochloride), a H1R antagonist, is an anti-allergic agent used in seasonal allergic rhinitis and chronic idiopathic urticarial (person aged ≥16 years) .
    Fexofenadine-d10 hydrochloride
  • HY-13272S2
    Dacomitinib-d10 dihydrochloride

    PF-00299804-d<sub>10sub> dihydrochloride; PF-299804-d<sub>10sub> dihydrochloride

    		 Isotope-Labeled Compounds EGFR Apoptosis Cancer
    Dacomitinib-d10 dihydrochloride is the deuterium labeled Dacomitinib dihydrochloride. Dacomitinib (PF-00299804) dihydrochloride is a specific and irreversible inhibitor of the ERBB family of kinases with IC50s of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively .
    Dacomitinib-d10 dihydrochloride
  • HY-13209S
    Ambrisentan-d10

    BSF 208075-d<sub>10sub>; LU 208075-d<sub>10sub>

    		 Isotope-Labeled Compounds Cardiovascular Disease
    Ambrisentan-d10 (BSF 208075-d10; LU 208075-d10) is the deuterium labled Ambrisentan (HY-13209). Ambrisentan is a selective ET type A receptor (ETAR) antagonist.
    Ambrisentan-d10
  • HY-Y1044S
    1,5-Dihydroxypentane-d10

    1,5-Pentamethylene glycol-d<sub>10sub>; Pentamethylene glycol-d<sub>10sub>; Pentylene glycol-d<sub>10sub>

    		 Isotope-Labeled Compounds Others
    1,5-Dihydroxypentane-d10 is the deuterium labeled 1,5-Dihydroxypentane .
    1,5-Dihydroxypentane-d10
  • HY-W728545
    Labetalol-d6 hydrochloride

    AH5158-d<sub>6sub> hydrochloride; Sch-15719W-d<sub>6sub>

    		 Isotope-Labeled Compounds Cardiovascular Disease Inflammation/Immunology Endocrinology
    Labetalol hydrochloride-d6 (AH-5158 hydrochloride-d6) is deuterium labeled Labetalol hydrochloride (HY-B1108). Labetalol (AH5158) hydrochloride is an orally available, selective α1-adrenergic recepto and non-selective β-adrenergic receptor competitive antagonist. Labetalol hydrochloride is an antihypertensive molecule that partially crosses the blood-brain barrier and has little effect on cardiac output. Labetalol hydrochloride can be used in the study of cardiovascular diseases, such as hypertension during pregnancy .
    Labetalol-d6 hydrochloride
  • HY-B1108S
    Labetalol hydrochloride-d5

    AH-5158 hydrochloride-d<sub>5sub>; Sch-15719W-d<sub>5sub>

    		 Isotope-Labeled Compounds Cardiovascular Disease Inflammation/Immunology Endocrinology
    Labetalol hydrochloride-d5 (AH-5158 hydrochloride-d5) is deuterium labeled Labetalol hydrochloride (HY-B1108). Labetalol (AH5158) hydrochloride is an orally available, selective α1-adrenergic recepto and non-selective β-adrenergic receptor competitive antagonist. Labetalol hydrochloride is an antihypertensive molecule that partially crosses the blood-brain barrier and has little effect on cardiac output. Labetalol hydrochloride can be used in the study of cardiovascular diseases, such as hypertension during pregnancy .
    Labetalol hydrochloride-d5
  • HY-146227
    DNA topoisomerase II inhibitor 1

    		Topoisomerase Apoptosis Cancer
    DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .
    DNA topoisomerase II inhibitor 1
  • HY-RS13999
    SUB1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SUB1 Human Pre-designed siRNA Set A
    SUB1 Human Pre-designed siRNA Set A
  • HY-RS18793
    Sub1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Sub1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sub1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Sub1 Mouse Pre-designed siRNA Set A
    Sub1 Mouse Pre-designed siRNA Set A
  • HY-RS25282
    Sub1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Sub1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sub1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Sub1 Rat Pre-designed siRNA Set A
    Sub1 Rat Pre-designed siRNA Set A
  • HY-W701541
    6-Aminocaproic acid-d10 hydrochloride

    EACA-d<sub>10sub> hydrochloride; Epsilon-Amino-n-caproic Acid-d<sub>10sub> hydrochloride; 6-Aminohexanoic acid-d<sub>10sub> hydrochloride

