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G2/Marrest

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5 alpha Reductase (2) 5-HT Receptor (3) ADC Payload (3) Adrenergic Receptor (1) Akt (24) Aldehyde Dehydrogenase (ALDH) (2) AMPK (4) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (2) Antibiotic (10) Antibody-Drug Conjugates (ADCs) (1) AP-1 (2) APC (2) Apolipoprotein (1) Apoptosis (371) ATM/ATR (3) Aurora Kinase (5) AUTACs (1) Autophagy (22) Bacterial (33) Bcl-2 Family (23) Biochemical Assay Reagents (33) BMI1 (1) c-Kit (1) c-Met/HGFR (8) c-Myc (4) Calcium Channel (3) Calmodulin (2) Carbonic Anhydrase (1) Carboxypeptidase (1) Casein Kinase (2) Caspase (30) CDK (29) Checkpoint Kinase (Chk) (7) Chloride Channel (1) Cholinesterase (ChE) (2) Complement System (1) COX (5) CXCR (1) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (12) Dihydrofolate reductase (DHFR) (1) Dipeptidyl Peptidase (1) DNA Alkylator/Crosslinker (4) DNA Methyltransferase (5) DNA Stain (1) DNA/RNA Synthesis (15) Dopamine Receptor (3) Drug Derivative (1) Drug Isomer (1) Drug Metabolite (3) E-Selectin (1) E1/E2/E3 Enzyme (3) EGFR (18) Endogenous Metabolite (31) Epigenetic Reader Domain (2) ERK (6) Estrogen Receptor/ERR (4) FAK (3) Fc Receptor (FcR) (1) Ferroptosis (3) FGFR (4) FLT3 (2) Fluorescent Dye (3) Fungal (4) G2A (GPR132) (3) GCGR (1) GLUT (1) Glutaminase (1) Glycosidase (1) GnRH Receptor (1) Guanylate Cyclase (1) HBV (6) HDAC (34) Hippo (MST) (2) Histone Acetyltransferase (1) Histone Demethylase (4) Histone Methyltransferase (1) HIV (1) HMG-CoA Reductase (HMGCR) (2) HSP (4) HSV (2) IAP (3) IKK (2) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (5) Insulin Receptor (1) Interleukin Related (3) IRAK (2) Isotope-Labeled Compounds (16) JAK (5) JNK (5) Keap1-Nrf2 (4) Kinesin (1) Lactate Dehydrogenase (3) MAP3K (2) MAPKAPK2 (MK2) (2) MARK (1) MASTL (1) MDM-2/p53 (12) Microtubule/Tubulin (104) Mitochondrial Metabolism (2) Mitosis (10) MMP (3) Molecular Glues (1) Monoamine Oxidase (1) Mps1 (1) mTOR (6) Na+/K+ ATPase (2) NADPH Oxidase (1) Necroptosis (2) NEDD8-activating Enzyme (1) NEKs (1) NF-κB (9) NO Synthase (3) Nucleoside Antimetabolite/Analog (5) P-glycoprotein (3) p38 MAPK (8) PAK (1) Parasite (4) PARP (15) PD-1/PD-L1 (4) PDK-1 (2) Phosphatase (4) PI3K (18) PI4K (1) Pim (2) PKC (3) Polo-like Kinase (PLK) (12) PPAR (3) Prostaglandin Receptor (1) PROTAC Linkers (1) PROTACs (11) Proteasome (2) Pyroptosis (2) Pyruvate Kinase (1) RAD51 (2) Raf (4) RAR/RXR (1) Ras (3) Reactive Oxygen Species (ROS) (26) Reference Standards (27) Ribosomal S6 Kinase (RSK) (1) ROS Kinase (1) Ser/Thr Kinase (1) Ser/Thr Protease (2) Sirtuin (4) Small Interfering RNA (siRNA) (20) Sodium Channel (6) SphK (1) Src (1) STAT (9) Survivin (2) TAM Receptor (1) TGF-beta/Smad (2) TGF-β Receptor (1) TMV (1) TNF Receptor (2) Topoisomerase (28) Transmembrane Glycoprotein (1) Trk Receptor (2) Tyrosinase (1) VEGFR (15) Wee1 (5) Wnt (3) YAP (1) β-catenin (4)
By Research Areas:	Cancer (508) Cardiovascular Disease (26) Endocrinology (5) Infection (54) Inflammation/Immunology (47) Metabolic Disease (25) Neurological Disease (24)
Click Chemistry:	Alkynes (4)
Oligonucleotides:	Solvents (1) Nucleosides and their Analogs (2) G (2) Rat Pre-designed siRNA Sets (5) Mouse Pre-designed siRNA Sets (5) Human Pre-designed siRNA Sets (10) siRNAs (20)

620

Inhibitors & Agonists

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W583317

sSPhos Pd G2	Biochemical Assay Reagents Endogenous Metabolite
sSPhos Pd G2 is a palladium catalyst with excellent cross-coupling reaction activity. sSPhos Pd G2 exhibits efficient catalytic ability in the synthesis of organic molecules and compounds. sSPhos Pd G2 can effectively promote the formation of CC bonds, optimize reaction conditions and increase yields. sSPhos Pd G2 is also used in a variety of transformation reactions, helping researchers develop new materials and compounds.

HY-N6983

Licoricesaponin G2	Others	Cancer
Licoricesaponin G2 is a pentacyclic triterpenoid isolated from Glycyrrhiza aspera .

HY-70003

Carboxypeptidase G2 (CPG2) Inhibitor CPG2 Inhibitor	Carboxypeptidase	Cancer
Carboxypeptidase G2 (CPG2) Inhibitor is a novel Carboxypeptidase G2 (CPG2) Inhibitor, Antitumor agents.

