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L-Phenylalanine-d<sub>5</sub>

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0215S3
    L-Phenylalanine-d2

    (S)-2-Amino-3-phenylpropionic acid-d<sub>2sub>

    		 Calcium Channel iGluR Endogenous Metabolite Metabolic Disease
    L-Phenylalanine-d2 is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .
    L-Phenylalanine-d2
  • HY-N0215S1
    L-Phenylalanine-d8

    (S)-2-Amino-3-phenylpropionic acid-d<sub>8sub>

    		 Calcium Channel iGluR Endogenous Metabolite Metabolic Disease
    L-Phenylalanine-d8 is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .
    L-Phenylalanine-d8
  • HY-N0215S12
    L-Phenylalanine-d5
    1 Publications Verification

    		 Calcium Channel iGluR Endogenous Metabolite Metabolic Disease
    L-Phenylalanine-d5 is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .
    L-Phenylalanine-d5
  • HY-N0215S13
    L-Phenylalanine-d1

    (S)-2-Amino-3-phenylpropionic acid-d<sub>1sub>

    		 Isotope-Labeled Compounds Calcium Channel iGluR Endogenous Metabolite Metabolic Disease
    L-Phenylalanine-d is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .
    L-Phenylalanine-d1
  • HY-N0215S
    L-Phenylalanine-d7

    (S)-2-Amino-3-phenylpropionic acid-d<sub>7sub>

    		 Isotope-Labeled Compounds Calcium Channel iGluR Endogenous Metabolite Metabolic Disease
    L-Phenylalanine-d7 is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .
    L-Phenylalanine-d7
  • HY-10844S1
    Pretomanid-d5

    PA-824-d<sub>5sub>; (S)-PA 824-d<sub>5sub>

    		 Antibiotic Bacterial Isotope-Labeled Compounds Infection Cancer
    Pretomanid-d5 is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.
    Pretomanid-d5
  • HY-146227
    DNA topoisomerase II inhibitor 1

    		Topoisomerase Apoptosis Cancer
    DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .
    DNA topoisomerase II inhibitor 1
  • HY-RS13999
    SUB1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SUB1 Human Pre-designed siRNA Set A
    SUB1 Human Pre-designed siRNA Set A
  • HY-RS18793
    Sub1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Sub1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sub1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Sub1 Mouse Pre-designed siRNA Set A
    Sub1 Mouse Pre-designed siRNA Set A
  • HY-RS25282
    Sub1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Sub1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sub1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Sub1 Rat Pre-designed siRNA Set A
    Sub1 Rat Pre-designed siRNA Set A
  • HY-N0215S6
    DL-Phenylalanine-d5 hydrochloride

    2-Amino-3-phenylpropionic acid-d<sub>5sub> hydrochloride

    		 Isotope-Labeled Compounds Calcium Channel iGluR Endogenous Metabolite Metabolic Disease
    DL-Phenylalanine-d5 (hydrochloride) is the deuterium labeled DL-Phenylalanine hydrochloride. L-Phenylalanine hydrochloride is an essential amino acid isolated from Escherichia coli. L-Phenylalanine hydrochloride is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine hydrochloride is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine hydrochloride is widely used in the production of food flavors and pharmaceuticals .
    DL-Phenylalanine-d5 hydrochloride
  • HY-79096S2
    BOC-L-phenylalanine-d8

    		Isotope-Labeled Compounds Biochemical Assay Reagents Drug Intermediate Others
    BOC-L-phenylalanine-d8 is the deuterium labeled BOC-L-phenylalanine (HY-79096). Boc-L-phenylalanine is a Boc-protected L-phenylalanine that can be used in the synthesis of other active compounds. Boc-L-phenylalanine is also a capping agent .
    BOC-L-phenylalanine-d8
  • HY-79096S1
    BOC-L-phenylalanine-d5

    		Isotope-Labeled Compounds Biochemical Assay Reagents Drug Intermediate Others
    BOC-L-phenylalanine-d5 is the deuterium labeled BOC-L-phenylalanine (HY-79096). Boc-L-phenylalanine is a Boc-protected L-phenylalanine that can be used in the synthesis of other active compounds. Boc-L-phenylalanine is also a capping agent .
    BOC-L-phenylalanine-d5
  • HY-P10215
    Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2

    		Parasite Infection
    Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent Plasmodium subtilisin-like protease 1 (SUB1) inhibitor. SUB1-IN-1 shows IC50 values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively .
    Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2
  • HY-N0215S9
    L-Phenylalanine-13C9,15N,d8

