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CML-d<sub>4</sub>

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4305

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4214

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Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W286743S1
    CML-d3

    N6-(Carboxymethyl)-L-lysine-d<sub>3sub>; Nε-(1-Carboxymethyl)-L-lysine-d<sub>3sub>

    		 Isotope-Labeled Compounds Others
    CML-d3 is the deuterium labeled CML.
    CML-d3
  • HY-W286743S
    CML-d4

    		Isotope-Labeled Compounds Others
    CML-d4 is the deuterium labeled Fmoc-L-Lys (Boc)-OH .
    CML-d4
  • HY-124828
    CMLD-2
    1 Publications Verification

    		 HuR Cancer
    CMLD-2, an inhibitor of HuR-ARE interaction, competitively binds HuR protein disrupting its interaction with adenine-uridine rich elements (ARE)-containing mRNAs (Ki=350 nM). CMLD-2 induces apoptosis exhibits antitumor activity in different cancer cells as colon, pancreatic, thyroid and lung cancer cell lines. Hu antigen R (HuR) is an RNA binding protein, can regulate target mRNAs stability and translation .
    CMLD-2
  • HY-146227
    DNA topoisomerase II inhibitor 1

    		Topoisomerase Apoptosis Cancer
    DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .
    DNA topoisomerase II inhibitor 1
  • HY-RS13999
    SUB1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SUB1 Human Pre-designed siRNA Set A
    SUB1 Human Pre-designed siRNA Set A
  • HY-RS18793
    Sub1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Sub1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sub1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Sub1 Mouse Pre-designed siRNA Set A
    Sub1 Mouse Pre-designed siRNA Set A
  • HY-RS25282
    Sub1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Sub1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sub1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Sub1 Rat Pre-designed siRNA Set A
    Sub1 Rat Pre-designed siRNA Set A
  • HY-176746
    CMLD009688

    		Fungal Infection
    CMLD009688 is a cationic amphiphilic antifungal agent. CMLD009688 selectively inhibits plant pathogenic fungi such as Fusarium graminearum. CMLD009688 interacts with biological membranes, perturbing vacuolar and mitochondrial membrane structures to induce fungal cell death. CMLD009688 is promising for research of plant fungal diseases (e.g., wheat head blight, gray mold) .
    CMLD009688
  • HY-129769
    CMLD012073

    		Eukaryotic Initiation Factor (eIF) Cancer
    CMLD012073 is an amidino-rocaglates and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012073 inhibits the growth of NIH/3T3 cells with an IC50 of 10 nM. CMLD012073 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A) .
    CMLD012073
  • HY-129767
    CMLD012612

    		Eukaryotic Initiation Factor (eIF) Cancer
    CMLD012612 is an amidino-rocaglate containing a hydroxamate group and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012612 inhibits cell translation and is cytotoxic to NIH/3T3 cells with an IC50 value of 2 nM. CMLD012612 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A) and possesses potent anti-neoplastic activity .
    CMLD012612
  • HY-129768
    CMLD012072

    		Eukaryotic Initiation Factor (eIF) Cancer
    CMLD012072 is an amidino-rocaglates and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012072 can induce RNA clamping of eIF4A1 and eIF4A2 and possess potent anti-neoplastic activity .
    CMLD012072
  • HY-119271A
    (-)-CMLD010509

    (-)-SDS-1-021

    		 c-Myc Apoptosis Cancer
    (-)-CMLD010509 ((-)-SDS-1-021) is an isomer of CMLD010509 (SDS-1-021) (HY-119271). CMLD010509 (SDS-1-021) is a highly specific inhibitor of the oncogenic translation program supporting multiple myeloma (MM)-including key oncoproteins such as MYC, MDM2, CCND1, MAF, and MCL-1. CMLD010509 (SDS-1-021) shows an IC50 below 10 nM for most MM cell lines and induces apoptosis. CMLD010509 (SDS-1-021) is a potent and selective translation inhibitor through an eIF4E phosphorylation-independent mechanism .
    (-)-CMLD010509
  • HY-119271
    CMLD010509