HY-N14080

Monamycin G2	Antibiotic Bacterial	Infection
Monamycin G2 is an ester peptide antibiotic. Monamycin G2 has activity against Gram-positive bacteria .

HY-116778

Prostaglandin G2	Biochemical Assay Reagents	Metabolic Disease
Prostaglandin G2 is an ester product.

HY-W543065

CPhos Pd G2	Biochemical Assay Reagents Endogenous Metabolite
CPhos Pd G2 is a highly efficient palladium catalyst with excellent cross-coupling reaction activity. CPhos Pd G2 is widely used in compound synthesis and material science, especially for the construction of complex organic molecules and the synthesis of bioactive compounds. CPhos Pd G2 is also favored for improving reaction selectivity and reducing the formation of by-products.

HY-N14188

Luminacin G2	Adrenergic Receptor	Cardiovascular Disease
Luminacin G2 has a strong inhibitory effect on capillary formation (IC₅₀ is less than 0.1 μg/mL) .

HY-W543082

P(o-tol)3 Pd G2 ChemBeads	Biochemical Assay Reagents Endogenous Metabolite	Others
P(o-tol)3 Pd G2 ChemBeads is a robust and air-stable catalyst featuring a bulky, electron-rich dialkylbiaryl phosphine, specifically designed for Pd-catalyzed cross-coupling reactions.

HY-158446

A2G2 glycan (G2), APTS labelled A2G2 N-linked oligosaccharide, APTS labelled	Biochemical Assay Reagents	Others
A2G2 glycan (G2), APTS labelled (A2G2 N-linked oligosaccharide, APTS labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158442

A2G2 glycan (G2) A2G2 N-linked oligosaccharide; A2G(4)2 glycan	Biochemical Assay Reagents	Others
A2G2 glycan (G2) (A2G2 N-linked oligosaccharide; A2G(4)2 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158445

A2G2 glycan (G2), 2-AB labelled A2G2 N-linked oligosaccharide, 2-AB labelled	Biochemical Assay Reagents	Others
A2G2 glycan (G2), 2-AB labelled (A2G2 N-linked oligosaccharide, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158447

A2G2 glycan (G2), procainamide labelled A2G2 N-linked oligosaccharide, procainamide labelled; A2G(4)2 glycan, procainamide labelled	Biochemical Assay Reagents	Others
A2G2 glycan (G2), procainamide labelled (A2G2 N-linked oligosaccharide, procainamide labelled; A2G(4)2 glycan, procainamide labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-125506

NP-G2-044 5 Publications Verification	β-catenin	Cancer
NP-G2-044 is a potent, orally active fascin inhibitor, with an IC₅₀ of ~2 μM. NP-G2-044 blocks tumor metastasis and increases antitumor immune response ^[2].

HY-153101

Gal-G2-CNP	Biochemical Assay Reagents	Others
Gal-G2-CNP, a galactopyranosylmaltoside, can be used as substrate for the determination of novel amylase and pancreatic amylase .

HY-P4978

CBP501 Affinity Peptide	Checkpoint Kinase (Chk)	Cancer
CBP501 Affinity Peptide is a Chk kinase inhibitor that can abrogate G2 arrest induced by DNA-damaging agents. CBP501 Affinity Peptide can be used in cancer research .

HY-133838

Ilmofosine BM41440	Parasite PKC	Infection Cancer
Ilmofosine (BM41440) is a potent and selective protein kinase C inhibitor. Ilmofosine induces cell cycle arrest at the G2 phase. Ilmofosine also is an anti-leishmanial agent ^[2].

HY-115683

NUN82647	Apoptosis	Cancer
NUN82647 is a potent cytotoxic compound that inhibits cell cycle at G2 phase and induces apoptosis. NUN82647 can be used for the study of leukemia .

HY-P991485

Anti-CD88/C5AR1 Antibody (G2_anti-C5aR)	Complement System	Inflammation/Immunology
Anti-CD88/C5AR1 Antibody (G2_anti-C5aR) is a human monoclonal antibody (mAb) targeting C5AR1.

HY-145291

CPT-Se4	Topoisomerase Apoptosis	Cancer
CPT-Se4, a selenoproagent of Camptothecin (CPT), shows improved potency in killing cancer cells and inhibiting tumor growth. CPT-Se4 decreases the GSH/GSSG ratio and total thiols, elevates the ROS level in Hep G2 cells, and eventually induces apoptosis of cancer cells. CPT-Se4 shows cytotoxicity against HeLa, Hep G2, A549, and SMMC-7721 cells (IC₅₀= 2.54-6.4 μM) .

HY-145290

CPT-Se3	Topoisomerase Apoptosis	Cancer
CPT-Se3, a selenoproagent of Camptothecin (CPT), shows improved potency in killing cancer cells and inhibiting tumor growth. CPT–Se3 decreases the GSH/GSSG ratio and total thiols, elevates the ROS level in Hep G2 cells, and eventually induces apoptosis of cancer cells. CPT-Se3 shows cytotoxicity against HeLa, Hep G2, A549, and SMMC-7721 cells (IC₅₀= 2.19-4.7 μM) .

HY-118518

Ronipamil	Calcium Channel	Cardiovascular Disease Cancer
Ronipamil is a calcium ion antagonist. Ronipamil increases the specific binding and internalization of human ¹²⁵I-LDL in human skin fibroblasts (HSF) and the human hepatoma cell line Hep G2 .

HY-161763

Tubulin polymerization-IN-65	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-65 is a tubulin polymerisation inhibitor with a broad spectrum cytotoxic. Tubulin polymerization-IN-65 induces G2 + M cell cycle arrest .

HY-20808

Antioxidant agent-15	COX	Cancer
Antioxidant agent-15 (Compound 4) is a potent antioxidant inhibition activity, with the IC₅₀ of 15.44 nM. Antioxidant agent-15 inhibits tumor cell growth in Hela, Hep G2 and Caco-2 cells, with the IC₅₀ of 395.26, 400.4 and 24.6 nM, respectively .