    		 Isotope-Labeled Compounds PAI-1 Drug Derivative Cancer
    6-Aminocaproic acid-d10 hydrochloride (EACA-d10 hydrochloride; Epsilon-Amino-n-caproic Acid-d10 hydrochloride; 6-Aminohexanoic acid-d10 hydrochloride) is the deuterium labeled 6-Aminocaproic acid hydrochloride (HY-B0236A). 6-Aminocaproic acid hydrochloride, a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders .
    6-Aminocaproic acid-d10 hydrochloride
  • HY-B0236S1
    6-Aminocaproic acid-d10

    EACA-d<sub>10sub>; Epsilon-Amino-n-caproic Acid-d<sub>10sub>; 6-Aminohexanoic acid-d<sub>10sub>

    		 Isotope-Labeled Compounds Metabolic Disease
    6-Aminocaproic acid-d10 is the deuterium labeled 6-Aminocaproic acid. 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders .
    6-Aminocaproic acid-d10
  • HY-B0978S
    Diethyltoluamide-d10

    DEET-d<sub>10sub>; N,N-Diethyl-m-toluamide-d<sub>10sub>

    		 Parasite Infection
    Diethyltoluamide-d10 is the deuterium labeled Diethyltoluamide . Diethyltoluamide is the most common active ingredient in insect repellents. It is intended to provide protection against mosquitoes, ticks, fleas, chiggers, leeches, and many other biting insects .
    Diethyltoluamide-d10
  • HY-W778582
    2-Aminoacetophenone-d5 hydrochloride

    α-Amino acetophenone hydrochloride-d<sub>5sub> hydrochloride

    		 Isotope-Labeled Compounds Others
    2-Aminoacetophenone-d5 hydrochloride (α-Amino acetophenone hydrochloride-d5 hydrochloride) is the deuterium labeled 2-Aminoacetophenone hydrochloride (HY-W002084).
    2-Aminoacetophenone-d5 hydrochloride
  • HY-14794AS
    Levomilnacipran-d10 hydrochloride

    (1S,2R)-Milnacipran-d<sub>10sub> hydrochloride; F2695-d<sub>10sub> hydrochloride

    		 Isotope-Labeled Compounds Serotonin Transporter Trk Receptor PI3K mTOR P-glycoprotein Akt Neurological Disease Inflammation/Immunology
    Levomilnacipran-d10 ((1S,2R)-Milnacipran-d10) hydrochloride is deuterium labeled Levomilnacipran hydrochloride (HY-B0168B). Levomilnacipran ((1S,2R)-Milnacipran) hydrochloride is the enantiomer of Milnacipran (HY-B0168) and a strong substrate of P-gp that can cross the blood-brain barrier. Levomilnacipran hydrochloride is a serotonin and norepinephrine reuptake inhibitor, with IC50 values of 10.5 nM and 19.0 nM, and Ki values of 92.2 nM and 1.2 nM for human norepinephrine transporter (NET) and serotonin transporter (SERT), respectively. Levomilnacipran hydrochloride has antidepressant and anxiolytic activities. Levomilnacipran hydrochloride can be used for the research of depression .
    Levomilnacipran-d10 hydrochloride
  • HY-W770206
    IDO-IN-7-d10

    NLG-919 analogue-d<sub>10sub>; GDC-0919 analogue-d<sub>10sub>

    		 Isotope-Labeled Compounds Indoleamine 2,3-Dioxygenase (IDO) Cancer
    IDO-IN-7-d10 (NLG-919 analogue-d10; GDC-0919 analogue-d10) is the deuterium labeled IDO-IN-7 (HY-13983). IDO-IN-7 (NLG-919 analogue) is a a potent IDO1 inhibitor with an IC50 of 38 nM.
    IDO-IN-7-d10
  • HY-B0134S1
    Bestatin-d10

    Ubenimex-d<sub>10sub>

    		 Isotope-Labeled Compounds Bacterial Antibiotic Aminopeptidase Infection Cancer
    Bestatin-d10 (Ubenimex-d10) is deuterium labeled Bestatin. Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor. Bestatin has anticancer effects .
    Bestatin-d10
  • HY-B0535S1
    Ethambutol-d10

    Emb-d<sub>10sub>

    		 Bacterial Antibiotic Infection
    Ethambutol-d10 is the deuterium labeled Ethambutol. Ethambutol is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases.
    Ethambutol-d10
  • HY-Y1067S
    Dibenzylamine-d10

