2. NF-κB Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Cell Cycle/DNA Damage Immunology/Inflammation
  3. Keap1-Nrf2 PPAR Interleukin Related
  4. CF-Carvacrol

CF-Carvacrol is an orally active lipid-lowering agent synthesized by merging the pharmacophores of Carvacrol (HY-N0711) and Clofibric acid (HY-B1415). CF-Carvacrol has a good affinity for PPAR-α. CF-Carvacrol has significant hypolipidemic activity and may exert antioxidant and anti-inflammatory activity by activating the Nrf2/HO-1 signaling pathway to reduce liver injury. CF-Carvacrol can be used for the study of CF-induced liver damage.

For research use only. We do not sell to patients.

CF-Carvacrol

CF-Carvacrol Chemical Structure

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CF-Carvacrol Related Antibodies

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Description

CF-Carvacrol is an orally active lipid-lowering agent synthesized by merging the pharmacophores of Carvacrol (HY-N0711) and Clofibric acid (HY-B1415). CF-Carvacrol has a good affinity for PPAR-α. CF-Carvacrol has significant hypolipidemic activity and may exert antioxidant and anti-inflammatory activity by activating the Nrf2/HO-1 signaling pathway to reduce liver injury. CF-Carvacrol can be used for the study of CF-induced liver damage[1].

In Vivo

CF-Carvacrol (46.3-185.2 mg/kg (0.1335-0.534 mmol/kg), i.g. daily, 7 days) demonstrates a significant and dose-dependent lipid-lowering effect in hyperlipidemic Kunming (KM) mice[1].
CF-Carvacrol (572.3 g/kg (1.65 mol/kg), i.g. daily, a month) decreases AST, ALT, and AKP levels in mouse plasma, mitigates oxidative stress and inflammation, and ameliorates liver tissue morphology in KM mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Hyperlipidemic KM mice induced by Triton WR 1339 (20 g)[1]
Dosage: 46.3, 92.6, 185.2 mg/kg
Administration: i.g. daily for 7 days
Result: Demonstrated notable efficacy in reducing lipid levels and showed reductions in TG levels by 37.5 % (185.2 mg/kg), 24.58 % (92.6 mg/kg ), and 19.31 % (46.3 mg/kg).
Animal Model: KM mice (20 g)[1]
Dosage: 572.3 g/kg
Administration: i.g. daily for a month
Result: Increased the liver weight and showed lower hepatic injury compared with clofibrate (CF).
Decreased ALT and AKP levels.
Elevated the levels of plasma SOD and GSH.
Elicited minimal oxidative stress response.
Decreased TNF-α and IL-6 levels compared to the CF group.
Showed no central venous congestion and extensive infiltration of inflammatory cells.
Upregulated the expression of Nrf2 and HO-1 proteins.
Molecular Weight

346.85

Formula

C20H23ClO3
SMILES

CC(C1=CC(OC(C(C)(OC2=CC=C(C=C2)Cl)C)=O)=C(C=C1)C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CF-Carvacrol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CF-CarvacrolKeap1-Nrf2PPARInterleukin RelatedPeroxisome proliferator-activated receptorsILNrf2/HO-1Carvacrol-clofibrateHypolipidemicHepatoprotectionAntioxidationAnti-inflammationInhibitorinhibitorinhibit

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