HY-144666

GLS-1-IN-1	Glutaminase	Cancer
GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor. GLS-1-IN-1 shows inhibitory effect against Hep G2, MCF 7, and MCF 10A cells .

HY-W747597

Ganglioside GD1b Disodium Salt (Bovine Brain) Disialoganglioside GD1b; Ganglioside C1; Ganglioside G2	Endogenous Metabolite	Cancer
Ganglioside GD1b Disodium Salt (Bovine Brain) (Disialoganglioside GD1b; Ganglioside C1) is an acidic glycosphingolipid containing two sialic acid residues linked to an internal galactose unit. Ganglioside GD1b Disodium Salt tightly packs with cholesterol to form lipid microdomains that modulate intracellular and intercellular signaling events. Concentrations of Ganglioside GD1b Disodium Salt (Bovine Brain) in the human brain increase with age and are positively correlated with pilocytic astrocytoma tumor grade. Ganglioside GD1b Disodium Salt has been detected in various other gliomas, including primitive neuroectodermal tumors, glioblastomas, and anaplastic astrocytomas.

HY-N10023

Physalin O	NO Synthase	Inflammation/Immunology
Physalin O is a physalin that can be isolated from Physalis angulata. Physalin O shows cytotoxicity to Hep G2 and MCF-7 cancer cells with IC₅₀ values of 31.1 and 11.4 µM, respectively. Physalin O inhibits the production of nitric oxide (NO) and shows anti-inflammatory activities ^[2].

HY-162580

SphK2-IN-3	SphK	Cancer
SphK2-IN-3 (compound 12q) is a selective active sphingosine kinase-2 inhibitor. SphK2-IN-3 has anti-proliferative activity against various cancer cells, inducing G2 phase arrest and apoptosis in liver cancer cells HepG2 .

HY-P4042

Hepatitis B Virus Receptor Binding Fragment hepatitis B peptide 4980	HBV	Infection Inflammation/Immunology
Hepatitis B Virus Receptor Binding Fragment (hepatitis B peptide 4980) is a synthetic peptide analog which specifically binds to Hep G2 cells. Hepatitis B Virus Receptor Binding Fragment is a promising immunogen expected to elicit protective antibodies based on the concept of the attachment blockade pathway of virus neutralization ^[2].

HY-138073

Cryptomoscatone D2	DNA/RNA Synthesis	Cancer
Cryptomoscatone D2 is a potent G2 checkpoint inhibitor .

HY-10919

C-1311	Topoisomerase Mitosis	Cancer
C-1311 shows to inhibit the catalytic activity of DNA topoisomerase II in vitro and in tumour cells. C-1311 prolongs G2 arrest followed by G2 to M transit and cell death during mitosis in the process of mitotic catastrophe .

HY-146189

Topoisomerase II inhibitor 9	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 9 (Compound 19b) is a Topo II inhibitor with an IC₅₀ of 0.97 μM. Topoisomerase II inhibitor 9 is also a classical DNA-intercalator with an IC₅₀ of 43.51 μM. Topoisomerase II inhibitor 9 arrests the cell cycle at the G2/M phase and induces apoptosis in Hep G‐2 cells .

HY-P99879

Efbemalenograstim alfa Benegrastim; Bineuta; F 627	STAT	Inflammation/Immunology
Efbemalenograstim alfa (F 627) is a recombinant fusion protein. Efbemalenograstim alfa is a long acting dimeric granulocyte colony-stimulating factor (G-CSF) that contains two human G-CSF fused to a human immunoglobulin G2 (hIgG2)-Fc fragment with a peptide linker. Efbemalenograstim alfa induces the production of white blood cells .

HY-147054

Zedoresertib WEE1-IN-5	Wee1 CDK	Cancer
WEE1-IN-5 is a potent WEE1 inhibitor with an IC₅₀ value of 0.8 nM. WEE1-IN-5 inhibits phospho-CDC2. WEE1-IN-5 abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells. WEE1-IN-5 can be used for researching anticancer .

HY-131143

Cadein1	Apoptosis	Cancer
Cadein1, an isoquinolinium derivative, leads to a G2/M delay and caspase-dependent apoptosis in cancer cells with non- functional p53 .

HY-P99606

Cirevetmab ZTS-00521426	TGF-beta/Smad	Inflammation/Immunology
Cirevetmab (ZTS-00521426) is an immunoglobulin G2-kappa, Canis lupus familiaris TGFB1 caninized monoclonal antibody. Cirevetmab is an immunomodulator .

HY-N2045

Musk ketone 1 Publications Verification	PI3K Akt Apoptosis Cytochrome P450	Neurological Disease
Musk ketone is a widely used artificial fragrance. Musk ketone is also a cytochrome P450 enzyme inducer. Musk ketone shows mutagenic and comutagenic effects in Hep G2 cells and induces neural stem cell proliferation and differentiation in cerebral ischemia via activation of the PI3K/Akt signaling pathway. In the brain, musk ketone is neuroprotective against stroke injury through inhibition of cell apoptosis ^[2] .

HY-139621

Colibactin 742	DNA Alkylator/Crosslinker	Cancer
Colibactin 742, a stable colibactin derivative, induces DNA interstrand-cross-links, activation of the Fanconi Anemia DNA repair pathway, and G2/M arrest.

HY-138819

IMB5046	Apoptosis	Cancer
IMB5046 is a microtubule inhibitor that induces apoptosis by blocking the G2/M phase of the cell cycle. IMB5046 has anti-tumor activity .

HY-156183

Antiproliferative agent-37	Others	Cancer
Antiproliferative agent-37 (compound 10J) shows anti-proliferative effect by arresting the cells at the G2/M phase of the cell cycle .

