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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

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4-4 cell

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (319) Cardiovascular Disease (22) Endocrinology (25) Infection (93) Inflammation/Immunology (141) Metabolic Disease (39) Neurological Disease (46)
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545

Inhibitors & Agonists

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Targets Recommended: Programmed Cell Death 4 (PDCD4) Itk TOPK NAMPT ALCAM/CD166 GDNF Receptor VISTA BCL6 Tim3 BMI1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P10553

*ARF(26–44), cell-permeable*	Apoptosis	Cancer
ARF(26–44), cell-permeable is a cell-penetrating peptide derived from a specific amino acid sequence of the p14ARF tumor suppressor protein. As a functional inhibitor of FoxM1, ARF(26–44) cell-permeable shows significant anti-tumor activity in the treatment of mouse hepatocellular carcinoma (HCC), significantly increasing tumor cell apoptosis and reducing tumor cell proliferation and angiogenesis. ARF(26–44), cell-permeable can be used in research on tumor therapy .

HY-N7171

4,4'-Di-O-methylellagic acid 4,4'-DiOMEA; Nasutin C	Wnt	Cancer
4,4'-Di-O-methylellagic acid (4,4'-DiOMEA; Nasutin C) can be isolated from the Australian termites. 4,4'-Di-O-methylellagic acid is blue-fluorescent under ultra-violet light . 4,4'-Di-O-methylellagic acid inhibits colon cancer cell proliferation via the wnt signal pathway .

HY-N15380

4,4′-Secalonic acid D	PARP Reactive Oxygen Species (ROS) Caspase Apoptosis Pyroptosis	Cancer
4,4′-Secalonic acid D (Compound 12) is a PARP1 inhibitor. 4,4′-Secalonic acid D induces the accumulation of ROS and DNA damage, activates the caspase-3/GSDME pathway, and triggers apoptosis and pyroptosis of tumor cells by inhibiting PARP1. 4,4′-Secalonic acid D has anti-tumor activity .

HY-W720006

4,4'-Diapo-ω,ω-carotene-4,4'-dial	Drug Derivative	Others
4,4'-Diapo-ω,ω-carotene-4,4'-dial is a carotenoid pigment. Carotenoids are important biological active, and may regulate cellular differentiation, growth control, photooxidative protection, cell membrane stability, photosynthesis, vision process and nutrition .

HY-N9257

8-Hydroxypinoresinol4,4'-di-O-β-D-glucopyranoside	Others	Neurological Disease
8-Hydroxypinoresinol4,4'-di-O-β-D-glucopyranoside (Compound 7) is a compound derived from roots and rhizomes. 8-Hydroxypinoresinol4,4'-di-O-β-D-glucopyranoside could prevent neurotoxicity in PC12 cells .

HY-144468

IDO1-IN-17	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1-IN-17 (I-4) is an IDO1 inhibitor, with an IC₅₀ of 0.44 μM in hela cells .

HY-N14893

Cetoniacytone B	Others	Cancer
Cetoniacytone B can inhibit the growth of HEPG2 and MCF7 human tumor cell lines, with GI₅₀ values of 4.4 μM .

HY-176172

BTK-IN-44	Btk	Cancer
BTK-IN-44 (Compound 10) is a potent noncovalent inhibitor of Bruton’s tyrosine kinase (BTK) with an IC₅₀ value of 24.7 nM. BTK-IN-44 interferes with signaling pathways of B cell malignancies, showing antitumor effects in lymphoma cells. BTK-IN-44 is promising for research of B cell malignancies (such as lymphoma) .

HY-161563

4,4'-Sulfonyldiphenol/BSA	Biochemical Assay Reagents	Inflammation/Immunology
4,4'-Sulfonyldiphenol/BSA is the antigen-adjuvant conjugate of 4,4'-Sulfonyldiphenol (HY-W011927) and Bovine Serum Albumin (BSA). By conjugating the antigen with a protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt major epitopes, and it can enhance cross-presentation and the production of antigen-specific T cells.

HY-145844

EGFR-IN-44	EGFR Apoptosis	Cancer
EGFR-IN-44 (Compound 6a) is a potent, orally active EGFR tyrosine kinase inhibitor with an IC₅₀ of 4.11 nM. EGFR-IN-44 induces cell apoptosis and shows an oral bioavailability value of 33.57%. EGFR-IN-44 can be studied for non-small-cell lung cancers .

HY-I0383

Canagliflozin hemihydrate 40+ Cited Publications JNJ 28431754 hemihydrate	SGLT	Metabolic Disease Cancer
Canagliflozin hemihydrate (JNJ28431754 hemihydrate) is a selective SGLT2 inhibitor with IC₅₀s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively .

HY-10451

Canagliflozin 40+ Cited Publications JNJ 28431754	SGLT	Metabolic Disease Cancer
Canagliflozin (JNJ 28431754) is a selective SGLT2 inhibitor with IC₅₀s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively .

HY-144361

Antitumor agent-44	Apoptosis	Cancer
Antitumor agent-44 (Compound 5n) disrupts the mitochondrial homeostasis, induces cell cycle arrest and apoptosis in human adenocarcinoma cells. Antitumor agent-44 (Compound 5n) possesses good anti-tumor activity in a lung-cancer-cell xenograft mice model .

HY-149897

HA-CD44 interaction inhibitor 2	Transmembrane Glycoprotein	Cancer
HA-CD44 interaction inhibitor 2 (compound 5) is a Hyaluronic acid (HA)-CD44 interaction inhibitor that effectively disrupts the integrity of cancer spheroids. HA-CD44 interaction inhibitor 2 also exhibits antiproliferative activity against cancer cells. HA-CD44 interaction inhibitor 2 inhibits MDA-MB-231 cells with EC50 value of 0.59 μM .

HY-170955

HA-CD44 interaction inhibitor 3	Transmembrane Glycoprotein	Cancer
HA-CD44 interaction inhibitor 3 (compound 5d) is a Hyaluronic acid (HY-B0633A) (HA)-CD44 interaction inhibitor with antiproliferative activities. HA-CD44 interaction inhibitor 3 inhibits MDA-MB-231 (CD44++) cells and MCF-7 cells (CD44--) with EC₅₀s of 4.24 μM and 14.74 μM, respectively. HA-CD44 interaction inhibitor 3 shows the potential for cancer research .

HY-173310

CDK2-IN-44	CDK	Cancer
CDK2-IN-44 (Compound 46) is an inhibitor of cyclin-dependent kinase 2 (CDK2). CDK2-IN-44 can effectively inhibit the proliferation of cancer cells and exert its activity in inhibiting cancer cell growth by arresting the cell cycle, promoting Apoptosis, and inducing cellular senescence. CDK2-IN-44 holds promise for use in the research of ovarian cancer and breast cancer .

HY-175010

STAT3-IN-44	STAT Apoptosis Bcl-2 Family Caspase	Cancer
STAT3-IN-44 is a potent STAT3 inhibitor with IC₅₀s of 1.84 (C6 cells) and 4.81 μM (A549 cells). STAT3-IN-44 inhibits STAT3 phosphorylation, downregulates Bcl-2, and upregulates Caspase-3 to promote late-stage apoptosis. STAT3-IN-44 significantly suppresses tumor cell proliferation and migration. STAT3-IN-44 can be used for the study of cancers such as glioma and lung cancer .

