2. Membrane Transporter/Ion Channel Neuronal Signaling Cell Cycle/DNA Damage MAPK/ERK Pathway Metabolic Enzyme/Protease
  3. Calcium Channel PERK JNK MMP
  4. Decursinol

Decursinol is an orally active coumarin compound that can be isolated from the roots of Angelica gigas. Decursinol is also a metabolite of Decursin (HY-18981) and Decursinol angelate (HY-N4322). Decursinol exhibits multiple activities such as analgesic, antinociceptive, anti-inflammatory, antioxidant, antimetastatic, and neuroprotective effects. Decursinol can be used for research on diseases such as tumors and nervous system disorders.

For research use only. We do not sell to patients.

Decursinol Chemical Structure

Decursinol Chemical Structure

CAS No. : 23458-02-8

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Decursinol:

Decursinol Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Decursinol

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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JNK1 JNK2 JNK3 JNK

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Decursinol is an orally active coumarin compound that can be isolated from the roots of Angelica gigas. Decursinol is also a metabolite of Decursin (HY-18981) and Decursinol angelate (HY-N4322). Decursinol exhibits multiple activities such as analgesic, antinociceptive, anti-inflammatory, antioxidant, antimetastatic, and neuroprotective effects. Decursinol can be used for research on diseases such as tumors and nervous system disorders[1][2][3][4].

IC50 & Target[2]

MMP-9

 

MMP-2

 

In Vitro

Decursinol (0.1-10 μM; 25 h) significantly reduces glutamate-induced cell death and intracellular calcium concentration elevation, prevents the decrease of glutathione and the reduction of glutathione peroxidase activity, and inhibits intracellular hydrogen peroxide production in primary cultured rat cortical cells[1].
Decursinol (1-20 μM; 20-24 h) decreases cell viability and DNA synthesis in CT-26 colon cancer cells, and inhibits cell invasion by suppressing ERK/JNK phosphorylation to downregulate MMP-9[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Decursinol Related Antibodies

Cell Viability Assay[2]

Cell Line: CT-26 colon cancer cells
Concentration: 1, 10 and 20 μM
Incubation Time: 24 h
Result: Inhibited the cell viability in a dose-dependent manner.

Western Blot Analysis[2]

Cell Line: CT-26 colon cancer cells
Concentration: 10 and 20 μM
Incubation Time: 24 h
Result: Decreased the expression levels of MMP-2 and MMP-9.
Inhibited the phosphorylation levels of ERK and JNK.
In Vivo

Decursinol (10 mg/kg; orlal gavage; 2 weeks) has a therapeutic effect in a mouse lung metastasis model induced by CT-26 colon cancer cells[2].
Decursinol (0-200 mg/kg; oral administration; single dose) has antinociceptive effects in multiple mouse pain models[3].
Pharmacokinetic Analysis in Rats[4]

Route Dose (mg/kg) Cmax (ng/mL) Tmax (h) AUC0-24 h (h·ng/mL) CL/F (L/h/kg) VZ/F (L/kg) MRT (h)
p.o. 37.5 10663 0.7 64769 0.6 2.5 5.0

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c mice treated CT-26 cells[2]
Dosage: 10 mg/kg
Administration: Oral gavage (i.g.); 2 weeks
Result: Significantly inhibited the formation of lung metastasis nodules by 77% and reduced lung weight gain caused by CT-26 cell metastasis, without altering the body weight of mice.
Animal Model: Male ICR mice (20-25 g) were used in various pain models including tail-flick test, hot-plate test, Acetic acid (HY-Y0319)-induced writhing test, formalin test, and intrathecal injection of pro-inflammatory cytokines (TNF-α, IL-1β, IFN-γ), Substance P (HY-P0201), or glutamate[3]
Dosage: 0, 5, 10, 25, 50, 100 and 200 mg/kg
Administration: Oral administration (p.o.); single dose
Result: Significantly prolonged tail-flick and hot-plate response latencies.
Reduced writhing numbers in acetic acid test.
Inhibited nociceptive behaviors in both phases of formalin test.
Decreased cumulative response time in cytokine-, substance P-, and glutamate-induced pain models in a dose-dependent manner.
Molecular Weight

246.26

Formula

C14H14O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O1)C=CC(C1=C2)=CC3=C2OC(C)(C)[C@@H](O)C3
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (406.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0607 mL 20.3036 mL 40.6072 mL
5 mM 0.8121 mL 4.0607 mL 8.1214 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (8.45 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (8.45 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.89%

SDS (393 KB)

COA (247 KB) HNMR (233 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0607 mL 20.3036 mL 40.6072 mL 101.5179 mL
5 mM 0.8121 mL 4.0607 mL 8.1214 mL 20.3036 mL
10 mM 0.4061 mL 2.0304 mL 4.0607 mL 10.1518 mL
15 mM 0.2707 mL 1.3536 mL 2.7071 mL 6.7679 mL
20 mM 0.2030 mL 1.0152 mL 2.0304 mL 5.0759 mL
25 mM 0.1624 mL 0.8121 mL 1.6243 mL 4.0607 mL
30 mM 0.1354 mL 0.6768 mL 1.3536 mL 3.3839 mL
40 mM 0.1015 mL 0.5076 mL 1.0152 mL 2.5379 mL
50 mM 0.0812 mL 0.4061 mL 0.8121 mL 2.0304 mL
60 mM 0.0677 mL 0.3384 mL 0.6768 mL 1.6920 mL
80 mM 0.0508 mL 0.2538 mL 0.5076 mL 1.2690 mL
100 mM 0.0406 mL 0.2030 mL 0.4061 mL 1.0152 mL
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Decursinol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Decursinol23458-02-8Calcium ChannelPERKJNKMMPCa2+ channelsCa channelsProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinasec-Jun N-terminal kinaseMatrix metalloproteinaseslung metastasis modelpain modelsCT-26 cellscortical cellsInhibitorinhibitorinhibit

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