2. JAK/STAT Signaling Stem Cell/Wnt
  3. STAT
  4. Butamirate

Butamirate is an orally active antitussive agent that acts centrally through the receptors in the brainstem. Butamirate also reduces the resistance in the airways by inhibiting bronchospasm and anti-inflammatory effect. Butamirate inhibits glioblastoma (GBM) growth and STAT3 activity. Butamirate can be used for the study of glioblastoma.

For research use only. We do not sell to patients.

Butamirate

Butamirate Chemical Structure

CAS No. : 18109-80-3

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Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

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Butamirate Related Antibodies

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Description

Butamirate is an orally active antitussive agent that acts centrally through the receptors in the brainstem. Butamirate also reduces the resistance in the airways by inhibiting bronchospasm and anti-inflammatory effect. Butamirate inhibits glioblastoma (GBM) growth and STAT3 activity. Butamirate can be used for the study of glioblastoma[1][2].

In Vitro

Butamirate (0.01-10 μM; 7 days) could effectively suppress sphere formation and STAT3 activity[2].
Butamirate effectively inhibits interactions of RRAD with pSTAT3[2].
Butamirate shows decreased EGFR, STAT3, ERK and AKT phosphorylation in U87MG[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Butamirate Related Antibodies

Cell Viability Assay[2]

Cell Line: U87MG, U87MG-TMZ-resistant (U87 TMZR), U87MG-Lapatinib-resistant (U87 LAPAR) and T98G (TMZ resistant) tumorspheres
Concentration: 0.01-10 μM
Incubation Time: 7 days
Result: Effectively suppressed growth of glioblastoma cell lines, including U87MG-TMZR and U87MG-LAPAR.
In Vivo

Butamirate (2 mg/kg; intraperitoneal administration) suppresses tumor growth in a glioblastoma xenograft mouse model without significant adverse effects[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c nude mice (6- to 8 week-old) were subcutaneously injected with U87MG cells[2]
Dosage: 2 mg/kg
Administration: i.p; once a day; for 36 days.
Result: Inhibited tumor growth in a glioblastoma mouse xenograft model.
Clinical Trial
Molecular Weight

307.43

Formula

C18H29NO3
CAS No.
Appearance

Liquid

SMILES

O=C(C(C1=CC=CC=C1)CC)OCCOCCN(CC)CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (813.19 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2528 mL 16.2639 mL 32.5277 mL
5 mM 0.6506 mL 3.2528 mL 6.5055 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2528 mL 16.2639 mL 32.5277 mL 81.3193 mL
5 mM 0.6506 mL 3.2528 mL 6.5055 mL 16.2639 mL
10 mM 0.3253 mL 1.6264 mL 3.2528 mL 8.1319 mL
15 mM 0.2169 mL 1.0843 mL 2.1685 mL 5.4213 mL
20 mM 0.1626 mL 0.8132 mL 1.6264 mL 4.0660 mL
25 mM 0.1301 mL 0.6506 mL 1.3011 mL 3.2528 mL
30 mM 0.1084 mL 0.5421 mL 1.0843 mL 2.7106 mL
40 mM 0.0813 mL 0.4066 mL 0.8132 mL 2.0330 mL
50 mM 0.0651 mL 0.3253 mL 0.6506 mL 1.6264 mL
60 mM 0.0542 mL 0.2711 mL 0.5421 mL 1.3553 mL
80 mM 0.0407 mL 0.2033 mL 0.4066 mL 1.0165 mL
100 mM 0.0325 mL 0.1626 mL 0.3253 mL 0.8132 mL
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Butamirate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Butamirate18109-80-3STATbronchial diseasescoughbronchospasmanti-inflammatoryInhibitorinhibitorinhibit

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