HY-N10670

Bursehernin Methylpluviatolide	Apoptosis	Cancer
Bursehernin (Methylpluviatolide) is an antitumor agent. Bursehernin induces Apoptosis and cell cycle arrest at G2/M phase. Bursehernin shows anti-proliferative activity ^[2].

HY-N9534

Xylopine	Reactive Oxygen Species (ROS) Apoptosis	Cancer
Xylopine is an aporphine alkaloid with cytotoxic activity on cancer cells. Xylopine induces oxidative stress, causes G2/M cell cycle arrest and apoptosis in cancer cells .

HY-16518

Voreloxin Hydrochloride 2 Publications Verification SNS-595 Hydrochloride; Vosaroxin Hydrochloride; AG 7352 Hydrochloride	Topoisomerase Apoptosis	Cancer
Voreloxin Hydrochloride is a first-in-class topoisomerase II inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis.

HY-N8882

Oleoside 11-methyl ester	Others	Cancer
Oleoside 11-methyl ester is a secoiridoid glucoside and possesses a strong cytotoxic activity against Hep-G2 cells .

HY-126020

Bractoppin 3 Publications Verification	DNA/RNA Synthesis RAD51	Cancer
Bractoppin is a potent and selective agent-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem(t) BRCT domain (binding IC₅₀: 74 nM). Bractoppin diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51. Bractoppin preferentially inhibits BRCA1 tBRCT-dependent steps in the DNA damage response .

HY-16375

Ozarelix D-63153	GnRH Receptor Apoptosis	Cancer
Ozarelix (D-63153) is a GnRH antagonist. Ozarelix induces cell apoptosis and arrests cell in G2/M phase. Ozarelix can be used in the research of prostate cancer .

HY-N14866

Monorden B	Bacterial	Infection Cancer
Monorden B has the effect of arresting the cell cycle of Jurket cells in G1 and G2/M phases. Monorden B has anti-Aspergillus niger activity .

HY-N15052

Monorden C	Bacterial	Infection Cancer
Monorden C has the effect of arresting the cell cycle of Jurket cells in G1 and G2/M phases. Monorden C has anti-Aspergillus niger activity .

HY-N14881

Monorden E	Bacterial	Infection Cancer
Monorden E has the effect of arresting the cell cycle of Jurket cells in G1 and G2/M phases. Monorden E has anti-Aspergillus niger activity .

HY-N11110

Inuviscolide	Apoptosis	Inflammation/Immunology Cancer
Inuviscolide is an apoptosis inducer. Inuviscolide can induce of G₂/M arrest in human melanoma cell lines. Inuviscolide exhibits antineoplastic and anti-inflammatory activities ^[2] .

HY-149630

VEGFR2/HDAC1-IN-1	VEGFR HDAC Apoptosis	Cancer
VEGFR2/HDAC1-IN-1 (compound 13) is a potent *VEGFR-2/HDAC* dual inhibitor, with IC₅₀s of 57.83 nM and 9.82 nM, respectively. VEGFR2/HDAC1-IN-1 arrests the cell cycle at the S and G2 phases, and induces apoptosis in HeLa cells. VEGFR2/HDAC1-IN-1 exhibits anti-angiogenic effect .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6983

Licoricesaponin G2	Other Terpenoids Classification of Application Fields Leguminosae Terpenoids Source classification Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer	Others
Licoricesaponin G2 is a pentacyclic triterpenoid isolated from Glycyrrhiza aspera .

HY-N9534

Xylopine	Alkaloids other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields Cancer	Reactive Oxygen Species (ROS) Apoptosis
Xylopine is an aporphine alkaloid with cytotoxic activity on cancer cells. Xylopine induces oxidative stress, causes G2/M cell cycle arrest and apoptosis in cancer cells .

HY-N14080

Monamycin G2	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification	Antibiotic Bacterial
Monamycin G2 is an ester peptide antibiotic. Monamycin G2 has activity against Gram-positive bacteria .

HY-116778

Prostaglandin G2	Microorganisms Source classification	Biochemical Assay Reagents
Prostaglandin G2 is an ester product.

HY-N14188

Luminacin G2	Structural Classification Natural Products Microorganisms Source classification	Adrenergic Receptor
Luminacin G2 has a strong inhibitory effect on capillary formation (IC₅₀ is less than 0.1 μg/mL) .

HY-N10023

Physalin O	Structural Classification Physalis minima Linn. Cardiacglycosides Source classification Plants Solanaceae Steroids	NO Synthase
Physalin O is a physalin that can be isolated from Physalis angulata. Physalin O shows cytotoxicity to Hep G2 and MCF-7 cancer cells with IC₅₀ values of 31.1 and 11.4 µM, respectively. Physalin O inhibits the production of nitric oxide (NO) and shows anti-inflammatory activities ^[2].

HY-138073

Cryptomoscatone D2	Structural Classification Cryptocarya mandioccana Meisn. Simple Phenylpropanols Source classification Phenylpropanoids Plants Lauraceae	DNA/RNA Synthesis
Cryptomoscatone D2 is a potent G2 checkpoint inhibitor .

HY-N10670

Bursehernin Methylpluviatolide	Structural Classification Hernandia sonora Linn. other families Source classification Lignans Phenylpropanoids Plants	Apoptosis
Bursehernin (Methylpluviatolide) is an antitumor agent. Bursehernin induces Apoptosis and cell cycle arrest at G2/M phase. Bursehernin shows anti-proliferative activity ^[2].

HY-N8882

Oleoside 11-methyl ester	Iridoids Classification of Application Fields Oleaceae Ligustrum lucidum Ait. Terpenoids Source classification Plants Disease Research Fields Cancer	Others
Oleoside 11-methyl ester is a secoiridoid glucoside and possesses a strong cytotoxic activity against Hep-G2 cells .