    Bisbenzylamine-d<sub>10sub>

    		 Isotope-Labeled Compounds Others
    Dibenzylamine-d10 (Bisbenzylamine-d10) is the deuterium labeled Dibenzylamine .
    Dibenzylamine-d10
  • HY-W004059S1
    Diphenylmethanol-d10

    Benzhydrol-d<sub>10sub>

    		 Isotope-Labeled Compounds Biochemical Assay Reagents Others
    Diphenylmethanol-d10 (Benzhydrol-d10) is the deuterium labeled Benzhydrol (HY-W004059). Diphenylmethanol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Diphenylmethanol-d10
  • HY-W721874
    Adrenosterone-d10

    (+)-Adrenosterone-d<sub>10sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite Androgen Receptor Cancer
    Adrenosterone-d10 ((+)-Adrenosterone-d10) is the deuterium labeled Adrenosterone (HY-17462). Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells .
    Adrenosterone-d10
  • HY-B1322AS1
    Amodiaquine-d10 hydrochloride

    Amodiaquin-d<sub>10sub>

    		 Nuclear Hormone Receptor 4A/NR4A Parasite Histone Methyltransferase Isotope-Labeled Compounds Infection Neurological Disease Inflammation/Immunology
    Amodiaquine-d10 hydrochloride is deuterated labeled Amodiaquine (HY-B1322A). Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect .
    Amodiaquine-d10 hydrochloride
  • HY-12199S
    Pitolisant-d10

    Tiprolisant-d<sub>10sub>

    		 Isotope-Labeled Compounds Histamine Receptor Neurological Disease Endocrinology
    Pitolisant-d10 (Tiprolisant-d10) is deuterium labeled Pitolisant. Pitolisant is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM) .
    Pitolisant-d10
  • HY-B1637S
    Ditiocarb-d10 sodium

    Sodium diethyldithiocarbamate-d<sub>10sub> sodium

    		 Isotope-Labeled Compounds HIV Biochemical Assay Reagents Infection Inflammation/Immunology Cancer
    Ditiocarb-d10 sodium (Sodium diethyldithiocarbamate-d10) is the deuterium labeled Ditiocarb sodium (HY-B1637). Ditiocarb sodium (Sodium diethyldithiocarbamate) is an orally active copper reagent. Ditiocarb sodium exhibits activities such as antioxidation, chelation, anti-tumor effects, immunomodulation, and anti-HIV properties. Ditiocarb sodium can be used in the research of tumors, inflammatory, and immune-related diseases .
    Ditiocarb-d10 sodium
  • HY-N0411S4
    β-Carotene-13C10

    Provitamin A-<sub>13<sub>C<sub>10<sub>; beta-Carotene-<sub>13<sub>C<sub>10<sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite Apoptosis Reactive Oxygen Species (ROS) Metabolic Disease Cancer
    β-Carotene- 13C10 (Provitamin A- 13C10) is the 13C-labeled β-Carotene (HY-N0411). β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities .
    β-Carotene-13C10
  • HY-N1150S11
    Thymidine-13C10

    DThyd-13C<sub>10sub>; NSC 21548-13C<sub>10sub>

    		 Isotope-Labeled Compounds DNA/RNA Synthesis Endogenous Metabolite Orthopoxvirus Cancer
    Thymidine- 13C10 (DThyd- 13C10; NSC 21548- 13C10) is 13C-labeled Thymidine (HY-N1150). Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.
    Thymidine-13C10
  • HY-N0097S4
    Guanosine-13C10

    DL-Guanosine-13C<sub>10sub>; Vernine-13C<sub>10sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite HSV Infection
    Guanosine- 13C10 is the 13C labeled Guanosine (HY-N0097). Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity .
    Guanosine-13C10
  • HY-B0228S13
    Adenosine-13C10

    Adenine riboside-13C<sub>10sub>; D-Adenosine-13C<sub>10sub>

    		 Isotope-Labeled Compounds Nucleoside Antimetabolite/Analog Endogenous Metabolite Autophagy Apoptosis Metabolic Disease Cancer
    Adenosine- 13C10 (Adenine riboside- 13C10; D-Adenosine- 13C10) is 13C-labeled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
    Adenosine-13C10

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