HY-N13163

2-Epitripdiolide	Others	Cancer
2-Epitripdiolide is a diterpenoid compound derived from Tripterygium hypoglaucum with significant antitumor activity. Its IC₅₀ values against A549, KB, KBvin, and MDA-MB-231 cells are 1.34, 0.4, 4.4, and 1.2 nM, respectively .

HY-150500

HDAC-IN-44	HDAC	Cancer
HDAC-IN-44 is a HDAC inhibitor with the IC₅₀ value of 61.2 nM. HDAC-IN-44 shows high anticancer activity towards multiple cancer cell lines .

HY-176257

STING agonist-44	STING	Cancer
STING agonist-44 (Compound 4) is a potent and selective STING agonist with an EC₅₀ value of 5.68 for IRF induction in THP1 cells and 2.212 μM in RAW cells. STING agonist-44 activates the STING pathway, inducing the production of type I interferons and pro-inflammatory cytokines (e.g., CXCL10, TNFα). STING agonist-44 is promising for research of cancers .

HY-B0688S3

Dapsone-15N2 4,4′-Diaminodiphenyl sulfone-¹⁵N₂; DDS-¹⁵N₂	Isotope-Labeled Compounds Antibiotic Reactive Oxygen Species (ROS) Bacterial Parasite	Infection Inflammation/Immunology
Dapsone- ¹⁵N₂ (4,4′-Diaminodiphenyl sulfone- ¹⁵N₂) is ¹⁵N labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities . Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .

HY-161327

HBV-IN-44	HBV	Infection
HBV-IN-44 (Compound (S)-2a) is a HBV inhibitor with a IC₅₀ value of 23 nM for HbsAg. HBV-IN-44 is less toxic to the neurite growth of HT22 cells and DRG neurons in vitro .

HY-N9101

4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan	Others	Cancer
4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan is a lignans that can be isolated from the Viburnum foetidum. 4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan has cytotoxicity against A549, SK-OV-3, SKMEL-2 and HCT15 cell line with IC₅₀s of 67.14, 67.38, 64.11 and 76.31 μg/mL, respectively .

HY-178032

PARP1-IN-44	PARP Apoptosis Reactive Oxygen Species (ROS) DNA/RNA Synthesis STING	Cancer
PARP1-IN-44, an Olaparib (HY-10162) derivative, is an orally active PARP1 inhibitor (IC₅₀ = 0.6 nM), and also inhibits PARP2 (IC₅₀ = 1.0 nM) and PARP7 (IC₅₀ = 7.5 nM). PARP1-IN-44 has selective antiproliferative activity against BRCA-deficient cancer cells with minimal toxicity to normal cells. PARP1-IN-44 induces G2/M phase arrest, promotes apoptosis, elevates ROS levels, disrupts mitochondrial membrane potential. PARP1-IN-44 suppresses PARylation while increasing γH2AX accumulation. PARP1-IN-44 activates the cGAS-STING pathway, upregulating IFN-β and CXCL10 expression. PARP1-IN-44 enhancing CD8+ T cell infiltration in a CT26 tumor mouse model, demonstrating robust in vivo antitumor efficacy .

HY-146286

Anticancer agent 44	Apoptosis	Cancer
Anticancer agent 44 (compound 2a) is a potent anticancer agent. Anticancer agent 44 shows cytotoxicity activity in cancer cells. Anticancer agent 44 induces apoptosis. Anticancer agent 44 shows low toxicity towards activated lymphocytes of human blood .

HY-149898

HA-CD44 interaction inhibitor 1	Transmembrane Glycoprotein	Cancer
HA-CD44 interaction inhibitor 1 (compound 6) is an inhibitor of hyaluronic acid (HY-B0633A) targeting to CD44, as well as an anti-tumor agent. Hyaluronic acid interacts with differentiation cluster 44 (CD44) and is involved in tumor growth and invasion. HA-CD44 interaction inhibitor 1 inhibits MDA-MB-231 cells with EC50 value of 1.77 μM .

HY-10451S2

Canagliflozin-d6 JNJ 28431754-d₆	SGLT	Metabolic Disease
Canagliflozin-d₆ is the deuterium labeled Canagliflozin . Canagliflozin (JNJ 28431754) is a selective SGLT2 inhibitor with IC₅₀s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively .

HY-122609

XO44 PF-6808472	CDK	Cancer
XO44 (PF-6808472) is a broad-spectrum covalent kinase probe. XO44 can bind in CDK2 and CDK1. XO44 also labels CDK4 proteins in cells .

HY-136530

SR18662	KLF	Cancer
SR18662 is a potent inhibitor of Krüppel-like factor five (KLF5) with an IC₅₀ of 4.4 nM and an analogue of ML264 (HY-19994) with improved inhibitory potency against colorectal cancer cells. SR18662 can be used for the study of colorectal cancer .

HY-175184

LSD1-IN-44	Histone Demethylase	Infection
LSD1-IN-44 (Compound 19) is a LSD1 inhibitor with an IC₅₀ of 0.02  μM for LSD1-CoREST enzymatic complex. LSD1-IN-44 has significant antischistosomal activity against transformed schistosomula (NTS) and Schistosoma mansoni adult worms while showing a delayed onset of action towards juvenile forms. LSD1-IN-44 has no significant toxicity to human cells. LSD1-IN-44 can be used for schistosomiasis research .

HY-155532

10m/ZS44	Apoptosis	Cancer
10m/ZS44 is a blood-brain barrier-permeable Glioblastoma (GBM) inhibitor. 10m/ZS44 significantly inhibits GBM tumor growth in a mouse xenograft model. 10m/ZS44 also activates the SIRT1/p53-mediated apoptosis pathway, thereby inhibiting the proliferation of U251 cells .

HY-155014

SARS-CoV-2-IN-44	SARS-CoV	Infection
SARS-CoV-2-IN-44, a inhibitor of SARS-CoV-2, inhibits viral replication, with an EC₅₀ of 0.6μM. SARS-CoV-2-IN-44 has no evident cytotoxic effect in Calu-3 cells and can be used for antiviral research .

HY-147281

BAY 1135626	Drug-Linker Conjugates for ADC	Cancer
BAY 1135626 is used to synthesize BAY 1129980, and use to anti-tumor research. BAY 1129980 is a Auristatin-based anti-C4.4A (LYPD3) antibody–agent conjugate (ADC), is used to non–small cell lung cancer (NSCLC) research .

HY-10451R

Canagliflozin (Standard) JNJ 28431754 (Standard)	Reference Standards SGLT	Metabolic Disease Cancer
Canagliflozin (Standard) is the analytical standard of Canagliflozin. This product is intended for research and analytical applications. Canagliflozin (JNJ 28431754) is a selective SGLT2 inhibitor with IC₅₀s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively .

HY-175809

SRT6	CD44 Src EGFR MAPKAPK2 (MK2)	Cancer
SRT6, an anticancer agent is a *CD44* inhibitor. SRT6 inhibits key CD44-associated kinases, including SRC, ERBB2 and MAPKAPK2. SRT6 has strong tumor selectivity over non-tumoral lung cells and significant antiproliferative activity against cancer cells (EC₅₀of 1.37  μM for NCI-H23 cells) .

