Meglumine (GMP Like)  (Synonyms: Methylglucamine (GMP Like); Meglumin (GMP Like); Methylglucamin (GMP Like))

Meglumine (GMP Like) (Methylglucamine (GMP Like)) is the GMP Like class Meglumine (HY-B0342) that can be used as pharmaceutical excipients. Meglumine (Methylglucamine) is an orally active amino sugar derived from sorbitol. Meglumine has anti-inflammatory and antitumor activity. Meglumine is often used as an excipient in active molecules and with iodinated compounds in contrast agents such as meglumine and meglumine iodide^[1][2][3].

Meglumine (GMP Like) (40 or 80 mM, 24 h; 50 mM, 24 h) dose-dependently reduces the levels of inflammatory factors in THP-1 human myeloid cells and RAW264.7 mouse macrophage cells (Elisa assay)^[2].
Meglumine (GMP Like) (0-300 mM, 60 min) dose-dependently increases SNARK expression levels in C2C12 mouse myoblasts^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Meglumine (GMP Like) (25 or 50 mM; 37.5 mM, taken orally dissolved in water) reduces levels of inflammatory factors and inhibits skin cancer tumor growth in rats and mice^[2].
Meglumine (GMP Like) (18 mM, oral gavage) improves muscle function, limits metabolic syndrome, and reduces diabetic complications in type 2 diabetic mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

195.21

Methylglucamine (GMP Like); Meglumin (GMP Like); Methylglucamin (GMP Like)

C₇H₁₇NO₅

6284-40-8

O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)CNC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. de Souza ALR, et al. Meglumine-based supra-amphiphile self-assembled in water as a skin drug delivery system: Influence of unfrozen bound water in the system bioadhesiveness. Colloids Surf B Biointerfaces. 2019 Dec 1;184:110523.  [Content Brief]

  [2]. Manley K, et al. Preclinical study of the long-range safety and anti-inflammatory effects of high-dose oral meglumine. J Cell Biochem. 2019 Jul;120(7):12051-12062.   [Content Brief]

  [3]. Guo R Y, et al. Meglumine promoted one-pot, four-component synthesis of pyranopyrazole derivatives. Tetrahedron, 2013, 69(47): 9931-9938.

  [4]. Bravo-Nuevo A, et al. Meglumine exerts protective effects against features of metabolic syndrome and type II diabetes. PLoS One. 2014 Feb 27;9(2):e90031.  [Content Brief]