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orally active anti-inflammatory

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-148456
    Anti-inflammatory agent 34

    		Others Inflammation/Immunology
    Anti-inflammatory agent 34 (Compound IVf) is an orally active anti-inflammatory and analgesic agent .
    Anti-inflammatory agent 34
  • HY-17463
    Prednisolone
    5+ Cited Publications

    		 Glucocorticoid Receptor Endogenous Metabolite Inflammation/Immunology Endocrinology Cancer
    Prednisolone is a potent, orally active corticosteroid and a glucocorticoid. Prednisolone possesses about four times the anti-inflammatory activity of hydrocortisone while causing less salt and water retention. Prednisolone can be used for ocular, anti-inflammatory research .
    Prednisolone
  • HY-N0661
    Alliin
    2 Publications Verification

    		 Others Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
    Alliin, an orally active sulfoxide compound that can be isolated from garlic, exhibits hypoglycemic, antioxidant, anti-inflammatory and antitumor activities .
    Alliin
  • HY-B1355
    Oxyphenbutazone monohydrate

    		Bacterial COX Infection Inflammation/Immunology
    Oxyphenbutazone monohydrate is a Phenylbutazone (HY-B0230) metabolite, with anti-inflammatory effect. Oxyphenbutazone monohydrate is an orally active non-selective COX inhibitor. Oxyphenbutazone monohydrate selectively kills non-replicating Mycobaterium tuberculosis .
    Oxyphenbutazone monohydrate
  • HY-123631
    Phenylbutazone trimethylgallate

    LH150

    		 Others Inflammation/Immunology
    Phenylbutazone trimethylgallate (LH150) is a non-steroidal and orally active anti-inflammatory agent .
    Phenylbutazone trimethylgallate
  • HY-17487
    Miroprofen

    Y 0213; Y 9213

    		 COX Neurological Disease Inflammation/Immunology
    Miroprofen (Y 0213) is an orally active nonsteroidal anti-inflammatory analgesic (NSAID). Miroprofen exhibits anti-inflammatory, analgesic and anti-platelet activities .
    Miroprofen
  • HY-146435
    Anti-inflammatory agent 22

    		TNF Receptor Inflammation/Immunology
    Anti-inflammatory agent 22 (compound 14a) is an orally active anti-inflammatory agent. Anti-inflammatory agent 22 inhibits LPS-induced TNF-α production with an IC50 value of 14.6 μM. Anti-inflammatory agent 22 has preventive effects on lymphedematous tissue via suppression of adipogenesis. Anti-inflammatory agent 22 suppresses limb lymphedema volume in mice .
    Anti-inflammatory agent 22
  • HY-130762
    Cinnamic acid sodium

    		Apoptosis Neurological Disease Inflammation/Immunology
    Cinnamic acid sodium is a orally active naturally occurring aromatic fatty acid of low toxicity. Cinnamic acid sodium shows neuroprotective and anti-inflammatory effects .
    Cinnamic acid sodium
  • HY-17491
    Proquazone

    RU 43-715; Sandoz-43-715

    		 Others Inflammation/Immunology
    Proquazone (RU 43-715) is a chemically distinctive non-steroidal anti-inflammatory agent (NSAID). unlike most other NSAIDs, Proquazone does not have a free acid group in its structure. Proquazone may inhibit or arrest progression of bone erosions. Proquazone is an orally active anti-inflammatory, analgesic and anti-pyretic agent .
    Proquazone
  • HY-146421
    Anti-inflammatory agent 21

    		NO Synthase NF-κB Reactive Oxygen Species (ROS) Inflammation/Immunology
    Anti-inflammatory agent 21 (compound 9o) is an orally active and low cytotoxic anti-inflammatory agent, with an IC50 value of 0.76 μM for NO. Anti-inflammatory agent 21 acts via accumulation ROS and blocks the NF-κB/MAPK signaling pathway. Anti-inflammatory agent 21 can ameliorate cartilage destruction and inflammatory cell infiltration in arthritis rats model .
    Anti-inflammatory agent 21
  • HY-110343
    DBM 1285 dihydrochloride

    		TNF Receptor Inflammation/Immunology
    DBM 1285 dihydrochloride is an orally active TNF-α production inhibitor with anti-inflammatory effects. DBM 1285 dihydrochloride inhibits Lipopolysaccharide (LPS)-induced TNF-α secretion in various cells of macrophage/monocyte lineage .
    DBM 1285 dihydrochloride
  • HY-121097
    Diapocynin