HY-N14866

Monorden B	Structural Classification Natural Products Microorganisms Source classification	Bacterial
Monorden B has the effect of arresting the cell cycle of Jurket cells in G1 and G2/M phases. Monorden B has anti-Aspergillus niger activity .

HY-N15052

Monorden C	Structural Classification Natural Products Microorganisms Source classification	Bacterial
Monorden C has the effect of arresting the cell cycle of Jurket cells in G1 and G2/M phases. Monorden C has anti-Aspergillus niger activity .

HY-N14881

Monorden E	Structural Classification Natural Products Microorganisms Source classification	Bacterial
Monorden E has the effect of arresting the cell cycle of Jurket cells in G1 and G2/M phases. Monorden E has anti-Aspergillus niger activity .

HY-N11110

Inuviscolide	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Erythrina arborescens Roxb.	Apoptosis
Inuviscolide is an apoptosis inducer. Inuviscolide can induce of G₂/M arrest in human melanoma cell lines. Inuviscolide exhibits antineoplastic and anti-inflammatory activities ^[2] .

HY-125132

Agelastatin A (-)-Agelastatin A; AglA	Structural Classification Alkaloids Animals Other Alkaloids Source classification	Apoptosis
Agelastatin A ((-)-Agelastatin A; AglA), a tetracyclic alkaloid isolated from the sponge Agelas dendromorpha, induces apoptosis and arrests cells in the G2/M phase of the cell cycle, exhibiting antitumor activity .

HY-N10798

Kusunokinin (-)-Kusunokinin	Structural Classification Source classification Lignans Piperaceae Phenylpropanoids Plants Piper nigrum Linn.	Apoptosis
Kusunokinin ((-)-Kusunokinin) is a nature product that could be isolated form P. nigrum. Kusunokinin has anticancer activity. Kusunokinin arrests cell cycle at G2/M phase and induce apoptosis .

HY-122496

Malvidin chloride Syringidin	Structural Classification Classification of Application Fields Source classification Vitis vinifera cv. Zalema Plants Vitaceae Anthocyans Flavonoids Microorganisms other families Phenols Polyphenols Disease Research Fields Cancer	Apoptosis
Malvidin (chloride) is a bioactive compound isolated from grape. Malvidin shows cytotoxicity through the arrest of the G₂/M phase of cell cycle and induction of apoptosis. Malvidin can be used for the research of cancer .

HY-N10394

Metachromins X	Quinones Structural Classification Classification of Application Fields Animals Terpenoids Sesquiterpenes Marine natural products Benzene Quinones Sponge Disease Research Fields Cancer	Others
Metachromins X is a sesquiterpene quinone that arrests the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase .

HY-N11050

Xerophilusin B	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Plants Cosmos sulphureus Cav.	Apoptosis
Xerophilusin B, an anticancer agent isolated from Isodon xerophilus, exhibits antiproliferative effects on esophageal squamous cell carcinoma (ESCC) cell lines, induces G2/M cell cycle arrest, and mediates apoptosis .

HY-N6011

9-Methoxycamptothecin	Alkaloids Structural Classification Classification of Application Fields Source classification Pyridine Alkaloids Camptotheca acuminata Decne. Plants Nyssaceae Isoquinoline Alkaloids Disease Research Fields Cancer	Topoisomerase Apoptosis
9-Methoxycamptothecin (MCPT), isolated from Camptotheca acuminata, has antitumor activities through topoisomerase inhibition. 9-Methoxycamptothecin (MCPT) induces strong G2/M arrest and apoptosis in cancer ^[2].

HY-N7152

6-Dehydrogingerdione	Zingiber officinale Roscoe Structural Classification Monophenols Classification of Application Fields Source classification Phenols Plants Disease Research Fields Zingiberaceae Cancer	Apoptosis
6-Dehydrogingerdione sensitizes human hepatoblastoma Hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5 .

HY-119736

Leptolstatin	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Others
Leptolstatin is an inhibitor of the progression of G1 and G2 phases of the mammalian cell cycle. Leptolstatin can be extracted from the fermentation broth of Streptomyces sp. SAM1595 .

HY-N6722

Swainsonine 1 Publications Verification Tridolgosir	Infection Alkaloids Piperidine Alkaloids Structural Classification Pyrrole Alkaloids Classification of Application Fields Leguminosae Source classification Plants Disease Research Fields Sphaerophysa salsula	Apoptosis Antibiotic
Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity ^[2] .

HY-N2374

Eupatorin 1 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Cruciferae Source classification Phenols Polyphenols Isatis tinctoria L. Plants Disease Research Fields Cancer	Apoptosis
Eupatorin, a naturally occurring flavone, arrests cells at the G2-M phase of the cell cycle and induces apoptotic cell death involving activation of multiple caspases, mitochondrial release of cytochrome c and poly(ADP-ribose) polymerase cleavage .

HY-P2698

1-Alaninechlamydocin	Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	HDAC Apoptosis
1-Alaninechlamydocin, a cyclic tetrapeptide, is a potent HDAC inhibitor (IC₅₀=6.4 nM). 1-Alaninechlamydocin induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells .

HY-126067

(-)-Pinoresinol	Structural Classification other families Hernandia nymphaeifolia (C. Presl) Kubitzki Source classification Lignans Phenylpropanoids Plants	Glycosidase Apoptosis
(-)-Pinoresinol is a plant-derived tetrahydrofuran lignan that inhibits α-glucosidase and acts as a hypoglycemic agent. (-)-Pinoresinol has some anti-inflammatory effects and acts as a chemopreventive agent, inducing increased apoptosis and cell cycle G2/M arrest .