    SDS-1-021

    		 c-Myc Apoptosis Cancer
    CMLD010509 (SDS-1-021) is a highly specific inhibitor of the oncogenic translation program supporting multiple myeloma (MM)-including key oncoproteins such as MYC, MDM2, CCND1, MAF, and MCL-1. CMLD010509 (SDS-1-021) shows an IC50 below 10 nM for most MM cell lines and induces apoptosis. CMLD010509 (SDS-1-021) is a potent and selective translation inhibitor through an eIF4E phosphorylation-independent mechanism .
    CMLD010509
  • HY-10844S1
    Pretomanid-d5

    PA-824-d<sub>5sub>; (S)-PA 824-d<sub>5sub>

    		 Antibiotic Bacterial Isotope-Labeled Compounds Infection Cancer
    Pretomanid-d5 is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.
    Pretomanid-d5
  • HY-P10215
    Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2

    		Parasite Infection
    Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent Plasmodium subtilisin-like protease 1 (SUB1) inhibitor. SUB1-IN-1 shows IC50 values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively .
    Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2
  • HY-41680S
    4-Aminobenzonitrile-d4

    4-Aminobenzonitrile-d<sub>4sub>; 4-Cyanoaniline-d<sub>4sub>; 4-Cyanobenzenamine-d<sub>4sub>

    		 Isotope-Labeled Compounds Others
    4-Aminobenzonitrile-d4 is the deuterium labeled 4-Aminobenzonitrile[1].
    4-Aminobenzonitrile-d4
  • HY-66005S
    Acetaminophen-d4

    Paracetamol-d<sub>4sub>; 4-Acetamidophenol-d<sub>4sub>; 4'-Hydroxyacetanilide-d<sub>4sub>

    		 COX Histone Acetyltransferase Endogenous Metabolite Inflammation/Immunology
    Acetaminophen-d4 is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor [4].
    Acetaminophen-d4
  • HY-Y1042S
    4-Cyanophenol-d4

    4-Hydroxybenzonitrile-d<sub>4sub>; 4-Hydroxycyanobenzene-d<sub>4sub>; NSC 400524-d<sub>4sub>

    		 Isotope-Labeled Compounds Others
    4-Cyanophenol-d4 is the deuterium labeled 4-Cyanophenol .
    4-Cyanophenol-d4
  • HY-17413S2
    Zidovudine-d4

    Azidothymidine-d<sub>4sub>; AZT-d<sub>4sub>; ZDV-d<sub>4sub>

    		 Isotope-Labeled Compounds HIV Infection Cancer
    Zidovudine-d4 is deuterated labeled Zidovudine (HY-17413). Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection.
    Zidovudine-d4
  • HY-B1008S
    4-Aminobenzoic acid-d4

    PABA-d<sub>4sub>; Vitamin Bx-d<sub>4sub>; Vitamin H1-d<sub>4sub>; p-Aminobenzoic acid-d<sub>4sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite Others
    4-Aminobenzoic acid-d4 is the deuterium labeled 4-Aminobenzoic acid. 4-Aminobenzoic acid is an intermediate in the synthesis of folate by bacteria, plants, and fungi.
    4-Aminobenzoic acid-d4
  • HY-N7434S
    N-Nitrosodiethylamine-d4

    Diethylnitrosamine-d<sub>4sub>; DEN-d<sub>4sub>; DENA-d<sub>4sub>

    		 DNA/RNA Synthesis Cancer
    N-Nitrosodiethylamine-d4 is the deuterium labeled N-Nitrosodiethylamine . N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.
    N-Nitrosodiethylamine-d4
  • HY-N0006S1
    Demethoxycurcumin-d4

    Curcumin II-d<sub>4sub>; Desmethoxycurcumin-d<sub>4sub>; Monodemethoxycurcumin-d<sub>4sub>

    		 Apoptosis Autophagy Bacterial Cancer
    Demethoxycurcumin-d4 is the deuterium labeled Demethoxycurcumin. Demethoxycurcumin (Curcumin II) is a major active curcuminoid; possess anti-inflammatory properties .
    Demethoxycurcumin-d4
  • HY-W700392
    IMPDH-IN-2

    		IMPDH Cancer
    IMPDH-IN-2 (compound 2) is an inhibitor of inosine monophosphate dehydrogenase (IMPDH) with IC50 for IMPDH I and IMPDH II >Values are 0.15 and 0.17 μM, respectively. IMPDH-IN-2 has antitumor activity .
    IMPDH-IN-2
  • HY-B0389S24
    D-Glucose-d4