    Dehydrodiacetovanillone

    		 NADPH Oxidase Neurological Disease Inflammation/Immunology
    Diapocynin (Dehydrodiacetovanillone), a dimeric derivative of Apocynin, is an orally active NADPH oxidase inhibitor. Diapocynin has anti-inflammatory, neuroprotection and antioxidant activities .
    Diapocynin
  • HY-159158
    COX-1/2-IN-8

    		COX Inflammation/Immunology
    COX-1/2-IN-8 (compound 11f) is an orally active and potent inhibitor of COX-1 and COX-2, with IC50 values of 2.14 and 0.58 µM, respectively. COX-1/2-IN-8 displays a higher significant anti-inflammatory activity than Celecoxib (HY-14398) .
    COX-1/2-IN-8
  • HY-N15720
    HN-saponin F

    Pulsatilla saponin B

    		 Others Inflammation/Immunology
    HN-saponin F (Pulsatilla saponin B) is an orally active triterpenoid saponin found in Lonicera macranthoides. HN-saponin F exerts anti-inflammatory activity by regulating inflammation-related pathways (e.g., inhibiting pro-inflammatory factor release). HN-saponin F is promising for research of inflammatory diseases .
    HN-saponin F
  • HY-117610
    Ro 31-8830

    Ro 32-0432 free base; Bisindolylmaleimide XI

    		 PKC Inflammation/Immunology
    Ro 31-8830 is an orally active, potent and selective inhibitor of protein kinase C with anti-inflammatory activity. Ro 31-8830 is promising for research of inflammatory disorders .
    Ro 31-8830
  • HY-13723
    Pimecrolimus
    3 Publications Verification

    SDZ-ASM 981

    		 Phosphatase Inflammation/Immunology
    Pimecrolimus (SDZ-ASM 981) is a potent, nonsteroid and orally active calcineurin inhibitor with a Ki of 117 nM. Pimecrolimus shows anti-inflammatory activity .
    Pimecrolimus
  • HY-161862
    COX-2-IN-44

    		COX Inflammation/Immunology
    COX-2-IN-44 is a potent and orally active COX-2 inhibitor with IC50 values of 0.18,1.14 µM for COX-2, COX-1, respectively. COX-2-IN-44 shows anti-inflammatory activity .
    COX-2-IN-44
  • HY-13723A
    Pimecrolimus hydrate

    SDZ-ASM 981 hydrate

    		 Phosphatase Inflammation/Immunology
    Pimecrolimus hydrate (SDZ-ASM 981 hydrate) is a potent, nonsteroid and orally active calcineurin inhibitor. Pimecrolimus hydrate shows anti-inflammatory activity. Pimecrolimus hydrate has the potential for the research of atopic dermatitis and oral erosive lichen planus .
    Pimecrolimus hydrate
  • HY-151232
    Rilzabrutinib

    PRN1008

    		 Btk Inflammation/Immunology
    Rilzabrutinib (PRN1008) is an orally active Bruton's tyrosine kinase (BTK) inhibitor with anti-inflammatory and immunomodulatory activities. Rilzabrutinib can be used in the research of various inflammatory and immune-related diseases such as acute respiratory distress syndrome and sepsis .
    Rilzabrutinib
  • HY-N8435
    Desoxo-narchinol A

    		TNF Receptor COX NO Synthase PGE synthase Infection Inflammation/Immunology
    Desoxo-narchinol A is an orally active and potent anti-inflammatory agent. Desoxo-narchinol A can be isolated from the roots and rhizomes of Nardostachys jatamansi. Desoxo-narchinol A can be used for septic shock and inflammatory diseases research .
    Desoxo-narchinol A
  • HY-B1355R
    Oxyphenbutazone monohydrate (Standard)

    		Reference Standards Bacterial COX Infection Inflammation/Immunology
    Oxyphenbutazone (monohydrate) (Standard) is the analytical standard of Oxyphenbutazone (monohydrate). This product is intended for research and analytical applications. Oxyphenbutazone monohydrate is a Phenylbutazone (HY-B0230) metabolite, with anti-inflammatory effect. Oxyphenbutazone monohydrate is an orally active non-selective COX inhibitor. Oxyphenbutazone monohydrate selectively kills non-replicating Mycobaterium tuberculosis .
    Oxyphenbutazone monohydrate (Standard)
  • HY-N0661R
    Alliin (Standard)