HY-N10188

Nidurufin	Quinones Microorganisms Classification of Application Fields Anthraquinones Source classification Disease Research Fields Cancer	Others
Nidurufin is a potent cell cycle inhibitor with antitumor activity.Nidurufin induces in vitro cell cycle arrest at G₂/M transition in the K562 cell line in a concentration and time dependent manner(IC₅₀=12.6 μM) .

HY-N7273

Soyasaponin III	Triterpenes Classification of Application Fields Leguminosae Glycine max (L.) merr Terpenoids Source classification Plants Disease Research Fields Cancer	Apoptosis
Soyasaponin III, a monodesmodic oleanane triterpenoid, is one of the main potentially bioactive saponins found in soy (Glycine max) and related products. Soyasaponin III can induce apoptosis in Hep-G2 cells .

HY-N9968

Cucurbitacin C	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Plants Cucumis sativus L.	Akt Apoptosis
Cucurbitacin C is a triterpenoid calabinoid that can be isolated from Cucurbitaceae plants. Cucurbitacin C has anti-cancer activity in vivo and in vitro. Cucurbitacin C can induce cell cycle arrest in G1 or G2/M phase and apoptosis by inhibiting Akt signaling .

HY-122496R

Malvidin chloride (Standard) Syringidin (Standard)	Structural Classification Anthocyans Flavonoids Microorganisms other families Source classification Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae	Reference Standards Apoptosis
Malvidin (chloride) (Standard) is the analytical standard of Malvidin (chloride). This product is intended for research and analytical applications. Malvidin (chloride) is a bioactive compound isolated from grape. Malvidin shows cytotoxicity through the arrest of the G2/M phase of cell cycle and induction of apoptosis. Malvidin can be used for the research of cancer .

HY-118921

Ovatodiolide	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Plants Artemisia persica Boiss.	Apoptosis
Ovatodiolide is a compound that can be isolated from Anisomeles indica. Ovatodiolide has anti-bacterial and anti-inflammatory properties. Ovatodiolide also has anti-cancer activity that induces cell cycle G2/M arrest and apoptosis via a ROS-dependent ATM/ATR signaling pathways .

HY-B0011

Docetaxel Maximum Cited Publications 119 Publications Verification RP-56976	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Microtubule/Tubulin Apoptosis Endogenous Metabolite
Docetaxel (RP-56976) is a microtubule depolymerization inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-126566

Trichostatin C	Structural Classification Natural Products Microorganisms Source classification	Fungal HDAC Apoptosis
Trichostatin C is an inhibitor for histone deacetylase (HDAC), induces apoptosis and arrests cell cycle at G2/M phase, and exhibits anticancer activity against lung cancer and urothelial bladder cancer . Trichostatin C induces differentation of Friend leukemic cells ^[2]. Trichostatin C exhibits antifungal activity .

HY-N3446

IVHD-valtrate	Structural Classification Natural Products Classification of Application Fields Source classification Valeriana officinalis Linn. Plants Valerianaceae Disease Research Fields Cancer	Apoptosis
IVHD-valtrate, an active Valeriana jatamansi derivative, is against human ovarian cancer cells in vitro and in vivo. IVHD-valtrate induces cancer cells apoptosis and arrests the ovarian cancer cells in the G2/M phase. IVHD-valtrate has the potential to be a novel chemotherapeutic agent for the human ovarian cancer research .

HY-N0421

Cinobufagin 5+ Cited Publications Cinobufagine	Structural Classification Animals Classification of Application Fields Source classification Disease Research Fields Steroids Cancer	Apoptosis
Cinobufagin is an anticancer agent that can be secreted by the Asiatic toad Bufo gargarizans. Cinobufagin induces the cell cycle arrests in the G1 phase or G2/M phase, leading to apoptosis in cancer cells. Cinobufagin inhibits tumor growth in melanoma and glioblastoma multiforme xenograft mouse models ^[2] .

HY-N2374R

Eupatorin (Standard)	Structural Classification Flavonoids Classification of Application Fields Cruciferae Source classification Phenols Isatis tinctoria L. Plants Disease Research Fields Cancer	Reference Standards Apoptosis
Eupatorin (Standard) is the analytical standard of Eupatorin. This product is intended for research and analytical applications. Eupatorin, a naturally occurring flavone, arrests cells at the G2-M phase of the cell cycle and induces apoptotic cell death involving activation of multiple caspases, mitochondrial release of cytochrome c and poly(ADP-ribose) polymerase cleavage .

HY-N0047

Polyphyllin I 3 Publications Verification	Structural Classification Liliaceae Classification of Application Fields Paris polyphylla Smith Plants Disease Research Fields Saccharides Steroids Cancer	JNK mTOR Akt PDK-1 Autophagy Apoptosis
Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis ^[2] .

HY-N7225

Yuanhuacine Gnidilatidin	Structural Classification Classification of Application Fields Terpenoids Thymelaeaceae Source classification Diterpenoids Plants Daphne genkwa Sieb. et Zucc. Disease Research Fields Cancer	DNA/RNA Synthesis
Yuanhuacine (Gnidilatidin), a diterpene from Daphne genkwa, is an effective and highly selective inhibitor of the basal-like 2 (BL2) subtype of TNBC. Yuanhuacine can induce G2/M cell cycle arrest and has broad anti-tumor activity. Yuanhuacine is an orally active DNA damaging agent ^[2] .

HY-N15419

Acutumidine	Structural Classification Alkaloids Other Alkaloids Source classification Plants Menispermaceae Hypserpa nitida Miers	HBV
Acutumidine (compound 4) is an alkaloid with anti-HBV activity that can be isolated from Hypserpa nitida Miers. Acutumidine inhibits the production of HBsAg in Hep G2.2.15 cells stably transfected with HBV genome with an IC₅₀ value of 2.023 mM .