    Glucose-d<sub>4sub>; D-(+)-Glucose-d<sub>4sub>; Dextrose-d<sub>4sub>

    		 Endogenous Metabolite Metabolic Disease Cancer
    D-Glucose-d4 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molec
    D-Glucose-d4
  • HY-B0329S
    Isoniazid-d4

    INH-d<sub>4sub>; Isonicotinic acid hydrazide-d<sub>4sub>; Isonicotinic hydrazide-d<sub>4sub>

    		 Bacterial Autophagy Mitophagy Antibiotic Infection
    Isoniazid-d4 is the deuterium labeled Isoniazid. Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity [4].
    Isoniazid-d4
  • HY-B0696S1
    Tiagabine-d4

    NO050328-d<sub>4sub>; NO328-d<sub>4sub>; TGB-d<sub>4sub>

    		 Isotope-Labeled Compounds Neurological Disease
    Tiagabine-d4 (NO050328-d4) is deuterium labeled Tiagabine. Tiagabine (NO050328) is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182 nM for [ 3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively .
    Tiagabine-d4
  • HY-109015S
    Tucidinostat-d4

    Chidamide-d<sub>4sub>; HBI-8000-d<sub>4sub>; CS 055-d<sub>4sub>

    		 Isotope-Labeled Compounds HDAC Cancer
    Tucidinostat-d4 is the deuterium labeled Tucidinostat. Tucidinostat is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, respectively .
    Tucidinostat-d4
  • HY-B0213S
    Sulfameter-d4

    Sulfametoxydiazine-d<sub>4sub>; 5-Methoxysulfadiazine-d<sub>4sub>; NSC 683528-d<sub>4sub>

    		 Isotope-Labeled Compounds Antibiotic Bacterial Infection
    Sulfameter-d4 (Sulfametoxydiazine-d4) is the deuterium labeled Sulfameter (HY-B0213) . Sulfameter (Sulfametoxydiazine) is an orally active long-acting sulfonamide antibiotic. Sulfameter is active against both Gram-positive and Gram-negative bacteria. Sulfameter can be used for the research of diseases such as respiratory and urinary tract infections .
    Sulfameter-d4
  • HY-19696AS
    Tauroursodeoxycholate-d4 sodium

    Tauroursodeoxycholic acid-d<sub>4sub> sodium; TUDCA-d<sub>4sub> sodium; UR 906-d<sub>4sub> sodium

    		 Isotope-Labeled Compounds ERK Caspase Apoptosis Endogenous Metabolite Cancer
    Tauroursodeoxycholate-d4 (sodium) is the deuterium labeled Tauroursodeoxycholate sodium. Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.
    Tauroursodeoxycholate-d4 sodium
  • HY-13273S
    Ostarine-d4

    MK-2866-d<sub>4sub>; GTX-024-d<sub>4sub>; Enobosarm-d<sub>4sub>

    		 Isotope-Labeled Compounds Androgen Receptor Cancer
    Ostarine-d4 is a deuterated labeled Ostarine .
    Ostarine-d4
  • HY-118861S
    Enclomiphene-d4 hydrochloride

    (E) -Clomiphene-d<sub>4sub> hydrochloride; trans-Clomiphene-d<sub>4sub> hydrochloride; Enclomifene-d<sub>4sub> hydrochloride

    		 Isotope-Labeled Compounds Estrogen Receptor/ERR Inflammation/Immunology
    Enclomiphene-d4 hydrochloride is a deuterium labeled Enclomiphene hydrochloride. Enclomiphen hydrochloride is a potent and orally active estrogen receptor antagonist with antioestrogenic property .
    Enclomiphene-d4 hydrochloride
  • HY-118861S1
    Enclomiphene-d4

    (E)-Clomiphene-d<sub>4sub>; trans-Clomiphene-d<sub>4sub> ; Enclomifene-d<sub>4sub>

    		 Isotope-Labeled Compounds Estrogen Receptor/ERR Inflammation/Immunology
    Enclomiphene-d4 ((E)-Clomiphene-d4) is a deuterium labeled Enclomiphene. Enclomiphen is a potent and orally active estrogen receptor antagonist with antioestrogenic property .
    Enclomiphene-d4
  • HY-19696S1
    Tauroursodeoxycholate-d4