    		Reference Standards Others Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
    Alliin (Standard) is the analytical standard of Alliin. This product is intended for research and analytical applications. Alliin, an orally active sulfoxide compound that can be isolated from garlic, exhibits hypoglycemic, antioxidant, anti-inflammatory and antitumor activities .
    Alliin (Standard)
  • HY-162661
    P2Y14R antagonist 2

    		P2Y Receptor Inflammation/Immunology
    P2Y14R antagonist 2 (compound 39) is a potent, selective and orally active P2Y14R antagonist with an IC50 value of 0.40 nM. P2Y14R antagonist 2 shows anti-inflammatory activity. P2Y14R antagonist 2 has the potential for the research of colitis .
    P2Y14R antagonist 2
  • HY-14180
    PHA 408

    		IKK Inflammation/Immunology
    PHA 408 (PHA-408) is a potent, selective and orally active IκB kinase-2 (IKK-2) inhibitor. PHA 408 is a powerful anti-inflammatory agent against lipopolysaccharide (LPS)- and cigarette smoke (CS)-mediated lung inflammation .
    PHA 408
  • HY-163736
    mPGES-1/5-LOX-IN-1

    		Lipoxygenase PGE synthase Inflammation/Immunology
    mPGES-1/5-LOX-IN-1 (compound 3j) is a potent and orally active mPGES-1 and 5-LOX dual inhibitor with IC50 values of 0.92, 1.89 µM, respectively. mPGES-1/5-LOX-IN-1 shows anti-inflammatory impact .
    mPGES-1/5-LOX-IN-1
  • HY-100516
    Cimicoxib

    UR-8880

    		 COX Inflammation/Immunology
    Cimicoxib (CX) is an orally active potent and selective COX-2 (cyclo-oxygenase-2) inhibitor. Cimicoxib exhibits promising anti-inflammatory and analgesic activity. The PK parameters of Cimicoxib in dogs given precise (2 mg/kg) and approximate doses (1.95-2.5 mg/kg) are similar .
    Cimicoxib
  • HY-13723R
    Pimecrolimus (Standard)

    SDZ-ASM 981 (Standard)

    		 Reference Standards Phosphatase Inflammation/Immunology
    Pimecrolimus (Standard) is the analytical standard of Pimecrolimus. This product is intended for research and analytical applications. Pimecrolimus (SDZ-ASM 981) is a potent, nonsteroid and orally active calcineurin inhibitor with a Ki of 117 nM. Pimecrolimus shows anti-inflammatory activity .
    Pimecrolimus (Standard)
  • HY-152149
    CTP Synthetase-IN-1

    		DNA/RNA Synthesis Inflammation/Immunology
    CTP Synthetase-IN-1 is a potent, orally active cytidine 5'-triphosphate synthetase (CTPS) inhibitor with IC50s of 32 nM and 18 nM for human CTPS1 and human CTPS2, respectively. CTP Synthetase-IN-1 has anti-inflammatory effects .
    CTP Synthetase-IN-1
  • HY-149120
    ASM-IN-1

    		Phospholipase Cardiovascular Disease Inflammation/Immunology
    ASM-IN-1 is a potent and orally active acid sphingomyelinase (ASM) inhibitor with an IC50 value of 1.5 µM. ASM-IN-1 reduces lipid plaques in the aortic arch and aorta and reduces plasma ceramide concentration and Ox-LDL levels. ASM-IN-1 shows antiatherosclerotic and anti-inflammatory activity .
    ASM-IN-1
  • HY-143444
    JAK-IN-20

    		JAK Inflammation/Immunology
    JAK-IN-20 is a potent, pan and orally active JAK inhibitor with an IC50s of 7 nM, 5 nM, 14 nM for JAK1, JAK2, JAK3, respectively. JAK-IN-20 shows excellent pharmacokinetics and displays anti-inflammatory efficacy in vivo .
    JAK-IN-20
  • HY-19151A
    Fuzapladib sodium