HY-N10018

Cimiside E 25-Anhydrocimigenol xyloside	Triterpenes Structural Classification Terpenoids Source classification Ranunculaceae Plants Cimicifuga racemosa (L.) Nutt.	Caspase
Cimiside E (25-Anhydrocimigenol xyloside) is a triterpene xyloside, Cimiside E possesses apoptotic action on gastric cancer cells, with an IC₅₀ value of 14.58 μM. Cimiside E induces cell cycle arrest at G2/M phase, and mediates apoptosis through the induction of the caspase cascade for both the extrinsic and intrinsic pathways ^[2].

HY-N2369

Chelidonine 1 Publications Verification	Infection Alkaloids Structural Classification Chelidonium majus Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae	Apoptosis Influenza Virus
Chelidonine, an isoquinoline alkaloid, can be isolated from Chelidonium majus L.. Chelidonine causes G_2/M arrest and induces caspase-dependent and caspase-independent apoptosis, and prevents cell cycle progression of stem cells in Dugesia japonica. Chelidonine has cytotoxic activity against melanoma cell lines. with anticancer and antiviral activity ^[2] .

HY-B1357

Digitoxin 5+ Cited Publications	Digitalis purpurea Linn. Cardiovascular Disease Structural Classification Microorganisms Classification of Application Fields Source classification Scrophulariaceae Plants Disease Research Fields Steroids	Bcl-2 Family Caspase Apoptosis HSV Na+/K+ ATPase Calcium Channel
Digitoxin is an anti-cancer agent. Digitoxin induces apoptosis, inhibits influenza cytokine storm, causes DNA double-stranded breaks (DSBs) and blocks the cell cycle at the G2/M phase. Digitoxin induces calcium uptake into cells by forming transmembrane calcium channels and can be used for research of heart failure ^[2] .

HY-W754691

Glaziovine	Structural Classification Alkaloids Other Alkaloids Source classification Plants Menispermaceae Hypserpa nitida Miers	HBV
Glaziovine is an antiviral agent found in Hypserpa nitida. Glaziovine exhibits significant inhibitory activity against HBV, capable of suppressing hepatitis B virus surface antigen (HBsAg) secretion in Hep G2.2.15 cells transfected with HBV, with an IC₅₀ of 8 nM .

HY-17583

Griseofulvin	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	Fungal Apoptosis Antibiotic Endogenous Metabolite Microtubule/Tubulin Wee1 Caspase Bcl-2 Family
Griseofulvin is an orally active antifungal antibiotic with antitumor activity. Griseofulvin induces apoptosis and G2/M cell cycle arrest in cancer cells. Griseofulvin also has cardiovascular modulatory activity, reducing angina pectoris, relieving hand artery spasm associated with onychomycosis, and peripheral vascular diseases such as shoulder-hand syndrome ^[2] .

HY-N3093

Periglaucine B (+)-Periglaucine B	Structural Classification Alkaloids Pyrrole Alkaloids Source classification Pericampylus glaucus (Lam.) Merr. Plants Menispermaceae	HBV
Periglaucine B ((+)-Periglaucine B) is an alkaloid and an HBsAg inhibitor. Periglaucine B can be isolated from Pericampylus glaucus. Periglaucine B inhibits the secretion of hepatitis B virus (HBV) surface antigen (HBsAg) in Hep G2.2.15 cells with an IC₅₀ of 0.47 mM .

HY-N1428

Citric acid 20+ Cited Publications	Cardiovascular Disease Structural Classification Preservatives Classification of Application Fields Anti-aging Source classification Endocrine diseases Metabolic Disease Endogenous metabolite Food Research Infection Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Inflammation/Immunology Disease Research Fields Cancer	Apoptosis Endogenous Metabolite Bacterial
Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries ^[2] .

HY-N13869

Asperlin	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Bacterial Apoptosis Reactive Oxygen Species (ROS) Bcl-2 Family NO Synthase COX TNF Receptor Interleukin Related
Asperlin is an orally active marine-derived antibiotic with antifungal, anticancer, anti-inflammatory and anti-atherosclerotic activities. Asperlin induces apoptosis. Asperlin increases reactive oxygen species (ROS)- and DNA damage-associated G2/M phase arrest and ATM phosphorylation. Asperlin is effective in preventing HFD-induced obesity and modulating gut microbiota ^[2] .

HY-N12563

γ-Sitosterol	Structural Classification Natural Products Leguminosae Source classification Plants Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	c-Myc Apoptosis
γ-Sitosterol is an inhibitor for c-Myc. γ-Sitosterol inhibits the proliferation of cancer cell MCF-7 and A549 with IC₅₀ of 240.73 μg/mL and 696.6 μg/mL, arrests the cell cycle at G2/M phase, and induces apoptosis. γ-Sitosterol upregulates the expression of cell cycle regulators cyclin B/E .

HY-N9942

Physalin A 1 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Alkekengi officinarum var. franchetii (Mast.) R.J.Wang Source classification Solanaceae Plants Disease Research Fields Cancer	Apoptosis Autophagy NF-κB p38 MAPK PI3K Akt mTOR STAT JAK
Physalin A is a biologically active withanolide. Physalin A shows anti-inflammatory, antifibrotic and ameliorative effects on autophagy in models of disc degeneration. Physalin A has antitumor activity and can induce apoptosis, ROS production and G2/M phase cell cycle arrest. Besides. Physalin A can significantly increase the activity of quinone reductase and increase the expression of detoxifying enzymesc ^[2] .

HY-N3627

Coronalolide methyl este NSC 680073	Structural Classification Natural Products Source classification Rubiaceae Plants Gardenia jasminoides Ellis	Others
Coronalolide methyl ester (NSC 680073) is a natural triterpene with anticancer effects. Coronalolide methyl ester shows moderately cytotoxic to KATO-3, SW-620, and Hep-G2 cells., with IC₅₀ values of 8.64 µg/mL, 6.19 µg/mL, and 6.8 µg/mL, respectively .

