2. Others Neuronal Signaling GPCR/G Protein Membrane Transporter/Ion Channel
  3. Drug Intermediate Cannabinoid Receptor TRP Channel
  4. TRPM8 antagonist 4 prodrug

TRPM8 antagonist 4 prodrug (Compound 8b) is an orally active CB2R agonist (EC50: 51.2 nM) and a weak TRPM8 antagonist. TRPM8 antagonist 4 prodrug is a prodrug of TRPM8 antagonist 4 (HY-174825). TRPM8 antagonist 4 prodrug exhibits anti-inflammatory and analgesic activities and can be used in the research of inflammation-related pain disorders.

For research use only. We do not sell to patients.

TRPM8 antagonist 4 prodrug Chemical Structure

TRPM8 antagonist 4 prodrug Chemical Structure

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TRPM8 antagonist 4 prodrug Related Antibodies

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Description

TRPM8 antagonist 4 prodrug (Compound 8b) is an orally active CB2R agonist (EC50: 51.2 nM) and a weak TRPM8 antagonist. TRPM8 antagonist 4 prodrug is a prodrug of TRPM8 antagonist 4 (HY-174825). TRPM8 antagonist 4 prodrug exhibits anti-inflammatory and analgesic activities and can be used in the research of inflammation-related pain disorders[1].

IC50 & Target[1]

CB2

51.2 nM (IC50)

TRPM8

 

Molecular Weight

371.47

Formula

C22H29NO4
SMILES

C/C(C)=C/CC/C(C)=C/COC1=CC(C2CC2)=C(C(N)=O)C(OC(C)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TRPM8 antagonist 4 prodrug Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRPM8 antagonist 4 prodrugDrug IntermediateCannabinoid ReceptorTRP ChannelDrug IintermediateTransient receptor potential channelsHEK293 cellsCHO cellsRAW264.7 cellsHepG2 cellsmiceinflammationpainInhibitorinhibitorinhibit

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