2. Anti-infection NF-κB Apoptosis
  3. Antibiotic Bacterial NF-κB Apoptosis
  4. Tylvalosin

Tylvalosin  (Synonyms: Acetylisovaleryltylo​sin)

Cat. No.: HY-128423A Purity: 99.00%
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Tylvalosin (Acetylisovaleryltylo?sin) is an orally active, broad-spectrum macrolide antibiotic with antimicrobial activity. Tylvalosin is an antiviral agent used to study PRRSV infection. Tylvalosin induces apoptosis. Tylvalosin also has anti-inflammatory activity, alleviates oxidative stress, and alleviates acute lung injury by inhibiting NF-κB activation.

For research use only. We do not sell to patients.

Tylvalosin

Tylvalosin Chemical Structure

CAS No. : 63409-12-1

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Based on 2 publication(s) in Google Scholar

Other Forms of Tylvalosin:

Tylvalosin Related Antibodies

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Description

Tylvalosin (Acetylisovaleryltylo?sin) is an orally active, broad-spectrum macrolide antibiotic with antimicrobial activity. Tylvalosin is an antiviral agent used to study PRRSV infection. Tylvalosin induces apoptosis. Tylvalosin also has anti-inflammatory activity, alleviates oxidative stress, and alleviates acute lung injury by inhibiting NF-κB activation[1][2][3].

In Vitro

Tylvalosin (10 μg/mL; 0.5, 1 h) increases caspase-3 cleavage in porcine neutrophils, leading to DNA fragmentation during apoptosis[4].
Tylvalosin (0.1-10 μg/mL; 0.5 h) promotes endocytosis of porcine neutrophils by macrophages without changing phagocytosis[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tylvalosin Related Antibodies

Apoptosis Analysis[4]

Cell Line: Porcine neutrophils
Concentration: 0.1, 1.0, or 10 µg/mL
Incubation Time: 0.5, 1 h
Result: Resulted induction of concentration- and time-dependent apoptosis in porcine monocyte-derived macrophages.
In Vivo

Tylvalosin tartrate (160 mg/kg; po; 7 d) can reduce the stress state of pigs during the immunization process with PRRSV inactivated vaccine and improve the health of pig[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: PRRSV-free commercial breed piglets[5]
Dosage: 800 mg/kg Aivlosin (20% Tylvalosin Tartrate Premix)
Administration: po; 7-14 days
Result: Attenuated the increase in total white blood cells induced by immunization at day one post-immunization (DPI) and induced an increase in monocyte counts after seven DPI.
Attenuate the reduction in the percentage of CD8+ T cells induced by PRRSV-inactivated vaccine immunization at seven DPI.
Molecular Weight

1042.25

Formula

C53H87NO19
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1[C@@H](C)O[C@@H](OC[C@H]([C@@H](CC)OC(C[C@@H](OC(C)=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@@H]3O[C@@H](C)[C@H](OC(CC(C)C)=O)[C@@](O)(C)C3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@H]4C)=O)/C=C(C)/C=C/C4=O)[C@H](OC)[C@@H]1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (95.95 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9595 mL 4.7973 mL 9.5946 mL
5 mM 0.1919 mL 0.9595 mL 1.9189 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9595 mL 4.7973 mL 9.5946 mL 23.9866 mL
5 mM 0.1919 mL 0.9595 mL 1.9189 mL 4.7973 mL
10 mM 0.0959 mL 0.4797 mL 0.9595 mL 2.3987 mL
15 mM 0.0640 mL 0.3198 mL 0.6396 mL 1.5991 mL
20 mM 0.0480 mL 0.2399 mL 0.4797 mL 1.1993 mL
25 mM 0.0384 mL 0.1919 mL 0.3838 mL 0.9595 mL
30 mM 0.0320 mL 0.1599 mL 0.3198 mL 0.7996 mL
40 mM 0.0240 mL 0.1199 mL 0.2399 mL 0.5997 mL
50 mM 0.0192 mL 0.0959 mL 0.1919 mL 0.4797 mL
60 mM 0.0160 mL 0.0800 mL 0.1599 mL 0.3998 mL
80 mM 0.0120 mL 0.0600 mL 0.1199 mL 0.2998 mL
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Tylvalosin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tylvalosin63409-12-1Acetylisovaleryltylo​sinAntibioticBacterialNF-κBApoptosisNuclear factor-κBNuclear factor-kappaBinflammatoryPRRSV infectionantiviralacute lung injuryporcine neutrophilsmacrophagesInhibitorinhibitorinhibit

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