HY-P2230

Angstrom6 1 Publications Verification A6 Peptide	PAI-1	Cancer
Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling .

HY-17592

Bithionol 3 Publications Verification	Parasite Bacterial	Infection Cancer
Bithionol is an antibacterial, anthelmintic, and algaecide agent. Bithionol is also a potent inhibitor of soluble adenylyl cyclase through binding to the allosteric activator site (IC₅₀: 4 μM) .

HY-17592R

Bithionol (Standard)	Reference Standards Parasite Bacterial	Infection Cancer
Bithionol (Standard) is the analytical standard of Bithionol. This product is intended for research and analytical applications. Bithionol is an antibacterial, anthelmintic, and algaecide agent. Bithionol is also a potent inhibitor of soluble adenylyl cyclase through binding to the allosteric activator site (IC₅₀: 4 μM) .

HY-P99126

Anti-Mouse/Human CD44 Antibody (IM7) 1 Publications Verification	Transmembrane Glycoprotein Apoptosis	Inflammation/Immunology Cancer
Anti-Mouse/Human CD44 Antibody (IM7) is an anti-huamn and mouse *CD44* IgG2b monoclonal antibody. Anti-Mouse/Human CD44 Antibody (IM7) relieves inflammation and induces cell apoptosis by blocking the interaction between CD44 and hyaluronic acid. Anti-Mouse/Human CD44 Antibody (IM7) can be used for researches on inflammation conditions and cancer such as arthritis and osteosarcoma .

HY-162650

SL44	ClpP	Cancer
SL44 is an agonist for human caseinolytic protease P (HsClpP), with an EC₅₀ of 1.30 μM. SL44 inhibits the proliferation of LM3 with an IC₅₀ of 3.1 μM. SL44 induces apoptosis in HCC cells, through the degradation of respiratory chain complex subunits. SL44 exhibits antitumor efficacy in mouse models without obvious toxicity (LD₅₀=400 mg/kg). SL44 exhibits good pharmacokinetic characters in rat models .

HY-175815

Apoptosis inducer 44	Apoptosis Bcl-2 Family Caspase MMP Cadherin	Cancer
Apoptosis inducer 44 is an apoptosis inducer. Apoptosis inducer 44 triggers apoptosis in MDA-MB-231 cells by increasing the levels of Bax and Cyt C, reducing Bcl-2, and initiating caspase-3 cleavage. Apoptosis inducer 44 suppresses the invasion and migration of MDA-MB-231 cells by down-regulating MMP-2 and MMP-9 expression and up-regulating E-cadherin protein levels. Apoptosis inducer 44 can be used for the study of breast cancer .

HY-135124

DC44SMe	ADC Payload	Cancer
DC44SMe, a phosphate proagent of cytotoxic DNA alkylator DC44, can be used in the synthesis of antibody-drug conjugate (ADC). DC44SMe exhibits IC₅₀s of 2.0 nM, 2.8 nM, and 1.9 nM for Ramos, Namalwa, and HL60/s cancer cells, respectively. DC44SMe can be used for the targeted treatment of cancer .

HY-123663

U-101958 maleate PNU-101958 maleate	Dopamine Receptor	Neurological Disease
U-101958 (PNU-101958) maleate is a highly selective ligand and antagonist for dopamine D4 receptor, with an IC₅₀ of 2.7 nM. U-101958 maleate behaves as an agonist in HEK-293 cells expressing the human recombinant D4.4 receptor. U-101958 maleate is an antipsychotic .

HY-164549

XMD15-44	RET	Cancer
XMD15-44 is a RET kinase inhibitor.XMD15-44 has a growth-inhibitory effect on RET/C634R and RET/M918T transformed RAT1 cells, with IC₅₀ values of 11.5 nM and 8.3 nM, respectively. XMD15-44 can inhibit RET kinase and signaling in human thyroid cancer cell lines carrying oncogenic RET alleles, reducing cell proliferation .

HY-161518

PD-1/PD-L1-IN-44	PD-1/PD-L1	Cancer
PD-1/PD-L1-IN-44 (Compound 22) selectively inhibits PD-1/PD-L1 proteins (IC₅₀=1.21 nM). PD-1/PD-L1-IN-44 inhibits tumor growth without toxicity in animal models and increases CD8 ⁺ cell infiltration .

HY-112393

TX-1918	HIV Src PKA PKC	Infection
TX-1918 is an inhibitor for eukaryotic elongation factor 2 kinase (eEF2-K) and Src kinase with IC₅₀ of 0.44 and 4.4 μM, respectively. TX-1918 exhibits cytotoxicity in cell HepG2 and HCT116, with IC₅₀ of 2.07 and 230 μM, respectively. TX-1918 inhibits the C-terminal domain of HIV-1 CA (CA CTD)(IC₅₀ =3.81 μM), and inhibits the viral replication (IC₅₀ =15.16 μM) .

HY-169194

Antimalarial agent 44	Parasite	Infection
Antimalarial agent 44 (Compound 3) is an antimalarial agent against parasite. Antimalarial agent 44 has a good permeability across MDCK-MDR1 cell monolayers and a high clearance by mouse liver microsomes .

HY-175722

JSZ16	Fungal	Infection
JSZ16 is a Succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 30.3  μM. JSZ16 has potent broad-spectrum fungicidal activity, such as Sclerotinia sclerotiorum, Botrytis cinerea and Colletotrichum fragariae, with an EC₅₀ of 4.4 mg/L for Sclerotinia sclerotiorum. JSZ16 influences the cell membrane permeability of pathogenic fungi. JSZ16 can be used for the development of fungicide .

HY-118907

Methyl Orange	Fluorescent Dye	Others
Methyl Orange is a soluble azo dye commonly used as an acid-base indicator and for staining cells and tissue sections, as well as for dyeing textiles. Methyl Orange appears red at a pH of 3.1 and changes to bright yellow as the pH increases to 4.4. Methyl Orange (500 mg/L) exhibits cytotoxicity and can cause DNA damage .

HY-155039

Antitumor agent-105	Drug Derivative	Cancer
Antitumor agent-105 (Compound 37) is an antitumor agent. Antitumor agent-105 has antitumor activity against A549, H1299, H460, HCT116, MDA-MB-231 cells, with IC₅₀ values of 6.7, 8.3, 4.3, 4.4, 6.7 μM respectively .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1713

29-Nor-20-oxolupeol	Triterpenes Classification of Application Fields Terpenoids Labiatae Source classification Plants Inflammation/Immunology Disease Research Fields Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	Others
29-Nor-20-oxolupeol, extracted from Impatiens basamina, reduces NO levels in LPS-activated murine microglial cells with an IC₅₀ of 44.21 µM .

HY-N7171

4,4'-Di-O-methylellagic acid 4,4'-DiOMEA; Nasutin C	Animals Source classification Phenols Polyphenols	Wnt
4,4'-Di-O-methylellagic acid (4,4'-DiOMEA; Nasutin C) can be isolated from the Australian termites. 4,4'-Di-O-methylellagic acid is blue-fluorescent under ultra-violet light . 4,4'-Di-O-methylellagic acid inhibits colon cancer cell proliferation via the wnt signal pathway .