    (S)-2-Amino-3-phenylpropionic acid-13C<sub>9sub>,15N,d<sub>8sub>

    		 Isotope-Labeled Compounds Calcium Channel iGluR Endogenous Metabolite Metabolic Disease
    L-Phenylalanine- 13C9, 15N,d8 is the deuterium, 13C-, and 15-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .
    L-Phenylalanine-13C9,15N,d8
  • HY-N0215S10
    L-Phenylalanine-13C9

    (S)-2-Amino-3-phenylpropionic acid-13C<sub>9sub>

    		 Isotope-Labeled Compounds Calcium Channel iGluR Endogenous Metabolite Metabolic Disease
    L-Phenylalanine- 13C9 is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .
    L-Phenylalanine-13C9
  • HY-N0215S8
    L-Phenylalanine-13C6

    (S)-2-Amino-3-phenylpropionic acid-13C<sub>6sub>

    		 Isotope-Labeled Compounds Calcium Channel iGluR Endogenous Metabolite Metabolic Disease
    L-Phenylalanine- 13C6 is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .
    L-Phenylalanine-13C6
  • HY-W738480
    L-Phenylalanine tert-butyl ester-d5

    (R)-Tert-Butyl 2-amino-3-phenylpropanoate-d<sub>5sub>

    		 Isotope-Labeled Compounds Others
    L-Phenylalanine tert-butyl ester-d5 ((R)-Tert-Butyl 2-amino-3-phenylpropanoate-d5) is the deuterium labeled (S)-tert-Butyl 2-amino-3-phenylpropanoate (HY-W108426).
    L-Phenylalanine tert-butyl ester-d5
  • HY-N0215S14
    L-Phenylalanine-15N,d8

    (S)-2-Amino-3-phenylpropionic acid-15N,d<sub>8sub>

    		 Isotope-Labeled Compounds Calcium Channel iGluR Endogenous Metabolite Metabolic Disease
    L-Phenylalanine- 15N,d8 is the deuterium and 15N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca2+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .
    L-Phenylalanine-15N,d8
  • HY-N0215S11
    L-Phenylalanine-13C9,15N

    (S)-2-Amino-3-phenylpropionic acid-13C<sub>9sub>,15N

    		 Calcium Channel iGluR Endogenous Metabolite Metabolic Disease
    L-Phenylalanine- 13C9, 15N is the 13C- and 15N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .
    L-Phenylalanine-13C9,15N
  • HY-W012481S
    Nirvanol-d5

    Ethylphenylhydantoin-d<sub>5sub>; Phenylethyihydantoin-d<sub>5sub>; Desmethylmephenytoin-d<sub>5sub>

    		 Isotope-Labeled Compounds Drug Metabolite Neurological Disease
    Nirvanol-d5 (Ethylphenylhydantoin-d5) is deuterium labeled Nirvanol (HY-W012481) . Nirvanol (Ethylphenylhydantoin) is a metabolite of Mephenytoin (HY-B1184) that exerts anticonvulsant effects in the maximal electroshock (M.E.S.) seizure model in mice. Nirvanol shows potential for research in epilepsy-related neurological disorders .
    Nirvanol-d5
  • HY-141901S1
    DHEA-d5

    Prasterone-d<sub>5sub>; Dehydroisoandrosterone-d<sub>5sub>; Dehydroepiandrosterone-d<sub>5sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite Androgen Receptor Cardiovascular Disease Endocrinology Cancer
    DHEA-d5 (Prasterone-d5; Dehydroisoandrosterone-d5; Dehydroepiandrosterone-d5) is the deuterium labeled DHEA (HY-14650). DHEA (Prasterone) is one of the most abundant steroid hormones. DHEA (Prasterone) mediates its action via multiple signaling pathways involving specific membrane receptors and via transformation into androgen and estrogen derivatives (e.g., androgens, estrogens, 7α and 7β DHEA, and 7α and 7β epiandrosterone derivatives) acting through their specific receptors.
    DHEA-d5
  • HY-14198S
    Selegiline-d5