HY-N15392

Lactonamycin Z	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Lactonamycin Z is an antitumor antibiotic. Lactonamycin Z has weak anti-Gram-positive bacterial activity. Lactonamycin Z can inhibit human tumor cells HMO2, MCF7 and Hep G2 with GI₅₀ (μg/mL) of 1.9, 0.85 and 5.11, respectively .

Cat. No.	Product Name	Chemical Structure

HY-B0114S

Oxcarbazepine-d4
Oxcarbazepine-d₄ (GP 47680-D₄) is the deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker . Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines ^[2]. Anti-cancer and anticonvulsant effects ^[2] .

HY-B0294S

Flubendazole-d3
Flubendazole-d₃ is the deuterium labeled Flubendazole. Flubendazole is a safe and efficacious anthelmintic agent, which is widely used for anthelmintic to human, rodents and ruminants. Flubendazole exerts anticancer activities by mechanisms including inhibition of microtubule function. Flubendazole induces p53-mediated apoptosis and arrests G2/M cell cycle ^[2].

HY-B0011S

Docetaxel-d9
Docetaxel-d₉ is the deuterium labeled Docetaxel. Docetaxel (RP-56976) is a microtubule?depolymerization inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of?bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-W654334

9-cis-Retinol-d5
9-cis-Retinol-d₅ is deuterium labeled 9-cis Retinol. 9-cis Retinol is a precursor of 9-cis-Retinal (HY-W009310). 9-cis Retinol can inhibit 9-cis-Retinoic acid (HY-15128) synthesis in Hep G2 cells ^[2].

HY-N1428S1

Citric acid-13C6

Citric acid- ¹³C₆ is the ¹³C-labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries ^[2] .

HY-B0114S1

Oxcarbazepine-d4-1
Oxcarbazepine-d₄-1 is deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker . Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines ^[2]. Anti-cancer and anticonvulsant effects ^[2] .

HY-B0114S2

Oxcarbazepine-d8-1
Oxcarbazepine-d8-1 is a deuterium of Oxcarbazepine. Oxcarbazepine is a sodium channel blocker . Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines ^[2]. Oxcarbazepine-d8-1 has anti-cancer and anticonvulsant effects ^[2].

HY-B0114S3

Oxcarbazepine-d10
Oxcarbazepine-d₁₀ (GP 47680-d₁₀) is deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker . Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines ^[2]. Anti-cancer and anticonvulsant effects ^[2] .

HY-W747797

Cinobufagine-d3
Cinobufagine-d₃ is the deuterium labeled Cinobufagin (HY-N0421). Cinobufagin is an anticancer agent that can be secreted by the Asiatic toad Bufo gargarizans. Cinobufagin induces the cell cycle arrests in the G1 phase or G2/M phase, leading to apoptosis in cancer cells. Cinobufagin inhibits tumor growth in melanoma and glioblastoma multiforme xenograft mouse models ^[2] .

HY-B0011AS

Docetaxel-d5 trihydrate

Docetaxel-d₅ (trihydrate) is the deuterium labeled Docetaxel (Trihydrate). Docetaxel Trihydrate (RP-56976 Trihydrate) is an antineoplastic agent and inhibits microtubule?depolymerization with an IC₅₀ value of 0.2 μM . Docetaxel Trihydrate is a semisynthetic analog of taxol and attenuates the effects of?bcl-2?and?bcl-xL?gene expression. Docetaxel Trihydrate arrests the cell cycle at G2/M and leads to cell apoptosis .

HY-N1428S2

Citric acid-13C2

Citric acid- ¹³C₂ is the ¹³C-labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries ^[2] .

HY-N1428S3

Citric acid-13C3

Citric acid- ¹³C₃ is the ¹³C-labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries ^[2] .

HY-N1428S

Citric acid-d4

Citric acid-d₄ is the deuterium labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries ^[2] .

HY-15149S2

Romidepsin-d7

Romidepsin-d₇ (FK 228-d₇) is deuterium labeled Romidepsin. Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC₅₀s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively . Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis ^[2].

HY-N1428S6

Citric acid-d4-1

Citric acid-d₄-1 is deuterated labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries ^[2] .

HY-A0004S

Decitabine-13C5

Decitabine- ¹³C₅ (5-Aza-2'-deoxycytidine- ¹³C₅) is ¹³C labeled Decitabine. Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell apoptosis. Decitabine has potent anticancer activity ^[2].

HY-W127841

Citric acid-2,4-13C2

Citric acid-2,4- ¹³C₂ is the ¹³C-labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries ^[2] .

HY-109583S

4-Oxofenretinide-d4
4-Oxofenretinide-d₄ (4-Oxo-4-HPR-d₄) is deuterium labeled 4-Oxofenretinide. 4-Oxofenretinide (4-Oxo-4-HPR) is a metabolite of Fenretinide (HY-15373). 4-Oxofenretinide induces cell growth inhibition in ovarian, breast, and neuroblastoma tumor cell lines. 4-Oxofenretinide causes a marked accumulation of cells in G2-M. 4-Oxofenretinide induces cancer cell apoptosis through caspase-9 ^[2].

HY-121605S

RL71-d6

RL71-d₆ is a deuterium labeled RL71 (HY-121605). RL71 is a curcuminoid anticancer agent that exhibits potent cytotoxicity against a variety of ER-negative breast cancer cells. RL71 (1 μM) induces cell cycle arrest in the G2/M phase and induces apoptosis in SKBr3 cells. RL7 also decreases HER2/neu phosphorylation and increases p27. RL71 also significantly reduced the phosphorylation of Akt and transiently increased the stress kinases JNK1/2 and p38 MAPK. Furthermore, RL71 exhibited anti-angiogenic potential in vitro, inhibiting the migration of HUVEC cells and the ability of these cells to form tubular networks .

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