HY-N15380

4,4′-Secalonic acid D	Xanthones Animals Source classification Phenols	PARP Reactive Oxygen Species (ROS) Caspase Apoptosis Pyroptosis
4,4′-Secalonic acid D (Compound 12) is a PARP1 inhibitor. 4,4′-Secalonic acid D induces the accumulation of ROS and DNA damage, activates the caspase-3/GSDME pathway, and triggers apoptosis and pyroptosis of tumor cells by inhibiting PARP1. 4,4′-Secalonic acid D has anti-tumor activity .

HY-W720006

4,4'-Diapo-ω,ω-carotene-4,4'-dial	Natural Products Source classification Araucariaceae Plants Araucaria cunninghamii Mudie	Drug Derivative
4,4'-Diapo-ω,ω-carotene-4,4'-dial is a carotenoid pigment. Carotenoids are important biological active, and may regulate cellular differentiation, growth control, photooxidative protection, cell membrane stability, photosynthesis, vision process and nutrition .

HY-N9257

8-Hydroxypinoresinol4,4'-di-O-β-D-glucopyranoside	Polysaccharides Source classification Plants Valerianaceae Valeriana amurensis Smir. ex Komarov Saccharides	Others
8-Hydroxypinoresinol4,4'-di-O-β-D-glucopyranoside (Compound 7) is a compound derived from roots and rhizomes. 8-Hydroxypinoresinol4,4'-di-O-β-D-glucopyranoside could prevent neurotoxicity in PC12 cells .

HY-N14893

Cetoniacytone B	Microorganisms Antibiotics Source classification Other Antibiotics	Others
Cetoniacytone B can inhibit the growth of HEPG2 and MCF7 human tumor cell lines, with GI₅₀ values of 4.4 μM .

HY-N13163

2-Epitripdiolide	Terpenoids Source classification Celastraceae Diterpenoids Tripterygium wilfordii Hook. f. Plants	Others
2-Epitripdiolide is a diterpenoid compound derived from Tripterygium hypoglaucum with significant antitumor activity. Its IC₅₀ values against A549, KB, KBvin, and MDA-MB-231 cells are 1.34, 0.4, 4.4, and 1.2 nM, respectively .

HY-N9101

4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan	Caprifoliaceae Source classification Lignans Phenylpropanoids Viburnum cylindricum Buch.-Ham. ex D. Don Plants	Others
4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan is a lignans that can be isolated from the Viburnum foetidum. 4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan has cytotoxicity against A549, SK-OV-3, SKMEL-2 and HCT15 cell line with IC₅₀s of 67.14, 67.38, 64.11 and 76.31 μg/mL, respectively .

HY-N16067

Penipanoid C	Alkaloids Marine natural products Source classification Quinoline Alkaloids Marine microorganism	Epigenetic Reader Domain
Penipanoid C (Compound 9) is a BRD4 inhibitor. Penipanoid C can be isolated from marine sediment-derived fungus Penicillium paneum SD-44. Penipanoid C has anti-inflammatory activity and cytotoxic activity against the SMMC-7721 cells. Penipanoid C can be used for inflammatory diseases research .

HY-N16050

Ethyl salvianolate A Ethyl salvionolate A	Simple Phenylpropanols Labiatae Source classification Salvia yunnanensis C. H. Wright Phenylpropanoids Plants	HIV Reverse Transcriptase HIV Integrase HIV Protease
Ethyl salvianolate A (Ethyl salvionolate A) is an anti-HIV-1 compound that can be extracted from the roots of Salvia yunnanensis. Ethyl salvianolate A inhibits P24 antigen in HIV-1 infected MT-4 cell cultures (EC₅₀: 1.44 μg/mL). Ethyl salvianolate A inhibits HIV-1 replicative enzymes, with IC₅₀s of 56.38 μM (Reverse transcriptase), 12.03 μM (Protease), 14.54 μM (Integrase), respectively .

HY-139054

4'-Methoxyflavone	Flavonoids Flavones Source classification Endogenous metabolite	Apoptosis
4'-Methoxyflavone is a flavonoid with antioxidant properties and anti-proliferative activity against cancer cells. 4'-Methoxyflavone can inhibit cycle-dependent kinases leading to cell cycle arrest and regulate cell signaling pathways to influence cell proliferation and apoptosis. 4'-Methoxyflavone can be used in cancer chemoprevention research .

HY-N13118

Sinopodophylline B	Flavonoids Flavones Sinopodophyllum hexandrum (Royle) Ying Source classification Plants Berberidaceae	Others
Sinopodophylline B (compound 2) is a flavonoid glycoside compound that is cytotoxic to breast cancer cells. For example, the IC₅₀ of Sinopodophylline B is 1.5 μM (T47D) and 44.2 μM (MDA-MB-231), respectively .

HY-N9194

5-Methoxycanthin-6-one	Infection Alkaloids Classification of Application Fields Source classification Rutaceae Pyridine Alkaloids Zanthoxylum chiloperone var. angustifolium Plants Disease Research Fields Indole Alkaloids	Parasite
5-Methoxycanthin-6-one is an orally active inhibitor of Leishmania strains. 5-Methoxycanthin-6-one shows cytotoxicity with an IC₅₀ of 5.44 μg/mL against Ailanthus altissima cells .

HY-N14264

Kistamicin A	Microorganisms Antibiotics Source classification Other Antibiotics	Influenza Virus Bacterial
Kistamicin A has antiviral effect, and its ID₅₀s against influenza virus MDCK cells and herpes simplex virus are respectively 3.6 μg/mL and 44 μg/mL. Kistamicin A also has anti-Gram-positive bacterial effects .

HY-N16010

4-HNE-Dimethylacetal	Lipid	Biochemical Assay Reagents
4-HNE-Dimethylacetal is an α,β-unsaturated hydroxyalkenal that can be produced by lipid peroxidation in cells. 4-HNE-Dimethylacetal can be studied in research on cell signal transduction including pathways from cell cycle events to cellular adhesion .

HY-B1899AR

Taurodeoxycholic acid sodium hydrate (Standard) Sodium taurodeoxycholate monohydrate (Standard)	Source classification Endogenous metabolite Steroids	Reference Standards G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite
(E)-Methyl 4-coumarate (Standard) is the analytical standard of (E)-Methyl 4-coumarate. This product is intended for research and analytical applications. (E)-Methyl 4-coumarate (Methyl 4-hydroxycinnamate), found in several plants, such as Allium cepa or Morinda citrifolia L. leaves. (E)-Methyl 4-coumarate cooperates with Carnosic Acid in inducing apoptosis and killing acute myeloid leukemia cells, but not normal peripheral blood mononuclear cells. Antioxidant and antimicrobial activity.

HY-N0841

Bruceine A 3 Publications Verification Dihydrobrusatol; NSC310616	Infection Triterpenes Simaroubaceae Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Brucea javanica (L.) Merr.	Parasite NF-κB p38 MAPK Phosphatase Apoptosis
Bruceine A (Dihydrobrusatol) is a natural quassinoid. Bruceine A is an inhibitor of parasites, NF-κB, and PFKFB4 (K_d: 44 nM). Bruceine A is an activator of P38α MAPK. Bruceine A has antiparasitic activity. Bruceine A has antitumor activity and inhibits cancer cell migration. Bruceine A blocks the cell cycle and induces apoptosis. Bruceine A can be used in parasites, pancreatic cancer, and breast cancer research .