    Deprenyl-d<sub>5sub>; (-)-Selegiline-d<sub>5sub>; (-)-Deprenyl-d<sub>5sub>

    		 Isotope-Labeled Compounds Monoamine Oxidase Neurological Disease
    Selegiline-d5 (Deprenyl-d5) is deuterium labeled Selegiline. Selegiline (Deprenyl) is a potent, selective and irreversible inhibitor of MAO-B, with an IC50 of 51 nM. Selegiline exhibits 450-flod selectivity for MAO-B over MAO-A (IC50=23 μM). Selegiline can be used for the research of Parkinson's disease, Alzheimer's disease and major depressive disorder .
    Selegiline-d5
  • HY-14199S
    Selegiline-d5 hydrochloride

    Deprenyl-d<sub>5sub> hydrochloride; (-)-Selegiline-d<sub>5sub> hydrochloride; (-)-Deprenyl-d<sub>5sub> hydrochloride

    		 Isotope-Labeled Compounds Monoamine Oxidase Neurological Disease
    Selegiline-d5 (hydrochloride) (Deprenyl-d5 (hydrochloride)) is deuterium labeled Selegiline (hydrochloride). Selegiline (Deprenyl) hydrochloride is a potent, selective and irreversible inhibitor of MAO-B, with an IC50 of 51 nM. Selegiline hydrochloride exhibits 450-flod selectivity for MAO-B over MAO-A (IC50=23 μM). Selegiline hydrochloride can be used for the research of Parkinson's disease, Alzheimer's disease and major depressive disorder .
    Selegiline-d5 hydrochloride
  • HY-U00315S
    Gidazepam-d5

    Gidasepam-d<sub>5sub>; Hidazepam-d<sub>5sub>; Hydazepam-d<sub>5sub>

    		 GABA Receptor Neurological Disease
    Gidazepam-d5 is a deuterium labeled Gidazepam. Gidazepam is an agonist of GABA receptor channels (GABA RCs), and has anticonvulsant effect .
    Gidazepam-d5
  • HY-B0184S1
    Felbamate-d5

    Felbamyl-d<sub>5sub>; Felbatol-d<sub>5sub>; Taloxa-d<sub>5sub>

    		 iGluR Neurological Disease
    Felbamate-d5 is the deuterium labeled Felbamate . Felbamate (W-554) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA) .
    Felbamate-d5
  • HY-W758934
    Stepronin-d5

    Prostenoglycine-d<sub>5sub>; TTPG-d<sub>5sub>; Tiase-d<sub>5sub>

    		 Isotope-Labeled Compounds Chloride Channel Endocrinology
    Stepronin-d5 (Prostenoglycine-d5; TTPG-d5; Tiase-d5) is the deuterium labeled Stepronin (HY-A0234). Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administration). Stepronin inhibits airway secretion in vitro by reducing Cl- secretion from epithelial cells and mucus glycoprotein secretion from submucosal glands .
    Stepronin-d5
  • HY-W700392
    IMPDH-IN-2

    		IMPDH Cancer
    IMPDH-IN-2 (compound 2) is an inhibitor of inosine monophosphate dehydrogenase (IMPDH) with IC50 for IMPDH I and IMPDH II >Values are 0.15 and 0.17 μM, respectively. IMPDH-IN-2 has antitumor activity .
    IMPDH-IN-2
  • HY-16560S
    Camptothecin-d5

    Campathecin-d<sub>5sub>; (S)-(+)-Camptothecin-d<sub>5sub>; CPT-d<sub>5sub>

    		 Isotope-Labeled Compounds Topoisomerase ADC Payload MicroRNA Influenza Virus Apoptosis Fungal Antibiotic Infection Cancer
    Camptothecin-d5 is the deuterium labeled Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM . Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells .
    Camptothecin-d5
  • HY-B0715S2
    Pentoxifylline-d5

    BL-191-d<sub>5sub>; PTX-d<sub>5sub>; Oxpentifylline-d<sub>5sub>

    		 Phosphodiesterase (PDE) Autophagy HIV Cardiovascular Disease Cancer
    Pentoxifylline-d5 is the deuterium labeled Pentoxifylline. Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation .
    Pentoxifylline-d5
  • HY-107819S
    5α-Cholestan-3β-ol-d5

    Dihydrocholesterol-d<sub>5sub>; 5α-Cholestanol-d<sub>5sub>; NSC 18188-d<sub>5sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite Others
    5α-Cholestan-3β-ol-d5 is the deuterium labeled 5α-Cholestan-3β-ol. 5α-Cholestan-3β-ol is a derivitized steroid compound .
    5α-Cholestan-3β-ol-d5
  • HY-W701362
    Glurate-d5

    4-Acetylbutyric acid-d<sub>5sub>; 5-Oxohexanoic acid-d<sub>5sub>; NSC-5281-d<sub>5sub>