    IS-741 sodium

    		 Integrin Phospholipase Inflammation/Immunology
    Fuzapladib (IS-741) sodium, an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib sodium is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib sodium exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site .
    Fuzapladib sodium
  • HY-19151B
    Fuzapladib potassium

    IS-741 potassium

    		 Integrin Phospholipase Inflammation/Immunology
    Fuzapladib (IS-741) potassium, an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib potassium is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib potassium exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site .
    Fuzapladib potassium
  • HY-129755
    CK-17

    		Interleukin Related Inflammation/Immunology
    CK-17 is an orally active and potent anti-inflammatory agent. CK-17 shows potent inhibition of ocular inflammation induced by lens protein, endotoxin, and IL-1. The effects on IL-1-induced inflammation are about 2 fold more potent than Prednisolone (HY-17463) .
    CK-17
  • HY-163752
    CS17919

    		MAP3K Metabolic Disease
    CS17919 is a potent, selective and orally active ASK1 inhibitor with an IC50 of 22.52 nM. CS17919 shows anti-inflammatory and antifibrotic effects. CS17919 can be used for the study of metabolic-related kidney and liver diseases .
    CS17919
  • HY-100516R
    Cimicoxib (Standard)

    UR-8880 (Standard)

    		 Reference Standards COX Inflammation/Immunology
    Cimicoxib (Standard) is the analytical standard of Cimicoxib. This product is intended for research and analytical applications. Cimicoxib (CX) is an orally active potent and selective COX-2 (cyclo-oxygenase-2) inhibitor. Cimicoxib exhibits promising anti-inflammatory and analgesic activity. The PK parameters of Cimicoxib in dogs given precise (2 mg/kg) and approximate doses (1.95-2.5 mg/kg) are similar .
    Cimicoxib (Standard)
  • HY-149961
    Anti-inflammatory agent 40

    		Parasite Infection Inflammation/Immunology
    Anti-inflammatory agent 40 is a potential and orally active anti-malarial and anti-inflammatory agent. Anti-inflammatory agent 40 inhibits carrageenan induced paw swelling in vivo.
    Anti-inflammatory agent 40
  • HY-117569
    KF24345 free base

    		TNF Receptor Inflammation/Immunology
    KF24345 free base is an orally active adenosine uptake inhibitor. KF24345 free base inhibits adenosine uptake by human, mouse, rabbit and hamster erythrocytes with IC50 values of 59.5, 130.1, 104.2 and 30.9 nM, respectively. KF24345 free base has anti-inflammatory activity and can inhibit LPS-induced TNF-α production and leukopenia in mice .
    KF24345 free base
  • HY-116005
    A-286501

    		Adenosine Kinase Neurological Disease Inflammation/Immunology
    A-286501 is an orally active and potent carbocyclic nucleoside adenosine kinase inhibitor with an IC50 value of 0.47 nM, which shows analgesic and anti-inflammatory effects. A-286501 reduces nociception in animal models of acute (thermal), inflammatory (formalin and carrageenan) and neuropathic (L5/L6 nerve ligation and streptozotocin-induced diabetic) pain. A-286501 also reduces Carrageenan (HY-125474)-induced paw edema and myeloperoxidase activity in the injured paw. A-286501 is promising for research of analgesic and anti-inflammatory agents .
    A-286501
  • HY-160851
    GDC-3280

    AK3287; AKEX0011

    		 ASK1 p38 MAPK Inflammation/Immunology
    GDC-3280 (AK3287; AKEX0011) is an orally active compound based on Pirfenidone (HY-B0673)'s phenyl pyridone scaffold. GDC-3280 alleviates the inflammatory and fibrotic reaction of silicosis by inhibiting the ASK1-p38 MAPK pathway and regulating macrophage polarization. GDC-3280 exhibits anti-inflammatory and anti-fibrotic effects .
    GDC-3280
  • HY-B1028S
    Pantethine-15N2

    D-Pantethine-15N2; LBF disulfide-15N2

    		 Isotope-Labeled Compounds Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer
    Pantethine- 15N2 is the 15N2 labeled Pantethine. Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration .
    Pantethine-15N2
  • HY-N0662
    Amentoflavone
    5+ Cited Publications

    Didemethyl-ginkgetin

    		 Reactive Oxygen Species (ROS) Apoptosis Bacterial Fungal RSV GABA Receptor Infection Neurological Disease Inflammation/Immunology Cancer
    Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase .
    Amentoflavone
  • HY-126382
    Hesperidin methylchalcone
    1 Publications Verification