HY-N2323

4'-Demethylpodophyllotoxin	Monophenols Classification of Application Fields Sinopodophyllum hexandrum (Royle) Ying Source classification Lignans Phenols Phenylpropanoids Plants Berberidaceae Disease Research Fields Cancer	Others
4'-Demethylpodophyllotoxin is an aryltetralin lignin contained in the root of Podophyllum hexandrum and P. peltatum. 4'-Demethylpodophyllotoxin exhibits cytotoxic potential in diverse cancer cell lines .

HY-N14293

4-Methylaeruginoic acid	Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
4-Methylaeruginoic acid is an antibiotic and is cytotoxic to several human tumor cell lines .

HY-N4286

4-Methyldaphnetin	other families Classification of Application Fields Source classification Coumarins Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer	Apoptosis
4-Methyldaphnetin is a precursor in the synthesis of derivatives of 4-methyl coumarin. 4-Methyldaphnetin has potent, selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines. 4-Methyldaphnetin possesses radical scavenging property and strongly inhibits membrane lipid peroxidation .

HY-137309

4-Deoxy-4α-phorbol	Terpenoids Source classification Euphorbia cooperi N. E. Br. ex A. Berger Diterpenoids Euphorbiaceae Plants	HIV
4-Deoxy-4α-phorbol is a tetracyclic diterpene found in E. desmondi. It has been used in the semisynthesis of inhibitors of the HIV-1-induced cytopathic effect on MT-4 cells and 4α-phorbol esters .

HY-N2640

4-O-Methylsappanol	Flavonoids Leguminosae Caesalpinia sappan L. Source classification Plants Other Flavonoids	Fungal
4-O-Methylsappanol is a natural isoflavonoid with antifungal activities. 4-O-Methylsappanol shows activity against *Beauveria bassiana* . 4-O-Methylsappanol (EC₅₀ of 4.6 μM) strongly suppresses Melanin (Melanin) synthesis in HMV-II cells .

HY-N7204

4-Hydroxyderricin 1 Publications Verification	Chalcones Monophenols Flavonoids Phenols Umbelliferae Plants Ondetia linearis Benth.	Monoamine Oxidase Dopamine β-hydroxylase Apoptosis
4-Hydroxyderricin, the major active ingredients of Angelica keiskei Koidzumi, is an orally active, potent selective MAO-B (Monoamine oxidase inhibitors) inhibitor with an IC₅₀ of 3.43 μM. 4-Hydroxyderricin also mildly inhibits dopamine β (DBH)-hydroxylase activity. 4-Hydroxyderricin has antidepressant activity, anti-allergic, anti-diabetic, anti-oxidant, and antitumor effects. 4-Hydroxyderricin promotes apoptosis and cell cycle arrest through regulating PI3K/AKT/mTOR pathway in hepatocellular cells. 4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation . 4-Hydroxyderricin is promising for research of inflammatory diseases .

HY-59208R

4-Quinolinol (Standard)	Alkaloids Source classification Quinoline Alkaloids Endogenous metabolite	Endogenous Metabolite
4-Quinolinol (Standard) is the analytical standard of 4-Quinolinol. This product is intended for research and analytical applications. 4-Quinolone (Kynurine) is a quinoline derivative. Kynurine pathway modulates tryptophan metabolism and involves in neuroprotective effect. Kynurine promotes tumor cell survival and motility by suppressing antitumor immune .

HY-N2208

4-Hydroxylonchocarpin 1 Publications Verification	Classification of Application Fields Source classification Metabolic Disease Plants Infection Chalcones Flavonoids Leguminosae Phenols Polyphenols Psoralea corylifolia L. Inflammation/Immunology Disease Research Fields	p38 MAPK Apoptosis Reactive Oxygen Species (ROS)
4-Hydroxylonchocarpin is a chalcone compound. 4-Hydroxylonchocarpin enhances the phosphorylation of p38 MAPK, JNK and ERK. 4-Hydroxylonchocarpin induces reactive oxygen species (ROS) and apoptosis in liver cancer cells. 4-Hydroxylonchocarpin has various pharmacological activities, including antibacterial, anticancer, anti-retroviral, anti-tuberculosis, anti-malarial and anti-inflammatory activities .

HY-30267R

4-Hydroxyphenyl acetate (Standard)	Monophenols Source classification Phenols Endogenous metabolite	Endogenous Metabolite
4-Hydroxyphenyl acetate (Standard) is the analytical standard of 4-Hydroxyphenyl acetate. This product is intended for research and analytical applications. 4-Hydroxyphenyl acetate (4-HPA) is a natural antioxidant and protects cells from oxidative stress-induced necrosis. 4-Hydroxyphenyl acetate blocks the increase of cellular ROS induced by oxidative stress, and up-regulates NQO1 and HO-1 genes by stabilizing and inducing the nuclear translocation of NRF2 transcription factor .

HY-103332

N-Arachidonylglycine 1 Publications Verification NA-Gly	Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	GlyT Endogenous Metabolite
N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC₅₀ = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC₅₀ = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration .

HY-W013605AR

4-Methoxycinnamaldehyde (Standard) p-Methoxycinnamaldehyde (Standard)	Araceae Ketones, Aldehydes, Acids Source classification Acorus gramineus Soland. Plants	Reference Standards RSV
4-Methoxycinnamaldehyde (Standard) is the analytical standard of 4-Methoxycinnamaldehyde. This product is intended for research and analytical applications. 4-Methoxycinnamaldehyde (p-Methoxycinnamaldehyde), an active constituent of Agastache rugosa, exhibits cytoprotective activity against respiratory syncytial virus (RSV) in human larynx carcinoma cell line. 4-Methoxycinnamaldehyde effectively inhibits cytopathic effect of RSV with an estimated IC50 of 0.055 μg/mL[1].

HY-N3286

Methyl 4-O-feruloylquinate	Simple Phenylpropanols Stemonaceae Source classification Phenylpropanoids Plants Stemona japonica (Bl.) Miq	Influenza Virus
Methyl 4-O-feruloylquinate (4-O-Feruloylquinic acid methyl ester) is a natural product. Methyl 4-O-feruloylquinate can be purified from Stemona Japonica by preparative high-performance liquid chromatography. Methyl 4-O-feruloylquinate has anti-H5N1 activity with a 3% protective rate at 5 μM in MDCK cells .

HY-30267

4-Hydroxyphenyl acetate 2 Publications Verification 4-HPA; 4-Acetoxyphenol	Monophenols Classification of Application Fields Source classification Other Diseases Phenols Endogenous metabolite Disease Research Fields	Quinone Reductase Endogenous Metabolite
4-Hydroxyphenyl acetate (4-HPA) is a natural antioxidant and protects cells from oxidative stress-induced necrosis. 4-Hydroxyphenyl acetate blocks the increase of cellular ROS induced by oxidative stress, and up-regulates NQO1 and HO-1 genes by stabilizing and inducing the nuclear translocation of NRF2 transcription factor .