    		 Isotope-Labeled Compounds HIV Drug Intermediate Infection
    Glurate-d5 (4-Acetylbutyric acid-d5; 5-Oxohexanoic acid-d5; NSC-5281-d5) is the deuterium labeled Glurate (HY-W001957). Glurate (4-Acetylbutyric acid) is an acylating agent. Glurate can be used in the development of antiviral compounds, especially those targeting retroviruses such as herpes virus and HIV. Glurate can be used in the synthesis of acyclic nucleoside derivatives and 5-hydroxyhexanoic acid .
    Glurate-d5
  • HY-13777S
    Zoledronic acid-d5

    Zoledronate-d<sub>5sub>; CGP 42446-d<sub>5sub>; CGP42446A-d<sub>5sub>; ZOL 446-d<sub>5sub>

    		 Bacterial Apoptosis Autophagy Isotope-Labeled Compounds Metabolic Disease Cancer
    Zoledronic acid-d5 is deuterated labeled Zoledronic Acid (HY-13777). Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects .
    Zoledronic acid-d5
  • HY-158252S
    Tiagabine-d5 hydrochloride

    NO050328-d<sub>5sub> hydrochloride; NO328-d<sub>5sub> hydrochloride; TGB-d<sub>5sub> hydrochloride

    		 Isotope-Labeled Compounds GABA Receptor Neurological Disease
    Tiagabine-d5 (hydrochloride) is deuterium labeled Tiagabine (hydrochloride). Tiagabine hydrochloride is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182 nM for [ 3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively .
    Tiagabine-d5 hydrochloride
  • HY-144162S
    (Rac)-Selegiline-d5 hydrochloride

    (Rac)-Deprenyl-d<sub>5sub> hydrochloride; (±)-Selegiline-d<sub>5sub> hydrochloride; (±)-Deprenyl-d<sub>5sub> hydrochloride

    		 Isotope-Labeled Compounds Others
    (Rac)-Selegiline-d5 (hydrochloride) is the deuterium labeled (Rac)-Selegiline hydrochloride .
    (Rac)-Selegiline-d5 hydrochloride
  • HY-66005S5
    Acetaminophen-d5

    Paracetamol-d<sub>5sub>; 4-Acetamidophenol-d<sub>5sub>; 4'-Hydroxyacetanilide-d<sub>5sub>

    		 Isotope-Labeled Compounds COX Histone Acetyltransferase Endogenous Metabolite Inflammation/Immunology Cancer
    Acetaminophen-d5 is deuterated-labeled Acetaminophen (HY-66005). Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .
    Acetaminophen-d5
  • HY-109044S
    Tapinarof-d5

    WBI-1001-d<sub>5sub>; Benvitimod-d<sub>5sub>; GSK2894512-d<sub>5sub>

    		 Isotope-Labeled Compounds Aryl Hydrocarbon Receptor Inflammation/Immunology
    Tapinarof-d5 (WBI-1001-d5) is deuterium labeled Tapinarof. Tapinarof (WBI-1001) is a natural aryl hydrocarbon receptor (AhR) agonist with an EC50 of 13 nM. Tapinarof resolves skin inflammation in mice .
    Tapinarof-d5
  • HY-W022036S
    2-Ethoxyphenol-d5

    Guaethol-d<sub>5sub>; Guethol-d<sub>5sub>; NSC 180-d<sub>5sub>

    		 Isotope-Labeled Compounds Others
    2-Ethoxyphenol-d5 is the deuterium labeled 2-Ethoxyphenol .
    2-Ethoxyphenol-d5
  • HY-B0828S
    Triazophos-d5

    Hostathion 40EC-d<sub>5sub>; Hostathion-d<sub>5sub>; Hostation-d<sub>5sub>

    		 Isotope-Labeled Compounds Others
    Triazophos-d5 is the deuterium labeled Triazophos(HY-B0828) .
    Triazophos-d5
  • HY-16562AS
    Irinotecan-d5 hydrochloride

    (+)-Irinotecan-d<sub>5sub> hydrochloride; CPT-11-d<sub>5sub> hydrochloride; VAL-413-d<sub>5sub>

    		 Autophagy Topoisomerase Isotope-Labeled Compounds Cancer
    Irinotecan-d5 hydrochloride is deuterated labeled Irinotecan hydrochloride (HY-16562A). Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer .
    Irinotecan-d5 hydrochloride
  • HY-B1480S
    Ethoxzolamide-d5

