2. JAK/STAT Signaling Stem Cell/Wnt
  3. STAT
  4. Butamirate

Butamirate is an orally active antitussive agent that acts centrally through the receptors in the brainstem. Butamirate also reduces the resistance in the airways by inhibiting bronchospasm and anti-inflammatory effect. Butamirate inhibits glioblastoma (GBM) growth and STAT3 activity. Butamirate can be used for the study of glioblastoma.

For research use only. We do not sell to patients.

Butamirate Chemical Structure

Butamirate Chemical Structure

CAS No. : 18109-80-3

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Based on 1 publication(s) in Google Scholar

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Butamirate Related Antibodies

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Description

Butamirate is an orally active antitussive agent that acts centrally through the receptors in the brainstem. Butamirate also reduces the resistance in the airways by inhibiting bronchospasm and anti-inflammatory effect. Butamirate inhibits glioblastoma (GBM) growth and STAT3 activity. Butamirate can be used for the study of glioblastoma[1][2].

In Vitro

Butamirate (0.01-10 μM; 7 days) could effectively suppress sphere formation and STAT3 activity[2].
Butamirate effectively inhibits interactions of RRAD with pSTAT3[2].
Butamirate shows decreased EGFR, STAT3, ERK and AKT phosphorylation in U87MG[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Butamirate Related Antibodies

Cell Viability Assay[2]

Cell Line: U87MG, U87MG-TMZ-resistant (U87 TMZR), U87MG-Lapatinib-resistant (U87 LAPAR) and T98G (TMZ resistant) tumorspheres
Concentration: 0.01-10 μM
Incubation Time: 7 days
Result: Effectively suppressed growth of glioblastoma cell lines, including U87MG-TMZR and U87MG-LAPAR.
In Vivo

Butamirate (2 mg/kg; intraperitoneal administration) suppresses tumor growth in a glioblastoma xenograft mouse model without significant adverse effects[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c nude mice (6- to 8 week-old) were subcutaneously injected with U87MG cells[2]
Dosage: 2 mg/kg
Administration: i.p; once a day; for 36 days.
Result: Inhibited tumor growth in a glioblastoma mouse xenograft model.
Clinical Trial
Molecular Weight

307.43

Formula

C18H29NO3
CAS No.
SMILES

O=C(C(C1=CC=CC=C1)CC)OCCOCCN(CC)CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Butamirate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Butamirate18109-80-3STATbronchial diseasescoughbronchospasmanti-inflammatoryInhibitorinhibitorinhibit

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