HY-N10403

4-Hydroxyestradiol 1 Publications Verification 4-Hydroxy-17β-estradiol	Classification of Application Fields Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields Steroids Cancer	Drug Metabolite Endogenous Metabolite
4-Hydroxyestradiol (4-Hydroxy-17β-estradiol) is an endogenous metabolite of Estradiol (HY-B0141). 4-Hydroxyestradiol is carcinogenic and shows mutagenic activity in breast epithelial cells. 4-Hydroxyestradiol inhibits the binding of Estradiol to the estrogen receptor in a competitive manner, with a K_i of 0.48 nM .

HY-Y0073R

4-Hydroxyacetophenone (Standard) P-hydroxyacetophenone (Standard)	Monophenols Ketones, Aldehydes, Acids Source classification Phenols Plants Compositae Artemisia capillaris Thunb.	Reference Standards HBV Myosin
4-Hydroxyacetophenone (Standard) is the analytical standard of 4-Hydroxyacetophenone. This product is intended for research and analytical applications. 4-Hydroxyacetophenone (P-hydroxyacetophenone) is a major hepatoprotective and choleretic compound found in Artemisia and Illicium plants, exhibiting antiviral and anti-inflammatory effects against hepatitis B virus. Additionally, 4-Hydroxyacetophenone inhibits cancer cell adhesion, invasion, and migration by remodeling actin. 4-Hydroxyacetophenone holds promise for research in the fields of inflammatory diseases and cancer .

HY-N7634

Tectol	Infection other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields	Farnesyl Transferase Parasite
Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM . Tectol is a farnesyltransferase (FTase) inhibitor with IC₅₀s of 2.09 and 1.73 μM for human and T. brucei FTase, respectively. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC₅₀ of 3.44 μM .

HY-N15536

N-trans-Feruloyltyramine 4′-O-β-D-glucopyranoside	Source classification Piperaceae Piper crocatum Ruiz & Pav. Plants Saccharides Monosaccharides	Reactive Oxygen Species (ROS)
N-trans-Feruloyltyramine 4′-O-β-D-glucopyranoside is a phenolic amide glycoside compound found in Suaeda japonica. N-trans-Feruloyltyramine 4′-O-β-D-glucopyranoside exhibits antioxidant activity, capable of effectively scavenging DPPH free radicals and reducing the production of ROS induced by H₂O₂ in cells, thus protecting cells from oxidative stress damage. N-trans-Feruloyltyramine 4′-O-β-D-glucopyranoside is promising for research of cardiovascular diseases and neurodegenerative diseases .

HY-N12033

4'-Demethylpodophyllotoxone	Source classification Podophyllum peltatum L. Lignans Phenylpropanoids Plants Berberidaceae	Others
4'-Demethylpodophyllotoxone is an intermediate product of the biotransformation of Alternaria alternata S-f6. After 4'-Demethylpodophyllotoxone is modified with 4-(2,3,5,6-tetramethylpyrazine-1) (4-TMP), the resulting novel compound can strongly inhibit the growth of human gastric cancer cell line (BGC-823) .

HY-W012814

4-Methylcatechol	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Other Diseases Phenols Polyphenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite Apoptosis Reactive Oxygen Species (ROS)
4-Methylcatechol is an intermediate in the degradation of some alkylbenzenes and an orally active suicide inhibitor of catechol 2,3-dioxygenase (C23O). 4-Methylcatechol induces apoptosis in melanoma cells through oxidative stress, but some studies have also shown that 4-Methylcatechol is carcinogenic. In addition, 4-Methylcatechol has antiplatelet and blood pressure-lowering activities. 4-Methylcatechol can also inhibit protein oxidation in beef but does not disulfide formation .

HY-N8426

4'-O-Methylnyasol Ellisinin A	Natural Products Liliaceae Source classification Anemarrhena asphodeloides Bunge Plants	Histamine Receptor
4'-O-Methylnyasol is an inhibitor of β-hexosaminidase. 4'-O-Methylnyasol inhibits β-hexosaminidase release from rat basophilic leukemia-2H3 cells with an IC₅₀ of 52.67 μM .

HY-W012814R

4-Methylcatechol (Standard)	Human Gut Microbiota Metabolites Microorganisms Source classification Phenols Polyphenols Endogenous metabolite	Reference Standards Endogenous Metabolite Apoptosis Reactive Oxygen Species (ROS)
4-Methylcatechol (Standard) is the analytical standard of 4-Methylcatechol. This product is intended for research and analytical applications. 4-Methylcatechol is an intermediate in the degradation of some alkylbenzenes and an orally active suicide inhibitor of catechol 2,3-dioxygenase (C23O). 4-Methylcatechol induces apoptosis in melanoma cells through oxidative stress, but some studies have also shown that 4-Methylcatechol is carcinogenic. In addition, 4-Methylcatechol has antiplatelet and blood pressure-lowering activities. 4-Methylcatechol can also inhibit protein oxidation in beef but does not disulfide formation[1][2][3][4][5][6].

HY-Y0073

4-Hydroxyacetophenone P-hydroxyacetophenone	Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Plants Compositae Inflammation/Immunology Disease Research Fields Artemisia capillaris Thunb.	HBV Myosin
4-Hydroxyacetophenone (P-hydroxyacetophenone) is a major hepatoprotective and choleretic compound found in Artemisia and Illicium plants, exhibiting antiviral and anti-inflammatory effects against hepatitis B virus. Additionally, 4-Hydroxyacetophenone inhibits cancer cell adhesion, invasion, and migration by remodeling actin. 4-Hydroxyacetophenone holds promise for research in the fields of inflammatory diseases and cancer .

HY-N0946

(-)-Pinoresinol 4-O-glucoside (-)-Pinoresinol 4-O-β-D-glucopyranoside	Cicer arietinum L. Source classification Plants Compositae Saccharides Monosaccharides	Glycosidase
(-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally active α-glucosidase inhibitor with an IC₅₀ value of 48.13 µM. (-)-Pinoresinol 4-O-glucoside increases cell migration and early differentiation of pre-osteoblasts. (-)-Pinoresinol 4-O-glucoside increases protein level of BMP2, p-Smad1/5/8, RUNX2. (-)-Pinoresinol 4-O-glucoside attenuates oxidative stress, hyperglycemia and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside has the potential for the research of osteoporosis and periodontal disease .

HY-N2213

Matairesinol 4′-O-β-D-glucopyranoside	Monophenols Classification of Application Fields Ranunculaceae Source classification Lignans Clematis chinensis Osbeck Phenols Phenylpropanoids Plants Disease Research Fields Cancer	Others
Matairesinol 4′-O-β-D-glucopyranoside displays cytotoxic activity against HeLa cell line with an IC₅₀ of 47.1 μM .

HY-W013605A

4-Methoxycinnamaldehyde p-Methoxycinnamaldehyde	Infection Classification of Application Fields Araceae Ketones, Aldehydes, Acids Source classification Acorus gramineus Soland. Plants Disease Research Fields	RSV
4-Methoxycinnamaldehyde (p-Methoxycinnamaldehyde), an active constituent of Agastache rugosa, exhibits cytoprotective activity against respiratory syncytial virus (RSV) in human larynx carcinoma cell line. 4-Methoxycinnamaldehyde effectively inhibits cytopathic effect of RSV with an estimated IC₅₀ of 0.055 μg/mL .