    		 NF-κB Inflammation/Immunology
    Hesperidin methylchalcone (Hesperidin methyl chalcone) is an orally active flavonoid that has analgesic, anti-inflammatory and antioxidant properties. Hesperidin methylchalcone exhibits vasoprotective activity. Hesperidin methylchalcone inhibits oxidative stress, cytokine production and NF-κB activation. Hesperidin methylchalcone can be used for the research of gout disease .
    Hesperidin methylchalcone
  • HY-146547
    Anti-inflammatory agent 17

    		Interleukin Related TNF Receptor Inflammation/Immunology
    Anti-inflammatory agent 17 is a potent and orally active anti-inflammatory agent. Anti-inflammatory agent 17 inhibits the release of IL-6 and TNF-α in vitro experiments without cytotoxicity. Anti-inflammatory agent 17 exhibits anti-inflammatory activity in vivo. Anti-inflammatory agent 17 has the potential for the research of Acute lung injury (ALI) .
    Anti-inflammatory agent 17
  • HY-N0236
    Corylin
    5+ Cited Publications

    		 Antibiotic STAT Infection Metabolic Disease Cancer
    Corylin is an orally active flavonoid anti-inflammatory and osteogenic agent that inhibits IL-6-induced STAT3 promoter activity and STAT3 phosphorylation. Corylin also has anticancer, antiatherosclerotic, and ameliorating activity in hyperlipidemia and insulin resistance, inducing adipocyte browning and lipolysis through SIRT1 or β3-AR-dependent pathways .
    Corylin
  • HY-W040265
    Fenamic acid

    N-Phenylanthranilic acid

    		 Chloride Channel Inflammation/Immunology
    Fenamic acid (N-Phenylanthranilic acid, NPAA) is an orally active chloride channel blocker. Fenamic acid is the basic constituent of non-steroidal anti-inflammatory agents (NSAIA), and derives into mefenamic, tofenacin, flufenac acid and melofenac acid. Fenamic acid also acts as antibacterial and analgesic agent - .
    Fenamic acid
  • HY-151261
    HDAC6-IN-13

    		HDAC Inflammation/Immunology
    HDAC6-IN-13 (Compound 35m) is a potent, highly selective, orally active HDAC6 inhibitor with an IC50 of 0.019 μM. HDAC6-IN-13 also inhibits HDAC1, HDAC2 and HDAC3 with IC50s of 1.53, 2.06 and 1.03 μM, respectively. HDAC6-IN-13 shows significant BBB permeability and anti-inflammatory activity .
    HDAC6-IN-13
  • HY-103595
    Epirizole

    Mepirizole; DA-398

    		 Others Inflammation/Immunology
    Epirizole (Mepirizole) is an orally active NSAID (nonsteroidal anti-inflammatory agent). Epirizole shows anti-inflammatory activity, and can be used in chronic rheumatoid arthritis research .
    Epirizole
  • HY-173504
    Anti-inflammatory agent 101

    		Others Inflammation/Immunology
    Anti-inflammatory agent 101 (Compound C04) is an orally active anti-inflammatory agent. Anti-inflammatory agent 101 has significant anti-lipid accumulation, anti-inflammatory and anti-fibrotic activities. Anti-inflammatory agent 101 works by reducing fatty acid uptake, stimulating fatty acid oxidation and alleviating inflammation. Anti-inflammatory agent 101 can be used in the study of NASH and its related liver fibrosis .
    Anti-inflammatory agent 101
  • HY-B0634
    Aceclofenac

    		COX Inflammation/Immunology
    Aceclofenac is an orally active nonsteroidal anti-inflammatory agent (NSAID), with analgesic and anti-inflammatory properties. Aceclofenac is used for the research of osteoarthritis, ankylosing spondylitis, rheumatoid arthritis .
    Aceclofenac
  • HY-115921
    Anti-inflammatory agent 9

    		COX Inflammation/Immunology
    Anti-inflammatory agent 9 (compound 28) is a tilomisole-based benzimidazothiazole derivative. Anti-inflammatory agent 9 expresses activity on COX-2 enzyme more than COX-1. Anti-inflammatory agent 9 is orally active .
    Anti-inflammatory agent 9

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