2. NF-κB Apoptosis
  3. RANKL/RANK TNF Receptor
  4. Y2641

Y2641, a etrahydro-β-carboline derivative, is an orally active dual RANKL/TNF-α inhibitor with Kd values of 3.984 μM and 18.59 μM for RANKL and TNF-α, respectively. Y2641 inhibits RANKL-induced osteoclastogenic and has anti-inflammatory and cartilage destruction. Y2641 can be used for study of osteoarthritis.

For research use only. We do not sell to patients.

Y2641 Chemical Structure

Y2641 Chemical Structure

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Y2641 Related Antibodies

Top Publications Citing Use of Products

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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Description

Y2641, a etrahydro-β-carboline derivative, is an orally active dual RANKL/TNF-α inhibitor with Kd values of 3.984 μM and 18.59 μM for RANKL and TNF-α, respectively. Y2641 inhibits RANKL-induced osteoclastogenic and has anti-inflammatory and cartilage destruction. Y2641 can be used for study of osteoarthritis[1].

Molecular Weight

436.55

Formula

C28H28N4O
SMILES

O=C([C@@H]1CC(C2=CC=CC=C2N3)=C3C4(CN(C4)C5=CC=CC=C5)N1)NC6=C(C=CC=C6C)C
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Y2641 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Y2641Y 2641Y-2641RANKL/RANKTNF ReceptorTumor Necrosis Factor ReceptorTNFROsteoarthritisACLT-Induced OA ratsRAW264.7 cellsbone marrow macrophagesInhibitorinhibitorinhibit

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