HY-W145699

D-myo-Inositol 4-monophosphate	Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Biochemical Assay Reagents Endogenous Metabolite
D-myo-Inositol 4-mono-phosphate, also known as IMP, is a phosphorylated form of inositol that is commonly found in various metabolic pathways, especially in the biosynthesis of phospholipids and cell signaling molecules. D-myo-Inositol 4-mono-phosphate has unique chemical properties that make it an important intermediate in the production of second messengers, such as inositol triphosphate (IP3) and diacylglycerol (DAG), which signal in cells plays a key role in. D-myo-Inositol 4-mono-phosphate is also used in dietary supplements and pharmaceuticals because of its potential health benefits, including improved insulin sensitivity and cognitive function.

HY-106843

Phospholine	Natural Products Microorganisms Source classification	Antibiotic Bacterial
Phospholine is an antibiotic. The IC₅₀ (μg/mL) of Ll 210, P388 and EL-4 cells are 3.37, 2.20 and 1.99, respectively .

HY-N2592

Isobutylshikonin	Quinones Classification of Application Fields Source classification Phenols Polyphenols Plants Lithospermum canescens Lehm. Naphthalene Quinones Boraginaceae Inflammation/Immunology Disease Research Fields	Others
Isobutylshikonin is a kind of shikonin pigments found in hairy root culture of Lithospermum canescens. Isobutylshikonin decreases cell viability induces marked changes in JA-4 cells with nuclear condensation and swelling in the presence of LPS (HY-D1056) .

HY-N15201

Betavulgarin	Natural Products Terpenoids Source classification Diterpenoids Beta vulgaris Linn. Plants Chenopodiaceae	STAT
Betavulgarin is an anticancer agent. Betavulgarin can be isolated from Sugar Beet (Beta vulgaris). Betavulgarin suppresses the proliferation, migration, colony formation, and mammosphere formation of breast cancer cells, and reduces the size of the CD44 ⁺/CD24 ⁻ subpopulation and the expression of the self-renewal- related genes C-Myc, Nanog and Oct4. Betavulgarin promotes BCSCs death through the regulation of Stat3/Sox2 signaling .

HY-B1941R

4-tert-Octylphenol (Standard)	Monophenols Source classification Phenols Endogenous metabolite	Reference Standards Endogenous Metabolite Apoptosis DNA/RNA Synthesis
4-tert-Octylphenol (Standard) is the analytical standard of 4-tert-Octylphenol. This product is intended for research and analytical applications. 4-tert-Octylphenol, a endocrine-disrupting chemical, is an estrogenic agent. 4-tert-Octylphenol is also a biodegradation product of non-ionic surfactants alkylphenol polyethoxylates. 4-tert-Octylphenol induces apoptosis in neuronal progenitor cells in offspring mouse brain. 4-tert-Octylphenol reduces bromodeoxyuridine (BrdU), mitotic marker Ki67, and phospho-histone H3 (p-Histone-H3), resulting in a reduction of neuronal progenitor proliferation. 4-tert-Octylphenol disrupts brain development and behavior in mice, which is promising for reserch of immune response, neuro-related diseases and ethology .

HY-N1904

4′-Hydroxywogonin 8-Methoxyapigenin	Flavonoids Flavones Verbenaceae Verbena littoralis H.B.K. Plants	IKK NF-κB p38 MAPK PI3K Akt Reactive Oxygen Species (ROS) Interleukin Related TNF Receptor Apoptosis Caspase Bcl-2 Family
4′-Hydroxywogonin (8-Methoxyapigenin), a flavonoid, could be isolated from a variety of plants including Scutellaria barbata and Verbena littoralis. 4′-Hydroxywogonin has anti-inflammatory activity via TAK1/IKK/NF-κB, MAPKs and PI3/AKT signaling pathways. 4′-Hydroxywogonin inhibits angiogenesis by disrupting PI3K/AKT signaling. 4′-Hydroxywogonin inhibits cell proliferation and induces apoptosis .

HY-B1941

4-tert-Octylphenol 1 Publications Verification	Monophenols Neurological Disease Classification of Application Fields Source classification Phenols Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite Apoptosis DNA/RNA Synthesis
4-tert-Octylphenol, a endocrine-disrupting chemical, is an estrogenic agent. 4-tert-Octylphenol is also a biodegradation product of non-ionic surfactants alkylphenol polyethoxylates. 4-tert-Octylphenol induces apoptosis in neuronal progenitor cells in offspring mouse brain. 4-tert-Octylphenol reduces bromodeoxyuridine (BrdU), mitotic marker Ki67, and phospho-histone H3 (p-Histone-H3), resulting in a reduction of neuronal progenitor proliferation. 4-tert-Octylphenol disrupts brain development and behavior in mice, which is promising for reserch of immune response, neuro-related diseases and ethology .

HY-N12260

Benanomicin A	Quinones Microorganisms Anthraquinones Source classification	HIV Bacterial
Benanomicin A is a microbial metabolite and can be isolated from Actinomycetes.Benanomicin has antifungal activitya and inhibits HIV-1 viral infection in MT-4 cells .

Cat. No.	Product Name	Chemical Structure

HY-B0688S1

Dapsone-d4

Dapsone-d₄ is the deuterium labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities . Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .

HY-117433S

4-Hydroperoxy Cyclophosphamide-d4

4-Hydroperoxy Cyclophosphamide-d₄ is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the proagent Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders .

HY-103332S

N-Arachidonylglycine-d8

N-Arachidonylglycine-d8 is a deuterated labeled N-Arachidonylglycine . N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC₅₀ = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC₅₀ = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration .

HY-B0688S3

Dapsone-15N2

Dapsone- ¹⁵N₂ (4,4′-Diaminodiphenyl sulfone- ¹⁵N₂) is ¹⁵N labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities . Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .

HY-10451S2

Canagliflozin-d6
Canagliflozin-d₆ is the deuterium labeled Canagliflozin . Canagliflozin (JNJ 28431754) is a selective SGLT2 inhibitor with IC₅₀s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively .

HY-B0688S2

Dapsone-13C12

Dapsone- ¹³C₁₂ is the ¹³C₁₂ labeled Dapsone (HY-B0688). Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .

HY-109583S

4-Oxofenretinide-d4

4-Oxofenretinide-d₄ (4-Oxo-4-HPR-d₄) is deuterium labeled 4-Oxofenretinide. 4-Oxofenretinide (4-Oxo-4-HPR) is a metabolite of Fenretinide (HY-15373). 4-Oxofenretinide induces cell growth inhibition in ovarian, breast, and neuroblastoma tumor cell lines. 4-Oxofenretinide causes a marked accumulation of cells in G2-M. 4-Oxofenretinide induces cancer cell apoptosis through caspase-9 .

HY-B1984S

p,p'-DDD-d8

p,p'-DDD-d₈ is the deuterium labeled p,p'-DDD[1]. p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats .

HY-W740121

4-Methoxy-d3 17b-estradiol
4-Methoxy-d₃ 17b-estradiol is the deuterium labeled 4-Methoxyestradiol (HY-148296). 4-Methoxyestradiol is methoxylestradiol that induces oxidative DNA damage in human lung epithelial cells. 4-Methoxyestradiol also elevates ROS and SOD activities in H1355 cells .