    Tauroursodeoxycholic acid-d<sub>4sub>; TUDCA-d<sub>4sub>; UR 906-d<sub>4sub>

    		 Isotope-Labeled Compounds ERK Caspase Endogenous Metabolite Apoptosis Cancer
    Tauroursodeoxycholate-d4 is deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.
    Tauroursodeoxycholate-d4
  • HY-B0696AS
    Tiagabine-d4 hydrochloride

    NO050328-dd<sub>4sub> hydrochloride; NO328-d<sub>4sub> hydrochloride; TGB-d<sub>4sub> hydrochloride

    		 GABA Receptor Isotope-Labeled Compounds Neurological Disease
    Tiagabine-d4 hydrochloride is deuterated labeled Tiagabine hydrochloride (HY-B0696A). Tiagabine hydrochloride is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182 nM for [ 3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively .
    Tiagabine-d4 hydrochloride
  • HY-34498S
    4-Chloro-2-methylphenol-d4

    4-Chloro-o-cresol-d<sub>4sub>; 4-Chlorocresol-d<sub>4sub>; 5-Chloro-2-hydroxytoluene-d<sub>4sub>

    		 Isotope-Labeled Compounds Others
    4-Chloro-2-methylphenol-d4 is the deuterium labeled 4-Chloro-2-methylphenol .
    4-Chloro-2-methylphenol-d4
  • HY-B0017S
    Telbivudine-d4

    Epavudine-d<sub>4sub>; L-Thymidine-d<sub>4sub>; NV 02B-d<sub>4sub>

    		 Isotope-Labeled Compounds HBV Infection
    Telbivudine-d4 is deuterium labeled Telbivudine. Telbivudine (Epavudine), an orally active thymidine nucleoside analog, is a potent antiviral inhibitor of hepatitis B virus (HBV) replication .
    Telbivudine-d4
  • HY-N5034S
    Phosphorylethanolamine-d4

    Monoaminoethyl phosphate-d<sub>4sub>; NSC 254167-d<sub>4sub>; O-Phosphoethanolamine-d<sub>4sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    Phosphorylethanolamine-d4 (Monoaminoethyl phosphate-d4; NSC 254167-d4) is a deuterium labeled Phosphorylethanolamine (HY-N5034). Phosphorylethanolamine is an endogenous metabolite.
    Phosphorylethanolamine-d4
  • HY-10581AS1
    Gatifloxacin-d4 hydrochloride

    AM-1155-d<sub>4sub> hydrochloride; BMS-206584-d<sub>4sub> hydrochloride; PD135432-d<sub>4sub> hydrochloride

    		 Antibiotic Bacterial Topoisomerase Isotope-Labeled Compounds Infection
    Gatifloxacin-d4 (AM-1155-d4; BMS-206584-d4; PD135432-d4) hydrochloride is deuterium-labeled Gatifloxacin (hydrochloride) (HY-10581A) .
    Gatifloxacin-d4 hydrochloride
  • HY-15202S3
    Binimetinib-d4

    MEK162-d<sub>4sub>; ARRY-162-d<sub>4sub>; ARRY-438162-d<sub>4sub>

    		 Isotope-Labeled Compounds Autophagy MEK Cancer
    Binimetinib-d4 (MEK162-d4) is deuterium labeled Binimetinib. Binimetinib (MEK162) is an oral and selective MEK1/2 inhibitor. Binimetinib (MEK162) inhibits MEK with an IC50 of 12 nM.
    Binimetinib-d4
  • HY-78004S1
    1,2-Diphenylethane-d4

    Dibenzil-d<sub>4sub>; s-Diphenylethane-d<sub>4sub>; Bibenzyl-d<sub>4sub>

    		 Isotope-Labeled Compounds Others
    1,2-Diphenylethane-d4 (Dibenzil-d4; s-Diphenylethane-d4; Bibenzyl-d4) is the deuterium labeled Bibenzyl (HY-78004) .
    1,2-Diphenylethane-d4
  • HY-B0579S
    Cyclosporin A-d4