    Redupresin-d<sub>5sub>; L-643786-d<sub>5sub>; PNU-4191-d<sub>5sub>

    		 Isotope-Labeled Compounds Carbonic Anhydrase Bacterial Infection Inflammation/Immunology
    Ethoxzolamide-d5 (Redupresin-d5) is deuterium labeled Ethoxzolamide. Ethoxzolamide is a carbonic anhydrase inhibitor with Ki of 1 nM.
    Ethoxzolamide-d5
  • HY-N0573S
    Umbelliferone-d5

    7-Hydroxycoumarin-d<sub>5sub>; Hydrangin-d<sub>5sub>; NSC 19790-d<sub>5sub>

    		 Isotope-Labeled Compounds Apoptosis Fluorescent Dye Neurological Disease Inflammation/Immunology Cancer
    Umbelliferone-d5 (7-Hydroxycoumarin-d5) is the deuterium labeled Umbelliferone (HY-N0573 ). Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats .
    Umbelliferone-d5
  • HY-125833
    Alpha-Naphthoflavone
    5+ Cited Publications

    		 Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis Cancer
    Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis .
    Alpha-Naphthoflavone
  • HY-10570S3
    Nevirapine-d5

    BI-RG 587-d<sub>5sub>; NSC 641530-d<sub>5sub>; NVP-d<sub>5sub>

    		 Isotope-Labeled Compounds Infection Cancer
    Nevirapine-d5 (BI-RG 587-d5) is deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a Ki of 270 μM .
    Nevirapine-d5
  • HY-B1207S
    Urethane-d5

    Ethyl carbamate-d<sub>5sub>; Carbamic acid ethyl ester-d<sub>5sub>; Ethylurethane-d<sub>5sub>

    		 Bacterial Parasite Infection Neurological Disease Cancer
    Urethane-d5 is the deuterium labeled Urethane. Urethane (Ethyl carbamate), the ethyl ester of carbamic acid, is a byproduct of fermentation found in various food products. Urethane has the ability to suppress bacterial, protozoal, sea urchin egg, and plant tissue growth in vitro .
    Urethane-d5
  • HY-77839S
    Cortodoxone-d5

    11-Deoxycortisol-d<sub>5sub>; cortexolone-d<sub>5sub>; Reichstein's substance S-d<sub>5sub>

    		 Isotope-Labeled Compounds Glucocorticoid Receptor Endogenous Metabolite Inflammation/Immunology Endocrinology
    Cortodoxone-d5 is the deuterium labeled Cortodoxone.
    Cortodoxone-d5
  • HY-10211S
    Tanespimycin-d5

    17-AAG-d<sub>5sub>; NSC 330507-d<sub>5sub>; CP 127374-d<sub>5sub>

    		 Isotope-Labeled Compounds Apoptosis Bacterial Autophagy HSP Mitophagy Antibiotic Cancer
    Tanespimycin-d5 (17-AAG-d5; NSC 330507-d5; CP 127374-d5) is the deuterium labeled Tanespimycin (HY-10211). Tanespimycin (17-AAG) is a potent HSP90 inhibitor with an IC50 of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90 [5]. Tanespimycin depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin also downregulates the stk38 gene expression .
    Tanespimycin-d5
  • HY-14814S
    Delafloxacin-d5

    RX-3341-d<sub>5sub>; WQ-3034-d<sub>5sub>; ABT492-d<sub>5sub>

    		 Isotope-Labeled Compounds Bacterial Antibiotic Infection
    Delafloxacin-d5 is deuterium labeled Delafloxacin. Delafloxacin (RX-3341; WQ-3034; ABT492) is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumonia .
    Delafloxacin-d5
  • HY-13636S1
    Fulvestrant-d5

    ICI 182780-d<sub>5sub>; ZD 9238-d<sub>5sub>; ZM 182780-d<sub>5sub>

    		 Isotope-Labeled Compounds Others
    Fulvestrant-d5 is a isotope of Fulvestrant .
    Fulvestrant-d5
  • HY-B1619S
    Cromolyn-d5

    Cromoglycate-d<sub>5sub>; Cromoglicic acid-d<sub>5sub>; FPL-670-d<sub>5sub> free acid

    		 Isotope-Labeled Compounds GSK-3 NF-κB Amyloid-β Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Cromolyn-d5 (Cromoglycate-d5) is the deuterium labeled Cromolyn (HY-B1619). Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC50 of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .
    Cromolyn-d5

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