HY-10046S

Plerixafor-d4
Plerixafor-d₄ is the deuterium labeled Plerixafor. Plerixafor (AMD 3100) is a selective CXCR4 antagonist with an IC₅₀ of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 and HIV-2 replication with an EC₅₀ of 1-10 nM .

HY-W002004S1

4-Amino-TEMPO-d17

4-Amino-TEMPO-d₁₇ (4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl-d₁₇) is the deuterium labeled 4-Amino-TEMPO (HY-W002004). 4-Amino-TEMPO (4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl) is a stable nitroxide radical and N-nucleophile based on TEMPO. 4-Amino-TEMPO has superoxide dismutase-mimetic activity, can protect cells from oxidative damage, and has radioprotective effects. 4-Amino-TEMPO is widely used in fields such as biomedicine, materials science, and industrial production. 4-Amino-TEMPO can be used as a spin label to detect free radicals, an oxidation catalyst in industrial production, and an antioxidant stabilizer for polymers, among others .

HY-10224S1

Panobinostat-d4 hydrochloride

Panobinostat-d₄ (hydrochloride) is deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[1][2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells[4]. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma[3].

HY-10224S

Panobinostat-d4

Panobinostat-d₄ is the deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[1][2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells[4]. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma[3].

HY-B0527AS

Amitriptyline-d6 hydrochloride

Amitriptyline-d₆ hydrochloride is the deuterium labeled Amitriptyline hydrochloride (HY-B0527A). Amitriptyline hydrochloride is an orally active tricyclic antidepressant (TCA). Amitriptyline hydrochloride mainly exerts its antidepressant effect by blocking SERT (K_i = 3.45 nM) and NET (K_i = 13.3 nM), thereby increasing the concentrations of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in the synaptic cleft. Amitriptyline hydrochloride is also an agonist at α2A and TrkA/TrkB receptors, thereby exerting analgesic and neurotrophic activities (inhibiting cell apoptosis). Amitriptyline hydrochloride can reduce inflammation, angiogenesis and fibrosis. Amitriptyline hydrochloride binds to DAT (with K_i = 2.58 μM). Amitriptyline hydrochloride has high affinity for a series of receptors and can antagonize muscarinic cholinergic receptors (M1/M2/M3/M4/M5 receptors) (K_i = 11-24 nM), H1 receptors (K_i = 0.5-1.1 nM), adrenergic α1 receptors (K_i = 4.4 nM), etc., resulting in a series of side effects. Amitriptyline hydrochloride can block sodium channels and hERG potassium channel (IC₅₀ = 4.78 μM) and it has cardiotoxicity.

HY-B1398S

Ampyrone-d3

Ampyrone-d₃ is the deuterium labeled Ampyrone (HY-B1398). Ampyrone (4-Aminophenazone; 4-Aminoantipyrine) is a reversible and low-damage optical clearing agent and non-selective COX inhibitor based on UV absorption properties. Ampyrone can improve the optical transmittance of mouse skin and other tissues. Ampyrone can induce tissue refractive index matching by enhancing UV absorption, reduce light scattering, and achieve tissue transparency in vivo. Ampyrone reduces the synthesis of prostaglandin PGE2, thereby exerting anti-inflammatory, analgesic and antipyretic effects. Ampyrone inhibits DNA damage, cell apoptosis and immune cell phagocytosis induced by Doxorubicin (HY-15142A) and Cisplatin (HY-17394), etc., and participates in the regulation of toxicity in tumor chemotherapy .

HY-W002004S

4-Amino-TEMPO-d17,15N

4-Amino-TEMPO-d₁₇, ¹⁵N (4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl-d₁₇, ¹⁵N) is the deuterium labeled 4-Amino-TEMPO-d₁₇ (HY-W002004S1). 4-Amino-TEMPO (4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl) is a stable nitroxide radical and N-nucleophile based on TEMPO. 4-Amino-TEMPO has superoxide dismutase-mimetic activity, can protect cells from oxidative damage, and has radioprotective effects. 4-Amino-TEMPO is widely used in fields such as biomedicine, materials science, and industrial production. 4-Amino-TEMPO can be used as a spin label to detect free radicals, an oxidation catalyst in industrial production, and an antioxidant stabilizer for polymers, among others .

HY-W778511

Levulinic acid-13C3
Levulinic acid- ¹³C₃ (4-Oxovaleric acid- ¹³C) is the ¹³C-labeled Levulinic acid (HY-Y0839). Levulinic acid is a precursor for the synthesis of biofuels, such as ethyl levulinate. Levulinic acid is also a 5-keto-pentanoic acid. Levulinic acid can be utilized by the cells as a cosubstrate for biopolymer synthesis. Levulinic acid can be used in antibacterial research .

HY-B1193S

Terfenadine-d3

Terfenadine-d₃ ((±)-Terfenadine-d₃) is the deuterium labeled Terfenadine. Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC₅₀ of 204 nM . Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9[2].

HY-13757S

Tamoxifen-d3 hydrochloride

Tamoxifen-d₃ hydrochloride is deuterated labeled Tamoxifen (Citrate) (HY-13757). Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells .Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.1 μM and 1.8 μM, respectively . Tamoxifen Citrate activates autophagy and induces apoptosis ^[4].Tamoxifen Citrate also can induce gene knockout of CreER(T2) transgenic mouse .

HY-N0349S1

Methyl paraben-13C6

Methyl Paraben- ¹³C₆ (Methyl 4-hydroxybenzoate- ¹³C₆) is a ¹³C labeled Methyl Paraben (HY-N0349) . Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, agents and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity .

HY-141582S

Ceramide 3-d3

Ceramide 3-d₃ (N-Stearoyl phytosphingosine-d₃) is deuterium labeled Ceramide 3. C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in the stratum corneum of Saccharomyces cerevisiae, wheat grain, and mammalian epidermis. Cer(t18:0/18:0) consists of a phytosphingosine backbone amine linked to a C18 fatty acid chain. Cer(t18:0/18:0) has the function of regulating apoptosis, cell differentiation, proliferation of smooth muscle cells and inhibition of mitochondrial respiratory chain. It also suppresses the expression of allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated mouse skin tissue. Formulations containing cer(t18:0/18:0) have been used as skin protectants in cosmetics as they reduce water loss and prevent epidermal dehydration and irritation .

HY-122129S

Dotriaconta-14,17,20,23,26,29-hexaenoic acid-d6

Dotriaconta-14,17,20,23,26,29-hexaenoic acid-d₆ is deuterium labeled Dotriaconta-14,17,20,23,26,29-hexaenoic acid. Very long chain polyunsaturated fatty acids (VLCPUFA) are present in retina, sperm, and brain. Though little is known of their biosynthesis or functional roles in these tissues, recent studies using the elongation of very long-chain FA-4 protein suggest a unique role for VLCPUFA in retinal development and macular degeneration. Dotriaconta-14,17,20,23,26,29-hexaenoic acid is a C32:6 VLCPUFA whose specific biological actions are largely unknown, but are thought to involve normal photoreceptor cell function in the retina .

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