    Cyclosporine A-d<sub>4sub>; Ciclosporin A-d<sub>4sub>; CsA-d<sub>4sub>

    		 Antibiotic Complement System Phosphatase Inflammation/Immunology Cancer
    Cyclosporin A-d4 is the deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 ad
    Cyclosporin A-d4
  • HY-107542S
    Oleoylethanolamide-d4

    N-Oleoylethanolamide-d<sub>4sub>; Oleamide MEA-d<sub>4sub>; Oleic acid monoethanolamide-d<sub>4sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite PPAR Cardiovascular Disease Metabolic Disease
    Oleoylethanolamide-d4 is the deuterium labeled Oleoylethanolamide. Oleoylethanolamide is a high affinity endogenous PPAR-α agonist, which plays an important role in the treatment of obesity and arteriosclerosis.
    Oleoylethanolamide-d4
  • HY-W703540
    Deracoxib-d4

    SC 046-d<sub>4sub>; SC 46-d<sub>4sub>; SC 59046-d<sub>4sub>

    		 Isotope-Labeled Compounds Apoptosis COX Inflammation/Immunology
    Deracoxib-d4 (SC 046-d4) is deuterium labeled Deracoxib.
    Deracoxib-d4
  • HY-16582AS
    Sonidegib-d4

    Erismodegib-d<sub>4sub>; LDE225-d<sub>4sub>; NVP-LDE225-d<sub>4sub>

    		 Isotope-Labeled Compounds Others
    Sonidegib-d4 is a isotope of Sonidegib. Sonidegib is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively .
    Sonidegib-d4
  • HY-50896S2
    Erlotinib-d4

    CP-358774-d<sub>4sub>; NSC 718781-d<sub>4sub>; OSI-774-d<sub>4sub>

    		 Isotope-Labeled Compounds Autophagy EGFR Cancer
    Erlotinib-d4 (CP-358774-d4) is deuterium labeled Erlotinib. Erlotinib (CP-358774) is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer . Erlotinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Erlotinib-d4
  • HY-W701071
    Vatalanib-d4

    PTK787-d<sub>4sub>; ZK-222584-d<sub>4sub>; CGP-79787-d<sub>4sub>

    		 Isotope-Labeled Compounds VEGFR Cancer
    Vatalanib-d4 (PTK787-d4; ZK-222584-d4; CGP-79787-d4) is the deuterium labeled Vatalanib (HY-10203). Vatalanib (PTK787; ZK-222584; CGP-79787) is an inhibitor of VEGFR2/KDR with IC50 of 37 nM.
    Vatalanib-d4
  • HY-W700069
    Gatifloxacin-d4

    AM-1155-d<sub>4sub>; BMS-206584-d<sub>4sub>; PD135432-d<sub>4sub>

    		 Isotope-Labeled Compounds Others
    Gatifloxacin-d4 is the deuterium labeled Gatifloxacin .
    Gatifloxacin-d4
  • HY-N0112S
    Dihydromyricetin-d4

    Ampelopsin-d<sub>4sub>; Ampeloptin-d<sub>4sub>

    		 Isotope-Labeled Compounds Autophagy Influenza Virus mTOR DNA/RNA Synthesis Infection Cancer
    Dihydromyricetin-d4 (Ampelopsin-d4) is deuterium labeled Dihydromyricetin. Dihydromyricetin is a potent inhibitor with an IC50 of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 22 μM.
    Dihydromyricetin-d4
  • HY-17422S1
    Acyclovir-d4

    Aciclovir-d<sub>4sub>; Acycloguanosine-d<sub>4sub>

    		 Isotope-Labeled Compounds HSV Bacterial Apoptosis Antibiotic Infection Cancer
    Acyclovir-d4 is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC50 of 0.85 μM), HSV-2 (IC50 of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination . Acyclovir prevents bacterial infections during induction therapy for acute leukaemia [4].
    Acyclovir-d4
  • HY-B0548AS1
    Hydroxyzine-d4' dihydrochloride

    Vistaril-d<sub>4sub>' dihydrochloride; Atarax-dd<sub>4sub>' dihydrochloride

    		 Histamine Receptor Inflammation/Immunology Endocrinology
    Hydroxyzine-d4 (dihydrochloride) is the deuterium labeled Hydroxyzine dihydrochloride. Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine?H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder .
    Hydroxyzine-d4' dihydrochloride

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